AutismKB 2.0

Annotation Detail for CLEC14A


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Basic Information Top
Gene Symbol:CLEC14A ( C14orf27,CEG1 )
Gene Full Name: C-type lectin domain family 14, member A
Band: 14q21.1
Quick LinksEntrez ID:161198; OMIM: NA; Uniprot ID:CLC14_HUMAN; ENSEMBL ID: ENSG00000176435; HGNC ID: 19832
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of CLEC14A mRNAdecreases expression 17484886
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in increased expression of CLEC14A mRNAincreases expression 17616710
C006253 pirinixic acid pirinixic acid results in decreased expression of CLEC14A mRNAdecreases expression 18445702
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of CLEC14A mRNAaffects binding|decreases expression 16214954
C025643 vinclozolin vinclozolin affects the expression of CLEC14A mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3811752688 15322242 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.7716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.7716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2911748828
MESH:D001008 Anxiety Disorders vinclozolin 3.9319015723
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9715746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2616227642 3786805 15673190 16192424 15700767 16050911 15721981 16124888 18705752 16011737 10355542 16097048
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0916835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8618788625
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5416120746 18670907 18850075
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4916835633
MESH:D002779 Cholestasis pirinixic acid 3.0819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2212621046 15668235 16354765 8697196 15340226
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.7420423518
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2715322242 20055451 10048152
MESH:D003456 Cryptorchidism vinclozolin 4.7814966744
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7317107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.004309450 15998439 21278145 3786805 2869522 6623471 15027814 3732212 17522070 7120509 16227642 6884620 9327722 19336974 10915739 15968718 7179309 19085960 10092053 7440962 16177239 11566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.0020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D004487 Edema pirinixic acid 7.7912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.7911000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.5118230668 16714409 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.379294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2711564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.9415959796 12795759 17595544 19224547 16045604 12631006 16239168 61145
MESH:D005234 Fatty Liver pirinixic acid 8.9420131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D005355 Fibrosis Carbon Tetrachloride 10.2618705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.2620067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.4716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.9116417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4910048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 4.0319900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 9.9219176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.9212621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.6615340226 16959395 8697196 18606429 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.0716899240
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0118850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5715338365
MESH:D007248 Infertility, Male vinclozolin 3.2616467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0112200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7116580747
MESH:D007984 Leydig Cell Tumor vinclozolin 5.2716417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9816943688 17334410 11408273 16239168 11903743 21278145 17157831 17174718 16221502
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5616248980 17823541 15730626 12666154 18156304 12546737 15876570 12445418 12632514 16015684 17640975 18395914 18210741 17714472 12445421 15818738 18429990 17557913 15673190 18054572 13678700 17698563 17721639 12389079 17525996 18006644 18418968 18412020 16027843 14620537 18279442 15925388 12667390 18376398 15338365 12898905 17708605 15931870 18205269 14716496 17761835 18251166 10355542 15370692 17805973 14512876 12586293 15959796 16136751 18705752 20821823 18481824 17944888 15996030 12649538 12958196 17900296 15893842 17976157 17766677 18317297 18395095 18277467 18472094 17922224 16011737 17565644 12609069 11481614 17481882 16097048 18187930 16638106 16192424 16116963 15362042 18420326 18472332 14724832 18339082 17869086 14716833 15123356 15052691 16033810 12741479 15650968 17631135 18263696 18166357 15057751 14748882 12632512
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5612878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1517285989 15720792 16964402 16246199 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.6515123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.0414706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.9919294768
MESH:D008113 Liver Neoplasms pirinixic acid 7.9916377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.9916984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.4512014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.4512151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009369 Neoplasms pirinixic acid 2.0917405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.6514600291
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 11.3511222880 11399792 11118676 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 11.3518042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.4718220299
MESH:D011472 Prostatitis vinclozolin 5.4718629315
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1816192470
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 5.4815864552
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.5112697716
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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