AutismKB 2.0

Annotation Detail for DBP


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Basic Information Top
Gene Symbol:DBP ( DABP )
Gene Full Name: D site of albumin promoter (albumin D-box) binding protein
Band: 19q13.33
Quick LinksEntrez ID:1628; OMIM: 124097; Uniprot ID:DBP_HUMAN; ENSEMBL ID: ENSG00000105516; HGNC ID: 2697
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
bone density
METABOLIC
obesity
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of DBP mRNAdecreases expression 19933214
C026137 3-hydroxyacetanilide 3-hydroxyacetanilide results in decreased expression of DBP mRNAdecreases expression 18544908
D000082 Acetaminophen Acetaminophen affects the expression of DBP mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of DBP mRNAdecreases expression 18544908
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DBP mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine results in decreased expression of DBP mRNAdecreases expression 12558987
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DBP mRNAaffects cotreatment|increases expression 18164116
C095105 bexarotene bexarotene results in decreased expression of DBP mRNAdecreases expression 16648578
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of DBP mRNA]increases expression|increases reaction 16006527
D016572 Cyclosporine Cyclosporine results in decreased expression of DBP mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of DBP mRNAdecreases expression 18457598
15238619
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of DBP mRNAdecreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in decreased expression of DBP mRNA]decreases expression|decreases reaction 17942915
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DBP mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of DBP mRNAdecreases expression 19638242
D004958 Estradiol Estradiol inhibits the reaction [Lipopolysaccharides results in increased expression of DBP mRNA]decreases reaction|increases expression 16977382
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of DBP mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DBP mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in increased expression of DBP mRNAincreases expression 18035473
D008070 Lipopolysaccharides Estradiol inhibits the reaction [Lipopolysaccharides results in increased expression of DBP mRNA]decreases reaction|increases expression 16977382
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of DBP mRNAdecreases expression 12057914
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of DBP mRNAincreases expression 16977382
C005219 methyl cellosolve methyl cellosolve results in increased expression of DBP mRNAincreases expression 19643169
D008770 Methylnitrosourea Methylnitrosourea results in decreased expression of DBP mRNAdecreases expression 16525678
D009151 Mustard Gas Mustard Gas results in decreased expression of DBP mRNAdecreases expression 15674843
D010126 Ozone Ozone results in decreased expression of DBP mRNAdecreases expression 12763052
D010634 Phenobarbital Phenobarbital results in increased expression of DBP mRNAincreases expression 19270015
C006253 pirinixic acid pirinixic acid affects the expression of DBP mRNAaffects expression 17950772
C006253 pirinixic acid pirinixic acid results in decreased expression of DBP mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased expression of DBP mRNAincreases expression 17426115
D011374 Progesterone Progesterone affects the expression of DBP mRNAaffects expression 17251523
C031280 pyrazole pyrazole results in decreased expression of DBP mRNAdecreases expression 17945193
D020849 Raloxifene Raloxifene results in increased expression of DBP mRNAincreases expression 15576828
C002979 selenomethylselenocysteine selenomethylselenocysteine results in increased expression of DBP mRNAincreases expression 19122877
C009250 sevoflurane sevoflurane affects the expression of DBP mRNAaffects expression 15967596
C017947 sodium arsenite sodium arsenite results in increased expression of DBP mRNAincreases expression 12760830
C017947 sodium arsenite sodium arsenite results in decreased expression of DBP mRNAdecreases expression 18812580
D013749 Tetrachlorodibenzodioxin AHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of DBP mRNA]affects reaction|decreases expression 16891777
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DBP mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of DBP mRNAdecreases expression 19933214
16891777
D014192 Trapidil Trapidil affects the reaction [PTH protein affects the expression of DBP mRNA]affects expression|affects reaction 18635661
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced methyl cellosolve 12.826474471 3652986 6499812
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 12.826195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.8215322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.3018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6817505938
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.2311850527 18653653
