AutismKB 2.0

Annotation Detail for DBH


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Basic Information Top
Gene Symbol:DBH ( DBM )
Gene Full Name: dopamine beta-hydroxylase (dopamine beta-monooxygenase)
Band: 9q34.2
Quick LinksEntrez ID:1621; OMIM: 609312; Uniprot ID:DOPO_HUMAN; ENSEMBL ID: ENSG00000123454; HGNC ID: 2689
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY66-301catecholamine biosynthesis
Pathway IDPathway Name
hsa00350Tyrosine metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Hormone biosynthesis
Metabolism of amino acids and derivatives
No data
Pathway IDPathway Name
P00001Adrenaline and noradrenaline biosynthesis
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1799Epilepsy
1807Autoimmune disease
1908Multiple system atrophy
2091Hypertension
1874Stress disorder, post-traumatic
2198Psychotic disorder
2221Behavior disease
Desease Name
Parkinson's disease
AGING
NORMALVARIATION
migrane. typical
personality
Dopamine beta-Hydroxylase Activity
CHEMDEPENDENCY
hormone disturbance
Attention-deficit/hyperactivity disorder
interpersonal sensitivity
alcohol withdrawal
PSYCH
alcoholism
migraine with aura
psychoticism
NEUROLOGICAL
attention deficit hyperactivity disorder
paranoia
schizophrenia
METABOLIC
paranoid ideation
Cognitive performance
Desease Name
Smoking behavior
Desease Name
Dopamine-beta-hydroxylase activity levels, plasma
Dopamine beta-hydroxylase deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000535 Aluminum Aluminum results in decreased activity of DBH proteindecreases activity 11787979
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DBH mRNAaffects expression 16483693
D001280 Atrazine Atrazine results in decreased expression of DBH proteindecreases expression 14550852
D001280 Atrazine Dexamethasone inhibits the reaction [Atrazine results in decreased expression of DBH protein]decreases expression|decreases reaction 14550852
D001280 Atrazine Forskolin inhibits the reaction [Atrazine results in decreased expression of DBH protein]decreases expression|decreases reaction 14550852
D016642 Bupropion DBH protein results in increased susceptibility to Bupropionincreases response to substance 15148402
D002211 Capsaicin Capsaicin results in decreased expression of DBH mRNAdecreases expression 18783367
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of DBH mRNAincreases expression 18812211
17452286
D015283 Citalopram DBH protein promotes the reaction [Citalopram results in increased abundance of Serotonin]increases abundance|increases reaction 15148402
C007168 cyanazine cyanazine results in increased expression of DBH proteinincreases expression 14550852
D015084 2,4-Dichlorophenoxyacetic Acid 2,4-Dichlorophenoxyacetic Acid results in decreased expression of DBH proteindecreases expression 16931444
D003891 Desipramine DBH protein results in increased susceptibility to Desipramineincreases response to substance 15148402
D003907 Dexamethasone Dexamethasone inhibits the reaction [Atrazine results in decreased expression of DBH protein]decreases expression|decreases reaction 14550852
D003907 Dexamethasone Dexamethasone inhibits the reaction [Simazine results in decreased expression of DBH protein]decreases expression|decreases reaction 14550852
D003907 Dexamethasone Dexamethasone results in increased expression of DBH proteinincreases expression 14550852
D003976 Diazinon Diazinon results in decreased expression of DBH mRNAdecreases expression 18812211
D003976 Diazinon Diazinon results in increased expression of DBH mRNAincreases expression 17452286
D004006 Dichlorvos Dichlorvos results in increased activity of DBH proteinincreases activity 12186780
D004006 Dichlorvos Nimodipine inhibits the reaction [Dichlorvos results in increased activity of DBH protein]decreases reaction|increases activity 12186780
D004026 Dieldrin Dieldrin results in decreased expression of DBH mRNAdecreases expression 18812211
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in decreased expression of DBH mRNAdecreases expression 15620428
D004221 Disulfiram DBH gene SNP affects the susceptibility to Disulfiramaffects response to substance 19462300
D004221 Disulfiram DBH gene polymorphism affects the susceptibility to Disulfiramaffects response to substance 16163519
D004221 Disulfiram Disulfiram results in decreased activity of DBH proteindecreases activity 16163519
D004280 Dobutamine DBH protein affects the susceptibility to Dobutamineaffects response to substance 10338466
D004298 Dopamine DBH gene polymorphism affects the abundance of Dopamineaffects abundance 16163519
D004298 Dopamine DBH protein affects the reaction [Dopamine binds to DRD2 protein]affects binding|affects reaction 15716360
D004298 Dopamine DBH protein results in increased metabolism of Dopamineincreases metabolic processing 16931444
16163519
D004837 Epinephrine DBH gene polymorphism affects the abundance of Epinephrineaffects abundance 16163519
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of DBH geneincreases mutagenesis 16495775
C011251 ferbam ferbam results in decreased activity of DBH proteindecreases activity 6420938
D005473 Fluoxetine DBH protein promotes the reaction [Fluoxetine results in increased abundance of Serotonin]increases abundance|increases reaction 15148402
D005473 Fluoxetine DBH protein results in increased susceptibility to Fluoxetineincreases response to substance 15148402
D005576 Forskolin Forskolin inhibits the reaction [Atrazine results in decreased expression of DBH protein]decreases expression|decreases reaction 14550852
D005576 Forskolin Forskolin inhibits the reaction [Simazine results in decreased expression of DBH protein]decreases expression|decreases reaction 14550852
D005576 Forskolin Forskolin results in increased expression of DBH proteinincreases expression 14550852
D012701 Serotonin DBH protein promotes the reaction [Citalopram results in increased abundance of Serotonin]increases abundance|increases reaction 15148402
D012701 Serotonin DBH protein promotes the reaction [Fluoxetine results in increased abundance of Serotonin]increases abundance|increases reaction 15148402
D009151 Mustard Gas Mustard Gas results in increased expression of DBH mRNAincreases expression 15674843
D009553 Nimodipine Nimodipine inhibits the reaction [Dichlorvos results in increased activity of DBH protein]decreases reaction|increases activity 12186780
D009638 Norepinephrine DBH gene polymorphism affects the abundance of Norepinephrineaffects abundance 16163519
D009638 Norepinephrine DBH protein results in increased abundance of Norepinephrineincreases abundance 15148402
D009638 Norepinephrine DBH protein results in increased chemical synthesis of Norepinephrineincreases chemical synthesis 16163519
16931444
D010293 Pargyline DBH protein results in increased susceptibility to Pargylineincreases response to substance 15148402
D017374 Paroxetine DBH protein results in increased susceptibility to Paroxetineincreases response to substance 15148402
C035988 procymidone procymidone results in increased expression of DBH mRNAincreases expression 15686871
C074679 reboxetine DBH protein results in increased susceptibility to reboxetineincreases response to substance 15148402
D020280 Sertraline DBH protein results in increased susceptibility to Sertralineincreases response to substance 15148402
D012839 Simazine Dexamethasone inhibits the reaction [Simazine results in decreased expression of DBH protein]decreases expression|decreases reaction 14550852
D012839 Simazine Forskolin inhibits the reaction [Simazine results in decreased expression of DBH protein]decreases expression|decreases reaction 14550852
D012839 Simazine Simazine results in decreased expression of DBH proteindecreases expression 14550852
D013893 Thiram Thiram results in decreased activity of DBH proteindecreases activity 6420938
C025643 vinclozolin vinclozolin results in increased expression of DBH mRNAincreases expression 15686871
D015039 Ziram Ziram results in decreased activity of DBH proteindecreases activity 6420938
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Capsaicin 12.6318926900
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 12.636734493
MESH:D000014 Abnormalities, Drug-Induced Disulfiram 12.6317676605
MESH:D000138 Acidosis Ammonium Chloride 3.1918287403
MESH:D000163 Acquired Immunodeficiency Syndrome Disulfiram 5.199207937
MESH:D058186 Acute Kidney Injury Capsaicin 4.2218460982
MESH:D000236 Adenoma Ethylnitrosourea 3.506695378
MESH:D000382 Agricultural Workers' Diseases 2,4-Dichlorophenoxyacetic Acid 28.4416132792
MESH:D000382 Agricultural Workers' Diseases Atrazine 28.4411874814
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 28.4417119214 11874814 16611668
MESH:D000382 Agricultural Workers' Diseases Diazinon 28.4416487989
MESH:D000382 Agricultural Workers' Diseases Dichlorvos 28.4416611668 12661182 17119214
MESH:D000382 Agricultural Workers' Diseases Simazine 28.4412661182
MESH:D000437 Alcoholism Disulfiram 4.6917079463 18968458 10841824
MESH:D000505 Alopecia Capsaicin 4.4417569567
MESH:D000544 Alzheimer Disease Aluminum 3.6310721010 17662457
MESH:D001008 Anxiety Disorders Citalopram 18.9518083778
MESH:D001008 Anxiety Disorders Fluoxetine 18.9518083778
MESH:D001008 Anxiety Disorders Sertraline 18.9518822694
MESH:D001008 Anxiety Disorders vinclozolin 18.9519015723
MESH:D001169 Arthritis, Experimental Dexamethasone 3.3117659584
MESH:D001249 Asthma Mustard Gas 2.6010378619
MESH:D001321 Autistic Disorder Citalopram 3.4519232924 18775368
MESH:D001321 Autistic Disorder Fluoxetine 3.4518775368 19232924
MESH:D001321 Autistic Disorder Norepinephrine 3.458570775
MESH:D001321 Autistic Disorder Serotonin 3.458570775 18062943 15132762 19221690 18405062 17157402 18361446
MESH:D001321 Autistic Disorder Sertraline 3.4518775368
MESH:D001480 Basal Ganglia Diseases Dichlorvos 5.6115303389
MESH:D001768 Blister Mustard Gas 4.7919167455
MESH:D001919 Bradycardia Capsaicin 10.0318207255
MESH:D001919 Bradycardia Serotonin 10.038112388
MESH:D001927 Brain Diseases Ethylnitrosourea 4.5614991843
MESH:D002545 Brain Ischemia Capsaicin 4.6119211983
MESH:D001932 Brain Neoplasms Ethylnitrosourea 3.9815144691 16436596 16357521 16651633 18412241
MESH:D001943 Breast Neoplasms Dieldrin 3.1711859874 15770527
MESH:D001943 Breast Neoplasms Disulfiram 3.1717026967
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.7915286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.6017687719 10378619
MESH:D002177 Candidiasis Disulfiram 5.4915325261
MESH:D002277 Carcinoma Disulfiram 4.4817026967
MESH:D002289 Carcinoma, Non-Small-Cell Lung Disulfiram 3.7817026967
MESH:D006332 Cardiomegaly Norepinephrine 4.1611179087
MESH:D002375 Catalepsy Norepinephrine 5.178216760
MESH:D002386 Cataract Disulfiram 4.2815003327 17936468
MESH:D002418 Cattle Diseases Dichlorvos 5.2814651886
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 3.4816003739
MESH:D002493 Central Nervous System Diseases Dichlorvos 5.3912670839
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.6117160924
MESH:D002659 Child Development Disorders, Pervasive Citalopram 6.6515782081
MESH:D002659 Child Development Disorders, Pervasive Serotonin 6.6521254450
MESH:D021081 Chronobiology Disorders Serotonin 6.3217157402
MESH:D019970 Cocaine-Related Disorders Disulfiram 5.3719462300
MESH:D003110 Colonic Neoplasms Dexamethasone 2.4315824018
MESH:D003128 Coma Dichlorvos 5.6215303389
MESH:D003371 Cough Capsaicin 4.8010350223
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.2717728286
MESH:D003456 Cryptorchidism vinclozolin 3.9914966744
MESH:D003866 Depressive Disorder Bupropion 32.0615014590
MESH:D003866 Depressive Disorder Citalopram 32.0615014590
MESH:D003866 Depressive Disorder Desipramine 32.063690436 15014590
MESH:D003866 Depressive Disorder Fluoxetine 32.0615014590
MESH:D003866 Depressive Disorder Paroxetine 32.0617072103 15014590
MESH:D003866 Depressive Disorder reboxetine 32.0612866714
MESH:D003866 Depressive Disorder Sertraline 32.0618822694 20305041 15014590
MESH:D003865 Depressive Disorder, Major Sertraline 5.0616968574
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.0712438553
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 3.8716882537
MESH:D003967 Diarrhea Dexamethasone 7.487237001
MESH:D003967 Diarrhea Serotonin 7.4811488427 10446763 8112388
MESH:C535600 Dopamine beta hydroxylase deficiency marker/mechanism
MESH:D004381 Duodenal Ulcer Capsaicin 4.3411535926 10671773
MESH:D004409 Dyskinesia, Drug-Induced Desipramine 5.813690436
MESH:D004417 Dyspnea Diazinon 4.4316487989
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.6118357618
MESH:D004485 Eczema Dexamethasone 4.1112438553
MESH:D004487 Edema Dexamethasone 13.9719703484
MESH:D004487 Edema Fluoxetine 13.9712798668
MESH:D004487 Edema Mustard Gas 13.9711428631 9260866 11428647 11402378
MESH:D004487 Edema Serotonin 13.9718841975
MESH:D004827 Epilepsy Epinephrine 7.16821787
MESH:D004827 Epilepsy Norepinephrine 7.16821787
MESH:D004890 Erythema Mustard Gas 4.799357497
MESH:D004892 Erythema Multiforme Thiram 6.2716750123
MESH:D004935 Esophageal Diseases Capsaicin 5.3419566590
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.5716973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.9316417039
MESH:D005909 Glioblastoma Capsaicin 7.0318405923
MESH:D005909 Glioblastoma Ethylnitrosourea 7.0316436596
MESH:D005910 Glioma Ethylnitrosourea 3.3418412241 16357521 16651633
MESH:D006356 Heartburn Capsaicin 5.3419566590
MESH:D006333 Heart Failure Dobutamine 4.2217440445
MESH:D006505 Hepatitis Diazinon 4.2316487989
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.947520565
MESH:D006734 Horse Diseases Dichlorvos 5.6216402567
MESH:D019584 Hot Flashes Fluoxetine 10.1014716179
MESH:D019584 Hot Flashes Paroxetine 10.1014716179
MESH:D006816 Huntington Disease Sertraline 5.6618403212
MESH:D006930 Hyperalgesia Capsaicin 4.0417043245 17434803
MESH:D006941 Hyperesthesia Dichlorvos 6.3212563396
MESH:D006973 Hypertension Dexamethasone 2.7917042910
MESH:D007022 Hypotension Dopamine 13.766740701
MESH:D007022 Hypotension Epinephrine 13.766740701
MESH:D007022 Hypotension Norepinephrine 13.766740701
MESH:D007246 Infertility ferbam 16.776420938
MESH:D007246 Infertility Thiram 16.776420938
MESH:D007246 Infertility Ziram 16.776420938
MESH:D007247 Infertility, Female Dieldrin 4.6010630421
MESH:D007248 Infertility, Male 2,4-Dichlorophenoxyacetic Acid 14.2012948887
MESH:D007248 Infertility, Male Atrazine 14.2012948887
MESH:D007248 Infertility, Male Diazinon 14.2016466525 12948887
MESH:D007248 Infertility, Male vinclozolin 14.2016467254
MESH:D007249 Inflammation Aluminum 13.8516052892
MESH:D007249 Inflammation Capsaicin 13.8516956363
MESH:D007249 Inflammation Dexamethasone 13.8511099482 8960868
MESH:D007249 Inflammation Fluoxetine 13.8512798668
MESH:D007249 Inflammation Mustard Gas 13.8511428631 17524151 11428647 8975870 9357497 9260866 16001271 11428620 11402378
MESH:D007674 Kidney Diseases Dichlorvos 4.0316798900
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 3.6417379185
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Disulfiram 4.0217026967
MESH:D007984 Leydig Cell Tumor vinclozolin 4.3616417039
MESH:D017880 Limb Deformities, Congenital Disulfiram 4.4517676605
MESH:D008064 Lipidoses Citalopram 12.2517567588
MESH:D008064 Lipidoses Fluoxetine 12.2515342952 17567588
MESH:D008064 Lipidoses Sertraline 12.2517567588
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 2.2616718785
MESH:D008107 Liver Diseases Capsaicin 4.5216956363
MESH:D008107 Liver Diseases Chlorpyrifos 4.5215991261
MESH:D008113 Liver Neoplasms Dieldrin 4.968742319 9539021
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 4.9611940454
MESH:D008133 Long QT Syndrome Dobutamine 4.4619353679
MESH:D008171 Lung Diseases Aluminum 11.3216052892
MESH:D008171 Lung Diseases Dobutamine 11.3216638327
MESH:D008171 Lung Diseases Mustard Gas 11.3218702808 18161513
MESH:D008175 Lung Neoplasms Dexamethasone 3.4215824018 11195469
MESH:D008175 Lung Neoplasms Ethylnitrosourea 3.4216271038 6695378 16019985 17703301
MESH:D008175 Lung Neoplasms Mustard Gas 3.428781369 3148597
MESH:D008223 Lymphoma Ethylnitrosourea 3.6815790496
MESH:D008228 Lymphoma, Non-Hodgkin 2,4-Dichlorophenoxyacetic Acid 4.8616132792
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 4.6915375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.2818041768 10767621 10838139
MESH:D008545 Melanoma Disulfiram 3.3015367699
MESH:D008579 Meningioma Ethylnitrosourea 5.6117943659
MESH:D001523 Mental Disorders Citalopram 25.7516856516
MESH:D001523 Mental Disorders Desipramine 25.7516856516
MESH:D001523 Mental Disorders Fluoxetine 25.7516856516
MESH:D001523 Mental Disorders Paroxetine 25.7516856516
MESH:D001523 Mental Disorders reboxetine 25.7516856516
MESH:D001523 Mental Disorders Sertraline 25.7516856516
MESH:D008654 Mesothelioma Atrazine 3.381916698
MESH:D016472 Motor Neuron Disease Dichlorvos 5.9611282359
MESH:D009101 Multiple Myeloma Capsaicin 6.9517505005
MESH:D009101 Multiple Myeloma Dexamethasone 6.9515744524 15867202 16118317
MESH:D020528 Multiple Sclerosis, Chronic Progressive Aluminum 6.0017086897
MESH:D020529 Multiple Sclerosis, Relapsing-Remitting Aluminum 6.0017086897
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.339809623
MESH:D017202 Myocardial Ischemia Dobutamine 4.7412447174
MESH:D015428 Myocardial Reperfusion Injury Norepinephrine 4.5615642760
MESH:D009207 Myoclonus Fluoxetine 5.518041377
MESH:D009349 Nematode Infections Dichlorvos 5.7716402567
MESH:D009361 Neoplasm Invasiveness Disulfiram 4.9618047805
MESH:D009362 Neoplasm Metastasis Disulfiram 3.8715367699
MESH:D009369 Neoplasms Dieldrin 5.378820588
MESH:D009369 Neoplasms Disulfiram 5.3717079463
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.0516707424
MESH:D009389 Neovascularization, Pathologic Disulfiram 4.9015367699
MESH:D009410 Nerve Degeneration Dichlorvos 4.6217850875 11282359
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.0516003739 17160924 16651423
MESH:D019636 Neurodegenerative Diseases Dichlorvos 8.7816635102
MESH:D019636 Neurodegenerative Diseases Nimodipine 8.7816635102
MESH:D020078 Neurogenic Inflammation Capsaicin 4.7517961222
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 12.2915081274
MESH:D020258 Neurotoxicity Syndromes Dichlorvos 12.2912186780
MESH:D020258 Neurotoxicity Syndromes Disulfiram 12.2911005259
MESH:D009503 Neutropenia Mustard Gas 3.637688884 16761898
MESH:D009765 Obesity Capsaicin 3.3019056576
MESH:D009771 Obsessive-Compulsive Disorder Fluoxetine 10.7120418887
MESH:D009771 Obsessive-Compulsive Disorder Paroxetine 10.7117503984
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.6117160924
MESH:D010009 Osteochondrodysplasias Thiram 5.2515518828 17954590 15899490
MESH:D012516 Osteosarcoma Disulfiram 4.8918047805
MESH:D010051 Ovarian Neoplasms Disulfiram 3.6417026967
MESH:D010146 Pain Capsaicin 6.7417043245 18987195 16996476 19081190 17084039 17434803
MESH:D010146 Pain Fluoxetine 6.7412798668
MESH:D010195 Pancreatitis Dichlorvos 4.5616258382
MESH:D010300 Parkinson Disease marker/mechanism
MESH:D010300 Parkinson Disease Atrazine 8.2617218051
MESH:D010300 Parkinson Disease Desipramine 8.2610965161
MESH:D010300 Parkinson Disease Dieldrin 8.2611181820 16112328 17291500 16809432 11445065
MESH:D010302 Parkinson Disease, Secondary Dichlorvos 5.2512645970
MESH:D020774 Pick Disease of the Brain Fluoxetine 5.648041377
MESH:D011041 Poisoning Diazinon 12.7817603234
MESH:D011041 Poisoning Dichlorvos 12.7818072136 15303389 12460839 16036766 17603234 17157343
MESH:D011041 Poisoning Mustard Gas 12.7815727166
MESH:D011115 Polyneuropathies Dichlorvos 5.2712563396
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.3421297632
MESH:D011248 Pregnancy Complications 2,4-Dichlorophenoxyacetic Acid 5.372087686
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 3.5318042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.5718220299
MESH:D011471 Prostatic Neoplasms Dichlorvos 2.4812661182
MESH:D011471 Prostatic Neoplasms Disulfiram 2.4819789329
MESH:D011471 Prostatic Neoplasms Simazine 2.4812661182
MESH:D011471 Prostatic Neoplasms Thiram 2.4819789329
MESH:D011472 Prostatitis vinclozolin 4.5718629315
MESH:D011537 Pruritus Mustard Gas 3.7318058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.7817620002 17894541 17720292 10334151 17266442
MESH:D015427 Reperfusion Injury Capsaicin 3.7819211983 18460982
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.6811700416 18379247
MESH:D012131 Respiratory Insufficiency Dichlorvos 5.2917350689 15303389
MESH:D012135 Respiratory Sounds Atrazine 14.3411874814
MESH:D012135 Respiratory Sounds Chlorpyrifos 14.3416611668 17119214 11874814
MESH:D012135 Respiratory Sounds Dichlorvos 14.3417119214 16611668
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 10.0116611668 17119214
MESH:D012140 Respiratory Tract Diseases Dichlorvos 10.0117119214 16611668
MESH:D012640 Seizures Dichlorvos 3.9617157343 12660363
MESH:D020230 Serotonin Syndrome Fluoxetine 5.528704074
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.716418539
MESH:D012871 Skin Diseases Mustard Gas 2.6215451306 16961503 12880345
MESH:D013272 Stomach Diseases Dexamethasone 3.9515472012
MESH:D013274 Stomach Neoplasms Dichlorvos 3.3211397402
MESH:D013276 Stomach Ulcer Dexamethasone 3.1715138204
MESH:D013322 Strongyloidiasis Dichlorvos 5.7714651886
MESH:D013610 Tachycardia Norepinephrine 5.093261545
MESH:D013705 Temporomandibular Joint Disorders Capsaicin 5.3517997062
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 4.7915790496
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Bupropion 5.6416785264
MESH:D014029 Tobacco Use Disorder Bupropion 6.2720388087
MESH:D016171 Torsades de Pointes Dobutamine 4.9819353679
MESH:D014570 Urologic Diseases Diazinon 4.9016487989
MESH:D014605 Uveitis Dexamethasone 4.441336536
Pathway ID Pathway Name
REACT:15314 Hormone biosynthesis
KEGG:01100 Metabolic pathways
REACT:13 Metabolism of amino acids and derivatives
KEGG:00350 Tyrosine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA136
    • Releated gene ID Related gene Name
    PA136DBH
    Releated disease ID Related disease Name
    PA447216Schizophrenia
    PA445876Tobacco Use Disorder
    PA444584Hypotension
    PA447062Parkinsonian Disorders
    PA443309Alcoholism
    PA446878Cocaine-Related Disorders
    PA445254Parkinson Disease
    Releated drug ID Related drug Name
    PA450626nicotine
    PA451822l-tyrosine
    PA161990676tetrahydrobiopterin
    PA449376disulfiram
    PA450649norepinephrine
    PA133822447catecholamines
    PA450213levodopa
    PA449396dopamine
    PA451898vitamin c
    PA448687bupropion
    PA164712720Drugs used in nicotine dependence
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00126 - Vitamin C Antioxidants;Essential Vitamins;Free Radical Scavengers;Vitamins (Vitamin C);Vitamins
    DB00822 antagonist Disulfiram Enzyme Inhibitors;Alcohol Deterrents
    DB00988 ligand Dopamine Dopamine Agents;Sympathomimetics;Cardiotonic Agents;Sympathomimetic
    Drugbank ID Action Drug Name Description
    DB00988 substrate Dopamine Dopamine Agents;Sympathomimetics;Cardiotonic Agents;Sympathomimetic
    No data
    No data

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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