AutismKB 2.0

Annotation Detail for DAO


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DAO ( DAAO,DAMOX,MGC35381,OXDA )
Gene Full Name: D-amino-acid oxidase
Band: 12q24.11
Quick LinksEntrez ID:1610; OMIM: 124050; Uniprot ID:OXDA_HUMAN; ENSEMBL ID: ENSG00000110887; HGNC ID: 2671
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00330Arginine and proline metabolism
hsa01100Metabolic pathways
hsa04146Peroxisome
hsa00260Glycine, serine and threonine metabolism
hsa00472D-Arginine and D-ornithine metabolism
Pathway IDPathway Name
Metabolism of amino acids and derivatives
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1902Kidney failure
1916Pervasive development disorder
2045Bipolar disorder
2198Psychotic disorder
Desease Name
PSYCH
schizophrenia
No data
Desease Name
Schizophrenia
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of DAO proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DAO mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene affects the expression of DAO mRNAaffects expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of DAO mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in decreased expression of DAO mRNAdecreases expression 20106945
D000431 Ethanol Ethanol results in increased expression of DAO mRNAincreases expression 16946407
D019810 Sodium Azide Sodium Azide results in decreased activity of DAO proteindecreases activity 16846222
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DAO mRNAaffects binding|decreases expression|increases activity 19710929
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of DAO mRNAaffects expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 9.4417676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.4415322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 11.4418287403
MESH:D000138 Acidosis Ethanol 11.4411192467
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4320127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.4311473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.8716835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.6415451039 15451040
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D000853 Anophthalmos Ethanol 5.0815513904
MESH:D001008 Anxiety Disorders Ethanol 4.1711141031
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001321 Autistic Disorder marker/mechanism 17629951
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.4619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.7917474063 20146248
MESH:D001943 Breast Neoplasms Estradiol 1.7917261762 18497071 12948864 19861407 17289903 17018787 14630087 16675129
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7920435547
MESH:D002056 Burns Ethanol 4.9116374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.8321507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.8316924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 4.8315289165 15763234 18788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D006332 Cardiomegaly Ethanol 7.1919332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.1918850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.0312371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.0318566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis Cyclosporine 8.2619486331
MESH:D002779 Cholestasis pirinixic acid 8.2619176532
MESH:D002971 Cleft Lip Ethanol 3.6815513904
MESH:D002972 Cleft Palate Ethanol 6.2015513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.2016354765 15340226 12621046 8697196 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D019465 Craniofacial Abnormalities Ethanol 2.6815451040 15451039 11198716 19302082 10194807 11873399 15513904
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6820055451 10048152 15322242
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5919279558
MESH:D056486 Drug-Induced Liver Injury Ethanol 4.1011566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.1020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema pirinixic acid 7.2312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2215322242 16714409 18230668
MESH:D016889 Endometrial Neoplasms Estradiol 3.1111473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.7516530937
MESH:D004938 Esophageal Neoplasms Ethanol 4.7516704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Cyclosporine 14.3619224547
MESH:D005234 Fatty Liver Ethanol 14.3619236843 16409862 18620774
MESH:D005234 Fatty Liver pirinixic acid 14.3619236843 20131406
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.9817920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.5816946407 15451040 10194807 15513904
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Cyclosporine 9.3612168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3620067830
MESH:D005756 Gastritis Ethanol 5.0115046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7711294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly pirinixic acid 9.1419176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.1412621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.3515709030
MESH:D019584 Hot Flashes Estradiol 4.0717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.368697196 18606429 15340226 16354765 16959395
MESH:D006930 Hyperalgesia Ethanol 3.8818783367
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006973 Hypertension Cyclosporine 5.1710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1718670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9512200463 12878042
MESH:D007333 Insulin Resistance Estradiol 7.6216627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.6216306350
MESH:D007569 Jaw Abnormalities Ethanol 10.8215513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.8216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.308314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 6.3015618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.8512371664
MESH:D007680 Kidney Neoplasms Estradiol 7.8515610895
MESH:D007859 Learning Disorders Ethanol 4.4715451040
MESH:D017880 Limb Deformities, Congenital Ethanol 3.9617676605
MESH:D008103 Liver Cirrhosis Ethanol 3.4715289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.3818295389
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.1114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 5.1118166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.1115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.1112878042
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.9117207112 17347304
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.242125692 18177683 15890375 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.2420195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 11.2416377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.2416984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.218603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2112151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4714755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4720869020 20464547 18569708 17053015 20135361 18520028 20064080 6695378 18816296
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4711884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6811807958 17203775 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.8019453300
MESH:D008569 Memory Disorders Ethanol 4.4218411066 15451040
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.7816810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.7816411023
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1311141357
MESH:D009369 Neoplasms pirinixic acid 5.1317405874
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4719348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 10.2716427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.2714600291
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010051 Ovarian Neoplasms Estradiol 2.2719401270
MESH:D010190 Pancreatic Neoplasms Ethanol 3.0312384795
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811896295 11118676 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0617292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.0616740699
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012559 Schizophrenia marker/mechanism 18583979
MESH:D012640 Seizures Ethanol 3.309754883
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7619755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7616192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.5720155912 2093021
MESH:D013274 Stomach Neoplasms Ethanol 2.5718456281
MESH:D013276 Stomach Ulcer Ethanol 3.7316755016 17189318 17918041 9562338 11906479 9211565
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.459754883
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013978 Tibial Fractures Estradiol 5.0019048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2417053015
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
Pathway ID Pathway Name
KEGG:00330 Arginine and proline metabolism
KEGG:00472 D-Arginine and D-ornithine metabolism
KEGG:00260 Glycine, serine and threonine metabolism
KEGG:01100 Metabolic pathways
REACT:13 Metabolism of amino acids and derivatives
KEGG:04146 Peroxisome
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27139
    • No data
    Releated disease ID Related disease Name
    PA447216Schizophrenia
    Releated drug ID Related drug Name
    PA449789glycine
    PA448055l-alanine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02838 - 3,4-Dihydro-2h-Pyrrolium-5-Carboxylate
    DB02988 - Imino-Tryptophan
    DB03147 - Flavin-Adenine Dinucleotide
    DB03225 - D-Tryptophan
    DB03531 - Flavin-Adenine Dinucleotide-N5-Isobutyl Ketone
    DB03793 - Benzoic Acid Food Preservatives
    DB04166 - 2-Aminobenzoic Acid Anticonvulsants
    DB07979 - (2E)-3-(3,4-DIHYDROXYPHENYL)-2-IMINOPROPANOIC ACID
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved