AutismKB 2.0

Annotation Detail for DAB2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DAB2 ( DOC-2,DOC2,FLJ26626 )
Gene Full Name: disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
Band: 5p13.1
Quick LinksEntrez ID:1601; OMIM: 601236; Uniprot ID:DAB2_HUMAN; ENSEMBL ID: ENSG00000153071; HGNC ID: 2662
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04144Endocytosis
Pathway IDPathway Name
Membrane Trafficking
Pathway IDPathway Name
200195TGF-beta receptor signaling
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
No data
Desease Name
Chronic kidney disease
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of DAB2 mRNAincreases expression 16788091
D000450 Aldosterone AGT protein affects the reaction [DAB2 protein results in increased secretion of Aldosterone]affects reaction|increases secretion 17303656
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DAB2 mRNAaffects expression 16483693
D001149 Arsenates Arsenates results in decreased expression of DAB2 mRNAdecreases expression 12773770
D001205 Ascorbic Acid Ascorbic Acid results in decreased expression of DAB2 mRNAdecreases expression 15305145
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of DAB2 mRNAdecreases expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of DAB2 mRNAincreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DAB2 mRNAdecreases expression 20018196
19150397
C095105 bexarotene bexarotene results in decreased expression of DAB2 mRNAdecreases expression 16648578
D019256 Cadmium Chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of DAB2 mRNAaffects cotreatment|decreases expression 12634122
C023600 chromium oxide [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of DAB2 mRNAaffects cotreatment|decreases expression 12634122
C017133 chromous chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of DAB2 mRNAaffects cotreatment|decreases expression 12634122
D002945 Cisplatin DAB2 protein results in decreased susceptibility to Cisplatindecreases response to substance 16734730
D004041 Dietary Fats Dietary Fats results in decreased expression of DAB2 mRNAdecreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of DAB2 mRNAincreases expression 19638242
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of DAB2 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of DAB2 mRNAincreases expression 19619570
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of DAB2 mRNAaffects expression 17351261
D005047 Etoposide DAB2 protein affects the susceptibility to Etoposideaffects response to substance 16217747
C056516 exemestane exemestane results in increased expression of DAB2 mRNAincreases expression 17254854
C475919 hydroxytamoxifen hydroxytamoxifen results in increased expression of DAB2 mRNAincreases expression 16849584
C005134 juglone juglone affects the phosphorylation of DAB2 proteinaffects phosphorylation 12881709
C008261 lead acetate [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of DAB2 mRNAaffects cotreatment|decreases expression 12634122
D019216 Metals, Heavy Metals, Heavy results in decreased expression of DAB2 mRNAdecreases expression 12773770
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of DAB2 mRNAincreases expression 20713471
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of DAB2 mRNAincreases expression 12634122
12773770
D019319 Okadaic Acid Okadaic Acid affects the phosphorylation of DAB2 proteinaffects phosphorylation 12881709
C041786 palm oil palm oil results in decreased expression of DAB2 mRNAdecreases expression 18042831
D010795 Phthalic Acids Phthalic Acids results in increased expression of DAB2 mRNAincreases expression 15728792
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DAB2 mRNAaffects binding|decreases expression|increases activity 19710929
C488333 Ro 65-7199 Ro 65-7199 results in decreased expression of DAB2 mRNAdecreases expression 14610520
C488334 Ro 66-0074 Ro 66-0074 affects the expression of DAB2 mRNAaffects expression 14610520
C104586 roscovitine roscovitine results in decreased phosphorylation of DAB2 proteindecreases phosphorylation 12881709
C104586 roscovitine roscovitine results in decreased phosphorylation of DAB2 proteindecreases phosphorylation 12881709
C017947 sodium arsenite [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of DAB2 mRNAaffects cotreatment|decreases expression 12634122
D017673 Sodium Chloride, Dietary Sodium Chloride, Dietary affects the expression of DAB2 mRNA alternative formaffects expression 17303656
D017673 Sodium Chloride, Dietary Sodium Chloride, Dietary affects the expression of DAB2 protein alternative formaffects expression 17303656
C004648 testosterone enanthate testosterone enanthate affects the expression of DAB2 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of DAB2 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of DAB2 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DAB2 mRNAincreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DAB2 mRNAincreases expression 18691609
19933214
D014212 Tretinoin Tretinoin results in increased expression of DAB2 mRNAincreases expression 18230668
D014212 Tretinoin Tretinoin results in increased expression of DAB2 mRNAincreases expression 17138961
D014212 Tretinoin Tretinoin results in increased expression of DAB2 mRNAincreases expression 16788091
C025643 vinclozolin vinclozolin affects the expression of DAB2 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.4715322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.1818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5517505938
MESH:D058186 Acute Kidney Injury Cisplatin 3.6215814532 17670903 12690470
MESH:D055371 Acute Lung Injury pirinixic acid 2.7718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.2720127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 9.2717638652 11798837
MESH:D000230 Adenocarcinoma Estradiol 9.2711473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.2714692618
MESH:D000236 Adenoma Benzo(a)pyrene 9.926695378
MESH:D000236 Adenoma Diethylnitrosamine 9.926695378 10737359
MESH:D000236 Adenoma Methylcholanthrene 9.926695378 10545420
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 15.0716434500 17620307 19061943 18056438 19052882 17162532
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.0716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.0716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3115276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5116712894 17306315
MESH:D000505 Alopecia Tretinoin 3.3215955085
MESH:D000544 Alzheimer Disease Metals, Heavy 4.2217430250
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6211748828
MESH:D001008 Anxiety Disorders vinclozolin 3.3419015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7019183758
MESH:D001161 Arteriosclerosis Dietary Fats 8.6715238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.6711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.4115885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.4116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1716292516
MESH:D001249 Asthma Tretinoin 2.2216456186
MESH:D050197 Atherosclerosis Methylcholanthrene 3.2311922910
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.1020106747
MESH:D001327 Autoimmune Diseases Metals, Heavy 5.8116045731
MESH:D001471 Barrett Esophagus Tretinoin 4.0416935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.3019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.3012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.3016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5215746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 10.9314601052
MESH:D019046 Bone Marrow Neoplasms Etoposide 10.9314601052
MESH:D001943 Breast Neoplasms Ascorbic Acid 9.1016443354
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 9.1017474063 20146248
MESH:D001943 Breast Neoplasms bexarotene 9.1016344269 16818667
MESH:D001943 Breast Neoplasms Cisplatin 9.1019526202 18382427
MESH:D001943 Breast Neoplasms Dietary Fats 9.1020435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 9.1017474063
MESH:D001943 Breast Neoplasms Estradiol 9.1017289903 18497071 12948864 17261762 14630087 17018787 16675129 19861407
MESH:D001943 Breast Neoplasms Etoposide 9.1016322251
MESH:D001943 Breast Neoplasms exemestane 9.1017892469 16002280 17952589
MESH:D001943 Breast Neoplasms Methylcholanthrene 9.1017474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 9.1020435547
MESH:D001943 Breast Neoplasms Tretinoin 9.1016443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2116813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0816111702
MESH:D002277 Carcinoma Methylcholanthrene 7.3410545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.3416835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.7716168501
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 8.1217982673
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.1218393292 16540662 17055752 16502159 3581430 16830150 3084413 19208518 19171122 16569478 19919837 16935385 16288022 18978308 19052882 20214788 17138121 20727157 19539802 16698587 17761372 16328049 19519916 20512989 17978847 19822196 19394651 19107877 18788625 19383236 10672840 18971187 19701751 20524982 16878318 17162532 16807293 20101231 20514400 20007298 20084675 18056438 18506893 16681979 19335982 18691550 18785209 20935162 17173139 20432363 18210153 18494052 17428255 19418558 16779866 11831363 18665156 21159647 10737359
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.1216924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.1215276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.121917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 5.4016247446
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 5.4012023789 16685392
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 9.7920419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 9.7917066447 6189445 18337622
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 9.7918572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 9.7916096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1518850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases Aldosterone 4.4611230374
MESH:D002386 Cataract Tretinoin 2.8717460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 22.9520889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 22.957505956 21159647 17174075 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 22.9518566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 22.9516192471
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 22.952727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 22.9520056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2116129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.2619052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.2616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 6.8115861022 16105132 17110522 17681005 17333356 11677210 16919318
MESH:D002779 Cholestasis pirinixic acid 6.8119176532
MESH:D002822 Choriocarcinoma Tretinoin 4.7716461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.208697196 12621046 15668235 15340226 16354765
MESH:D002972 Cleft Palate Tretinoin 5.209407595
MESH:D003092 Colitis Tretinoin 3.3317035595
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3215273666
MESH:D003139 Common Cold Ascorbic Acid 5.0917323712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7414669216 17141729
MESH:D019465 Craniofacial Abnormalities lead acetate 3.6619769572
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6610048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.669224671 17551590 16925845 9664655 9142499 10589399 9125849 14991402 8800419 9211117
MESH:D003456 Cryptorchidism vinclozolin 3.9814966744
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2418249437
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 6.5616506275
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.5620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.5617107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.0919279558
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.3319107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.3320420201
MESH:D004362 Drug Toxicity Cisplatin 7.2412649298 15033597 19839026 12231392
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.2411462148
MESH:D050171 Dyslipidemias Dietary Fats 3.1818367378
MESH:C538011 Eales disease Ascorbic Acid 5.099068938
MESH:D004487 Edema pirinixic acid 5.4312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.4311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.6516714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.6518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.8312538720
MESH:D016643 Encephalopathy, Bovine Spongiform Metals, Heavy 6.9316481041
MESH:D016889 Endometrial Neoplasms Estradiol 6.5818566989 19148513 11473722
MESH:D016889 Endometrial Neoplasms Tretinoin 6.5816569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.6910568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7316302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.6320426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.6316530937
MESH:D004938 Esophageal Neoplasms Cisplatin 6.6317638652 15173087 16785472 15464296 16481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.9011564622
MESH:D005124 Eye Abnormalities Tretinoin 7.909664655 16938888
MESH:D005234 Fatty Liver Dietary Fats 15.9719551842 17967931 18296743 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 15.9721071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.9715345470
MESH:D005234 Fatty Liver pirinixic acid 15.9720131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0811858732
MESH:D005317 Fetal Growth Retardation lead acetate 5.0219769572
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.5610962813 14633661
MESH:D005355 Fibrosis Dietary Fats 12.6218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.6220067830
MESH:D005355 Fibrosis Tretinoin 12.6217994277
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.5516973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.9116417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3016452187
MESH:D005909 Glioblastoma Okadaic Acid 6.8817312396
MESH:D005909 Glioblastoma Tretinoin 6.8817312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2110696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 7.0515464296 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.0516096774
MESH:D034381 Hearing Loss Cisplatin 3.9819898482
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.7716084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.1115464296
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 14.3016080930
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 14.3020471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 14.3011294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 14.3014991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.3020558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0011000095
MESH:D006529 Hepatomegaly pirinixic acid 7.0319772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.0315340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.3416490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.6415709030
MESH:D006561 Herpes Simplex Etoposide 4.1810809021
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.3617440010
MESH:D006689 Hodgkin Disease Cisplatin 10.5716170182 16200630
MESH:D006689 Hodgkin Disease Etoposide 10.5715147373 18180244 16135485 17606976 16200630
MESH:D006689 Hodgkin Disease sodium arsenite 10.5712676792
MESH:D019584 Hot Flashes Estradiol 3.3717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6618606429 15340226 16959395 8697196 16354765
MESH:D006930 Hyperalgesia Tretinoin 2.9216870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.2621332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2016778211
MESH:D006943 Hyperglycemia pirinixic acid 2.8520558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.2721332399
MESH:D006973 Hypertension Sodium Chloride, Dietary 5.3518524855
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3518670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4416569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.7217937319
MESH:D007248 Infertility, Male sodium arsenite 9.7212646999 15346721
MESH:D007248 Infertility, Male vinclozolin 9.7216467254
MESH:D007249 Inflammation Dietary Fats 7.0920412841
MESH:D007249 Inflammation Diethylnitrosamine 7.0918785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.0912200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 10.8311836018 18457598
MESH:D007333 Insulin Resistance Estradiol 10.8316627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 10.8316306350
MESH:D007410 Intestinal Diseases Tretinoin 3.4017994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.8016580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.8017551590 15992940
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.7515464296
MESH:D007674 Kidney Diseases Cadmium Chloride 12.6716962696
MESH:D007674 Kidney Diseases Cisplatin 12.6712649298 15190930 19839026 18289764 12231392
MESH:D007674 Kidney Diseases Estradiol 12.6715618244
MESH:D007674 Kidney Diseases sodium arsenite 12.6720008137
MESH:D007680 Kidney Neoplasms Estradiol 2.6815610895
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.4111231351
MESH:D007938 Leukemia roscovitine 6.3616275999
MESH:D007938 Leukemia Tretinoin 6.3617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.3619285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0117596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9017301526 17712046 16140955 9834237 17107899 16891316 16766008 19075265 19035177 17649720 17339181 17361223 17217047 17506722 15748426 16823087 19642359 12679006 16331271 16788101 19029980 17294898 19225113 17368321 16935935
MESH:D007984 Leydig Cell Tumor vinclozolin 4.3516417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.049224671
MESH:D008103 Liver Cirrhosis Dietary Fats 5.9218296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 5.9220032147 19638242 18665156 18407596 18522880
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.1714716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Metals, Heavy 6.1715383259
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.1715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.1712878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.1716248980 18397230
MESH:D008107 Liver Diseases Diethylnitrosamine 2.0117034775
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 12.5721137059 20195826
MESH:D008113 Liver Neoplasms Diethylnitrosamine 12.5720501860 19850985 21071580 20434301 16942905 21167192 19642983 19294768 19833225 18977376 15885732 20101389 19090486 19996281 2862719 18648771 19427195 20583210 9163691 19255062 2422723 19812893 19256749 20137499 19073162 10737359 19551842 21278145 18978307 20452335 20118626 19254457 18754104 15175105 18644402 19426721 21047994 12112319 20492335 20405173 19690152 12771043 19638242 19499222
MESH:D008113 Liver Neoplasms pirinixic acid 12.5715890375 16377806 20007298
MESH:D008113 Liver Neoplasms sodium arsenite 12.5715276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 12.5716984957
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 12.2018544905
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 12.2018282651 17942915 17854601 19009564 16842330 18775883 18308698 18544905 21159647 3124819 17174075 19539802 19126423 16267830 19519916 18079962 18253720 19004024 18164116 9362446 18093689 2563599
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 12.20598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.2012151625
MESH:D008171 Lung Diseases Ascorbic Acid 6.8716863852
MESH:D008171 Lung Diseases sodium arsenite 6.8719095001
MESH:D008175 Lung Neoplasms Ascorbic Acid 12.0116401635
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 12.0117053015 20064080 6695378 20869020 18520028 18569708 20135361 20464547 18816296
MESH:D008175 Lung Neoplasms bexarotene 12.0117849452
MESH:D008175 Lung Neoplasms Cisplatin 12.016189445 11798837 17225452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 12.016695378 20970405 20512841 21163286
MESH:D008175 Lung Neoplasms Methylcholanthrene 12.0117909032 16337739 10545420 21163286 11893704 16271038 20970405 9230183 20512841 7750092 6695378 15390079 1399818
MESH:D008175 Lung Neoplasms sodium arsenite 12.0117077188 16712894 19931552 17306315 15276417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 12.0111884234 19555203
MESH:D008223 Lymphoma Etoposide 3.6512854902 12556972
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.7711161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 5.4419196722 19196723 15591091
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.4411408345 11807958 17203775 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.0919453300
MESH:D008527 Medulloblastoma Tretinoin 2.6317453147
MESH:D008545 Melanoma Cisplatin 4.7216248763 18176117 15577323 16809738 18505091 12393984 16432458 17023156 12374674 17761969 18332650 11135225 12883367
MESH:D008545 Melanoma sodium arsenite 4.7216487513 19082730
MESH:D008545 Melanoma Tretinoin 4.7216752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.3915990972
MESH:D008591 Meningomyelocele Tretinoin 4.0516940565
MESH:D008654 Mesothelioma Cisplatin 3.0917638057
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.5117671175
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9016381670
MESH:D009135 Muscular Diseases pirinixic acid 3.1416239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.8617596541
MESH:D009203 Myocardial Infarction pirinixic acid 1.9819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.2816810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.2816411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.419029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 13.6311141357
MESH:D009369 Neoplasms Cisplatin 13.6316773208
MESH:D009369 Neoplasms pirinixic acid 13.6317405874
MESH:D009369 Neoplasms sodium arsenite 13.6311559025
MESH:D009369 Neoplasms Tretinoin 13.6316946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3020056578
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.4019196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3517289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.1115464296
MESH:D009421 Nervous System Malformations Estradiol 14.2416427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.2414600291
MESH:D009421 Nervous System Malformations Tretinoin 14.249125849
MESH:D009436 Neural Tube Defects sodium arsenite 6.4812854658
MESH:D009436 Neural Tube Defects Tretinoin 6.489142499
MESH:D009447 Neuroblastoma Cisplatin 3.258761367
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.0320387270
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.328761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7320387270
MESH:D009765 Obesity Ascorbic Acid 6.8617217161
MESH:D009765 Obesity Dietary Fats 6.8619632207 18674790 21332399 20132043 17217161 18457598 11836018 16723640 20518802
MESH:D009765 Obesity pirinixic acid 6.8620558911
MESH:D010051 Ovarian Neoplasms Cisplatin 10.2219769630 17225452 15464296 6897625
MESH:D010051 Ovarian Neoplasms Estradiol 10.2219401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 10.2217306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 10.2216936753
MESH:D010146 Pain Tretinoin 2.6116870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 11.1719003803
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.1716540662
MESH:D010190 Pancreatic Neoplasms Etoposide 11.1719003803
MESH:D010190 Pancreatic Neoplasms Tretinoin 11.1715976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8612520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 3.9515464296
MESH:D010997 Pleural Neoplasms Cisplatin 4.9517638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2018163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.232563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.2211222880 11896295 11399792 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.2218042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.5518220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5420887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9317292933
MESH:D011471 Prostatic Neoplasms Estradiol 1.9316740699
MESH:D011471 Prostatic Neoplasms Etoposide 1.9317172428
MESH:D011471 Prostatic Neoplasms roscovitine 1.9316140939
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.9316039940
MESH:D011472 Prostatitis vinclozolin 4.5518629315
MESH:D011507 Proteinuria Tretinoin 3.2616636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.9315861022 16919318
MESH:D011625 Pterygium Tretinoin 4.4116723453
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 4.9414606601
MESH:D051437 Renal Insufficiency Cisplatin 4.0415464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.2019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4718990726
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.2016849425
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.7516283617 16116481
MESH:D012512 Sarcoma, Ewing's Cisplatin 15.5014601052
MESH:D012512 Sarcoma, Ewing's Etoposide 15.5014601052
MESH:D012512 Sarcoma, Ewing's roscovitine 15.5016230394
MESH:D012871 Skin Diseases Ascorbic Acid 3.1118709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 15.9519755658 10029692
MESH:D012878 Skin Neoplasms Okadaic Acid 15.9512628509
MESH:D012878 Skin Neoplasms sodium arsenite 15.9518572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 15.9516192470
MESH:D012878 Skin Neoplasms Tretinoin 15.9516467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.9515464296
MESH:D013088 Spermatocele Ethinyl Estradiol 3.5516709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5012854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.372093021 20155912
MESH:D013274 Stomach Neoplasms Cisplatin 4.3718396642 17522103 15958060
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.3718456281
MESH:D013274 Stomach Neoplasms Tretinoin 4.3717261132
MESH:D013276 Stomach Ulcer Ascorbic Acid 3.5618726076
MESH:D020521 Stroke Ascorbic Acid 3.9916517955 16403987
MESH:D013736 Testicular Neoplasms Cisplatin 4.2817225452 15464296
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5112697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.227505956
MESH:D013964 Thyroid Neoplasms Tretinoin 6.2216026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.3019048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.4616051514
MESH:D014376 Tuberculosis Tretinoin 2.9916040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.4517053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 7.4517225452 12973940 15464296
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 7.4516452187 17306315 11723127 16712894
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 14.0016803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 14.0011813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 14.0016129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9414692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.2216752155
MESH:D014625 Vaginal Neoplasms Cisplatin 4.2415577323
MESH:D014652 Vascular Diseases sodium arsenite 4.0417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2015869587 14671159
MESH:D014820 Vitiligo Tretinoin 3.6916761959
MESH:D014839 Vomiting Cisplatin 4.3311897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8615886252
MESH:D015430 Weight Gain Dietary Fats 3.4216723640
MESH:D009396 Wilms Tumor Tretinoin 3.6516287080
Pathway ID Pathway Name
KEGG:04144 Endocytosis
REACT:11123 Membrane Trafficking
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved