Annotation Detail for DGKB
Basic Information Top
| Gene Symbol: | DGKB ( DAGK2,DGK,DGK-BETA,KIAA0718 ) |
|---|---|
| Gene Full Name: | diacylglycerol kinase, beta 90kDa |
| Band: | 7p21.2 |
| Quick Links | Entrez ID:1607; OMIM: 604070; Uniprot ID:DGKB_HUMAN; ENSEMBL ID: ENSG00000136267; HGNC ID: 2850 |
| Relate to Another Database: | SFARIGene; denovo-db |
| No data |
| No data |
| Desease Name |
|---|
| response to treatment for acute lymphoblastic leukemia |
| PHARMACOGENOMIC |
| fasting glucose-related traits |
| METABOLIC |
| Desease Name |
|---|
| Response to treatment for acute lymphoblastic leukemia |
| Fasting glucose-related traits |
| No data |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| C055494 | caffeic acid phenethyl ester | [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DGKB mRNA | affects cotreatment|decreases expression | 20360939 |
| D004052 | Diethylnitrosamine | [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DGKB mRNA | affects cotreatment|decreases expression | 20360939 |
| D005419 | Flavonoids | Flavonoids results in increased expression of DGKB mRNA | increases expression | 18035473 |
| C025299 | polyphenols | polyphenols results in decreased expression of DGKB mRNA | decreases expression | 16293270 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000236 | Adenoma | Diethylnitrosamine | 3.05 | 10737359 6695378 | |
| MESH:D018248 | Adenoma, Liver Cell | Diethylnitrosamine | 4.53 | 16434500 17620307 17162532 19061943 18056438 19052882 | |
| MESH:D001943 | Breast Neoplasms | Diethylnitrosamine | 2.19 | 17474063 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Diethylnitrosamine | 1.88 | 18393292 16779866 17162532 16698587 19418558 18691550 16569478 20007298 16502159 16681979 17978847 21159647 19919837 16830150 20101231 20935162 16935385 16540662 18971187 19383236 19539802 19107877 19052882 17428255 17138121 19335982 10737359 3581430 16878318 20432363 18665156 18056438 17055752 19822196 16328049 18978308 19208518 18494052 3084413 17173139 20214788 19394651 20512989 16288022 19171122 20084675 17761372 18506893 18210153 20524982 10672840 19519916 20727157 18785209 18788625 16807293 20514400 11831363 19701751 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Diethylnitrosamine | 3.12 | 2727394 17174075 7505956 21159647 | |
| MESH:D018281 | Cholangiocarcinoma | Diethylnitrosamine | 4.05 | 19052882 | |
| MESH:D003110 | Colonic Neoplasms | polyphenols | 2.72 | 16293270 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Diethylnitrosamine | 2.26 | 20387270 | |
| MESH:D056486 | Drug-Induced Liver Injury | Diethylnitrosamine | 4.48 | 19107877 | |
| MESH:D056486 | Drug-Induced Liver Injury | polyphenols | 4.48 | 19370779 | |
| MESH:D004931 | Esophageal Achalasia | Diethylnitrosamine | 5.84 | 16302075 | |
| MESH:D005234 | Fatty Liver | Diethylnitrosamine | 3.61 | 20387270 21071580 | |
| MESH:D007249 | Inflammation | Diethylnitrosamine | 9.54 | 18785209 | |
| MESH:D007249 | Inflammation | Flavonoids | 9.54 | 17296493 | |
| MESH:D007249 | Inflammation | polyphenols | 9.54 | 16366677 | |
| MESH:D007414 | Intestinal Neoplasms | caffeic acid phenethyl ester | 4.98 | 10783313 | |
| MESH:D007674 | Kidney Diseases | caffeic acid phenethyl ester | 3.75 | 15369732 | |
| MESH:D015473 | Leukemia, Promyelocytic, Acute | caffeic acid phenethyl ester | 4.23 | 16766008 | |
| MESH:D008103 | Liver Cirrhosis | Diethylnitrosamine | 3.01 | 18665156 19638242 18407596 18522880 20032147 | |
| MESH:D008107 | Liver Diseases | Diethylnitrosamine | 4.60 | 17034775 | |
| MESH:D008107 | Liver Diseases | polyphenols | 4.60 | 16698588 | |
| MESH:D008113 | Liver Neoplasms | Diethylnitrosamine | 2.35 | 19073162 19090486 19427195 19850985 20583210 19690152 16942905 19812893 19255062 19551842 19256749 20501860 19996281 2422723 20118626 20434301 19833225 12112319 9163691 18977376 21047994 15175105 18978307 19294768 21167192 20452335 21071580 18754104 19642983 18648771 15885732 18644402 2862719 19254457 21278145 20101389 20492335 10737359 12771043 20137499 20405173 19638242 19499222 19426721 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Diethylnitrosamine | 2.85 | 2563599 17942915 17854601 18253720 16267830 18164116 18079962 18093689 18544905 18282651 19009564 17174075 19539802 19004024 18775883 21159647 19519916 3124819 18308698 19126423 9362446 16842330 | |
| MESH:D008175 | Lung Neoplasms | Diethylnitrosamine | 1.77 | 6695378 20970405 21163286 20512841 | |
| MESH:D009362 | Neoplasm Metastasis | Diethylnitrosamine | 2.69 | 3581430 9029167 | |
| MESH:D019636 | Neurodegenerative Diseases | Diethylnitrosamine | 3.69 | 20387270 | |
| MESH:D009461 | Neurologic Manifestations | Diethylnitrosamine | 5.84 | 20387270 | |
| MESH:D010190 | Pancreatic Neoplasms | Diethylnitrosamine | 2.53 | 16540662 | |
| MESH:D011230 | Precancerous Conditions | Diethylnitrosamine | 3.92 | 2563599 | |
| MESH:D013274 | Stomach Neoplasms | Diethylnitrosamine | 1.76 | 18456281 | |
| MESH:D013705 | Temporomandibular Joint Disorders | polyphenols | 5.97 | 17997062 | |
| MESH:D013964 | Thyroid Neoplasms | Diethylnitrosamine | 3.29 | 7505956 |
| Pathway ID | Pathway Name |
|---|---|
| KEGG:00561 | Glycerolipid metabolism |
| KEGG:00564 | Glycerophospholipid metabolism |
| REACT:604 | Hemostasis |
| KEGG:01100 | Metabolic pathways |
| KEGG:04070 | Phosphatidylinositol signaling system |
| REACT:14797 | Signaling by GPCR |
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