AutismKB 2.0

Annotation Detail for CYP27B1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CYP27B1 ( CP2B,CYP1,CYP1alpha,CYP27B,P450c1,PDDR,VDD1,VDDR,VDDRI,VDR )
Gene Full Name: cytochrome P450, family 27, subfamily B, polypeptide 1
Band: 12q14.1
Quick LinksEntrez ID:1594; OMIM: 609506; Uniprot ID:CP27B_HUMAN; ENSEMBL ID: ENSG00000111012; HGNC ID: 2606
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-60761,25-dihydroxyvitamin D3 biosynthesis
Pathway IDPathway Name
hsa01100Metabolic pathways
hsa00100Steroid biosynthesis
Pathway IDPathway Name
Hormone biosynthesis
Metabolism of vitamins and cofactors
Metabolism of lipids and lipoproteins
Biological oxidations
No data
Pathway IDPathway Name
P04396Vitamin D metabolism and pathway
Pathway IDPathway Name
500600Vitamin D (calciferol) metabolism
500202Vitamins
Related Diseases/Disorders Top
Desease IDDesease Name
Metabolic diseases
Diabetes
H00408Type I diabetes mellitus
Desease IDDesease Name
1807Autoimmune disease
1831Prostate cancer
1897Seminoma
1904Diabetes mellitus
1944Breast cancer
1961Endometrium cancer
2066Lung cancer
2138Osteoporosis
Desease Name
CARDIOVASCULAR
diabetes, type 1
thyroiditis, chronic lymphocytic
hypertension
multiple sclerosis
IMMUNE
Graves' disease
Heart Failure
Addison's disease
No data
Desease Name
Vitamin D-dependent rickets, type I
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C097949 1,25-dihydroxyvitamin D CYP27B1 protein results in increased activity of 1,25-dihydroxyvitamin Dincreases activity 15781002
C482452 1-(4-(4-(4-((4-(2,4-difluorophenyl)-4-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-2-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-3-(1-methylethyl)-2-imidazolidinone 1-(4-(4-(4-((4-(2,4-difluorophenyl)-4-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-2-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-3-(1-methylethyl)-2-imidazolidinone results in decreased activity of CYP27B1 proteindecreases activity 15328084
C104450 25-hydroxyvitamin D CYP27B1 protein promotes the reaction [25-hydroxyvitamin D results in increased expression of TRPV6 mRNA]increases expression|increases reaction 16362534
D000082 Acetaminophen Acetaminophen affects the expression of CYP27B1 mRNAaffects expression 17562736
D013196 Dihydrotestosterone Dihydrotestosterone affects the expression of CYP27B1 mRNAaffects expression 17659868
C004541 biochanin A biochanin A affects the activity of CYP27B1 proteinaffects activity 17659868
C004541 biochanin A biochanin A affects the expression of CYP27B1 mRNAaffects expression 17659868
C004541 biochanin A biochanin A analog affects the expression of CYP27B1 mRNAaffects expression 17659868
C004541 biochanin A biochanin A analog results in increased activity of CYP27B1 proteinincreases activity 15795327
C004541 biochanin A biochanin A analog results in increased expression of CYP27B1 mRNAincreases expression 15795327
C004541 biochanin A biochanin A results in increased activity of CYP27B1 proteinincreases activity 15795327
C004541 biochanin A biochanin A results in increased expression of CYP27B1 mRNAincreases expression 15795327
D002118 Calcium Calcium affects the expression of CYP27B1 mRNAaffects expression 15913539
D002136 Calcium, Dietary Calcium, Dietary affects the expression of CYP27B1 mRNAaffects expression 15905206
D016572 Cyclosporine Cyclosporine results in increased expression of CYP27B1 mRNAincreases expression 20106945
D003907 Dexamethasone Dexamethasone affects the activity of CYP27B1 proteinaffects activity 10694374
D003907 Dexamethasone Dexamethasone affects the expression of CYP27B1 mRNAaffects expression 10694374
D002117 Calcitriol Calcitriol results in increased expression of CYP27B1 mRNAincreases expression 16061850
D002117 Calcitriol Calcitriol affects the expression of CYP27B1 proteinaffects expression 11796525
D002117 Calcitriol CYP27B1 protein affects the abundance of Calcitriolaffects abundance 12846736
D002117 Calcitriol GH1 protein affects the reaction [CYP27B1 protein affects the abundance of Calcitriol]affects abundance|affects reaction 11316734
D002117 Calcitriol CYP27B1 protein affects the chemical synthesis of Calcitriolaffects chemical synthesis 15816500
D004317 Doxorubicin Doxorubicin results in increased expression of CYP27B1 mRNAincreases expression 17716971
D004958 Estradiol Estradiol affects the activity of CYP27B1 proteinaffects activity 17659868
D004958 Estradiol Estradiol affects the expression of CYP27B1 mRNAaffects expression 17659868
D004958 Estradiol Estradiol results in increased activity of CYP27B1 proteinincreases activity 15795327
D005047 Etoposide Etoposide results in increased expression of CYP27B1 mRNAincreases expression 17716971
D005419 Flavonoids Flavonoids results in increased expression of CYP27B1 mRNAincreases expression 18035473
D019833 Genistein Genistein affects the activity of CYP27B1 proteinaffects activity 17659868
D019833 Genistein Genistein affects the expression of CYP27B1 mRNAaffects expression 17659868
D019833 Genistein Genistein results in increased activity of CYP27B1 proteinincreases activity 15795327
D019833 Genistein Genistein results in increased expression of CYP27B1 mRNAincreases expression 15795327
D002112 Calcifediol CYP27B1 protein affects the metabolism of Calcifediolaffects metabolic processing 16061850
D002112 Calcifediol CYP27B1 protein affects the metabolism of Calcifediolaffects metabolic processing 16061850
D017964 Itraconazole Itraconazole results in decreased activity of CYP27B1 proteindecreases activity 15328084
D007654 Ketoconazole Ketoconazole results in decreased activity of CYP27B1 proteindecreases activity 16483768
C093973 PD 98059 PD 98059 inhibits the reaction [FGF23 protein results in decreased expression of CYP27B1 mRNA]decreases expression|decreases reaction 17699549
D010710 Phosphates Phosphates affects the activity of CYP27B1 proteinaffects activity 15265826
D010710 Phosphates Phosphates affects the expression of CYP27B1 mRNAaffects expression 15265826
D010710 Phosphates Phosphates affects the expression of CYP27B1 proteinaffects expression 15265826
D010758 Phosphorus Phosphorus affects the reaction [FGF23 protein results in decreased expression of CYP27B1 mRNA]affects reaction|decreases expression 17699549
D016226 Phosphorus, Dietary Phosphorus, Dietary affects the activity of CYP27B1 proteinaffects activity 12865326
D016226 Phosphorus, Dietary Phosphorus, Dietary results in increased expression of CYP27B1 mRNAincreases expression 16123154
D016226 Phosphorus, Dietary Phosphorus, Dietary affects the expression of CYP27B1 mRNAaffects expression 11316734
15877868
D016226 Phosphorus, Dietary Phosphorus, Dietary affects the expression of CYP27B1 proteinaffects expression 11316734
D011374 Progesterone Progesterone results in decreased expression of CYP27B1 mRNAdecreases expression 17404688
D020849 Raloxifene Raloxifene results in increased expression of CYP27B1 mRNAincreases expression 15795327
C446685 systhane systhane results in increased expression of CYP27B1 mRNAincreases expression 16643972
D013629 Tamoxifen Tamoxifen results in decreased expression of CYP27B1 mRNAdecreases expression 15590111
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CYP27B1increases expression 19367694
C032910 triadimefon triadimefon results in increased expression of CYP27B1 mRNAincreases expression 16643972
D014501 Uranium Uranium results in increased expression of CYP27B1 mRNAincreases expression 16502312
D002762 Cholecalciferol CYP27B1 protein affects the metabolism of Cholecalciferolaffects metabolic processing 15816500
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2514745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5611752688 14514962 15322242
MESH:D000230 Adenocarcinoma Doxorubicin 6.7017418594
MESH:D000230 Adenocarcinoma Estradiol 6.7011473722
MESH:D000230 Adenocarcinoma Genistein 6.7011473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.0816835633
MESH:D000419 Albuminuria Doxorubicin 10.5221441931
MESH:D000419 Albuminuria Raloxifene 10.5217308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.4815800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6911748828
MESH:D000799 Angioedema Acetaminophen 3.5410982225
MESH:D001169 Arthritis, Experimental Dexamethasone 3.3617659584
MESH:D001321 Autistic Disorder Acetaminophen 1.4518445737
MESH:D001327 Autoimmune Diseases Cholecalciferol 4.7416142846
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.7812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5815746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 11.1614601052
MESH:D019046 Bone Marrow Neoplasms Etoposide 11.1614601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0417868700
MESH:D001930 Brain Injuries Progesterone 10.0015665606 15845082 15380490
MESH:D001930 Brain Injuries Raloxifene 10.0016580743
MESH:D001932 Brain Neoplasms Doxorubicin 3.5617150277
MESH:D001943 Breast Neoplasms Calcitriol 5.5211237771
MESH:D001943 Breast Neoplasms Doxorubicin 5.5218628466 18382427 18695136 17426702 19526202 17369602 15136595 16826403 16096432 15994142 16264153 15567936 15939500 17983394 18234424 15634643 16115903 15692762 16935488 16595493 15668708 15993339 16322301 11325840
MESH:D001943 Breast Neoplasms Estradiol 5.5217289903 16675129 17261762 14630087 19861407 12948864 18497071 17018787
MESH:D001943 Breast Neoplasms Etoposide 5.5216322251
MESH:D001943 Breast Neoplasms Genistein 5.5216873071 17200150 16541309
MESH:D001943 Breast Neoplasms Progesterone 5.5216175315 15562024 17614352
MESH:D001943 Breast Neoplasms Raloxifene 5.5217952589 15758505 17049068 16912660 15775269 15572757 16837676 17893378 17595753 17440819 17242785 17261762
MESH:D001943 Breast Neoplasms Tamoxifen 5.5219410462 20065188 19288272 16818667 19289846 18821012 16273361 17242785 18425577 19189210 21138602 16202921 20390343 19221464 20859285 17893378 17261762 18351453 18984771 18855134 20005174 19244106 17049068 19084267 19487384 19059307 19103187 20544844 16873071 18997820 21152245 18629630 17440819 19066611 19200415 19142967 15565566 18815881 15668708 19189212 19115204 11161223 20135344 19155303 19011961
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.5220435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1716111702
MESH:D002276 Carcinoid Tumor Doxorubicin 4.5116051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5716835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2219066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.323084413
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 8.3216234567 18059187 17876044 16023760
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.3216924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 8.3216924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.3216924424
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.021485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.6011237771
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 4.606189445
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.6517572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.6517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2118850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.3416278810 16651473 15811867 16731534 16612575 16364871 17007740 17131338 15792986 17329180 16455267 17519947 17382496 17308081 16242529 15476868 16952015 15505089 16269455 16109756 17351982 17928571 17924179 17974986 18627295
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8416243910 17334414
MESH:D002318 Cardiovascular Diseases Genistein 6.8316332659
MESH:D002318 Cardiovascular Diseases Raloxifene 6.8315775269
MESH:D002386 Cataract Acetaminophen 2.4110977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 5.9112371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 5.9118566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9216835633
MESH:D002779 Cholestasis Cyclosporine 2.7019486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.738697196 16354765 15340226 12621046 15668235
MESH:D002972 Cleft Palate triadimefon 5.7316781842
MESH:D003072 Cognition Disorders Raloxifene 4.3315800139
MESH:D003110 Colonic Neoplasms Calcium, Dietary 5.8217182828
MESH:D003110 Colonic Neoplasms Dexamethasone 5.8215824018
MESH:D003110 Colonic Neoplasms Genistein 5.8217182828
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418802399 18259882
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8117141729 14669216
MESH:D019465 Craniofacial Abnormalities Dexamethasone 3.7617728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7615322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities triadimefon 3.7615834900 16875885
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0719031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9217474826
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.1312438553
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.0716647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0717107852
MESH:D003928 Diabetic Nephropathies Estradiol 13.6019279558
MESH:D003928 Diabetic Nephropathies Raloxifene 13.6015920148 17308373 17451421
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.6019279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.2017187935
MESH:D003967 Diarrhea Dexamethasone 3.427237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.2612705907 16485898 10663392 15619225 16781746 10774834 18713872 12153990 18071297 11743745 19416960 11529661 14725611 12540782 11461765 11739529 11421492 12392966 17906064 16393943 19923254 19370779 11834606 14550746 11287661 17562736 16227642 16081117 16177239 19739265 2444490 16109766 14986274 10915739 19085960 12594235 17522070 19164858 19420014 15968718 12958197
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 8.2617416283
MESH:D056486 Drug-Induced Liver Injury Ketoconazole 8.2618289764
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.2620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8019426721
MESH:D004362 Drug Toxicity Doxorubicin 7.3918602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.3911462148
MESH:D004485 Eczema Dexamethasone 4.1812438553
MESH:D004487 Edema Dexamethasone 10.0419703484
MESH:D004487 Edema Raloxifene 10.0415860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.0411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6018230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 19.6515138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 19.6517692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 19.6515845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 19.6519031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.2916402032
MESH:D016889 Endometrial Neoplasms Doxorubicin 16.2217359293
MESH:D016889 Endometrial Neoplasms Estradiol 16.2219148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Genistein 16.2211473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 16.2216202921 20544844 17893378 19155303
MESH:D004715 Endometriosis Progesterone 8.0816134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.0810568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.8618037988
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8011564622
MESH:D005234 Fatty Liver Cyclosporine 11.6419224547
MESH:D005234 Fatty Liver Raloxifene 11.6417473493
MESH:D005234 Fatty Liver Tamoxifen 11.6414986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0616709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2314745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 10.4519069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 10.4519069698
MESH:D005355 Fibrosis Cyclosporine 7.5212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.5220067830
MESH:D005756 Gastritis Acetaminophen 3.3816983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.928708960
MESH:D005909 Glioblastoma biochanin A 11.0216598420
MESH:D005909 Glioblastoma Doxorubicin 11.0217150277
MESH:D005909 Glioblastoma Genistein 11.0216598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2910696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.3315692506
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1811294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 7.1717888722 16330681 16144979 18674790 12587719 16244372 16244371 17875725 16495754 14766674 18006777 16707910 16879835
MESH:D006331 Heart Diseases Raloxifene 7.1711110106
MESH:D006333 Heart Failure 25-hydroxyvitamin D 7.6817162251
MESH:D006333 Heart Failure Doxorubicin 7.6817481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.6415692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0711000095
MESH:D006529 Hepatomegaly systhane 13.0917178688 17178689
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.0912621046 15340226 16120746
MESH:D006529 Hepatomegaly triadimefon 13.0917178688 17178689
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.977520565
MESH:D006558 Herpes Genitalis Estradiol 4.7315709030
MESH:D006561 Herpes Simplex Etoposide 4.2710809021
MESH:D006689 Hodgkin Disease Doxorubicin 6.9318501091 17606976 15147373
MESH:D006689 Hodgkin Disease Etoposide 6.9318180244 15147373 16135485 16200630 17606976
MESH:D019584 Hot Flashes Estradiol 3.4517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7516354765 16959395 15340226 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.4716870215
MESH:D006973 Hypertension Cyclosporine 11.4310903974
MESH:D006973 Hypertension Dexamethasone 11.4317042910
MESH:D006973 Hypertension Raloxifene 11.4317577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.4318670907 18850075
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1115869954
MESH:D007249 Inflammation Dexamethasone 14.2211099482 8960868
MESH:D007249 Inflammation Flavonoids 14.2217296493
MESH:D007249 Inflammation Progesterone 14.2215869954
MESH:D007249 Inflammation Tamoxifen 14.2219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.2212200463 12878042
MESH:D007333 Insulin Resistance Estradiol 2.7816627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.4416580747
MESH:D007569 Jaw Abnormalities triadimefon 9.4415992940 15834900
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1415604871
MESH:D007674 Kidney Diseases Acetaminophen 13.0212587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 13.0218776723 10903974 8314463
MESH:D007674 Kidney Diseases Doxorubicin 13.0215699352 15369732 16775033
MESH:D007674 Kidney Diseases Estradiol 13.0215618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.8916707910
MESH:D007680 Kidney Neoplasms Cyclosporine 11.0012371664
MESH:D007680 Kidney Neoplasms Estradiol 11.0015610895
MESH:D007680 Kidney Neoplasms Tamoxifen 11.0018625569
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.7516316344
MESH:D007889 Leiomyoma Raloxifene 4.2216973256
MESH:D016773 Leishmaniasis, Cutaneous Itraconazole 8.8214988693 11528583
MESH:D016773 Leishmaniasis, Cutaneous Ketoconazole 8.8219744259 2166429 1311351 8889330
MESH:D007898 Leishmaniasis, Visceral Ketoconazole 4.3211332679
MESH:D007938 Leukemia Genistein 2.8818980019 17468513
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.8616085563
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 4.9316972261
MESH:D008064 Lipidoses Ketoconazole 7.6117567588
MESH:D008064 Lipidoses Tamoxifen 7.6115342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 8.2116718785
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 8.2116595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.2114659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.2117823541
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.2118564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.2112878042
MESH:D008107 Liver Diseases Acetaminophen 4.0416611625 12969438 12587719 19784758 19460945 19014921 16610002 11587558
MESH:D008107 Liver Diseases triadimefon 4.0419363144
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9816871587 17185352
MESH:D008113 Liver Neoplasms Tamoxifen 6.8716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 6.8716984957
MESH:D008113 Liver Neoplasms triadimefon 6.8719028983
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 12.7316842330 17085340
MESH:D008114 Liver Neoplasms, Experimental systhane 12.7317178689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.7312151625
MESH:D008114 Liver Neoplasms, Experimental triadimefon 12.7317178689
MESH:D008175 Lung Neoplasms Dexamethasone 4.5615824018 11195469
MESH:D008175 Lung Neoplasms Doxorubicin 4.566189445 17418594
MESH:D008175 Lung Neoplasms Tamoxifen 4.5618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.5611884234 19555203
MESH:D008223 Lymphoma Doxorubicin 7.2216098063
MESH:D008223 Lymphoma Etoposide 7.2212854902 12556972
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.5517654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.2815621674
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4719428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 16.8215458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 16.8217203775 11408345 16891317 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 16.8214578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 16.8211408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 16.8211731420 16827153 14580682 19196723 19196722
MESH:D020149 Manganese Poisoning Estradiol 11.6519453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.6519453300
MESH:D008545 Melanoma Doxorubicin 3.2316827129
MESH:D008545 Melanoma Tamoxifen 3.2319393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2819513568
MESH:D001523 Mental Disorders Phosphates 4.7212686366
MESH:D008654 Mesothelioma Doxorubicin 2.9417638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4916801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.2315792986
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.2515863610
MESH:D052016 Mucositis Doxorubicin 4.4917415656
MESH:D009101 Multiple Myeloma Dexamethasone 6.8715867202 16118317 15744524
MESH:D009101 Multiple Myeloma Raloxifene 6.8716497877
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.379809623
MESH:D009203 Myocardial Infarction Doxorubicin 5.5615857846 19429709
MESH:D009203 Myocardial Infarction Genistein 5.5617141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7912213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.7716810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 7.7717141266
MESH:D009232 Myxoma Raloxifene 5.2516343187
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.4718259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.4719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4219410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7019200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4417289903
MESH:D009401 Nephrosis Doxorubicin 4.4816636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.4819348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.4815640375 16889571
MESH:D009421 Nervous System Malformations Estradiol 14.7411399458 16427766
MESH:D009421 Nervous System Malformations Genistein 14.7416427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.7414600291
MESH:D009447 Neuroblastoma Doxorubicin 3.1115555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6318514411
MESH:D014009 Onychomycosis Itraconazole 6.6219954708
MESH:D010024 Osteoporosis Calcium 10.9517882678
MESH:D010024 Osteoporosis Genistein 10.9519401787
MESH:D010024 Osteoporosis Raloxifene 10.9517882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.2416169203
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 9.2417823083 15758505 17893378 15579764
MESH:D012516 Osteosarcoma Doxorubicin 3.8815930896
MESH:D010051 Ovarian Neoplasms Estradiol 7.3519401270
MESH:D010051 Ovarian Neoplasms Genistein 7.3519005980
MESH:D010051 Ovarian Neoplasms Progesterone 7.3517393432 16525653
