AutismKB 2.0

Annotation Detail for DAPK1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DAPK1 ( DAPK,DKFZp781I035 )
Gene Full Name: death-associated protein kinase 1
Band: 9q21.33
Quick LinksEntrez ID:1612; OMIM: 600831; Uniprot ID:DAPK1_HUMAN; ENSEMBL ID: ENSG00000196730; HGNC ID: 2674
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05219Bladder cancer
hsa05200Pathways in cancer
Pathway IDPathway Name
Apoptosis
Pathway IDPathway Name
200074Netrin-mediated signaling
200110IFN-gamma pathway
No data
Pathway IDPathway Name
500280Role of DCC in regulating apoptosis
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
Cancers of the urinary system and male genital organs
H00022Bladder cancer
Desease IDDesease Name
1799Epilepsy
1934Cancer
2005Bronchial disease
2038Gastritis
Desease Name
CHEMDEPENDENCY
Alzheimer's disease
NEUROLOGICAL
smoking cessation
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of DAPK1 mRNAincreases expression 19933214
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of DAPK1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of DAPK1 mRNAaffects expression 21346803
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of DAPK1 mRNAdecreases expression 12419474
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased methylation of DAPK1 promoterincreases methylation 15172992
C010643 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased expression of DAPK1 mRNA]decreases reaction|increases expression 19477266
D000082 Acetaminophen [Dietary Carbohydrates co-treated with Acetaminophen] results in increased expression of DAPK1 mRNAaffects cotreatment|increases expression 17093179
D000082 Acetaminophen Acetaminophen affects the expression of DAPK1 mRNAaffects expression 17562736
D000111 Acetylcysteine Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of DAPK1 mRNA]decreases reaction|increases expression 19477266
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in decreased expression of DAPK1 mRNAdecreases expression 18687144
D001374 Azacitidine Azacitidine affects the methylation of DAPK1 promoteraffects methylation 17557868
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of DAPK1 mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DAPK1 mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of DAPK1 mRNAdecreases expression 15336504
12419474
D002087 Butyrates Butyrates results in increased expression of DAPK1 mRNAincreases expression 16042588
D002784 Cholesterol 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased expression of DAPK1 mRNA]decreases reaction|increases expression 19477266
D002784 Cholesterol Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of DAPK1 mRNA]decreases reaction|increases expression 19477266
D002784 Cholesterol Cholesterol analog results in increased expression of DAPK1 mRNAincreases expression 19477266
C014347 decitabine decitabine affects the expression of DAPK1 mRNAaffects expression 17133271
C014347 decitabine decitabine inhibits the reaction [sodium arsenite results in decreased expression of DAPK1 protein]decreases expression|decreases reaction 19577553
C014347 decitabine decitabine results in decreased methylation of DAPK1 promoterdecreases methylation 17690560
C014347 decitabine decitabine results in increased expression of DAPK1 mRNAincreases expression 19037991
19215824
D004040 Dietary Carbohydrates [Dietary Carbohydrates co-treated with Acetaminophen] results in increased expression of DAPK1 mRNAaffects cotreatment|increases expression 17093179
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of DAPK1 proteinaffects cotreatment|decreases expression 20970405
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of DAPK1 promoteraffects cotreatment|increases methylation 20970405
D002117 Calcitriol Calcitriol results in decreased expression of DAPK1 mRNAdecreases expression 16002434
C025034 doxifluridine DAPK1 protein results in increased susceptibility to doxifluridineincreases response to substance 16734730
C045651 epigallocatechin gallate epigallocatechin gallate results in decreased expression of DAPK1 mRNAdecreases expression 12628509
D004958 Estradiol Estradiol results in decreased expression of DAPK1 mRNAdecreases expression 16202921
D006830 Hydralazine Hydralazine results in decreased methylation of DAPK1 promoterdecreases methylation 15862127
D006830 Hydralazine Hydralazine results in increased expression of DAPK1 mRNAincreases expression 15862127
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of DAPK1 mRNAdecreases expression 12419474
D008748 Methylcholanthrene [Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of DAPK1 proteinaffects cotreatment|decreases expression 20970405
D008748 Methylcholanthrene [Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of DAPK1 promoteraffects cotreatment|increases methylation 20970405
D008752 Methylene Chloride Methylene Chloride results in increased methylation of DAPK1 promoterincreases methylation 15172992
D008942 Mitoxantrone DAPK1 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
C064769 N-acetylsphingosine N-acetylsphingosine results in increased activity of DAPK1 proteinincreases activity 17087515
C064769 N-acetylsphingosine N-acetylsphingosine results in increased activity of DAPK1 proteinincreases activity 17087515
D010656 Phenylephrine Phenylephrine results in decreased expression of DAPK1 mRNAdecreases expression 18158353
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DAPK1 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DAPK1 mRNAaffects binding|increases activity|increases expression 19710929
C017947 sodium arsenite decitabine inhibits the reaction [sodium arsenite results in decreased expression of DAPK1 protein]decreases expression|decreases reaction 19577553
C017947 sodium arsenite sodium arsenite results in decreased expression of DAPK1 proteindecreases expression 19577553
C017947 sodium arsenite sodium arsenite results in increased methylation of DAPK1 promoterincreases methylation 17683884
19577553
C017947 sodium arsenite U 0126 inhibits the reaction [sodium arsenite results in decreased expression of DAPK1 protein]decreases expression|decreases reaction 19577553
D018038 Sodium Selenite Sodium Selenite results in decreased expression of DAPK1 mRNAdecreases expression 18175754
16705456
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DAPK1 mRNAincreases expression 15972635
19933214
D014212 Tretinoin Tretinoin results in increased expression of DAPK1 mRNAincreases expression 16249480
C012589 trichostatin A trichostatin A results in increased expression of DAPK1 mRNAincreases expression 16865256
C113580 U 0126 U 0126 inhibits the reaction [sodium arsenite results in decreased expression of DAPK1 protein]decreases expression|decreases reaction 19577553
C025643 vinclozolin vinclozolin affects the expression of DAPK1 mRNAaffects expression 19015723
C017963 vinyl carbamate vinyl carbamate results in increased methylation of DAPK1 promoterincreases methylation 15172992
C088658 zoledronic acid zoledronic acid results in decreased expression of DAPK1 mRNAdecreases expression 19036117
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.4511752688 14514962 15322242
MESH:D000168 Acrocephalosyndactylia U 0126 5.0817694057
MESH:D058186 Acute Kidney Injury zoledronic acid 4.1019715164
MESH:D055371 Acute Lung Injury pirinixic acid 2.7518653653
MESH:D000210 Acute-Phase Reaction zoledronic acid 5.0720200999
MESH:D000230 Adenocarcinoma marker/mechanism 15172992
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.5920127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 6.5911473722
MESH:D000230 Adenocarcinoma vinyl carbamate 6.5916247444 17363558
MESH:D000236 Adenoma 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 14.0516176798
MESH:D000236 Adenoma Benzo(a)pyrene 14.056695378
MESH:D000236 Adenoma Diethylnitrosamine 14.0510737359 6695378
MESH:D000236 Adenoma Methylcholanthrene 14.0510545420 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 21.5916434500 19061943 17162532 17620307 18056438 19052882
MESH:D018248 Adenoma, Liver Cell pirinixic acid 21.5916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 21.5916835633
MESH:D018248 Adenoma, Liver Cell vinyl carbamate 21.5912371669
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.2815276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.4917306315 16712894
MESH:D000505 Alopecia Tretinoin 3.2915955085
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.8410965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6011748828
MESH:D000799 Angioedema Acetaminophen 3.4310982225
MESH:D001008 Anxiety Disorders vinclozolin 3.3219015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.6819183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.7617460149
MESH:D001169 Arthritis, Experimental Tretinoin 2.8216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1616292516
MESH:D001249 Asthma epigallocatechin gallate 4.7716516891
MESH:D001249 Asthma Tretinoin 4.7716456186
MESH:D050197 Atherosclerosis Cholesterol 6.5016632123
MESH:D050197 Atherosclerosis Methylcholanthrene 6.5011922910
MESH:D001321 Autistic Disorder Acetaminophen 1.4618445737
MESH:D001327 Autoimmune Diseases epigallocatechin gallate 4.6719761891
MESH:D001471 Barrett Esophagus Tretinoin 4.0216935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.1719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.1712125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.1716206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5015746008
MESH:D001859 Bone Neoplasms zoledronic acid 4.5811697798 16121404 17312309 15867366 16778634 19442620
MESH:D001862 Bone Resorption zoledronic acid 4.3418404659 18496637 15845617 16769263 11869084 8053405
MESH:D001919 Bradycardia Phenylephrine 4.1415306635
MESH:D001932 Brain Neoplasms marker/mechanism 17319784
MESH:D001943 Breast Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 7.7120146248
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 7.7120146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 7.7111237771
MESH:D001943 Breast Neoplasms decitabine 7.7118320071 19208741
MESH:D001943 Breast Neoplasms Diethylnitrosamine 7.7117474063
MESH:D001943 Breast Neoplasms Estradiol 7.7117289903 18497071 12948864 17018787 16675129 14630087 17261762 19861407
MESH:D001943 Breast Neoplasms Methylcholanthrene 7.7117474063
MESH:D001943 Breast Neoplasms Methylene Chloride 7.7115986119
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 7.7120435547
MESH:D001943 Breast Neoplasms Tretinoin 7.7116166294 16443354 16873071
MESH:D001943 Breast Neoplasms zoledronic acid 7.7118695136 16096432
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.1816813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0616111702
MESH:D002277 Carcinoma Methylcholanthrene 7.2710545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.2716835633
MESH:D003528 Carcinoma, Adenoid Cystic marker/mechanism 16762588
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.7416168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 15.5416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 15.5416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 15.543084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 15.5416502159 19383236 19171122 10737359 17138121 18785209 16569478 19418558 20727157 20512989 19052882 20101231 17978847 18665156 16878318 16698587 16935385 19519916 3084413 20084675 20214788 18691550 17761372 20432363 16288022 16681979 17173139 19394651 19919837 20514400 19208518 17428255 18788625 17055752 18506893 18971187 16328049 17162532 19701751 3581430 18393292 19107877 20007298 16830150 19822196 21159647 20524982 19335982 18210153 16807293 19539802 20935162 10672840 11831363 16779866 18494052 18056438 16540662 18978308
MESH:D006528 Carcinoma, Hepatocellular Estradiol 15.5416924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 15.5415276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 15.541917145
MESH:D006528 Carcinoma, Hepatocellular vinyl carbamate 15.5412371669
MESH:D002289 Carcinoma, Non-Small-Cell Lung marker/mechanism 11313923
MESH:D002289 Carcinoma, Non-Small-Cell Lung vinyl carbamate 5.8916247446
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 5.8919233551
MESH:D002292 Carcinoma, Renal Cell marker/mechanism 17133271
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 3.6518507039
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 16.3417015178
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 16.3420419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 16.3411237771
MESH:D002294 Carcinoma, Squamous Cell decitabine 16.3419215824
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 16.3418572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 16.3416051514 16096774
MESH:D002295 Carcinoma, Transitional Cell marker/mechanism 17133271
MESH:D006332 Cardiomegaly Phenylephrine 6.1111179087 16170337 17124262 17287366 15728586 11754973
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.1116120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.2316936243
MESH:D002386 Cataract Acetaminophen 6.4110977129
MESH:D002386 Cataract Tretinoin 6.4117460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 27.476135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 27.4720889678
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 27.4718226522
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 27.4721159647 17174075 7505956 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 27.4718566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 27.4716192471
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 27.4720056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.1816129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.1919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.1916835633
MESH:D002779 Cholestasis pirinixic acid 2.5319176532
MESH:D002822 Choriocarcinoma Tretinoin 4.7416461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.3515894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.1612621046 8697196 15668235 16354765 15340226
MESH:D002972 Cleft Palate Tretinoin 5.169407595
MESH:D003092 Colitis Tretinoin 3.3117035595
MESH:D003110 Colonic Neoplasms Butyrates 3.8915936596
MESH:D003110 Colonic Neoplasms decitabine 3.8917616700
MESH:D015179 Colorectal Neoplasms Azacitidine 2.7919934284
MESH:D015179 Colorectal Neoplasms decitabine 2.7918981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7217141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.3115322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.319142499 16925845 8800419 10589399 9211117 17551590 9664655 14991402 9224671 9125849
MESH:D003456 Cryptorchidism vinclozolin 3.9514966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.5718551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.5718551238
MESH:D003550 Cystic Fibrosis Acetylcysteine 4.0319747007
