AutismKB 2.0

Annotation Detail for DCC


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Basic Information Top
Gene Symbol:DCC ( CRC18,CRCR1,IGDCC1 )
Gene Full Name: deleted in colorectal carcinoma
Band: 18q21.2
Quick LinksEntrez ID:1630; OMIM: 120470; Uniprot ID:DCC_HUMAN; ENSEMBL ID: ENSG00000187323; HGNC ID: 2701
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04360Axon guidance
hsa05210Colorectal cancer
hsa05200Pathways in cancer
Pathway IDPathway Name
Axon guidance
Apoptosis
Pathway IDPathway Name
200074Netrin-mediated signaling
Pathway IDPathway Name
P00009Axon guidance mediated by netrin
P00008Axon guidance mediated by Slit/Robo
Pathway IDPathway Name
500090Netrin mediated repulsion signals
500091Role of second messengers in netrin-1 signaling
500089DCC mediated attractive signaling
500088Netrin-1 signaling
500280Role of DCC in regulating apoptosis
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
Cancers of the digestive system
H00018Gastric cancer
H00044Cancer of the anal canal
Desease IDDesease Name
1934Cancer
No data
No data
Desease Name
Colorectal cancer
Mirror movements, congenital
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of DCC mRNAincreases expression 12205029
D003913 Dextroamphetamine SOD1 inhibits the reaction [Dextroamphetamine results in increased expression of DCC mRNA]decreases reaction|increases expression 12205029
C014347 decitabine decitabine results in increased expression of DCC mRNAincreases expression 19329758
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of DCC mRNAincreases expression 15766595
D005472 Fluorouracil DCC protein results in increased susceptibility to [Fluorouracil co-treated with Levamisole]affects cotreatment|increases response to substance 15148649
D009151 Mustard Gas Mustard Gas results in increased expression of DCC mRNAincreases expression 15674843
D010100 Oxygen Oxygen deficiency results in increased expression of DCC mRNAincreases expression 17914565
C003377 taxifolin taxifolin results in increased expression of DCC mRNAincreases expression 17541156
D007978 Levamisole DCC protein results in increased susceptibility to [Fluorouracil co-treated with Levamisole]affects cotreatment|increases response to substance 15148649
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury Oxygen 4.7916759491
MESH:D000230 Adenocarcinoma Fluorouracil 2.4717638652
MESH:D000686 Amyloidosis Diethylstilbestrol 4.7615469931
MESH:D000740 Anemia Fluorouracil 3.9415504547 17963324 16511603
MESH:D000860 Anoxia Oxygen 5.3920872349
MESH:D001249 Asthma Mustard Gas 2.7710378619
MESH:D050197 Atherosclerosis Oxygen 3.9316391483
MESH:D001768 Blister Mustard Gas 5.5019167455
MESH:D001943 Breast Neoplasms decitabine 2.0819208741 18320071
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.0815324884 17129689
MESH:D001943 Breast Neoplasms Fluorouracil 2.0818357371 16557594 16110121 16595493 19217205 18608205 15136595
MESH:D001943 Breast Neoplasms Oxygen 2.0817263869
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.5015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.3517687719 10378619
MESH:D002276 Carcinoid Tumor Fluorouracil 5.0416051944
MESH:D002277 Carcinoma Fluorouracil 3.7617121937
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 3.3516924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.3516332177 17045692 17971768 18930000 17088986 16799960
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1118695887
MESH:D002294 Carcinoma, Squamous Cell decitabine 5.0419215824
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 5.0417066447 16757204 16280240 18986760
MESH:D002418 Cattle Diseases Levamisole 6.8114651886
MESH:D003110 Colonic Neoplasms decitabine 3.9917616700
MESH:D003110 Colonic Neoplasms Fluorouracil 3.9916510598 16340194 17725105 18772588 15001691 17287894 17169374 17016597 17172411 17018589
MESH:D015179 Colorectal Neoplasms marker/mechanism 15365072
MESH:D015179 Colorectal Neoplasms decitabine 3.8818981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.8818448328 17454858 16391804 20501625 15289873 16303861 18949393 16282729 18288408 18509181 14970324 17695437 17255274 18383874 16331619 18802399 17094418 16524972 17401013 15148649 17594712 17016601
MESH:D015179 Colorectal Neoplasms Levamisole 3.8815148649
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.8416002989 12952375
MESH:D007644 Darier Disease Fluorouracil 5.1316733453
MESH:D004417 Dyspnea Oxygen 5.2120016425
MESH:D004487 Edema Mustard Gas 3.5511428631 9260866 11402378 11428647
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.4919294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 5.0316402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.6116804899 15700306
MESH:D004890 Erythema Mustard Gas 5.509357497
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.5015173087 16481741 16337965 16785472 17638652
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7916002989 16611131 15751030 16534752 16513791
MESH:D005739 Gas Poisoning Oxygen 5.5920016425
