AutismKB 2.0

Annotation Detail for SLC5A8


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SLC5A8 ( AIT,MGC125354,SMCT,SMCT1 )
Gene Full Name: solute carrier family 5 (iodide transporter), member 8
Band: 12q23.1-q23.2
Quick LinksEntrez ID:160728; OMIM: 608044; Uniprot ID:SC5A8_HUMAN; ENSEMBL ID: ENSG00000139357; HGNC ID: 19119
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Transmembrane transport of small molecules
Amino acid and oligopeptide SLC transporters
No data
No data
Pathway IDPathway Name
500342Organic anion transporters
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of SLC5A8 mRNAincreases expression 18648102
D002087 Butyrates SLC5A8 protein results in increased transport of [Butyrates co-treated with Sodium]affects cotreatment|increases transport 15090606
D002264 Carboxylic Acids SLC5A8 protein results in increased transport of [Carboxylic Acids co-treated with Sodium]affects cotreatment|increases transport 15090606
C014347 decitabine [decitabine affects the methylation of SLC5A8 gene] which affects the expression of SLC5A8 mRNAaffects expression|affects methylation 18559491
D005232 Fatty Acids, Volatile SLC5A8 protein results in increased transport of [Fatty Acids, Volatile co-treated with Sodium]affects cotreatment|increases transport 15090606
C029424 hydrazine hydrazine results in decreased expression of SLC5A8 mRNAdecreases expression 15282401
D007052 Ibuprofen Ibuprofen results in decreased activity of SLC5A8 proteindecreases activity 15090606
16670197
D019344 Lactic Acid SLC5A8 protein results in increased transport of [Lactic Acid co-treated with Sodium]affects cotreatment|increases transport 15090606
D009539 Nicotinic Acids SLC5A8 protein results in increased transport of [Nicotinic Acids co-treated with Sodium]affects cotreatment|increases transport 15090606
C006253 pirinixic acid pirinixic acid results in decreased expression of SLC5A8 mRNAdecreases expression 17426115
D011339 Probenecid Probenecid results in decreased activity of SLC5A8 proteindecreases activity 15090606
D011422 Propionates SLC5A8 protein results in increased transport of [Propionates co-treated with Sodium]affects cotreatment|increases transport 15090606
D012964 Sodium SLC5A8 protein results in increased transport of [Butyrates co-treated with Sodium]affects cotreatment|increases transport 15090606
D012964 Sodium SLC5A8 protein results in increased transport of [Carboxylic Acids co-treated with Sodium]affects cotreatment|increases transport 15090606
D012964 Sodium SLC5A8 protein results in increased transport of [Fatty Acids, Volatile co-treated with Sodium]affects cotreatment|increases transport 15090606
D012964 Sodium SLC5A8 protein results in increased transport of [Lactic Acid co-treated with Sodium]affects cotreatment|increases transport 15090606
D012964 Sodium SLC5A8 protein results in increased transport of [Nicotinic Acids co-treated with Sodium]affects cotreatment|increases transport 15090606
D012964 Sodium SLC5A8 protein results in increased transport of [Propionates co-treated with Sodium]affects cotreatment|increases transport 15090606
D012964 Sodium SLC5A8 protein results in increased transport of [Valerates co-treated with Sodium]affects cotreatment|increases transport 15090606
D014631 Valerates SLC5A8 protein results in increased transport of [Valerates co-treated with Sodium]affects cotreatment|increases transport 15090606
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carboxylic Acids 6.638875741
MESH:D000138 Acidosis Lactic Acid 6.6220872349 18406487
MESH:D058186 Acute Kidney Injury Ibuprofen 4.506375363
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000230 Adenocarcinoma Ibuprofen 3.2610697514
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.783712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.5616434500
MESH:D000544 Alzheimer Disease Ibuprofen 3.1818351690
MESH:D000707 Anaphylaxis Ibuprofen 5.329532969
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.121440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2019483382
MESH:D002545 Brain Ischemia Ibuprofen 4.9615837124
MESH:D001943 Breast Neoplasms decitabine 2.5718320071 19208741
MESH:D002100 Cachexia Ibuprofen 5.5515141370
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.753581430 7296757
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.707296757
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6119215824
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.797505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.9819486331 9022650
MESH:D002779 Cholestasis pirinixic acid 7.9819176532
MESH:D003110 Colonic Neoplasms marker/mechanism 15090606 16670197
MESH:D003110 Colonic Neoplasms Butyrates 4.2115936596
MESH:D003110 Colonic Neoplasms decitabine 4.2117616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.8711298694 18759878 11906362 8156756 8970840 2524372 14531868 12868966
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.552952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 1.971440618 8291058 9328219 18289764 9653073 7440962 18692083 6679447 9022650 16192314 11289319 18648102 6482804
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 5.7018450898 18446180 16133044
MESH:D004487 Edema pirinixic acid 2.5312083418
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.2119294695
MESH:D004715 Endometriosis Ibuprofen 4.6615652904
MESH:D019446 Endotoxemia Ibuprofen 5.0511545620
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.123581430
MESH:D005234 Fatty Liver pirinixic acid 2.8219236843 20131406
MESH:D005334 Fever Ibuprofen 4.6316997862
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.126705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.107505956
MESH:D006258 Head and Neck Neoplasms decitabine 3.5219215824
MESH:D006333 Heart Failure pirinixic acid 2.5720558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.586705139
MESH:D006529 Hepatomegaly pirinixic acid 3.0716221962 19772884 18467677 19176532
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0115034207
MESH:D006984 Hypertrophy Ibuprofen 5.0316672835
MESH:D007235 Infant, Premature, Diseases Ibuprofen 5.9316133044
MESH:D007248 Infertility, Male decitabine 3.2417581917
MESH:D007249 Inflammation Ibuprofen 3.473291741
MESH:D007333 Insulin Resistance pirinixic acid 2.6616306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.128074119 9022650
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.016582329
MESH:D007938 Leukemia decitabine 3.1018980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 4.0619117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3919010910 17679729 19387464 18704418 18206229 18460780
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.5618055864
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008113 Liver Neoplasms pirinixic acid 1.8416377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.566587162 3712494 1399818 598648
MESH:D008223 Lymphoma decitabine 3.4619470736
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 3.7410697514
MESH:D008545 Melanoma decitabine 2.2517785578 16505122
MESH:D009101 Multiple Myeloma decitabine 3.3818172295
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4119157545 16882708 19010910 18608210
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9916411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.493581430
MESH:D009369 Neoplasms decitabine 5.1019470736 17925555 19116145
MESH:D009369 Neoplasms pirinixic acid 5.1017405874
MESH:D009395 Nephritis, Interstitial Ibuprofen 5.086375363
MESH:D009410 Nerve Degeneration Ibuprofen 4.4310961664
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.956679447
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.476482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.123988306
MESH:D010003 Osteoarthritis Ibuprofen 4.167009135
MESH:D010051 Ovarian Neoplasms decitabine 2.6619331143 19259094
MESH:D010146 Pain Ibuprofen 3.973291741
MESH:D010149 Pain, Postoperative Ibuprofen 5.2416678543
MESH:D010190 Pancreatic Neoplasms decitabine 5.8119294695
MESH:D010190 Pancreatic Neoplasms Ibuprofen 5.8112384795
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.557296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.576228378
MESH:D055728 Primary Myelofibrosis decitabine 4.8017616702
MESH:D011471 Prostatic Neoplasms Ibuprofen 4.2317409433
MESH:D011507 Proteinuria Ibuprofen 4.686375363
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.413692021
MESH:D012208 Rhabdomyosarcoma decitabine 4.4619155313
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 12.386582329 6587162 7505956 1399818 3712494
MESH:D013964 Thyroid Neoplasms Butyrates 12.3817967635
MESH:D013964 Thyroid Neoplasms decitabine 12.3817967635
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.238074119
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.2317616700 19087683
MESH:D014604 Uveal Neoplasms decitabine 5.0117785578
MESH:D020301 Vasospasm, Intracranial Ibuprofen 5.2719057314
Pathway ID Pathway Name
REACT:19419 Amino acid and oligopeptide SLC transporters
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134989874
    • No data
    No data
    Releated drug ID Related drug Name
    PA449597fenoprofen
    PA449957ibuprofen
    PA450149ketoprofen
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved