AutismKB 2.0

Annotation Detail for AP2A2


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Basic Information Top
Gene Symbol:AP2A2 ( ADTAB,CLAPA2,HIP9,HYPJ )
Gene Full Name: adaptor-related protein complex 2, alpha 2 subunit
Band: 11p15.5
Quick LinksEntrez ID:161; OMIM: 607242; Uniprot ID:AP2A2_HUMAN; ENSEMBL ID: ENSG00000183020; HGNC ID: 562
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04144Endocytosis
hsa05016Huntington's disease
Pathway IDPathway Name
Synaptic Transmission
Signalling by NGF
Axon guidance
Signaling by EGFR
HIV Infection
No data
Pathway IDPathway Name
P00029Huntington disease
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of AP2A2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of AP2A2 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of AP2A2 mRNAincreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of AP2A2 mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of AP2A2 mRNAincreases expression 17484886
D006220 Haloperidol Haloperidol results in decreased expression of AP2A2 mRNAdecreases expression 15860345
D007657 Ketone Bodies Ketone Bodies results in decreased expression of AP2A2 mRNAdecreases expression 16807920
C006253 pirinixic acid pirinixic acid results in increased expression of AP2A2 mRNAincreases expression 16985257
D012643 Selenium Selenium results in increased expression of AP2A2 mRNAincreases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of AP2A2 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.843712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7216434500
MESH:D001321 Autistic Disorder Haloperidol 2.7318080171 19368416
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.281440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 10.6615700767 16097048 15673190 18705752 15721981 16011737 16192424 16124888 16227642 16050911 3786805 10355542
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 10.6616050911
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7616705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7616705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.763581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.7618788625
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.757296757
MESH:D002375 Catalepsy Haloperidol 5.151977408 15215559
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.046135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.047505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.279022650 19486331
MESH:D002779 Cholestasis pirinixic acid 8.2719176532
MESH:D003092 Colitis Selenium 3.9917936198
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.6318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.6318551238
MESH:D016757 Death, Sudden, Cardiac Haloperidol 5.0320210726
MESH:D003704 Dementia Haloperidol 4.7511575062
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.012524372 8156756 18759878 11906362 14531868 12868966 11298694 8970840
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.672952479 3621924
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.5221346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.5221346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.5218692083 8291058 9328219 6482804 6679447 11289319 18648102 7440962 18289764 9022650 9653073 16192314 1440618
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.522869522 21278145 6884620 7440962 10092053 10915739 11566570 15968718 3786805 19085960 6623471 16177239 7120509 3732212 19336974 4309450 16227642 15027814 9327722 7179309 17522070 15998439
MESH:D056486 Drug-Induced Liver Injury Selenium 12.5215131321
MESH:C538011 Eales disease Vitamin E 4.979068938
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.143581430
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.2517595544 12795759 16239168 15959796 12631006 61145 19224547 16045604
MESH:D005234 Fatty Liver pirinixic acid 8.2520131406 19236843
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005355 Fibrosis Carbon Tetrachloride 3.6718705752
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0716080930
MESH:D006333 Heart Failure pirinixic acid 7.2820558911
MESH:D006333 Heart Failure Selenium 7.2817162251
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.896705139
MESH:D006505 Hepatitis Carbon Tetrachloride 9.8919110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 3.2119772884 19176532 16221962 18467677
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7516490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.2414716179
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D007251 Influenza, Human Selenium 11.8616624496
MESH:D007251 Influenza, Human Vitamin E 11.8616624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.288074119 9022650
MESH:D007674 Kidney Diseases Vitamin E 2.8912488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0616518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.2516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.2516705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.256582329
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8916221502 17157831 17174718 11408273 17334410 16943688 21278145 16239168 11903743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5715959796 15362042 18481824 12632512 18429990 12741479 18156304 17708605 18166357 15730626 16027843 15123356 15876570 16136751 18705752 17481882 15057751 18376398 18420326 17805973 17640975 18277467 12445421 15673190 17525996 16192424 12667390 17631135 18418968 17761835 12609069 18472332 18395095 18210741 17976157 12586293 16033810 12632514 16011737 18187930 11481614 15996030 16097048 18395914 17900296 16248980 20821823 12958196 13678700 12898905 18205269 17766677 18279442 15338365 17944888 18412020 10355542 17714472 14724832 12546737 18263696 18472094 14716833 17557913 17721639 18251166 17565644 18339082 18006644 12649538 12389079 15818738 16638106 17869086 15650968 14748882 17823541 16015684 15052691 14620537 14716496 18054572 12666154 15370692 15925388 14512876 17698563 16116963 18317297 17922224 15931870 12445418 15893842
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5715474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5716169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1215720792 16246199 15830285 17285989 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8516899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.737678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.7319294768
MESH:D008113 Liver Neoplasms pirinixic acid 7.7320007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.442876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.446587162 1399818 3712494 598648
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.4415583823 12014681
MESH:D008171 Lung Diseases Vitamin E 3.2916863852
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8615318939
MESH:D001523 Mental Disorders Haloperidol 4.2516856516
MESH:D008654 Mesothelioma Selenium 2.8515107826
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.1518551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.1518551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.533581430
MESH:D009369 Neoplasms pirinixic acid 2.0217405874
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.026679447
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 16.0312819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 16.0316049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 16.036482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D010954 Plasmacytoma Selenium 5.1515087411
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2815084515
MESH:D011595 Psychomotor Agitation Haloperidol 5.1711575062
MESH:D011618 Psychotic Disorders Haloperidol 4.3711575062
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.503692021
MESH:D012559 Schizophrenia Haloperidol 2.8219369910 18513383 1830565 20107430
MESH:D012640 Seizures 2,4-dinitrotoluene 6.2518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.2518551238
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D020521 Stroke Vitamin E 3.6616517955
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.9020210726
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.011399818 6582329 7505956 6587162 3712494
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.6316049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.6316049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.638074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.8010091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.8010091137
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:04961 Endocrine and other factor-regulated calcium reabsorption
KEGG:04144 Endocytosis
REACT:6185 HIV Infection
KEGG:05016 Huntington's disease
REACT:9417 Signaling by EGFR
REACT:11061 Signalling by NGF
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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