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2318249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.4416285004
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.5420387270
MESH:D003924 Diabetes Mellitus, Type 2 epigallocatechin gallate 6.5416988119
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.5417107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.0719279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 16.5821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 16.5818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 16.5810663392 17906064 15619225 19085960 14550746 19739265 12540782 11743745 12153990 10915739 12392966 16081117 19420014 16781746 11529661 14725611 10774834 14986274 19923254 16109766 12958197 16177239 11834606 11461765 17562736 19416960 2444490 11287661 11421492 11739529 16227642 12705907 19164858 18713872 12594235 15968718 19370779 18071297 17522070 16393943 16485898
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 16.5811287661
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 16.5819107877
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 16.5815131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 16.5820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6819426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4611462148
MESH:D004487 Edema pirinixic acid 5.3612083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.3611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.5616714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.5618230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 3.5515138306
MESH:D004701 Endocrine Gland Neoplasms decitabine 12.6519294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 12.6519294695
MESH:D016889 Endometrial Neoplasms Estradiol 6.5219148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Tretinoin 6.5216569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.6710568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7016302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 3.9620426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 3.9616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.8311564622
MESH:D005124 Eye Abnormalities Tretinoin 7.839664655 16938888
MESH:D005234 Fatty Liver Diethylnitrosamine 6.4921071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 6.4919236843 20131406
MESH:D005264 Femoral Fractures zoledronic acid 5.4216234978
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0611858732
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.5314633661 10962813
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.3020067830
MESH:D005355 Fibrosis Tretinoin 7.3017994277
MESH:D005756 Gastritis Acetaminophen 3.2616983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.5316973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.8916417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.2716452187
MESH:D005909 Glioblastoma Tretinoin 6.5317312396
MESH:D005909 Glioblastoma trichostatin A 6.5318801729
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1810696789
MESH:D006258 Head and Neck Neoplasms decitabine 6.9119215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 6.9116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.7416084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.8020471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.8011294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 9.809664655 14991402
MESH:D006331 Heart Diseases Mitoxantrone 3.8716019553
MESH:D006333 Heart Failure pirinixic acid 2.2820558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9711000095
MESH:D006529 Hepatomegaly pirinixic acid 6.9516221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.9515340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.6215709030
MESH:D006689 Hodgkin Disease sodium arsenite 2.8212676792
MESH:D019584 Hot Flashes Estradiol 3.3417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6315340226 18606429 8697196 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 11.2916870215
MESH:D006930 Hyperalgesia Tretinoin 11.2916870215
MESH:D006930 Hyperalgesia zoledronic acid 11.2916769263
MESH:D006934 Hypercalcemia zoledronic acid 4.6819622757 18089816
MESH:D006937 Hypercholesterolemia Cholesterol 4.6116933029
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.1716778211
MESH:D006943 Hyperglycemia pirinixic acid 2.8320558911
MESH:D006973 Hypertension Phenylephrine 4.7512717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7518670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.2316612254
MESH:D006984 Hypertrophy Phenylephrine 4.1912791704 18502941
MESH:D006996 Hypocalcemia zoledronic acid 5.7812669777
MESH:D007248 Infertility, Male decitabine 9.7117581917
MESH:D007248 Infertility, Male sodium arsenite 9.7115346721 12646999
MESH:D007248 Infertility, Male vinclozolin 9.7116467254
MESH:D007249 Inflammation Diethylnitrosamine 4.1818785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.1812878042 12200463
MESH:D007333 Insulin Resistance Estradiol 10.7516627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 10.7516306350
MESH:D007333 Insulin Resistance Sodium Selenite 10.7514714311
MESH:D007410 Intestinal Diseases Tretinoin 3.3717994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.7216580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.7215992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 8.6415629191 12587719
MESH:D007674 Kidney Diseases Estradiol 8.6415618244
MESH:D007674 Kidney Diseases sodium arsenite 8.6420008137
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 3.9116518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 10.5016705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 10.5016705839
MESH:D007680 Kidney Neoplasms Estradiol 10.5015610895
MESH:D007859 Learning Disorders Cholesterol 4.7017134702
MESH:D007938 Leukemia Azacitidine 9.3919148494
MESH:D007938 Leukemia decitabine 9.3919235587 18980019
MESH:D007938 Leukemia Tretinoin 9.3917143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.6118172266
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 4.4118089816
MESH:D007948 Leukemia, Monocytic, Acute U 0126 4.9016972261
MESH:D007951 Leukemia, Myeloid Azacitidine 14.0219077051
MESH:D007951 Leukemia, Myeloid decitabine 14.0219117987 18454857 17236224
MESH:D007951 Leukemia, Myeloid Tretinoin 14.0219285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 8.1018720364 17596541
MESH:D015470 Leukemia, Myeloid, Acute decitabine 8.1019387464 18704418 18206229 18460780 17679729 19010910
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 8.1019850784 17596541 16294345
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 8.1018206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.0518055864
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 4.8219299654
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.8817217047 16788101 12679006 17649720 17506722 19225113 16140955 19075265 16331271 19029980 15748426 17361223 16766008 17294898 17368321 17301526 9834237 16823087 17712046 19035177 19642359 17107899 16935935 17339181 16891316
MESH:D007984 Leydig Cell Tumor vinclozolin 4.3216417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.029224671
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.6020032147 19638242 18522880 18407596 18665156
MESH:D008106 Liver Cirrhosis, Experimental epigallocatechin gallate 6.1017481882
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.1014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.1015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.1012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.1016248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 3.5219460945 11587558 12587719 16611625 19784758 16610002 12969438 19014921
MESH:D008107 Liver Diseases Diethylnitrosamine 3.5217034775
MESH:D017114 Liver Failure, Acute Acetaminophen 2.8816871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 19.327678174
MESH:D008113 Liver Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 19.3215890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 19.3221137059 20195826
MESH:D008113 Liver Neoplasms Diethylnitrosamine 19.3219427195 19833225 19690152 21047994 16942905 21167192 19426721 20434301 20101389 20405173 18977376 20118626 12112319 19073162 21278145 19642983 18754104 20501860 19638242 21071580 19294768 20583210 20137499 19996281 12771043 19090486 19812893 20492335 18644402 19850985 19499222 18978307 19254457 19551842 20452335 10737359 15175105 19255062 18648771 2422723 9163691 2862719 15885732 19256749
MESH:D008113 Liver Neoplasms pirinixic acid 19.3220007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 19.3216712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 19.3216984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 12.006135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 12.0018775883 17942915 18544905 9362446 16267830 17174075 18079962 19004024 19009564 21159647 18253720 18282651 18164116 2563599 19126423 18308698 18093689 19519916 19539802 3124819 16842330 17854601
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 12.00598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.0012151625
MESH:D008171 Lung Diseases Acetylcysteine 6.8512815614
MESH:D008171 Lung Diseases sodium arsenite 6.8519095001
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.6317365036
MESH:D008175 Lung Neoplasms marker/mechanism 15172992
MESH:D008175 Lung Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 14.2119931552 17139156 9255578 16061637 14755239 16401635 18508827 18813816 15893417 15172992 12438228
MESH:D008175 Lung Neoplasms Azacitidine 14.2121224363
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 14.2120064080 18569708 20869020 18816296 18520028 20464547 17053015 6695378 20135361
MESH:D008175 Lung Neoplasms Diethylnitrosamine 14.2120512841 20970405 21163286 6695378
MESH:D008175 Lung Neoplasms Methylcholanthrene 14.211399818 21163286 7750092 6695378 16337739 20512841 15390079 16271038 11893704 20970405 10545420 9230183 17909032
MESH:D008175 Lung Neoplasms Methylene Chloride 14.2115172992
MESH:D008175 Lung Neoplasms sodium arsenite 14.2117077188 15276417 17306315 19931552 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 14.2119555203 11884234
MESH:D008175 Lung Neoplasms vinyl carbamate 14.2112438228 14755239 15172992 17363558 16885199 16247444 12765245 11195469 15824018 11134547 17361011 17163412 12117777
MESH:D008223 Lymphoma decitabine 3.1319470736
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.6814737004
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.5011408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 5.5017312309
MESH:D020149 Manganese Poisoning Estradiol 4.0719453300
MESH:D008527 Medulloblastoma Tretinoin 2.6217453147
MESH:D008545 Melanoma 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 11.4117992120
MESH:D008545 Melanoma decitabine 11.4116505122 17785578
MESH:D008545 Melanoma epigallocatechin gallate 11.4117992120 11746506
MESH:D008545 Melanoma sodium arsenite 11.4119082730 16487513
MESH:D008545 Melanoma Tretinoin 11.4116752155
MESH:D008545 Melanoma trichostatin A 11.4116505122
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1719513568
MESH:D008591 Meningomyelocele Tretinoin 4.0316940565
MESH:D008654 Mesothelioma Asbestos, Crocidolite 6.1116166281 16966607 18303189
MESH:D008654 Mesothelioma zoledronic acid 6.1116675582
MESH:D009006 Monosomy Azacitidine 5.6719299654
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.8816381670
MESH:D009101 Multiple Myeloma Azacitidine 15.0019549372 18443271
MESH:D009101 Multiple Myeloma decitabine 15.0018172295
MESH:D009101 Multiple Myeloma trichostatin A 15.0018172295
MESH:D009101 Multiple Myeloma zoledronic acid 15.0019621390 18089719 16996129
MESH:D009134 Muscular Atrophy, Spinal epigallocatechin gallate 5.0817962980
MESH:D009135 Muscular Diseases pirinixic acid 3.1116239165
MESH:D009190 Myelodysplastic Syndromes Azacitidine 11.0718720364 19805378 17611569 17596541
MESH:D009190 Myelodysplastic Syndromes decitabine 11.0719010910 16882708 19157545 18608210
MESH:D009190 Myelodysplastic Syndromes Tretinoin 11.0717596541
MESH:D009203 Myocardial Infarction pirinixic acid 1.9719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.2216810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.2216411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 8.9918551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 8.997678174 18551238
MESH:D009362 Neoplasm Metastasis marker/mechanism 17319784
MESH:D009362 Neoplasm Metastasis Acetylcysteine 8.7414720322
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.749029167 3581430
MESH:D009362 Neoplasm Metastasis zoledronic acid 8.7415867366 17312309 19139120
MESH:D009369 Neoplasms Benzo(a)pyrene 17.0511141357
MESH:D009369 Neoplasms decitabine 17.0519470736 19116145 17925555
MESH:D009369 Neoplasms Mitoxantrone 17.0516640825
MESH:D009369 Neoplasms pirinixic acid 17.0517405874
MESH:D009369 Neoplasms sodium arsenite 17.0511559025
MESH:D009369 Neoplasms Tretinoin 17.0516594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.2720056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3317289903
MESH:D009421 Nervous System Malformations Estradiol 14.1016427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.1014600291
MESH:D009421 Nervous System Malformations Tretinoin 14.109125849
MESH:D009436 Neural Tube Defects Acetylcysteine 10.7219446573
MESH:D009436 Neural Tube Defects sodium arsenite 10.7212854658
MESH:D009436 Neural Tube Defects Tretinoin 10.729142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.0918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.0920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7020387270
MESH:D052556 Niemann-Pick Disease, Type C Cholesterol 5.3120557099 9802331
MESH:D009765 Obesity pirinixic acid 1.7120558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.7212819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 7.7216049721
MESH:D010014 Osteolysis zoledronic acid 4.9615867366
MESH:D010024 Osteoporosis zoledronic acid 3.7817882678
MESH:D010051 Ovarian Neoplasms decitabine 17.0219331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 17.0219401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 17.0215276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 17.0216936753
MESH:D010051 Ovarian Neoplasms trichostatin A 17.0219331143
MESH:D010051 Ovarian Neoplasms U 0126 17.0216211241
MESH:D010146 Pain Acetaminophen 9.4516870215
MESH:D010146 Pain Tretinoin 9.4516870215
MESH:D010146 Pain zoledronic acid 9.4516475674
MESH:D010190 Pancreatic Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 14.6412384795
MESH:D010190 Pancreatic Neoplasms decitabine 14.6419294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 14.6416540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 14.6415976015
MESH:D010190 Pancreatic Neoplasms trichostatin A 14.6419294695
MESH:D010212 Papilloma Hydrogen Peroxide 3.6912065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8312520081
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.0911550810
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.5010923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1718163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.212563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.1411118676 11896295 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.1418042343 18220299 19015723
MESH:D055728 Primary Myelofibrosis decitabine 11.1017616702
MESH:D055728 Primary Myelofibrosis trichostatin A 11.1017616702
MESH:D011469 Prostatic Diseases vinclozolin 4.5318220299
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.3715572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5220887781
MESH:D011471 Prostatic Neoplasms Azacitidine 2.3418324645
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.3417292933
MESH:D011471 Prostatic Neoplasms Calcitriol 2.3412479363 18247401 16289102 15754350 16644109
MESH:D011471 Prostatic Neoplasms Estradiol 2.3416740699
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.3416039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.3418760546
MESH:D011471 Prostatic Neoplasms trichostatin A 2.3419789329 18798265
MESH:D011471 Prostatic Neoplasms zoledronic acid 2.3412438248 19103299
MESH:D011472 Prostatitis vinclozolin 4.5318629315
MESH:D011507 Proteinuria Tretinoin 3.2316636307
MESH:D011625 Pterygium Tretinoin 4.3816723453
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.8717365031 17322281 17975199 15814490
MESH:D015427 Reperfusion Injury pirinixic acid 2.1819058328
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 4.1512210543
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4518990726
MESH:D012208 Rhabdomyosarcoma decitabine 9.7019155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 9.7016116481 16283617
MESH:D012468 Salivary Gland Neoplasms marker/mechanism 16762588
MESH:D012512 Sarcoma, Ewing's zoledronic acid 4.5516121404
MESH:D012640 Seizures 2,4-dinitrotoluene 4.9518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 4.9518551238
MESH:D012852 Sinusitis Phenylephrine 4.307327846
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 19.8510029692 19755658
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 19.8512065085
MESH:D012878 Skin Neoplasms sodium arsenite 19.8519524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 19.858532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 19.8516192470
MESH:D012878 Skin Neoplasms Tretinoin 19.8516467112
MESH:D016135 Spinal Dysraphism sodium arsenite 3.4812854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.322093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 4.3219037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.3218456281
MESH:D013274 Stomach Neoplasms Tretinoin 4.3217261132
MESH:D013276 Stomach Ulcer Acetylcysteine 3.6517918041
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4912697716
MESH:D013964 Thyroid Neoplasms Butyrates 14.6317967635
MESH:D013964 Thyroid Neoplasms decitabine 14.6317967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 14.637505956
MESH:D013964 Thyroid Neoplasms Tretinoin 14.6316026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.2719048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.4416051514
MESH:D014376 Tuberculosis Tretinoin 2.9716040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 13.9616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 13.9616049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 13.9617053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 13.9617616700 19087683
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 13.9616452187 16712894 11723127 17306315
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.6310091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.6310091137
MESH:D014581 Urticaria Acetaminophen 2.6110982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.2411813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.2416129372
MESH:D014604 Uveal Neoplasms decitabine 11.4517785578
MESH:D014604 Uveal Neoplasms Tretinoin 11.4516752155
MESH:D014652 Vascular Diseases sodium arsenite 4.0217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1812125929
MESH:D014820 Vitiligo Tretinoin 3.6716761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8315886252
MESH:D009396 Wilms Tumor Tretinoin 3.6316287080
Pathway ID Pathway Name
REACT:578 Apoptosis
KEGG:05219 Bladder cancer
KEGG:05200 Pathways in cancer
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27142
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB04069 - 5,6-Dihydro-Benzo[H]Cinnolin-3-Ylamine
    DB04395 - Phosphoaminophosphonic Acid-Adenylate Ester
    DB07444 - 6-(3-AMINOPROPYL)-4,9-DIMETHYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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