AutismKB 2.0

Annotation Detail for SLFN5


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SLFN5 ( MGC150611,MGC150612,MGC19764 )
Gene Full Name: schlafen family member 5
Band: 17q12
Quick LinksEntrez ID:162394; OMIM: NA; Uniprot ID:SLFN5_HUMAN; ENSEMBL ID: ENSG00000166750; HGNC ID: 28286
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SLFN5 proteinaffects expression 20106945
D000638 Amiodarone Amiodarone results in increased expression of SLFN5 mRNAincreases expression 19774075
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of SLFN5 mRNAincreases expression 20064835
20106945
C006780 bisphenol A bisphenol A affects the expression of SLFN5 mRNAaffects expression 20170705
D016572 Cyclosporine Cyclosporine results in increased expression of SLFN5 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SLFN5 mRNAaffects expression 20170705
D019833 Genistein Genistein results in increased expression of SLFN5 mRNAincreases expression 18847459
C025643 vinclozolin vinclozolin affects the expression of SLFN5 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.3620127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.3614692618
MESH:D000230 Adenocarcinoma Genistein 7.3611473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.786695378
MESH:D001008 Anxiety Disorders vinclozolin 3.8319015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.0318057881 20041841 18218290
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001281 Atrial Fibrillation Amiodarone 4.0818651412 19698954
MESH:D001778 Blood Coagulation Disorders Amiodarone 4.1419483382
MESH:D001862 Bone Resorption bisphenol A 4.1011985600
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9420146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 1.9417123778
MESH:D001943 Breast Neoplasms Genistein 1.9416541309 17200150 16873071
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.2712907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Genistein 3.2716924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.3317123778
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9619225199 15710769
MESH:D002318 Cardiovascular Diseases Genistein 3.4616332659
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.4218974383
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6812371664
MESH:D002779 Cholestasis Cyclosporine 8.3719486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.3716919318 15861022 17681005 17333356 16105132 11677210 17110522
MESH:D003110 Colonic Neoplasms Genistein 2.3217182828
MESH:D003456 Cryptorchidism vinclozolin 4.6214966744
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5316647724
MESH:D056486 Drug-Induced Liver Injury Amiodarone 2.4415265979 18218290
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4712538720
MESH:D004714 Endometrial Hyperplasia Genistein 4.9316402032
MESH:D016889 Endometrial Neoplasms Genistein 3.5111473722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005234 Fatty Liver Amiodarone 14.5614986274
MESH:D005234 Fatty Liver Cyclosporine 14.5619224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.5615345470
MESH:D005355 Fibrosis Cyclosporine 3.4512639820 12168785
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6816417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D005909 Glioblastoma Genistein 3.4016598420
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7720471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006529 Hepatomegaly Amiodarone 4.0515265979
MESH:D006937 Hypercholesterolemia Amiodarone 4.128137927 9751232
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 4.8217991464 18020914
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.1717937319
MESH:D007248 Infertility, Male vinclozolin 7.1716467254
MESH:D007333 Insulin Resistance bisphenol A 3.4416393666
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4618776723 8314463 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9312371664
MESH:D007938 Leukemia Genistein 3.1317468513 18980019
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0716417039
MESH:D008064 Lipidoses Amiodarone 3.6815342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.0617823541
MESH:D008113 Liver Neoplasms Aflatoxin B1 4.8215890375 9163691 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.8220195826 21137059
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.888603461
MESH:D008133 Long QT Syndrome Amiodarone 3.7617391786 11989578 15350150
MESH:D008171 Lung Diseases Amiodarone 3.5312587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.8518516814
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.4714755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4718569708 18520028 6695378 17053015 18816296 20869020 20135361 20464547 20064080
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.0812929590 14578162
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D009181 Mycoses Amiodarone 5.2812754197 17974566
MESH:D009203 Myocardial Infarction Genistein 2.9417141266
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.8417141266
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2711141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 10.8416427766 11399458
MESH:D009421 Nervous System Malformations Genistein 10.8416427766
MESH:D010024 Osteoporosis Genistein 3.3919401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.3516169203
MESH:D010049 Ovarian Diseases bisphenol A 5.3311985600
MESH:D010051 Ovarian Neoplasms Genistein 2.6619005980
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 10.9210548101
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.9218220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.2718220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.4520887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5517292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.5516740699
MESH:D011471 Prostatic Neoplasms Genistein 2.5515256057 15378649 16925846
MESH:D011472 Prostatitis vinclozolin 5.2718629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.6516919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D011629 Puberty, Precocious bisphenol A 5.1210548101
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9312490602 12832656 11597910
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.4218724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4610029692 19755658
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013276 Stomach Ulcer Amiodarone 3.5518087811
MESH:D019966 Substance-Related Disorders bisphenol A 4.3216045194 16684133
MESH:D013610 Tachycardia Amiodarone 4.5711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.4719225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013959 Thyroid Diseases Amiodarone 5.1319731979
MESH:D013971 Thyrotoxicosis Amiodarone 5.1718020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.5311989578 17467628
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2517053015
MESH:D014591 Uterine Diseases bisphenol A 5.3814652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved