AutismKB 2.0

Annotation Detail for DBC1


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Basic Information Top
Gene Symbol:DBC1 ( DBCCR1,FAM5A )
Gene Full Name: deleted in bladder cancer 1
Band: 9q32-q33
Quick LinksEntrez ID:1620; OMIM: 602865; Uniprot ID:DBC1_HUMAN; ENSEMBL ID: ENSG00000078725; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1860Brain tumor
1934Cancer
Desease Name
Parkinson's disease
multiple sclerosis
IMMUNE
NEUROLOGICAL
Desease Name
Parkinson's disease
Multiple sclerosis
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DBC1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of DBC1 mRNAincreases expression 15761015
D019324 beta-Naphthoflavone beta-Naphthoflavone results in increased expression of DBC1 mRNAincreases expression 19737606
D016572 Cyclosporine Cyclosporine results in decreased expression of DBC1 mRNAdecreases expression 20106945
C014347 decitabine [decitabine co-treated with trichostatin A] inhibits the reaction [sodium arsenite affects the methylation of DBC1 promoter]affects cotreatment|affects methylation|decreases reaction 18448484
C014347 decitabine decitabine inhibits the reaction [sodium arsenite affects the methylation of DBC1 promoter]affects methylation|decreases reaction 18448484
D005419 Flavonoids Flavonoids results in decreased expression of DBC1 mRNAdecreases expression 18035473
C406082 monomethylarsonous acid [monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of DBC1 promoteraffects acetylation|affects methylation 18448484
C406082 monomethylarsonous acid monomethylarsonous acid results in decreased expression of DBC1 mRNAdecreases expression 20375083
C017947 sodium arsenite [decitabine co-treated with trichostatin A] inhibits the reaction [sodium arsenite affects the methylation of DBC1 promoter]affects cotreatment|affects methylation|decreases reaction 18448484
C017947 sodium arsenite decitabine inhibits the reaction [sodium arsenite affects the methylation of DBC1 promoter]affects methylation|decreases reaction 18448484
C017947 sodium arsenite [sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of DBC1 promoteraffects acetylation|affects methylation 18448484
C017947 sodium arsenite sodium arsenite results in decreased expression of DBC1 mRNAdecreases expression 18448484
C012589 trichostatin A [decitabine co-treated with trichostatin A] inhibits the reaction [sodium arsenite affects the methylation of DBC1 promoter]affects cotreatment|affects methylation|decreases reaction 18448484
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3311798837 19825857
MESH:D000236 Adenoma beta-Naphthoflavone 3.4419389873
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.0215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.2217306315 16712894
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.8816206674
MESH:D001943 Breast Neoplasms decitabine 2.5519208741 18320071
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5511589617
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.1911135700 16217749 15073043 14691202 15553829
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.1915276417 17306315 16507464
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3112490120
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.9719215824
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.9718572023
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.1412371664
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 12.1419716837
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 12.1420056578 19524636
MESH:D002779 Cholestasis Cyclosporine 3.0619486331
MESH:D003110 Colonic Neoplasms decitabine 2.3617616700
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6220501625
MESH:D015179 Colorectal Neoplasms decitabine 2.6218981723
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3215213294
MESH:D004701 Endocrine Gland Neoplasms decitabine 15.1119294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 15.1119294695
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3512903497
MESH:D005234 Fatty Liver arsenic trioxide 8.4515073043
MESH:D005234 Fatty Liver Cyclosporine 8.4519224547
MESH:D005355 Fibrosis Cyclosporine 3.4012639820 12168785
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5016904648
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.9616452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D005909 Glioblastoma trichostatin A 3.9618801729
MESH:D006258 Head and Neck Neoplasms decitabine 3.6219215824
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006689 Hodgkin Disease sodium arsenite 3.3312676792
MESH:D006973 Hypertension Cyclosporine 2.1610903974
MESH:D007248 Infertility, Male decitabine 7.3517581917
MESH:D007248 Infertility, Male sodium arsenite 7.3515346721 12646999
MESH:D007249 Inflammation Flavonoids 2.7417296493
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.3818776723 10903974 8314463
MESH:D007674 Kidney Diseases sodium arsenite 6.3820008137
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9012371664
MESH:D007938 Leukemia arsenic trioxide 6.7615070760
MESH:D007938 Leukemia decitabine 6.7618980019 19235587
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0012560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 10.2819077051
MESH:D007951 Leukemia, Myeloid decitabine 10.2819117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 6.4616968895 17050201 16467208 20471514 19850784
MESH:D015470 Leukemia, Myeloid, Acute decitabine 6.4617679729 18460780 19010910 18206229 19387464 18704418
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 6.4618206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.7818055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.349834237 19075265 17712046 17869043 19035177 15622746 12712474 12679006 17649720 15213294 16823087 15748426 19642359 11161223 16891316 16966277 17107899 16330433 17217047 16112521 12018890 16331271 19225113 15336539 11468182
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5916882451
MESH:D008113 Liver Neoplasms arsenic trioxide 7.9614682389
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 7.9619389873 21295105
MESH:D008113 Liver Neoplasms sodium arsenite 7.9615276417 16712894
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.5820377131
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 6.5818164116
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5115213294
MESH:D008171 Lung Diseases sodium arsenite 3.3019095001
MESH:D008175 Lung Neoplasms arsenic trioxide 2.5811798837 19825857
MESH:D008175 Lung Neoplasms sodium arsenite 2.5815276417 17306315 16712894 17077188 19931552
MESH:D008223 Lymphoma decitabine 3.5619470736
MESH:D008545 Melanoma decitabine 5.4416505122 17785578
MESH:D008545 Melanoma sodium arsenite 5.4416487513 19082730
MESH:D008545 Melanoma trichostatin A 5.4416505122
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D009101 Multiple Myeloma arsenic trioxide 13.0814977855 19417148 19549372 15949261 11468182
MESH:D009101 Multiple Myeloma decitabine 13.0818172295
MESH:D009101 Multiple Myeloma trichostatin A 13.0818172295
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.8616882451 16105982
MESH:D009190 Myelodysplastic Syndromes decitabine 7.8619157545 16882708 19010910 18608210
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2016624393
MESH:D009369 Neoplasms decitabine 5.5317925555 19116145 19470736
MESH:D009369 Neoplasms sodium arsenite 5.5311559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.9220056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4719348381 18481113
MESH:D009436 Neural Tube Defects arsenic trioxide 7.7610525206
MESH:D009436 Neural Tube Defects sodium arsenite 7.7612854658
MESH:D010051 Ovarian Neoplasms arsenic trioxide 11.8212452020 16624393 19769630
MESH:D010051 Ovarian Neoplasms decitabine 11.8219259094 19331143
MESH:D010051 Ovarian Neoplasms sodium arsenite 11.8217306315 15276417
MESH:D010051 Ovarian Neoplasms trichostatin A 11.8219331143
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 9.1515580305
MESH:D010190 Pancreatic Neoplasms decitabine 9.1519294695
MESH:D010190 Pancreatic Neoplasms trichostatin A 9.1519294695
MESH:D010235 Paraganglioma arsenic trioxide 4.3819927285
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D055728 Primary Myelofibrosis decitabine 13.3117616702
MESH:D055728 Primary Myelofibrosis trichostatin A 13.3117616702
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.6619131511
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.6616039940
MESH:D011471 Prostatic Neoplasms trichostatin A 2.6618798265 19789329
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D012208 Rhabdomyosarcoma decitabine 4.6219155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2016646077
MESH:D012871 Skin Diseases monomethylarsonous acid 3.4217431481
MESH:D012878 Skin Neoplasms sodium arsenite 2.7818572023 19524636
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9512854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.6117007042
MESH:D013274 Stomach Neoplasms decitabine 2.6119037991
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.8419014326
MESH:D013964 Thyroid Neoplasms decitabine 7.8417967635
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2415213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.6012973940 11780464 12845720 20435036
MESH:D001749 Urinary Bladder Neoplasms decitabine 12.6017616700 19087683
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 12.6020375083
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 12.6016712894 16452187 17306315 11723127
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9611813266
MESH:D014604 Uveal Neoplasms decitabine 5.2317785578
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D014652 Vascular Diseases sodium arsenite 4.7117056641
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27156
    • No data
    Releated disease ID Related disease Name
    PA444987Multiple Sclerosis
    PA444987Multiple Sclerosis
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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