AutismKB 2.0

Annotation Detail for DAB1


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Basic Information Top
Gene Symbol:DAB1 ( - )
Gene Full Name: disabled homolog 1 (Drosophila)
Band: 1p32.2
Quick LinksEntrez ID:1600; OMIM: 603448; Uniprot ID:DAB1_HUMAN; ENSEMBL ID: ENSG00000173406; HGNC ID: 2661
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200114Lissencephaly gene (LIS1) in neuronal migration and development
200051Reelin signaling pathway
No data
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Related Diseases/Disorders Top
No data
Desease IDDesease Name
1860Brain tumor
2035Brain disease
Desease Name
CHEMDEPENDENCY
smoking cessation
No data
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of DAB1 mRNAincreases expression 20127859
D003024 Clozapine Clozapine results in increased expression of DAB1 mRNAincreases expression 19359144
D005473 Fluoxetine Fluoxetine results in increased expression of DAB1 proteinincreases expression 19359144
D008628 Mercury Mercury results in increased expression of DAB1 mRNAincreases expression 16823088
C029938 nickel sulfate nickel sulfate results in increased expression of DAB1 mRNAincreases expression 16780908
C076029 olanzapine olanzapine results in decreased expression of DAB1 proteindecreases expression 19359144
C006253 pirinixic acid pirinixic acid results in decreased expression of DAB1 mRNAdecreases expression 17426115
C006253 pirinixic acid pirinixic acid results in increased expression of DAB1 mRNAincreases expression 18301758
D014635 Valproic Acid Valproic Acid results in decreased expression of DAB1 proteindecreases expression 19359144
D014635 Valproic Acid Valproic Acid results in increased expression of DAB1 mRNAincreases expression 19359144
D002762 Cholecalciferol Cholecalciferol results in increased expression of DAB1 mRNAincreases expression 17170073
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.778875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1319490988
MESH:D055371 Acute Lung Injury nickel sulfate 9.8911954676 16100012 19131640 12718980
MESH:D055371 Acute Lung Injury pirinixic acid 9.8918653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000380 Agranulocytosis Clozapine 5.3114617031 12649775 16160616
MESH:D000550 Amblyopia Valproic Acid 5.5517688650
MESH:D001008 Anxiety Disorders Fluoxetine 9.8818083778
MESH:D001008 Anxiety Disorders Valproic Acid 9.8817497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001321 Autistic Disorder marker/mechanism 15820235
MESH:D001321 Autistic Disorder Fluoxetine 2.9319232924 18775368
MESH:D001321 Autistic Disorder Mercury 2.9317497416
MESH:D001321 Autistic Disorder olanzapine 2.9318685284 17069543
MESH:D001321 Autistic Disorder Valproic Acid 2.9316609825 17507914 18396377 18316065 17157402 18985861 18177632 17688650 18940202 18558336 18775368 19460635 20603192 15238991 19232924
MESH:D001327 Autoimmune Diseases Cholecalciferol 12.1116142846
MESH:D001327 Autoimmune Diseases Mercury 12.1116634805
MESH:D001714 Bipolar Disorder Valproic Acid 3.1717594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.528888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0120146248 17474063
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.5110334427
MESH:D002389 Catatonia olanzapine 6.5716772815 18071103
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7720734317
MESH:D002779 Cholestasis pirinixic acid 2.9719176532
MESH:D003072 Cognition Disorders Clozapine 5.2217123785
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 8888407 16575769
MESH:D003866 Depressive Disorder Fluoxetine 4.7415014590
MESH:D017449 Dermatitis, Allergic Contact Mercury 8.3716823706
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 8.3711298694 16780908 16823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D002658 Developmental Disabilities olanzapine 4.8217069543
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 3.0116402076
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.8715331141
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.221733752 19641884
MESH:D050171 Dyslipidemias Clozapine 4.3316402076
MESH:D004421 Dystonia Valproic Acid 4.271851702
MESH:D004487 Edema Fluoxetine 7.9612798668
MESH:D004487 Edema pirinixic acid 7.9612083418
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.413659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.233922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0320417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.776426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.353659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0516530937
