AutismKB 2.0

Annotation Detail for AP2B1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:AP2B1 ( ADTB2,AP105B,AP2-BETA,CLAPB1,DKFZp781K0743 )
Gene Full Name: adaptor-related protein complex 2, beta 1 subunit
Band: 17q12
Quick LinksEntrez ID:163; OMIM: 601025; Uniprot ID:AP2B1_HUMAN; ENSEMBL ID: ENSG00000006125; HGNC ID: 563
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04144Endocytosis
hsa05016Huntington's disease
Pathway IDPathway Name
Synaptic Transmission
Signalling by NGF
Axon guidance
Signaling by EGFR
HIV Infection
No data
No data
Pathway IDPathway Name
500756Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
500760Nef Mediated CD8 Down-regulation
500172Trafficking of GluR2-containing AMPA receptors
500759Nef Mediated CD4 Down-regulation
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of AP2B1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of AP2B1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of AP2B1 mRNAaffects expression 17562736
D001241 Aspirin Aspirin results in decreased expression of AP2B1 mRNAdecreases expression 11906190
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of AP2B1 mRNAaffects expression 12734012
D003024 Clozapine Clozapine results in increased expression of AP2B1 mRNAincreases expression 15860345
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of AP2B1 mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of AP2B1 mRNA]decreases reaction|increases expression 17942915
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of AP2B1 mRNAincreases expression 15149470
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AP2B1 mRNAaffects cotreatment|increases expression 17942748
D006220 Haloperidol Haloperidol affects the expression of AP2B1 mRNAaffects expression 15860345
C051890 irinotecan irinotecan analog results in decreased expression of AP2B1 mRNAdecreases expression 18927307
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of AP2B1 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of AP2B1 mRNAincreases expression 19482888
19270015
C004648 testosterone enanthate testosterone enanthate affects the expression of AP2B1 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AP2B1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of AP2B1 mRNAincreases expression 16960034
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of AP2B1 mRNAincreases expression 16960034
C025643 vinclozolin vinclozolin affects the expression of AP2B1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.466195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.4614514962 11752688 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0017505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8214692618
MESH:D000236 Adenoma Diethylnitrosamine 2.876695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.6617620307 17162532 19061943 16434500 19052882 18056438
MESH:D018248 Adenoma, Liver Cell Phenobarbital 17.6617620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.6616835633
MESH:D000380 Agranulocytosis Clozapine 5.1012649775 14617031 16160616
MESH:D000686 Amyloidosis Diethylstilbestrol 4.5215469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D001008 Anxiety Disorders vinclozolin 3.6619015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6815885639
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.7220485159 12372130
MESH:D001321 Autistic Disorder Acetaminophen 2.1218445737
MESH:D001321 Autistic Disorder Haloperidol 2.1219368416 18080171
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D001932 Brain Neoplasms Aspirin 4.4415481559
MESH:D001943 Breast Neoplasms Aspirin 2.0015161893
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.0017474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.0015324884 17129689
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0020435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8215673190 15721981 16227642 16050911 18705752 3786805 16011737 15700767 10355542 16192424 16124888 16097048
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 14.1816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 14.1816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 14.183084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 14.1818788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 14.1819208518 16935385 19418558 20214788 19383236 16878318 18978308 3084413 19919837 19052882 18691550 20727157 10737359 18788625 17162532 16502159 19107877 16569478 17055752 18210153 20512989 16328049 20432363 18393292 18971187 20514400 16681979 17761372 20101231 19519916 10672840 17173139 18494052 16540662 18056438 17428255 18665156 18785209 16779866 20084675 20524982 20935162 19171122 20007298 16698587 17978847 19539802 17138121 19701751 19822196 21159647 16288022 19335982 19394651 18506893 16830150 11831363 3581430 16807293
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 14.1815948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 14.1820007298 1701930 20935162 17173139 6705139
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3818670907 16120746 18850075
MESH:D002375 Catalepsy Haloperidol 4.961977408 15215559
MESH:D002386 Cataract Acetaminophen 2.6010977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.766135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.767505956 17174075 2727394 21159647
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.294080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.4119052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.4116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8917110522 16105132 11677210 15861022 17333356 16919318 17681005
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1112621046 16354765 15340226 8697196 15668235
MESH:D003072 Cognition Disorders Clozapine 5.0117123785
MESH:D003110 Colonic Neoplasms Aspirin 4.2612411196
MESH:D003110 Colonic Neoplasms irinotecan 4.2617725105 17287894
MESH:D015179 Colorectal Neoplasms Aspirin 3.0117047198
MESH:D015179 Colorectal Neoplasms irinotecan 3.0118259882 16303861 17159606 17454858 16391804 15273666 18509181
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 15322242 20055451
MESH:D003456 Cryptorchidism Diethylstilbestrol 11.4912952375 16002989
MESH:D003456 Cryptorchidism vinclozolin 11.4914966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.0418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.0418551238
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.8720210726
MESH:D003704 Dementia Haloperidol 4.6111575062
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 7.2116402076
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.2120387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.2117107852
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.6215331141
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.3821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.3821346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.3817522070 10663392 19164858 19416960 16109766 12705907 14986274 14725611 19420014 11461765 12958197 10915739 2444490 18071297 19085960 18713872 11421492 16781746 19923254 19739265 16177239 11287661 16081117 16393943 15968718 11739529 16227642 12153990 12594235 12540782 17906064 14550746 11834606 10774834 15619225 19370779 11529661 17562736 16485898 12392966 11743745
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 15.382869522 15998439 10915739 7120509 7179309 10092053 21278145 19336974 15027814 6623471 9327722 3732212 6884620 3786805 4309450 11566570 17522070 7440962 19085960 15968718 16177239 16227642
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 15.3819107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.3820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:D050171 Dyslipidemias Clozapine 4.2016402076
MESH:D004421 Dystonia Phenobarbital 4.041851702
MESH:D004487 Edema Aspirin 7.1517259670
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.1512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9618230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2212538720
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.7416402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.4816804899 15700306
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.059294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.153659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.9311558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.9020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.576401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.297750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.073659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1816302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.2715959796 61145 16045604 19224547 16239168 12795759 17595544 12631006
MESH:D005234 Fatty Liver Diethylnitrosamine 13.2720387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.2715345470
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.6716513791 16534752 15751030 16611131 16002989
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D005355 Fibrosis Carbon Tetrachloride 8.7418705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.7420067830
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9816973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.3616417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.0016452187
MESH:D005909 Glioblastoma Aspirin 3.9712870263
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006261 Headache Aspirin 5.0215240983
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3411294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6319900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 8.5816109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.5816120746 12621046 15340226
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.8117440010
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1116959395 15340226 18606429 8697196 16354765
MESH:D012001 Hyperacusis Aspirin 5.8215240983
MESH:D006930 Hyperalgesia Acetaminophen 2.7216870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5816899240
MESH:D006948 Hyperkinesis Clozapine 4.9616046005
MESH:D006965 Hyperplasia Diethylstilbestrol 4.4814722030 12960047
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9118850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1315338365
MESH:D007021 Hypospadias Diethylstilbestrol 11.3916002989
MESH:D007021 Hypospadias Ethinyl Estradiol 11.3916945680 16569931
MESH:D007246 Infertility Diethylstilbestrol 4.3915036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.7217937319
MESH:D007248 Infertility, Male vinclozolin 6.7216467254
MESH:D007249 Inflammation Diethylnitrosamine 4.9418785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.9412200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2115629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.6016705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.6016705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 12.6014681315 16762066 15003126
MESH:D007859 Learning Disorders Diethylstilbestrol 4.1017184923
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7816417039
MESH:D008064 Lipidoses Clozapine 3.9817567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 11.1121278145 16221502 11408273 17157831 16239168 17174718 17334410 11903743 16943688
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 11.1120032147 18407596 19638242 18665156 18522880
MESH:D008103 Liver Cirrhosis Phenobarbital 11.1121047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.2918412020 15931870 16015684 17869086 12546737 18481824 18251166 16116963 12445418 17481882 18376398 15996030 18054572 17922224 12898905 15893842 15818738 12741479 15925388 14716833 14620537 18705752 18006644 12649538 18395914 15650968 12389079 18395095 17698563 17976157 17557913 17565644 17714472 20821823 15370692 18277467 14512876 18420326 17823541 16011737 12666154 14748882 14716496 17900296 12445421 16638106 17708605 18472332 16248980 14724832 12667390 12958196 18205269 16097048 18339082 16033810 18210741 18472094 15730626 12609069 15673190 16136751 17640975 11481614 17721639 17944888 18418968 18263696 17766677 18317297 15876570 15052691 17525996 18166357 18156304 15057751 18429990 15959796 18279442 12586293 18187930 12632512 10355542 16192424 15123356 13678700 16027843 12632514 15338365 17805973 15362042 17761835 17631135
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2912878042
MESH:D008107 Liver Diseases Acetaminophen 9.4311587558 16611625 12587719 12969438 19014921 19784758 19460945 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 9.4316964402 15720792 17285989 16246199 15830285
MESH:D008107 Liver Diseases Diethylnitrosamine 9.4317034775
MESH:D008107 Liver Diseases Phenobarbital 9.4319363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2115123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.5016871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.5014706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 18.137678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 18.1319294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 18.1319073162 19294768 19499222 18644402 21278145 18754104 10737359 18977376 12112319 20452335 16942905 19812893 19833225 21071580 20405173 19090486 20137499 18648771 21047994 2862719 20583210 15175105 19255062 19850985 19996281 20118626 9163691 21167192 19427195 20101389 19426721 19642983 19638242 20501860 20492335 2422723 19690152 15885732 19256749 18978307 12771043 19551842 19254457 20434301
MESH:D008113 Liver Neoplasms Diethylstilbestrol 18.1316712894 15890375
MESH:D008113 Liver Neoplasms Phenobarbital 18.1319482888 8742319 19073162 19812893 15975961 21047994
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.1316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 18.832876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 18.8315583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 18.8318775883 18253720 16267830 19519916 19009564 3124819 18079962 18282651 19539802 19126423 18544905 17942915 16842330 18164116 18308698 18093689 21159647 2563599 19004024 9362446 17174075 17854601
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 18.8318308698 1399818 17172636 6150874 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 18.8312151625
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.2621163286 20512841 20970405 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2619555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.2015166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.4915700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.5816002989
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D001523 Mental Disorders Clozapine 8.5316856516
MESH:D001523 Mental Disorders Haloperidol 8.5316856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.4319142101
MESH:D008881 Migraine Disorders Aspirin 4.0815240983
MESH:D052016 Mucositis irinotecan 5.0617159606
MESH:D009203 Myocardial Infarction Aspirin 3.5612692751
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5317484760
MESH:D009325 Nausea Aspirin 5.2815240983
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.5218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.5218551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.999029167 3581430
MESH:D009362 Neoplasm Metastasis irinotecan 5.9918259882
MESH:D009369 Neoplasms Diethylstilbestrol 2.7815313581
MESH:D009421 Nervous System Malformations Diethylstilbestrol 9.7611399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.7614600291
MESH:D009447 Neuroblastoma irinotecan 3.498761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.2618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.2620387270
MESH:D017599 Neuroectodermal Tumors irinotecan 4.788761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1820387270
MESH:D009765 Obesity Clozapine 3.0218515891 19142110
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.9816049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.9816049721
MESH:D010003 Osteoarthritis Aspirin 4.077009135
MESH:D010018 Osteomalacia Phenobarbital 4.4117016548
MESH:D010146 Pain Acetaminophen 7.0116870215
MESH:D010146 Pain Aspirin 7.016363464 6995502
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.2916540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.2916965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7211578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.5911156591
MESH:D020795 Photophobia Aspirin 5.8215240983
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.2314722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.7115687265 16977796
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.172563599
MESH:D011230 Precancerous Conditions Phenobarbital 9.172563599
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 16.5917184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 16.5911118676 11399792 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 16.5919015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.9818220299
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.5715846301 17136230 15046698
MESH:D011472 Prostatitis vinclozolin 4.9818629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.3616919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.5612752131
MESH:D011595 Psychomotor Agitation Haloperidol 5.0011575062
MESH:D011618 Psychotic Disorders Clozapine 9.2215331141
MESH:D011618 Psychotic Disorders Haloperidol 9.2211575062
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012220 Rhinitis Aspirin 4.4012372130
MESH:D012559 Schizophrenia Clozapine 4.1119369910 20107430 17123785 20580759 16141801 17726453 20521320 17667964 11151749 20168265 18806925 20521326 20452607 11763009 18855531
MESH:D012559 Schizophrenia Haloperidol 4.1119369910 20107430 18513383 1830565
MESH:D012640 Seizures 2,4-dinitrotoluene 9.9218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 9.9218551238
MESH:D012640 Seizures Phenobarbital 9.923137016 11442880 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.876407741
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.3012269725
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0516192470
MESH:D013088 Spermatocele Diethylstilbestrol 11.9316002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 11.9316709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.6318456281
MESH:D013274 Stomach Neoplasms irinotecan 2.6315723263
MESH:D020521 Stroke Aspirin 4.4016403987
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.7420210726
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6511994571
MESH:D013927 Thrombosis Aspirin 9.2817672075
MESH:D013927 Thrombosis Ethinyl Estradiol 9.2815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.257505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.251399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.4116049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.4116049721
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 8.4116452187 16712894 17306315
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.1610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.1610091137
MESH:D014581 Urticaria Acetaminophen 9.0110982225
MESH:D014581 Urticaria Aspirin 9.0110982225 20485159
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.0616175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.2314652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 9.6015809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.6014692618
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.4816002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5715869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
MESH:D015430 Weight Gain Clozapine 4.4920564506 20107430 16402076 16141801 17502770 20521320
MESH:D015431 Weight Loss Clozapine 5.1317933447
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:04961 Endocrine and other factor-regulated calcium reabsorption
KEGG:04144 Endocytosis
REACT:6185 HIV Infection
KEGG:05016 Huntington's disease
REACT:9417 Signaling by EGFR
REACT:11061 Signalling by NGF
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24854
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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