MESH:D010146 Pain Acetaminophen 2.1616870215
MESH:D010190 Pancreatic Neoplasms Etoposide 3.1619003803
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9512520081
MESH:D003557 Phyllodes Tumor Doxorubicin 4.8617983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.8617638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2818163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.9812371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.3821297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9011399792 11896295 11118676 11222880
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.4815572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6220887781
MESH:D011471 Prostatic Neoplasms biochanin A 4.0912111696
MESH:D011471 Prostatic Neoplasms Calcifediol 4.0916289102
MESH:D011471 Prostatic Neoplasms Calcitriol 4.0916289102 15754350 12479363 16644109 18247401
MESH:D011471 Prostatic Neoplasms Cholecalciferol 4.0917024972
MESH:D011471 Prostatic Neoplasms Doxorubicin 4.0915749863 18437689 16888761 15897917 16868541 16729912
MESH:D011471 Prostatic Neoplasms Estradiol 4.0916740699
MESH:D011471 Prostatic Neoplasms Etoposide 4.0917172428
MESH:D011471 Prostatic Neoplasms Genistein 4.0916925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms Ketoconazole 4.0917404083
MESH:D011471 Prostatic Neoplasms Raloxifene 4.0915731164 16536755 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 4.0915067354
MESH:D011565 Psoriasis Cyclosporine 2.1216882103
MESH:D011693 Purpura Raloxifene 5.2515770314
MESH:D051437 Renal Insufficiency Doxorubicin 3.9317922066
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.7518379247 11700416
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5618990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7518045962
MESH:D012509 Sarcoma Doxorubicin 3.7315625365 18313854 17710206 15675481 16767912 17203757
MESH:D012512 Sarcoma, Ewing's Doxorubicin 9.6214601052 16326096
MESH:D012512 Sarcoma, Ewing's Etoposide 9.6214601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.4917846226
MESH:D012878 Skin Neoplasms Doxorubicin 5.2215692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.2216192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.2815625365 17203757 16767912
MESH:D013088 Spermatocele Tamoxifen 3.9916709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.8915862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.8919457130
MESH:D013272 Stomach Diseases Dexamethasone 4.0315472012
MESH:D013276 Stomach Ulcer Dexamethasone 3.2315138204
MESH:D020521 Stroke Raloxifene 3.5916837676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6012697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 6.9717909728 16010429
MESH:D013964 Thyroid Neoplasms triadimefon 6.9717178689
MESH:D013978 Tibial Fractures Estradiol 12.7119048282
MESH:D013978 Tibial Fractures Raloxifene 12.7119048282
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 7.7317653716
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 7.7317572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 7.7316712894 17572228 8653321
MESH:D014581 Urticaria Acetaminophen 2.7110982225
MESH:D014605 Uveitis Cyclosporine 10.771336536
MESH:D014605 Uveitis Dexamethasone 10.771336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2912125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.9116837676
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.9316364871 17638931 17334414 17678736
OMIM:264700 VITAMIN D HYDROXYLATION-DEFICIENT RICKETS, TYPE 1A marker/mechanism
MESH:D014846 Vulvar Neoplasms Raloxifene 5.2516343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.1417120751
Pathway ID Pathway Name
REACT:13433 Biological oxidations
REACT:15314 Hormone biosynthesis
KEGG:01100 Metabolic pathways
REACT:22258 Metabolism of lipids and lipoproteins
REACT:11193 Metabolism of vitamins and cofactors
KEGG:00100 Steroid biosynthesis
KEGG:05152 Tuberculosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27099
    • No data
    Releated disease ID Related disease Name
    PA443450Asthma
    PA443879Dermatitis, Atopic
    PA444370Heart Failure
    PA444552Hypertension
    Releated drug ID Related drug Name
    PA448717calcitriol
    Drug Bank Top
    No data
    Drugbank ID Action Drug Name Description
    DB00146 substrate Calcidiol Antihypocalcemic Agents;Antihypoparathyroid Agents;Vitamins (Vitamin D);Bone Density Conservation Agents;Vitamins
    DB00153 substrate Timed Release Multi Vitamin with Chelated Minerals Essential Vitamin;Antihypocalcemic Agents;Antihypoparathyroid Agents;Vitamins (Vitamin D);Bone Density Conservation Agents;Vitamins
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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