AutismKB 2.0

Annotation Detail for DARS


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Basic Information Top
Gene Symbol:DARS ( DKFZp781B11202,MGC111579 )
Gene Full Name: aspartyl-tRNA synthetase
Band: 2q21.3
Quick LinksEntrez ID:1615; OMIM: 603084; Uniprot ID:SYDC_HUMAN; ENSEMBL ID: ENSG00000115866; HGNC ID: 2678
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
TRNA-CHARGING-PWYtRNA charging pathway
Pathway IDPathway Name
hsa00970Aminoacyl-tRNA biosynthesis
Pathway IDPathway Name
Gene Expression
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of DARS mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DARS mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of DARS mRNAincreases expression 20504355
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of DARS mRNAincreases expression 15336504
D002995 Clofibric Acid Clofibric Acid affects the expression of DARS mRNAaffects expression 17602206
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of DARS mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DARS mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil Fluorouracil affects the expression of DARS mRNAaffects expression 16584549
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to DARS protein]affects binding|increases reaction 17220478
D011794 Quercetin Quercetin results in increased expression of DARS mRNAincreases expression 19729006
D018038 Sodium Selenite Sodium Selenite results in increased expression of DARS mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DARS mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0414514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.2320464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.2314692618
MESH:D000230 Adenocarcinoma Fluorouracil 7.2317638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000740 Anemia Fluorouracil 9.1217963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.1211748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.3817084956
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001260 Ataxia Telangiectasia Quercetin 5.1715336622
MESH:D001327 Autoimmune Diseases Quercetin 4.5819761891
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9717474063 20146248
MESH:D001943 Breast Neoplasms Fluorouracil 1.9716110121 15136595 19217205 18357371 16557594 16595493 18608205
MESH:D001943 Breast Neoplasms Quercetin 1.9718628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D002105 Cadmium Poisoning Quercetin 5.7616962696
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8916051944
MESH:D002277 Carcinoma Fluorouracil 8.5617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.5616835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7816705839
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.7817045692 18930000 16332177 17088986 16799960 17971768
MESH:D006528 Carcinoma, Hepatocellular Quercetin 4.7812508355 19519916
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.1317234771
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0718695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7620419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.7616757204 18986760 17066447 16280240
MESH:D006332 Cardiomegaly Quercetin 7.0419794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.0418670907 16120746 18850075
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9816919318 17110522 16105132 17681005 15861022 17333356 11677210
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9315894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1516354765 15340226 12621046 8697196 15668235
MESH:D003110 Colonic Neoplasms Fluorouracil 3.9817725105 17016597 16510598 17287894 15001691 16340194 17169374 17172411 17018589 18772588
MESH:D003110 Colonic Neoplasms Quercetin 3.9811134977 16640504 19056647 15741050 17191121 17148506 19440933
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.6916331619 16282729 17401013 15148649 14970324 17695437 15289873 16524972 16391804 18509181 18448328 16303861 17094418 17454858 17594712 18802399 17016601 20501625 17255274 18383874 18949393 18288408
MESH:D015179 Colorectal Neoplasms Quercetin 2.6918095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1918551238
MESH:D007644 Darier Disease Fluorouracil 4.9916733453
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9016285004
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.8519496084
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.4318551238 21346803
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.4315131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1215322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3512538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5916530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.5916337965 16481741 15173087 16785472 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 2.9515345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Quercetin 9.3519474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3520067830
MESH:D005909 Glioblastoma Quercetin 3.4819804834
MESH:D005910 Glioma Fluorouracil 6.3516145905
MESH:D005910 Glioma Quercetin 6.3517643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4818337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6710048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0715340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2615340226 16959395 8697196 18606429 16354765
MESH:D006943 Hyperglycemia Quercetin 4.1611834736 18262572
MESH:D006973 Hypertension Quercetin 5.3818356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3818850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9212878042 12200463
MESH:D007251 Influenza, Human Quercetin 4.7216624496
MESH:D007333 Insulin Resistance Sodium Selenite 3.3614714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007627 Keloid Quercetin 5.1317086741
MESH:D007674 Kidney Diseases Quercetin 3.1716962696
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.8816705839
MESH:D007680 Kidney Neoplasms Fluorouracil 7.8816985049
MESH:D007938 Leukemia Quercetin 3.2217468513
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 2.4812741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.4812878042
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.7820195826 21137059
MESH:D008113 Liver Neoplasms Clofibric Acid 14.7817602206
MESH:D008113 Liver Neoplasms Fluorouracil 14.7816603448 15113037 17045692 18383874
MESH:D008113 Liver Neoplasms Quercetin 14.7818980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.7816984957
MESH:D008114 Liver Neoplasms, Experimental Quercetin 6.2019519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2012151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9718569708 20869020 18816296 20135361 17053015 20064080 20464547 6695378 18520028
MESH:D008175 Lung Neoplasms Fluorouracil 4.9715246190
MESH:D008175 Lung Neoplasms Quercetin 4.9716280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9719555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9915086387
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2114737004
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.8916381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.8916757204 18986760
MESH:D009203 Myocardial Infarction Quercetin 3.0419595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.9019207477
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0518551238
MESH:D009369 Neoplasms Benzo(a)pyrene 8.7111141357
MESH:D009369 Neoplasms Fluorouracil 8.7118600527 18239605 16928823
MESH:D009369 Neoplasms Quercetin 8.7115185748
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D020078 Neurogenic Inflammation Quercetin 4.5117929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5316436463
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5616049721 12819281
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.3719495926
MESH:D010051 Ovarian Neoplasms Quercetin 2.7719005980
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.6315113037 16929163 16500647 19003803
MESH:D010190 Pancreatic Neoplasms Quercetin 5.6316965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Quercetin 4.1019056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811896295 11118676 11399792 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0817292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0818626508 19082440
MESH:D011471 Prostatic Neoplasms Quercetin 2.0814715546 17292933
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.0818760546
MESH:D011537 Pruritus Ethinyl Estradiol 3.5115861022 16919318
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1416160472 18722050 18286688 15538739
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012554 Schistosomiasis japonica Quercetin 5.7616862918
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6218551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.7519755658 10029692
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.758532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.7516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4520155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4516424979 18396642 19015929 17522103 17172411 18567086 15786421 17498489 19084572 16951190
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1216280240
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.6316049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.6317053015
MESH:D001749 Urinary Bladder Neoplasms Quercetin 8.6316720314
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5110091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0116803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
Pathway ID Pathway Name
KEGG:00970 Aminoacyl-tRNA biosynthesis
REACT:71 Gene Expression
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27146
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA449789glycine
    PA448055l-alanine
    PA448478l-arginine
    PA449173l-cysteine
    PA10090l-glutamine
    PA449882l-histidine
    PA450197l-leucine
    PA450280l-lysine
    PA450423l-methionine
    PA450931l-phenylalanine
    PA451125l-proline
    PA451330l-serine
    PA451673l-threonine
    PA10323l-tryptophan
    PA451822l-tyrosine
    PA451843l-valine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00128 - L-Aspartic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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