AutismKB 2.0

Annotation Detail for DAPK3


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Basic Information Top
Gene Symbol:DAPK3 ( FLJ36473,ZIP,ZIPK )
Gene Full Name: death-associated protein kinase 3
Band: 19p13.3
Quick LinksEntrez ID:1613; OMIM: 603289; Uniprot ID:DAPK3_HUMAN; ENSEMBL ID: ENSG00000167657; HGNC ID: 2676
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05219Bladder cancer
hsa05200Pathways in cancer
Pathway IDPathway Name
Apoptosis
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2011Leukoencephalopathy
2151Neuroblastoma
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of DAPK3 mRNAdecreases expression 12958071
D000082 Acetaminophen Acetaminophen affects the expression of DAPK3 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DAPK3 mRNAaffects expression 16483693
C095105 bexarotene bexarotene results in decreased expression of DAPK3 mRNAdecreases expression 16648578
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in decreased expression of DAPK3 mRNAdecreases expression 17553608
C459604 candoxin candoxin results in increased expression of DAPK3 mRNAincreases expression 16309724
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of DAPK3 mRNAincreases expression 16934159
D016572 Cyclosporine Cyclosporine results in increased expression of DAPK3 mRNAincreases expression 20106945
C014347 decitabine decitabine results in increased expression of DAPK3 mRNAincreases expression 19037991
D000431 Ethanol Ethanol results in increased expression of DAPK3 mRNAincreases expression 15353170
D008727 Methotrexate DAPK3 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DAPK3 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of DAPK3 mRNAdecreases expression 18445702
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of DAPK3 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in increased expression of DAPK3 mRNAincreases expression 19244175
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of DAPK3 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of DAPK3 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 9.2617676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 9.2612039119
MESH:D000138 Acidosis Ammonium Chloride 10.7518287403
MESH:D000138 Acidosis Ethanol 10.7511192467
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.5616434500
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.4215451040 15451039
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D000853 Anophthalmos Ethanol 4.8915513904
MESH:D001008 Anxiety Disorders Ethanol 4.0511141031
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.1117286800
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2019483382
MESH:D001943 Breast Neoplasms bexarotene 2.1616344269 16818667
MESH:D001943 Breast Neoplasms decitabine 2.1619208741 18320071
MESH:D001943 Breast Neoplasms Methotrexate 2.1616978400
MESH:D002056 Burns Ethanol 4.7216374292
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0016050911
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.073084413
MESH:D006528 Carcinoma, Hepatocellular Ethanol 3.0718788625 15289165 15763234
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.2416247446
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6119215824
MESH:D006332 Cardiomegaly Ethanol 3.4619332462
MESH:D002386 Cataract Acetaminophen 2.6110977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.5612371664
MESH:D002779 Cholestasis Cyclosporine 7.8919486331
MESH:D002779 Cholestasis pirinixic acid 7.8919176532
MESH:D002971 Cleft Lip Ethanol 3.6115513904
MESH:D002972 Cleft Palate Ethanol 3.1915513904
MESH:D003092 Colitis Selenium 3.8517936198
MESH:D003110 Colonic Neoplasms decitabine 2.3417616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D019465 Craniofacial Abnormalities Ethanol 4.0519302082 11198716 15451039 15451040 11873399 15513904 10194807
MESH:D019465 Craniofacial Abnormalities Methotrexate 4.0512039119 9562676
MESH:D019465 Craniofacial Abnormalities Vitamin E 4.0519769572
MESH:D003550 Cystic Fibrosis Methotrexate 4.2919747007
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003882 Dermatomyositis Methotrexate 5.1920191521
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.1812594235 15968718 14550746 14725611 19164858 11287661 12540782 19416960 12153990 11461765 16393943 11743745 16485898 18071297 2444490 19085960 11529661 11739529 17562736 16109766 19370779 14986274 19923254 17906064 10663392 16081117 15619225 16177239 12958197 10915739 10774834 16781746 17522070 12705907 19420014 19739265 16227642 18713872 12392966 11834606 11421492
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 9.1817851650
MESH:D056486 Drug-Induced Liver Injury Ethanol 9.1811566570
MESH:D056486 Drug-Induced Liver Injury Selenium 9.1815131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:C538011 Eales disease Vitamin E 4.809068938
MESH:D004487 Edema pirinixic acid 2.5312083418
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.2119294695
MESH:D004938 Esophageal Neoplasms Ethanol 2.7716704527
MESH:D005234 Fatty Liver Cyclosporine 13.4519224547
MESH:D005234 Fatty Liver Ethanol 13.4518620774 19236843 16409862
MESH:D005234 Fatty Liver pirinixic acid 13.4520131406 19236843
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.7617920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.3815451040 16946407 15513904 10194807
MESH:D005355 Fibrosis Cyclosporine 3.2112168785 12639820
MESH:D005756 Gastritis Acetaminophen 11.4616983495
MESH:D005756 Gastritis Ethanol 11.4615046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D006086 Graft vs Host Disease Methotrexate 5.2216518429
MESH:D006258 Head and Neck Neoplasms decitabine 3.5219215824
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0116080930
MESH:D006333 Heart Failure pirinixic acid 7.0620558911
MESH:D006333 Heart Failure Selenium 7.0617162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006529 Hepatomegaly pirinixic acid 3.0718467677 19772884 16221962 19176532
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7216490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.0714716179
MESH:D006930 Hyperalgesia Acetaminophen 7.9516870215
MESH:D006930 Hyperalgesia Ethanol 7.9518783367
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006973 Hypertension Cyclosporine 2.1210903974
MESH:D007248 Infertility, Male decitabine 3.2417581917
MESH:D007251 Influenza, Human Selenium 11.2916624496
MESH:D007251 Influenza, Human Vitamin E 11.2916624496
MESH:D007333 Insulin Resistance pirinixic acid 2.6616306350
MESH:D007569 Jaw Abnormalities Ethanol 4.4615513904
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007674 Kidney Diseases Acetaminophen 10.1812587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.188314463 10903974 18776723
MESH:D007674 Kidney Diseases Vitamin E 10.1812488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9416518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.7812371664
MESH:D007805 Language Development Disorders Methotrexate 5.169562676
MESH:D007859 Learning Disorders Ethanol 4.2815451040
MESH:D007938 Leukemia decitabine 3.1019235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.0618454857 17236224 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3918460780 19010910 19387464 17679729 18206229 18704418
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.5618055864
MESH:D017880 Limb Deformities, Congenital Ethanol 3.8517676605
MESH:D008103 Liver Cirrhosis Ethanol 7.2315289165
MESH:D008103 Liver Cirrhosis Methotrexate 7.2314986274
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.1818295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 3.5818166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5815474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5816169303
MESH:D008107 Liver Diseases Acetaminophen 1.6419460945 16611625 12969438 11587558 19784758 12587719 16610002 19014921
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.7217347304 17207112
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2916871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 1.8420007298 16377806 15890375
MESH:D008171 Lung Diseases Vitamin E 3.2116863852
MESH:D017563 Lung Diseases, Interstitial Methotrexate 5.1218516814
MESH:D008175 Lung Neoplasms bexarotene 2.7917849452
MESH:D008175 Lung Neoplasms Vitamin E 2.7911062179
MESH:D008223 Lymphoma decitabine 8.0319470736
MESH:D008223 Lymphoma Methotrexate 8.0317352296
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 5.2211161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 6.4415591091 19196723 19196722
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.4415318939
MESH:D008545 Melanoma decitabine 2.2517785578 16505122
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008569 Memory Disorders Ethanol 4.2518411066 15451040
MESH:D008654 Mesothelioma Selenium 2.8115107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D052016 Mucositis Methotrexate 5.3617488658
MESH:D009101 Multiple Myeloma decitabine 3.3818172295
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4119010910 16882708 19157545 18608210
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9916411023
MESH:D009369 Neoplasms decitabine 5.1019470736 19116145 17925555
MESH:D009369 Neoplasms pirinixic acid 5.1017405874
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.8819196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3318481113 19348381
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9118514411
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D010051 Ovarian Neoplasms decitabine 2.6619259094 19331143
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D010190 Pancreatic Neoplasms decitabine 5.6219294695
MESH:D010190 Pancreatic Neoplasms Ethanol 5.6212384795
MESH:D010954 Plasmacytoma Selenium 4.9915087411
MESH:D011230 Precancerous Conditions Cyclosporine 3.2712371664
MESH:D055728 Primary Myelofibrosis decitabine 4.8017616702
MESH:D011471 Prostatic Neoplasms Vitamin E 3.3015084515
MESH:D011565 Psoriasis Cyclosporine 5.9716882103
MESH:D011565 Psoriasis Methotrexate 5.9717410198
MESH:D051437 Renal Insufficiency Methotrexate 4.7817352296
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D012208 Rhabdomyosarcoma decitabine 4.4619155313
MESH:D012640 Seizures Ethanol 3.209754883
MESH:D012871 Skin Diseases Vitamin E 2.4518709164
MESH:D013274 Stomach Neoplasms decitabine 2.7419037991
MESH:D013274 Stomach Neoplasms Ethanol 2.7418456281
MESH:D013276 Stomach Ulcer Ethanol 3.589562338 16755016 17189318 11906479 9211565 17918041
MESH:D020521 Stroke Vitamin E 3.5616517955
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.309754883
MESH:D013576 Syndactyly Methotrexate 5.109562676
MESH:D013964 Thyroid Neoplasms decitabine 3.3717967635
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.7419087683 17616700
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D014604 Uveal Neoplasms decitabine 5.0117785578
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
Pathway ID Pathway Name
REACT:578 Apoptosis
KEGG:05219 Bladder cancer
KEGG:05200 Pathways in cancer
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB04716 - 2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE
DB07125 - 4-(6-{[(1R)-1-(hydroxymethyl)propyl]amino}imidazo[1,2-b]pyridazin-3-yl)benzoic acid
DB07242 - (4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile
No data
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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