AutismKB 2.0

Annotation Detail for ADSS


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Basic Information Top
Gene Symbol:ADSS ( ADEH,MGC20404 )
Gene Full Name: adenylosuccinate synthase
Band: 1q44
Quick LinksEntrez ID:159; OMIM: 103060; Uniprot ID:PURA2_HUMAN; ENSEMBL ID: ENSG00000035687; HGNC ID: 292
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-841purine nucleotides de novo biosynthesis II
Pathway IDPathway Name
hsa00250Alanine, aspartate and glutamate metabolism
hsa00230Purine metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of nucleotides
No data
Pathway IDPathway Name
P02738De novo purine biosynthesis
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ADSS mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of ADSS mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of ADSS mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in decreased expression of ADSS proteindecreases expression 19364129
D002995 Clofibric Acid Clofibric Acid affects the expression of ADSS mRNAaffects expression 17602206
D016572 Cyclosporine Cyclosporine results in increased expression of ADSS mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ADSS mRNAincreases expression 17942748
D005472 Fluorouracil Fluorouracil results in decreased expression of ADSS mRNAdecreases expression 16709241
D005472 Fluorouracil Fluorouracil results in increased expression of ADSS proteinincreases expression 16803524
15585135
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of ADSS mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of ADSS mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of ADSS mRNAincreases expression 18301758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.686195326
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma arsenic trioxide 7.3119825857 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.3114692618
MESH:D000230 Adenocarcinoma Fluorouracil 7.3117638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.843712494
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.9317620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.9316434500
MESH:D000740 Anemia Fluorouracil 3.8716511603 17963324 15504547
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.2811289319 1440618
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.5816206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.5819483382
MESH:D001943 Breast Neoplasms Fluorouracil 2.4615136595 16557594 19217205 16110121 16595493 18608205 18357371
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5111589617
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9316051944
MESH:D002277 Carcinoma Fluorouracil 3.7017121937
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.7216705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 11.727296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.723084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 11.7211135700 16217749 15553829 15073043 14691202
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 11.7216332177 17088986 17045692 16799960 17971768 18930000
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 11.726705139 17173139 20007298 20935162 1701930
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1419014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.747296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.7418695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2812490120
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5316280240 18986760 16757204 17066447
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.826135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.827505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.8212371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.474080065
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 20.289022650 19486331
MESH:D002779 Cholestasis Cyclosporine 20.2819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 20.2817681005 11677210 17110522 16919318 17333356 15861022 16105132
MESH:D002779 Cholestasis pirinixic acid 20.2819176532
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2617016597 15001691 16340194 16510598 17169374 18772588 17172411 17725105 17018589 17287894
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5820501625
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.5815148649 17016601 16524972 18949393 17695437 17594712 16391804 18288408 18802399 17255274 16282729 17094418 18448328 18509181 20501625 16331619 15289873 17401013 14970324 18383874 17454858 16303861
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.2318551238
MESH:D007644 Darier Disease Fluorouracil 5.0316733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2815213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.018156756 11906362 11298694 14531868 18759878 12868966 8970840 2524372
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.672952479 3621924
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.4321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.439328219 16192314 6679447 18648102 11289319 1440618 18289764 8291058 18692083 7440962 6482804 9653073 9022650
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4314725611 10774834 16781746 19420014 12958197 16227642 12705907 19164858 15968718 19085960 18071297 11834606 11461765 19370779 17522070 12594235 19416960 16485898 11421492 16081117 15619225 16177239 11739529 17562736 17906064 14986274 11287661 12392966 19739265 16393943 18713872 16109766 12153990 14550746 19923254 10663392 11529661 10915739 2444490 11743745 12540782
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004421 Dystonia Phenobarbital 4.191851702
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3812538720
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.323659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.143922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.696401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.477750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.263659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.503581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.5012903497
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.5017638652 16337965 16481741 15173087 16785472
MESH:D005234 Fatty Liver arsenic trioxide 20.2315073043
MESH:D005234 Fatty Liver Cyclosporine 20.2319224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.2315345470
MESH:D005234 Fatty Liver pirinixic acid 20.2319236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005355 Fibrosis Cyclosporine 3.3612639820 12168785
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4616904648
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D005910 Glioma Fluorouracil 2.9316145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5018337622 15102660 15162350
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.716705139
MESH:D006529 Hepatomegaly Phenobarbital 9.2116109766
MESH:D006529 Hepatomegaly pirinixic acid 9.2118467677 19772884 16221962 19176532
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D006973 Hypertension Cyclosporine 2.1510903974
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5917937319
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.288074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1015629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.108314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 18.9916705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 18.996582329
MESH:D007680 Kidney Neoplasms Cyclosporine 18.9912371664
MESH:D007680 Kidney Neoplasms Fluorouracil 18.9916985049
MESH:D007938 Leukemia arsenic trioxide 2.9115070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9717077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9319077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1616467208 16968895 17050201 20471514 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.329834237 15622746 16330433 19225113 15336539 16823087 12018890 15213294 19035177 17869043 15748426 12679006 16331271 16966277 17217047 16891316 12712474 11161223 19075265 17649720 16112521 17107899 19642359 17712046 11468182
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5516882451
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9821047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.309327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Acetaminophen 4.0616610002 19460945 16611625 19784758 11587558 19014921 12587719 12969438
MESH:D008107 Liver Diseases Phenobarbital 4.0619363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 18.777678174
MESH:D008113 Liver Neoplasms arsenic trioxide 18.7714682389
MESH:D008113 Liver Neoplasms Clofibric Acid 18.7717602206
MESH:D008113 Liver Neoplasms Fluorouracil 18.7717045692 15113037 18383874 16603448
MESH:D008113 Liver Neoplasms Phenobarbital 18.7721047994 15975961 19073162 19482888 19812893 8742319
MESH:D008113 Liver Neoplasms pirinixic acid 18.7720007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.992876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.996587162 3712494 598648 1399818
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 14.9920377131
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 14.9917172636 2563599 1399818 18308698 6150874
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4815213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.6211798837 19825857
MESH:D008175 Lung Neoplasms Fluorouracil 2.6215246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0315086387
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7616757204 18986760
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2214977855 11468182 19417148 19549372 15949261
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2316105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7117484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.1018551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1616624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.533581430
MESH:D009369 Neoplasms Fluorouracil 5.2418600527 16928823 18239605
MESH:D009369 Neoplasms pirinixic acid 5.2417405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.616679447
MESH:D009436 Neural Tube Defects arsenic trioxide 7.6110525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5516436463
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.4316049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.436482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010018 Osteomalacia Phenobarbital 4.6017016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4519769630 16624393 12452020
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.9715580305
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.9715113037 16929163 16500647 19003803
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.9716965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010235 Paraganglioma arsenic trioxide 4.3519927285
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D011230 Precancerous Conditions Cyclosporine 9.4812371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.482563599
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.3019131511
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3019082440 18626508
MESH:D011537 Pruritus Ethinyl Estradiol 3.5516919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.7612752131
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1615538739 18722050 16160472 18286688
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.503692021
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1616646077
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3118551238
MESH:D012640 Seizures Phenobarbital 6.3111442880 16876388 3137016 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.066407741
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.5717007042
MESH:D013274 Stomach Neoplasms Fluorouracil 2.5717172411 17522103 17498489 19015929 18567086 16424979 19084572 18396642 15786421 16951190
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 12.746587162 6582329 7505956 3712494 1399818
MESH:D013964 Thyroid Neoplasms arsenic trioxide 12.7419014326
MESH:D013964 Thyroid Neoplasms Phenobarbital 12.741399818
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1516280240
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2015213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.6616049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.668074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.6612973940 20435036 11780464 12845720
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5610091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0416803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7115869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
KEGG:00250 Alanine, aspartate and glutamate metabolism
KEGG:01100 Metabolic pathways
REACT:1698 Metabolism of nucleotides
KEGG:00230 Purine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24601
    • No data
    No data
    Releated drug ID Related drug Name
    PA449167cyclosporine
    PA451578tacrolimus
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00128 - L-Aspartic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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