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.2816452187
MESH:D005910 Glioma Fluorouracil 2.9516145905
MESH:D006258 Head and Neck Neoplasms decitabine 8.4219215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 8.4215162350 15102660 18337622
MESH:D006965 Hyperplasia Diethylstilbestrol 4.7412960047 14722030
MESH:D007021 Hypospadias Diethylstilbestrol 4.8916002989
MESH:D007246 Infertility Diethylstilbestrol 4.6415036965
MESH:D007248 Infertility, Male decitabine 3.3517581917
MESH:D007249 Inflammation Mustard Gas 2.8917524151 9260866 11428620 16001271 8975870 11402378 9357497 11428647 11428631
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 8.3414681315 16762066 15003126
MESH:D007680 Kidney Neoplasms Fluorouracil 8.3416985049
MESH:D007859 Learning Disorders Diethylstilbestrol 4.3717184923
MESH:D007938 Leukemia decitabine 3.1819235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.2418454857 17236224 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4117679729 18704418 18460780 19387464 18206229 19010910
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.8418055864
MESH:D008113 Liver Neoplasms Diethylstilbestrol 5.0916712894 15890375
MESH:D008113 Liver Neoplasms Fluorouracil 5.0915113037 17045692 16603448 18383874
MESH:D008171 Lung Diseases Mustard Gas 3.6018161513 18702808
MESH:D055370 Lung Injury Oxygen 4.8118339021
MESH:D008175 Lung Neoplasms Fluorouracil 2.7415246190
MESH:D008175 Lung Neoplasms Mustard Gas 2.748781369 3148597
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.1315086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.4915166399
MESH:D008223 Lymphoma decitabine 8.2919470736
MESH:D008223 Lymphoma Diethylstilbestrol 8.2915700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.8916002989
MESH:D008545 Melanoma decitabine 2.2717785578 16505122
OMIM:157600 MIRROR MOVEMENTS, CONGENITAL marker/mechanism
MESH:D009041 Motion Sickness Dextroamphetamine 5.901613127
MESH:D009062 Mouth Neoplasms Fluorouracil 3.8118986760 16757204
MESH:D009101 Multiple Myeloma decitabine 3.5118172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.5119010910 16882708 18608210 19157545
MESH:D009369 Neoplasms decitabine 9.0319116145 17925555 19470736
MESH:D009369 Neoplasms Diethylstilbestrol 9.0315313581
MESH:D009369 Neoplasms Fluorouracil 9.0318600527 18239605 16928823
MESH:D009421 Nervous System Malformations Diethylstilbestrol 4.4211399458
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5916436463
MESH:D009503 Neutropenia Mustard Gas 4.237688884 16761898
MESH:D010051 Ovarian Neoplasms decitabine 2.7119331143 19259094
MESH:D010190 Pancreatic Neoplasms decitabine 5.7019294695
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.7019003803 16929163 16500647 15113037
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.5514722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.9815687265 16977796
MESH:D011041 Poisoning Mustard Gas 4.0615727166
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 4.4517184923
MESH:D055728 Primary Myelofibrosis decitabine 5.0317616702
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.3915046698 15846301 17136230
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3919082440 18626508
MESH:D011537 Pruritus Mustard Gas 4.4318058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 3.0010334151 17894541 17620002 17266442 17720292
MESH:D012004 Rectal Neoplasms Fluorouracil 4.2318722050 15538739 16160472 18286688
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 4.7717627322 18339021
MESH:D012208 Rhabdomyosarcoma decitabine 4.6619155313
MESH:D012871 Skin Diseases Mustard Gas 2.7612880345 15451306 16961503
MESH:D013088 Spermatocele Diethylstilbestrol 5.0916709447 16002989
MESH:D013274 Stomach Neoplasms decitabine 2.6719037991
MESH:D013274 Stomach Neoplasms Fluorouracil 2.6717498489 17172411 19084572 19015929 15786421 16951190 16424979 17522103 18396642 18567086
MESH:D013322 Strongyloidiasis Levamisole 7.3014651886
MESH:D013398 Sudden Infant Death Oxygen 5.8812563064
MESH:D013964 Thyroid Neoplasms decitabine 3.5117967635
MESH:D014062 Tongue Neoplasms Fluorouracil 4.2216280240
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.6217616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 5.6216712894 16452187 17306315
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 10.3516175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 10.3516803524
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.5514652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.3515809267 16690809
MESH:D014604 Uveal Neoplasms decitabine 5.2917785578
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.7416002989 16513791
Pathway ID Pathway Name
REACT:578 Apoptosis
REACT:18266 Axon guidance
KEGG:04360 Axon guidance
KEGG:05210 Colorectal cancer
REACT:23853 Interactions of the immunoglobulin superfamily (IgSF) member proteins
KEGG:05200 Pathways in cancer
REACT:22291 Phosphorylation of PLCgamma by Netrin-1
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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