MESH:D005234 Fatty Liver pirinixic acid 8.4219236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 8.4214986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.2016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.3718558336 8888407
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7520471113
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006529 Hepatomegaly pirinixic acid 3.2519176532 16221962 18467677 19772884
MESH:D019584 Hot Flashes Fluoxetine 5.6314716179
MESH:D006849 Hydrocephalus Valproic Acid 5.1517688650
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006948 Hyperkinesis Clozapine 5.1916046005
MESH:D006963 Hyperphagia olanzapine 6.5117933447
MESH:D007249 Inflammation Fluoxetine 3.9412798668
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007674 Kidney Diseases Mercury 3.6717934191
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1817596541 16294345
MESH:D008064 Lipidoses Clozapine 9.1117567588
MESH:D008064 Lipidoses Fluoxetine 9.1115342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.5920195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 4.5920007298 15890375 16377806
MESH:D008133 Long QT Syndrome olanzapine 4.8820210726
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5817228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5620464547 20064080 18816296 17053015 18569708 6695378 20869020 20135361 18520028
MESH:D001523 Mental Disorders Clozapine 15.2716856516
MESH:D001523 Mental Disorders Fluoxetine 15.2716856516
MESH:D001523 Mental Disorders olanzapine 15.2716856516
MESH:D008659 Metabolic Diseases olanzapine 5.6019142110
MESH:D024821 Metabolic Syndrome X Clozapine 4.5819142101
MESH:D008881 Migraine Disorders Valproic Acid 3.3318765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.238888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2617596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009207 Myoclonus Fluoxetine 6.168041377
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1311141357
MESH:D009369 Neoplasms pirinixic acid 5.1317405874
MESH:D009436 Neural Tube Defects Valproic Acid 3.2516359493 8888407
MESH:D009765 Obesity Clozapine 7.9218515891 19142110
MESH:D009765 Obesity olanzapine 7.9218515891
MESH:D009765 Obesity pirinixic acid 7.9220558911
MESH:D009771 Obsessive-Compulsive Disorder Fluoxetine 5.6520418887
MESH:D010146 Pain Fluoxetine 4.5012798668
MESH:D020774 Pick Disease of the Brain Fluoxetine 6.268041377
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.1120603192
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.4817292933
MESH:D011471 Prostatic Neoplasms Cholecalciferol 3.4817024972
MESH:D019310 Pseudolymphoma Valproic Acid 4.8611422049 12752131
MESH:D011595 Psychomotor Agitation olanzapine 5.8418685284
MESH:D011618 Psychotic Disorders Clozapine 4.3315331141
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4019155313
MESH:D012559 Schizophrenia Clozapine 5.9617726453 16141801 20521326 18855531 11763009 19369910 20580759 17667964 20452607 20168265 18806925 17123785 20107430 11151749 20521320
MESH:D012559 Schizophrenia olanzapine 5.9617726453 20521326 20107430
MESH:D012559 Schizophrenia Valproic Acid 5.9615737665 19110320
MESH:D012640 Seizures Valproic Acid 2.873137016 11738929 1511512 15475178 11044598 17978042 16876388 14763951
MESH:D020230 Serotonin Syndrome Fluoxetine 6.218704074
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4519755658 10029692
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8612833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D017180 Tachycardia, Ventricular olanzapine 5.5720210726
MESH:D014178 Translocation, Genetic Valproic Acid 5.5517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.813119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2417053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.908888407
MESH:D015430 Weight Gain Clozapine 10.9717502770 16141801 20107430 16402076 20564506 20521320
MESH:D015430 Weight Gain olanzapine 10.9717933447 20107430 19434072
MESH:D015431 Weight Loss Clozapine 5.3617933447
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27131
    • No data
    No data
    Releated drug ID Related drug Name
    PA152241909PP2
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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