AutismKB 2.0

Annotation Detail for DGKG


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Basic Information Top
Gene Symbol:DGKG ( DAGK3,DGK-GAMMA,MGC104993,MGC133330 )
Gene Full Name: diacylglycerol kinase, gamma 90kDa
Band: 3q27.2-q27.3
Quick LinksEntrez ID:1608; OMIM: 601854; Uniprot ID:DGKG_HUMAN; ENSEMBL ID: ENSG00000058866; HGNC ID: 2853
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00561Glycerolipid metabolism
hsa00564Glycerophospholipid metabolism
hsa01100Metabolic pathways
hsa04070Phosphatidylinositol signaling system
Pathway IDPathway Name
Signaling by GPCR
Hemostasis
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2128CNS metastases
Desease Name
Body mass index
weight
METABOLIC
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DGKG mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of DGKG mRNAaffects expression 12734012
D011794 Quercetin Quercetin affects the expression of DGKG mRNAaffects expression 18178720
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of DGKG mRNAdecreases expression 17337447
C025643 vinclozolin vinclozolin affects the expression of DGKG mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3811752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.9216835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2911748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.6117084956
MESH:D001008 Anxiety Disorders vinclozolin 3.9319015723
MESH:D001260 Ataxia Telangiectasia Quercetin 5.5215336622
MESH:D001327 Autoimmune Diseases Quercetin 4.8919761891
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9715746008
MESH:D001943 Breast Neoplasms Quercetin 2.0918628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0920435547
MESH:D002105 Cadmium Poisoning Quercetin 6.1616962696
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2616050911 15700767 16011737 16124888 18705752 16097048 16192424 15721981 3786805 10355542 16227642 15673190
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0916835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.3018788625
MESH:D006528 Carcinoma, Hepatocellular Quercetin 3.3012508355 19519916
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.4417234771
MESH:D006332 Cardiomegaly Quercetin 7.3819794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.3816120746 18850075 18670907
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4916835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2216354765 8697196 12621046 15340226 15668235
MESH:D003110 Colonic Neoplasms Quercetin 2.4619440933 16640504 17148506 17191121 11134977 19056647 15741050
MESH:D015179 Colorectal Neoplasms Quercetin 2.1918095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2715322242 20055451 10048152
MESH:D003456 Cryptorchidism vinclozolin 4.7814966744
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 4.0419496084
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7317107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.007440962 3786805 21278145 16227642 9327722 4309450 2869522 19336974 10915739 17522070 15968718 7120509 16177239 3732212 19085960 7179309 15027814 10092053 6623471 15998439 6884620 11566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.0020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.5116714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.379294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2711564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.5412631006 61145 15959796 16239168 16045604 19224547 12795759 17595544
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D005355 Fibrosis Carbon Tetrachloride 17.8318705752
MESH:D005355 Fibrosis Quercetin 17.8319474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.8320067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.4716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.9116417039
MESH:D005909 Glioblastoma Quercetin 3.6119804834
MESH:D005910 Glioma Quercetin 3.1717643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4911294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 4.0319900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3712621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.6616354765 15340226 16959395 18606429 8697196
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.0716899240
MESH:D006943 Hyperglycemia Quercetin 4.3818262572 11834736
MESH:D006973 Hypertension Quercetin 5.5918356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.5918850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5715338365
MESH:D007248 Infertility, Male vinclozolin 3.2616467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0112200463 12878042
MESH:D007251 Influenza, Human Quercetin 5.1216624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7116580747
MESH:D007627 Keloid Quercetin 5.4417086741
MESH:D007674 Kidney Diseases Quercetin 3.2816962696
MESH:D007938 Leukemia Quercetin 3.3117468513
MESH:D007984 Leydig Cell Tumor vinclozolin 5.2716417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9811408273 17174718 17157831 17334410 16943688 21278145 16221502 11903743 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.6812586293 18472094 15996030 18277467 12546737 15931870 18376398 17708605 12898905 18210741 12632512 16248980 18251166 16638106 17631135 17922224 15818738 12445418 12741479 12632514 16192424 15338365 17714472 18412020 12958196 17805973 17557913 18054572 18420326 16136751 18205269 14748882 18006644 15673190 15925388 17481882 17565644 17761835 14724832 17869086 18279442 18472332 14512876 15730626 16011737 16015684 16116963 18395914 15057751 12649538 17976157 14716833 15370692 15959796 15650968 17944888 12666154 15123356 18339082 15893842 16097048 18187930 16033810 18263696 17525996 17766677 18429990 14620537 15876570 18418968 10355542 17721639 18317297 13678700 12389079 18395095 18166357 17640975 18481824 12667390 15052691 12609069 14716496 20821823 17823541 18156304 12445421 17900296 15362042 16027843 11481614 18705752 17698563
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 3.6812741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6812878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1515830285 16964402 16246199 15720792 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.6515123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.0416899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 8.1019294768
MESH:D008113 Liver Neoplasms Quercetin 8.1018980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 8.1016984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 11.0712014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Quercetin 11.0719519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 11.0712151625
MESH:D008175 Lung Neoplasms Quercetin 2.4916280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4911884234 19555203
MESH:D009203 Myocardial Infarction Quercetin 3.1119595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3112213967
MESH:D015428 Myocardial Reperfusion Injury Quercetin 4.0719207477
MESH:D009369 Neoplasms Quercetin 2.9415185748
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.6514600291
MESH:D020078 Neurogenic Inflammation Quercetin 4.7717929310
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.6219495926
MESH:D010051 Ovarian Neoplasms Quercetin 2.8219005980
MESH:D010190 Pancreatic Neoplasms Quercetin 2.9516965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011230 Precancerous Conditions Quercetin 4.3119056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 11.3511222880 11118676 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 11.3519015723 18042343 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.4718220299
MESH:D011471 Prostatic Neoplasms Quercetin 3.5414715546 17292933
MESH:D011472 Prostatitis vinclozolin 5.4718629315
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
MESH:D012554 Schistosomiasis japonica Quercetin 6.1616862918
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1816192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.5112697716
MESH:D001749 Urinary Bladder Neoplasms Quercetin 2.9116720314
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
Pathway ID Pathway Name
KEGG:00561 Glycerolipid metabolism
KEGG:00564 Glycerophospholipid metabolism
REACT:604 Hemostasis
KEGG:01100 Metabolic pathways
KEGG:04070 Phosphatidylinositol signaling system
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00144 - Phosphatidylserine Dietary supplement;Micronutrient
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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