MESH:D055371 Acute Lung Injury pirinixic acid 8.2318653653
MESH:D000230 Adenocarcinoma Estradiol 6.7411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.7414692618
MESH:D000230 Adenocarcinoma Methylnitrosourea 6.7415113128 15688392
MESH:D000236 Adenoma beta-Naphthoflavone 6.3819389873
MESH:D000236 Adenoma Diethylnitrosamine 6.3810737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 22.6819061943 19052882 17162532 16434500 17620307 18056438
MESH:D018248 Adenoma, Liver Cell Phenobarbital 22.6817620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 22.6816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 22.6816835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6416712894 17306315
MESH:D000419 Albuminuria Raloxifene 4.3417451421 17308373
MESH:D000544 Alzheimer Disease Ozone 4.1615513908
MESH:D000544 Alzheimer Disease Raloxifene 4.1615800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7211748828
MESH:D000748 Anemia, Macrocytic methyl cellosolve 6.083699323
MESH:D000799 Angioedema Acetaminophen 3.5810982225
MESH:D001161 Arteriosclerosis Dietary Fats 9.0515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.0511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5015885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5015570426
MESH:D053627 Asthenozoospermia methyl cellosolve 5.263987992
MESH:D001249 Asthma Mustard Gas 4.8110378619
MESH:D001249 Asthma Ozone 4.8116373670 17854713
MESH:D001284 Atrophy methyl cellosolve 4.946705890 3699323 2626667
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001768 Blister Mustard Gas 4.9019167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.9919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.9912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6015746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0717868700
MESH:D001930 Brain Injuries Progesterone 10.1115665606 15845082 15380490
MESH:D001930 Brain Injuries Raloxifene 10.1116580743
MESH:D001943 Breast Neoplasms bexarotene 5.5616344269 16818667
MESH:D001943 Breast Neoplasms Dietary Fats 5.5620435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 5.5617474063
MESH:D001943 Breast Neoplasms Estradiol 5.5612948864 19861407 17289903 17261762 18497071 16675129 17018787 14630087
MESH:D001943 Breast Neoplasms Methylnitrosourea 5.5616253758 11306469 14633655
MESH:D001943 Breast Neoplasms Progesterone 5.5615562024 16175315 17614352
MESH:D001943 Breast Neoplasms Raloxifene 5.5617261762 15758505 15572757 16912660 17893378 17049068 15775269 17242785 16837676 17440819 17952589 17595753
MESH:D001943 Breast Neoplasms selenomethylselenocysteine 5.5618855134
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.5620435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.4716777450 14754758 18417511 17626835 18315731 19059883 15516495
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.9015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.7117687719 10378619
MESH:D002100 Cachexia Ozone 4.4816183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2016111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5216011737 16097048 16192424 16124888 3786805 15721981 18705752 15673190 16050911 10355542 16227642 15700767
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 10.793084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 10.7918788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 10.7918665156 19539802 3581430 18210153 20432363 3084413 18494052 19052882 16807293 18506893 18691550 20214788 18056438 16935385 18785209 19919837 18971187 19701751 10737359 16569478 17761372 18788625 19822196 10672840 20512989 19208518 20524982 16878318 20084675 17173139 19418558 16288022 21159647 17055752 16681979 17138121 16779866 19171122 11831363 17978847 19519916 16328049 17428255 16502159 20935162 20727157 18978308 16830150 19394651 20514400 20007298 16698587 18393292 16540662 19383236 17162532 19335982 19107877 20101231
MESH:D006528 Carcinoma, Hepatocellular Estradiol 10.7916924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 10.796705139 17173139 20007298 20935162 1701930
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 10.7915276417 17306315 16507464
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.1416247446
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.3118572023
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.8517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2216120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Raloxifene 3.2715775269
MESH:D002386 Cataract Acetaminophen 7.0510977129
MESH:D002386 Cataract Methylnitrosourea 7.0512484553
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 19.2112371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 19.212727394 21159647 17174075 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 19.2118566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 19.212727394 7505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 19.2119524636 20056578
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.994080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.5919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.5916835633
MESH:D002764 Cholecystitis methyl cellosolve 5.536499794
MESH:D002779 Cholestasis Cyclosporine 12.2319486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.2317681005 15861022 16919318 17110522 17333356 16105132 11677210
MESH:D002779 Cholestasis pirinixic acid 12.2319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9916354765 15340226 15668235 8697196 12621046
MESH:D003072 Cognition Disorders Raloxifene 4.3615800139
MESH:D000013 Congenital Abnormalities methyl cellosolve 8.706499821 12530607
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.7014669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2410048152 20055451 15322242
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9417474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3018249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 3.9920387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.9917107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.2819279558
MESH:D003928 Diabetic Nephropathies Raloxifene 8.2817451421 17308373 15920148
MESH:D003929 Diabetic Neuropathies Progesterone 4.2317187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.1411739529 12153990 11743745 15619225 14550746 10663392 17906064 2444490 12540782 19923254 11529661 18713872 11461765 19420014 14725611 10774834 17562736 12594235 17522070 19164858 14986274 16393943 16485898 12705907 16081117 15968718 19416960 19370779 12958197 16177239 11421492 11834606 12392966 19739265 16781746 16109766 19085960 10915739 11287661 18071297 16227642
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.146623471 16227642 15998439 2869522 6884620 10915739 10092053 7440962 7179309 15968718 15027814 21278145 11566570 16177239 3732212 19085960 9327722 7120509 17522070 4309450 19336974 3786805
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.1419107877
MESH:D056486 Drug-Induced Liver Injury pyrazole 11.1412499123
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.1420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5711462148
MESH:D050171 Dyslipidemias Dietary Fats 3.2718367378
MESH:D004421 Dystonia Phenobarbital 3.761851702
MESH:D004487 Edema Mustard Gas 14.5211402378 9260866 11428647 11428631
MESH:D004487 Edema pirinixic acid 14.5212083418
MESH:D004487 Edema Raloxifene 14.5215860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.5212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6418230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 13.9312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 13.9317692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 13.9315845917
MESH:D016889 Endometrial Neoplasms Estradiol 2.8111473722 19148513 18566989
MESH:D004715 Endometriosis Progesterone 8.1716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.179294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 4.1315328337 15821434 17637181
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.853659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.6111558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.7620417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.326401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.997750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.763659116
MESH:D004890 Erythema Mustard Gas 4.909357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8516302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8211564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 33.3515959796 19224547 16045604 61145 12795759 16239168 12631006 17595544
MESH:D005234 Fatty Liver Cyclosporine 33.3519224547
MESH:D005234 Fatty Liver Dietary Fats 33.3519551842 19004024 18296743 17967931
MESH:D005234 Fatty Liver Diethylnitrosamine 33.3520387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 33.3515345470
MESH:D005234 Fatty Liver pirinixic acid 33.3519236843 20131406
MESH:D005234 Fatty Liver Raloxifene 33.3517473493
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2011858732
MESH:D005327 Fetal Resorption methyl cellosolve 5.283987992 6474471 6499812 6499821
MESH:D020567 Fetal Weight methyl cellosolve 5.536499812 6474471 6499821
MESH:D005334 Fever Lipopolysaccharides 3.7911852909 9205823
MESH:D005354 Fibrosarcoma Methylnitrosourea 4.9711555667
MESH:D005355 Fibrosis Carbon Tetrachloride 19.0118705752
MESH:D005355 Fibrosis Cyclosporine 19.0112168785 12639820
MESH:D005355 Fibrosis Dietary Fats 19.0118296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.0120067830
MESH:D005532 Foot Deformities, Congenital methyl cellosolve 5.233652986
MESH:D005756 Gastritis Acetaminophen 3.4116983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4216452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.958708960
MESH:D005910 Glioma Methylnitrosourea 3.469825942
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3310696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1911294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.3611110106
MESH:D006333 Heart Failure pirinixic acid 2.3820558911
MESH:D006345 Heart Septal Defects, Ventricular methyl cellosolve 5.526499821
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1615720958
MESH:D006461 Hemolysis methyl cellosolve 5.1917874071
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.1616366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1011000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3519110552 19900420
MESH:D006529 Hepatomegaly Phenobarbital 12.8916109766
MESH:D006529 Hepatomegaly pirinixic acid 12.8919176532 16221962 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.8912621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.7615709030
MESH:D006689 Hodgkin Disease sodium arsenite 2.9412676792
MESH:D019584 Hot Flashes Estradiol 3.4917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7818606429 16354765 15340226 16959395 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.5016870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2716899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3621332399
MESH:D006943 Hyperglycemia pirinixic acid 2.9620558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.3721332399
MESH:D006973 Hypertension Cyclosporine 7.9910903974
MESH:D006973 Hypertension Raloxifene 7.9917577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.9918850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8315338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5516569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1415869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 14.7117937319
MESH:D007248 Infertility, Male methyl cellosolve 14.713987992
MESH:D007248 Infertility, Male Methylnitrosourea 14.717193160
MESH:D007248 Infertility, Male sodium arsenite 14.7112646999 15346721
MESH:D007249 Inflammation Dietary Fats 22.1520412841
MESH:D007249 Inflammation Diethylnitrosamine 22.1518785209
MESH:D007249 Inflammation Flavonoids 22.1517296493
MESH:D007249 Inflammation Lipopolysaccharides 22.1512878042 17237260 9205823 17255318 17963957
MESH:D007249 Inflammation Mustard Gas 22.158975870 11428647 9260866 9357497 11428620 16001271 17524151 11428631 11402378
MESH:D007249 Inflammation Progesterone 22.1515869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 22.1512878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 11.3111836018 18457598
MESH:D007333 Insulin Resistance Estradiol 11.3116627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 11.3116306350
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.3917255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1016580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1715604871
MESH:D007674 Kidney Diseases Acetaminophen 13.1715629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 13.178314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 13.1715618244
MESH:D007674 Kidney Diseases sodium arsenite 13.1720008137
MESH:D007680 Kidney Neoplasms Cyclosporine 6.5712371664
MESH:D007680 Kidney Neoplasms Estradiol 6.5715610895
MESH:D007859 Learning Disorders sevoflurane 4.5219212262
MESH:D007889 Leiomyoma Raloxifene 4.2516973256
MESH:D007970 Leukopenia Lipopolysaccharides 4.4315821434
MESH:D017880 Limb Deformities, Congenital methyl cellosolve 8.286499821
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 8.2815526292
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 14.5711408273 16221502 16943688 17334410 16239168 21278145 17157831 17174718 11903743
MESH:D008103 Liver Cirrhosis Dietary Fats 14.5718296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 14.5718665156 18407596 20032147 19638242 18522880
MESH:D008103 Liver Cirrhosis Phenobarbital 14.5721047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.3517805973 16097048 14748882 12389079 17761835 12667390 16015684 15893842 16638106 18420326 17922224 15876570 18210741 17944888 15931870 15370692 12445418 18395095 16248980 13678700 15730626 17631135 18395914 18429990 18054572 16033810 15673190 14620537 18472094 15057751 18277467 10355542 12632514 14716496 12649538 14716833 17708605 18205269 17481882 18006644 15338365 15925388 18472332 18279442 17869086 12445421 16136751 20821823 17714472 17698563 12741479 12666154 15996030 18317297 12898905 16192424 18251166 16116963 12586293 15959796 17766677 17721639 15362042 17525996 15818738 15052691 12546737 16011737 18339082 14512876 17557913 11481614 15123356 18166357 18187930 18156304 18376398 14724832 12958196 17976157 18412020 17823541 12632512 17640975 18481824 18263696 16027843 18418968 12609069 17900296 17565644 15650968 18705752
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.3514716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 6.3512878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.3515474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.3512878042
MESH:D008107 Liver Diseases Acetaminophen 8.7712969438 16611625 19014921 16610002 19460945 12587719 19784758 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.7716246199 16964402 15720792 17285989 15830285
MESH:D008107 Liver Diseases Diethylnitrosamine 8.7717034775
MESH:D008107 Liver Diseases Phenobarbital 8.7719363144
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9115123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.6517185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.6516899240 14706259
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 20.3419389873 21295105
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 20.3419294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 20.3420492335 19255062 9163691 19996281 19850985 19294768 20452335 21167192 20118626 21071580 15885732 20583210 21047994 19642983 19256749 12112319 19833225 19426721 20405173 21278145 18978307 20101389 16942905 18644402 19427195 19499222 20434301 19638242 2422723 19254457 19073162 18754104 19812893 18977376 10737359 12771043 19090486 20137499 2862719 15175105 19551842 19690152 20501860 18648771
MESH:D008113 Liver Neoplasms Phenobarbital 20.348742319 19812893 15975961 19073162 19482888 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 20.3420007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 20.3416712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.3416984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 16.9218164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 16.9215583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 16.9219009564 17942915 16267830 3124819 19539802 19004024 18308698 17174075 19519916 18775883 18282651 16842330 17854601 9362446 2563599 18093689 18253720 19126423 18079962 18164116 18544905 21159647
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 16.9218308698 1399818 6150874 2563599 17172636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 16.9212151625
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.2116080182
MESH:D008171 Lung Diseases Mustard Gas 11.3918702808 18161513
MESH:D008171 Lung Diseases Ozone 11.3919066396 8266340
MESH:D008171 Lung Diseases sodium arsenite 11.3919095001
MESH:D055370 Lung Injury Lipopolysaccharides 8.3821114838
MESH:D055370 Lung Injury Ozone 8.3820417186
MESH:D008175 Lung Neoplasms bexarotene 10.1717849452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 10.1721163286 20970405 6695378 20512841
MESH:D008175 Lung Neoplasms Methylnitrosourea 10.1718062963
MESH:D008175 Lung Neoplasms Mustard Gas 10.178781369 3148597
MESH:D008175 Lung Neoplasms Ozone 10.178597069 7614698
MESH:D008175 Lung Neoplasms sodium arsenite 10.1715276417 16712894 17077188 19931552 17306315
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.1719555203 11884234
MESH:D008223 Lymphoma Methylnitrosourea 3.8311418001 16257854
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 4.5314633661
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.8911161223
MESH:D008231 Lymphopenia methyl cellosolve 5.523699323
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 17.0919196722 19196723 15591091
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 17.0911408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 17.0915113128 16944150 10767621 15688392 11807958 15313902 16619500 11751437 14999141 17020996 17131329 16827153 19196723 14633655 10838139 12931682 16051031
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 17.0917203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental selenomethylselenocysteine 17.0915318939
MESH:D020149 Manganese Poisoning Estradiol 4.2219453300
MESH:D008545 Melanoma sodium arsenite 2.0019082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3119513568
MESH:D008569 Memory Disorders sevoflurane 4.5019212262
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5216801185
MESH:D008679 Metaplasia Ozone 4.8410496685
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.2915863610
MESH:D009041 Motion Sickness Dextroamphetamine 5.251613127
MESH:D009101 Multiple Myeloma Raloxifene 3.2616497877
MESH:D009135 Muscular Diseases pirinixic acid 3.2516239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.5916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.5916411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2117484760
MESH:D009232 Myxoma Raloxifene 5.2916343187
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.463581430 9029167
MESH:D009369 Neoplasms Methylnitrosourea 7.6015533788
MESH:D009369 Neoplasms pirinixic acid 7.6017405874
MESH:D009369 Neoplasms sodium arsenite 7.6011559025
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 8.5412696579
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.5420056578
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.5219196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0619348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 8.6311399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.6314600291
MESH:D009436 Neural Tube Defects sodium arsenite 2.9712854658
MESH:D009442 Neurilemmoma Methylnitrosourea 5.2211555667
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.4818514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.4820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8520387270
MESH:D009503 Neutropenia Mustard Gas 3.7316761898 7688884
MESH:D009765 Obesity Dietary Fats 4.2020132043 17217161 11836018 21332399 18674790 16723640 20518802 19632207 18457598
MESH:D009765 Obesity pirinixic acid 4.2020558911
MESH:D009845 Oligospermia methyl cellosolve 4.923987992
MESH:D010018 Osteomalacia Phenobarbital 4.1017016548
MESH:D010024 Osteoporosis Raloxifene 3.2417882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.9817823083 15579764 15758505 17893378
MESH:D010051 Ovarian Neoplasms Estradiol 7.4019401270
MESH:D010051 Ovarian Neoplasms Progesterone 7.4017393432 16525653
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.4015276417 17306315
MESH:D010146 Pain Acetaminophen 2.1916870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.1716540662
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 8.1716965848
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.1716965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9812520081
MESH:D010538 Peritonitis Ozone 3.8716369182
MESH:D011014 Pneumonia Lipopolysaccharides 10.2212224865 11605937
MESH:D011014 Pneumonia Ozone 10.2218007984 18929643 18381685
MESH:D011041 Poisoning Mustard Gas 3.5615727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3118163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.0012371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.002563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.002563599
MESH:D011297 Prenatal Exposure Delayed Effects methyl cellosolve 9.0012530607 7974496 6499817
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.0011118676 11399792 11896295 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6520887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.1816740699
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 2.1812376480 15682402
MESH:D011471 Prostatic Neoplasms Raloxifene 2.1816220300 15731164 16536755
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.1816039940
MESH:D011537 Pruritus Ethinyl Estradiol 8.6516919318 15861022
MESH:D011537 Pruritus Mustard Gas 8.6518058305
MESH:D019310 Pseudolymphoma Phenobarbital 4.2312752131
MESH:D011565 Psoriasis Cyclosporine 2.1416882103
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8317266442 17720292 17894541 17620002 10334151
MESH:D011693 Purpura Raloxifene 5.2915770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.2619058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.5610835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5918990726
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.2218172121 18155124
MESH:D012175 Retinoblastoma Methylnitrosourea 5.2211555667
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7618045962
MESH:D012640 Seizures Phenobarbital 2.5211442880 3137016 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.566407741
MESH:D012871 Skin Diseases Mustard Gas 2.6512880345 15451306 16961503
MESH:D012878 Skin Neoplasms sodium arsenite 5.1818572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.1816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6816709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.0215862959 16503802
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6012854658
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.6818456281
MESH:D013274 Stomach Neoplasms Methylnitrosourea 2.6816257854 15930296 18593901
MESH:D020521 Stroke Raloxifene 3.6216837676
MESH:D013733 Testicular Diseases methyl cellosolve 10.036499806
MESH:D013733 Testicular Diseases pyrazole 10.036499806
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.9415821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9315669648
MESH:D013953 Thymus Neoplasms Methylnitrosourea 4.9711418001
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6412697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.957505956
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 10.957505956 3078959
MESH:D013964 Thyroid Neoplasms Phenobarbital 10.951399818
MESH:D013978 Tibial Fractures Estradiol 12.8219048282
MESH:D013978 Tibial Fractures Raloxifene 12.8219048282
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 4.9417572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 4.9417306315 11723127 16452187 16712894
MESH:D014581 Urticaria Acetaminophen 2.7410982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.5411813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0514692618
MESH:D014605 Uveitis Cyclosporine 3.721336536
MESH:D014652 Vascular Diseases sodium arsenite 4.1617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3312125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.9416837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3014671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.2916343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9815886252
MESH:D015430 Weight Gain Dietary Fats 3.5216723640
MESH:D014985 Xerophthalmia Cyclosporine 4.1717120751
Pathway ID Pathway Name
REACT:24941 Circadian Clock
REACT:24972 Circadian Clock (mouse)
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27165
    • No data
    No data
    Releated drug ID Related drug Name
    PA449014cisplatin
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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