AutismKB 2.0

Annotation Detail for DCI


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DCI ( - )
Gene Full Name: dodecenoyl-CoA isomerase
Band: 16p13.3
Quick LinksEntrez ID:1632; OMIM: 600305; Uniprot ID:D3D2_HUMAN; ENSEMBL ID: ENSG00000167969; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5137fatty acid beta-oxidation III (unsaturated, odd number)
FAO-PWYfatty acid beta-oxidation I
Pathway IDPathway Name
hsa00071Fatty acid metabolism
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ECI1 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of ECI1 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of ECI1 mRNAaffects expression 17562736
C040534 alpha-hexachlorocyclohexane alpha-hexachlorocyclohexane affects the expression of ECI1 mRNAaffects expression 16940010
C040534 alpha-hexachlorocyclohexane alpha-hexachlorocyclohexane results in decreased expression of ECI1 mRNAdecreases expression 16940010
C040534 alpha-hexachlorocyclohexane alpha-hexachlorocyclohexane results in increased expression of ECI1 mRNAincreases expression 16940010
D000638 Amiodarone Amiodarone affects the expression of ECI1 mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ECI1 mRNAaffects expression 16483693
D001553 Benzbromarone Benzbromarone affects the expression of ECI1 mRNAaffects expression 19483382
C095105 bexarotene bexarotene results in increased expression of ECI1 mRNAincreases expression 16648578
C006780 bisphenol A bisphenol A results in decreased expression of ECI1 mRNAdecreases expression 12075121
C032036 bromobenzene bromobenzene results in increased expression of ECI1 mRNAincreases expression 12628495
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of ECI1 mRNAdecreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of ECI1 mRNAaffects expression 15963342
D002994 Clofibrate Clofibrate affects the expression of ECI1 mRNAaffects expression 19483382
12011481
D002994 Clofibrate Clofibrate results in increased expression of ECI1 mRNAincreases expression 15585944
D002995 Clofibric Acid Clofibric Acid affects the expression of ECI1 mRNAaffects expression 17602206
C030123 coumarin coumarin affects the expression of ECI1 mRNAaffects expression 16963487
D016572 Cyclosporine Cyclosporine results in decreased expression of ECI1 mRNAdecreases expression 20106945
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in decreased expression of ECI1 mRNAaffects cotreatment|decreases expression 18313992
D004041 Dietary Fats Dietary Fats results in increased expression of ECI1 mRNAincreases expression 16357043
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of ECI1 mRNAdecreases expression 17557909
D005001 Ethionine Ethionine affects the expression of ECI1 mRNAaffects expression 19483382
D011345 Fenofibrate Fenofibrate results in increased expression of ECI1 mRNAincreases expression 11798191
D015248 Gemfibrozil Gemfibrozil affects the expression of ECI1 mRNAaffects expression 12011481
D007657 Ketone Bodies Ketone Bodies results in increased expression of ECI1 mRNAincreases expression 16807920
C008493 methylselenic acid methylselenic acid results in decreased expression of ECI1 mRNAdecreases expression 18548127
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of ECI1 mRNAdecreases expression 17616710
D009853 Omeprazole Omeprazole affects the expression of ECI1 mRNAaffects expression 19483382
C076994 perfluorooctane sulfonic acid perfluorooctane sulfonic acid results in increased expression of ECI1 mRNAincreases expression 16221955
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of ECI1 mRNAincreases expression 17681415
18281256
18467677
C023036 perfluorooctanoic acid PPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of ECI1 mRNA]increases expression|increases reaction 18467677
18281256
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of ECI1 mRNAincreases expression 16221955
D010634 Phenobarbital Phenobarbital results in decreased expression of ECI1 mRNAdecreases expression 12011481
16940010
D010634 Phenobarbital Phenobarbital results in increased expression of ECI1 mRNAincreases expression 12082028
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ECI1 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of ECI1 mRNAincreases expression 20059764
17426115
18467677
16357043
11798191
15375163
15777286
18301758
C006253 pirinixic acid PPARA protein affects the reaction [pirinixic acid results in increased expression of ECI1 mRNA]affects reaction|increases expression 15777286
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of ECI1 mRNA]increases expression|increases reaction 20059764
18467677
C006253 pirinixic acid pirinixic acid affects the expression of ECI1 mRNAaffects expression 19483382
C006253 pirinixic acid pirinixic acid results in increased expression of ECI1 mRNAincreases expression 12011481
D011441 Propylthiouracil Propylthiouracil affects the expression of ECI1 mRNAaffects expression 19483382
D020849 Raloxifene Raloxifene affects the expression of ECI1 mRNAaffects expression 16079270
C488333 Ro 65-7199 Ro 65-7199 affects the expression of ECI1 mRNAaffects expression 14610520
C488334 Ro 66-0074 Ro 66-0074 results in increased expression of ECI1 mRNAincreases expression 14610520
D013752 Tetracycline Tetracycline results in decreased expression of ECI1 mRNAdecreases expression 16917069
D013853 Thioacetamide Thioacetamide affects the expression of ECI1 mRNAaffects expression 19483382
D014303 Trinitrotoluene Trinitrotoluene affects the expression of ECI1 mRNAaffects expression 21346803
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in decreased expression of ECI1 mRNAaffects cotreatment|decreases expression 18313992
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.496195326
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 7.497525203
MESH:D000138 Acidosis Ammonium Chloride 3.1718287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5417505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.449612607
MESH:D055371 Acute Lung Injury pirinixic acid 2.7618653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.7114692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.523712494
MESH:D018248 Adenoma, Liver Cell Phenobarbital 8.8117620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.8116434500
MESH:D000419 Albuminuria Raloxifene 4.2217451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.4515800139
MESH:D000799 Angioedema Acetaminophen 3.4410982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.4620041841 18218290 18057881
MESH:D001161 Arteriosclerosis Dietary Fats 8.6315238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.6311256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4215885639
MESH:D001281 Atrial Fibrillation Amiodarone 3.6118651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.4618445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.621440618 11289319
MESH:D001778 Blood Coagulation Disorders Amiodarone 44.4019483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 44.4019483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 44.4019483382
MESH:D001778 Blood Coagulation Disorders Ethionine 44.4019483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 44.4019483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 44.4019483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 44.4019483382
MESH:D001778 Blood Coagulation Disorders Thioacetamide 44.4019483382
MESH:D001862 Bone Resorption bisphenol A 3.5111985600
MESH:D001930 Brain Injuries Raloxifene 4.0916580743
MESH:D001943 Breast Neoplasms bexarotene 1.9716344269 16818667
MESH:D001943 Breast Neoplasms bisphenol A 1.9717123778
MESH:D001943 Breast Neoplasms Dietary Fats 1.9720435547
MESH:D001943 Breast Neoplasms Raloxifene 1.9717242785 15572757 16912660 17893378 17595753 17049068 17261762 17440819 15775269 15758505 17952589 16837676
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4016192424 15700767 16050911 15673190 16097048 18705752 16124888 15721981 3786805 16227642 10355542 16011737
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 12.9316705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 12.937296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 12.933084413
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 12.931701930
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 12.9318788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 12.9320935162 17173139 20007298 1701930 6705139
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 12.9317997003
MESH:D002278 Carcinoma in Situ bisphenol A 4.5917123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.0816247446
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.487296757
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.7317572228
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7519225199 15710769
MESH:D002318 Cardiovascular Diseases Raloxifene 3.1715775269
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.6918974383
MESH:D002386 Cataract Acetaminophen 6.7210977129
MESH:D002386 Cataract Trinitrotoluene 6.7215817613 14694615
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 9.667505956
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 9.661399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 9.6612371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.874080065
MESH:D002637 Chest Pain Omeprazole 4.7115447763
MESH:D018281 Cholangiocarcinoma Thioacetamide 3.9618291259
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 16.829022650 19486331
MESH:D002779 Cholestasis Cyclosporine 16.8219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 16.8215861022 17333356 16919318 11677210 16105132 17110522 17681005
MESH:D002779 Cholestasis pirinixic acid 16.8219176532
MESH:D003072 Cognition Disorders Raloxifene 4.2315800139
MESH:D000013 Congenital Abnormalities Trinitrotoluene 4.0715095906
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.9518551238
MESH:D003490 Cyanosis Trinitrotoluene 9.9518551238
MESH:D003865 Depressive Disorder, Major Raloxifene 3.8317474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.448156756 8970840 12868966 11906362 18759878 2524372 14531868 11298694
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2418249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.132952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 3.1019647726
MESH:D003928 Diabetic Nephropathies Raloxifene 3.6117308373 15920148 17451421
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 23.3318551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 23.331440618 16192314 7440962 9328219 18692083 6482804 18289764 6679447 9022650 11289319 18648102 9653073 8291058
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 23.3311739529 19923254 16393943 11421492 11529661 15619225 12392966 16227642 19420014 19739265 16485898 10915739 11743745 14986274 17562736 2444490 19370779 16781746 10663392 19085960 14550746 15968718 10774834 14725611 12540782 16109766 12594235 16081117 18071297 12705907 18713872 16177239 11461765 11834606 19416960 17522070 12153990 12958197 11287661 17906064 19164858
MESH:D056486 Drug-Induced Liver Injury Amiodarone 23.3315265979 18218290
MESH:D056486 Drug-Induced Liver Injury bromobenzene 23.3312628495 10092053
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 23.332869522 19336974 10092053 3732212 4309450 7179309 6884620 15027814 17522070 7120509 15968718 3786805 16227642 11566570 21278145 7440962 9327722 6623471 10915739 15998439 19085960 16177239
MESH:D056486 Drug-Induced Liver Injury Tetracycline 23.3317522070
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 23.3312963478
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 23.3321346803 18551238
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7019426721
MESH:D004362 Drug Toxicity Lamivudine 7.8215040536
MESH:D004362 Drug Toxicity Zidovudine 7.8215040536
MESH:D004381 Duodenal Ulcer Omeprazole 3.9621218061 17151854 16613094 15991576
MESH:D050171 Dyslipidemias Clofibrate 18.4516707586
MESH:D050171 Dyslipidemias Dietary Fats 18.4518367378
MESH:D050171 Dyslipidemias Fenofibrate 18.4516707586
MESH:D050171 Dyslipidemias Gemfibrozil 18.4516707586
MESH:D004421 Dystonia Phenobarbital 3.641851702
MESH:D004487 Edema perfluorooctanoic acid 9.5817259670 12083418
MESH:D004487 Edema pirinixic acid 9.5812083418
MESH:D004487 Edema Raloxifene 9.5815860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.8712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 7.8715845917
MESH:D016889 Endometrial Neoplasms Fenofibrate 3.8316569247
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.723659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.473922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.6820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.216401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.877750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.633659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.273581430
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.2716704527 16805852 15878914 15623463 16510608 15547721 15264214 15150132 15547733
MESH:D005218 Fat Necrosis Thioacetamide 5.3216456712
MESH:D005234 Fatty Liver Amiodarone 48.8814986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 48.8816045604 12631006 17595544 15959796 16239168 19224547 12795759 61145
MESH:D005234 Fatty Liver Clofibrate 48.8819224547
MESH:D005234 Fatty Liver Cyclosporine 48.8819224547
MESH:D005234 Fatty Liver Dietary Fats 48.8817967931 18296743 19551842 19004024
MESH:D005234 Fatty Liver Ethinyl Estradiol 48.8815345470
MESH:D005234 Fatty Liver pirinixic acid 48.8820131406 19236843
MESH:D005234 Fatty Liver Raloxifene 48.8817473493
MESH:D005234 Fatty Liver Tetracycline 48.8816917069 19224547
MESH:D005234 Fatty Liver Zidovudine 48.8818299183
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.626705139
MESH:D005355 Fibrosis Carbon Tetrachloride 12.5618705752
MESH:D005355 Fibrosis Cyclosporine 12.5612639820 12168785
MESH:D005355 Fibrosis Dietary Fats 12.5618296743
MESH:D005756 Gastritis Acetaminophen 3.2716983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.828708960
MESH:D005909 Glioblastoma perfluorooctane sulfonic acid 4.0017162496
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.677505956
MESH:D006331 Heart Diseases Raloxifene 3.2611110106
MESH:D006333 Heart Failure pirinixic acid 2.2920558911
MESH:D006402 Hematologic Diseases Zidovudine 4.3512579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0315720958
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.2218665440 15929193 17276928
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 13.566705139
MESH:D006505 Hepatitis Carbon Tetrachloride 13.5619110552 19900420
MESH:D006505 Hepatitis Thioacetamide 13.5616456712
MESH:D006509 Hepatitis B Lamivudine 4.7517703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 4.7516476009 15274664 15631357 12044531 15309715
MESH:D006529 Hepatomegaly Amiodarone 23.0715265979
MESH:D006529 Hepatomegaly perfluorooctanoic acid 23.073609246
MESH:D006529 Hepatomegaly Phenobarbital 23.0716109766
MESH:D006529 Hepatomegaly pirinixic acid 23.0718467677 19176532 19772884 16221962
MESH:D006529 Hepatomegaly Trinitrotoluene 23.0715817613
MESH:D015658 HIV Infections Lamivudine 6.3517530837 9296927 11141242 20032539
MESH:D015658 HIV Infections Zidovudine 6.3511698656 17358032 20032539 11363243 11141242
MESH:D006930 Hyperalgesia Acetaminophen 6.8316870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 6.8312083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1416899240
MESH:D006937 Hypercholesterolemia Amiodarone 8.008137927 9751232
MESH:D006937 Hypercholesterolemia Dietary Fats 8.0021332399
MESH:D006943 Hyperglycemia pirinixic acid 2.8420558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.2621332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.5515034207
MESH:D006973 Hypertension Cyclosporine 4.7610903974
MESH:D006973 Hypertension Raloxifene 4.7617577099 15787275
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4216569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 10.3317991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 10.338137927 18031379
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.0117937319
MESH:D007248 Infertility, Male Trinitrotoluene 6.0112150543
MESH:D007249 Inflammation Dietary Fats 4.6620412841
MESH:D007249 Inflammation perfluorooctanoic acid 4.6612083418
MESH:D007333 Insulin Resistance bisphenol A 10.8216393666
MESH:D007333 Insulin Resistance Dietary Fats 10.8211836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 10.8216306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.628074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0415604871
MESH:D007674 Kidney Diseases Acetaminophen 5.0212587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.028314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 15.1716705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 15.176582329
MESH:D007680 Kidney Neoplasms Cyclosporine 15.1712371664
MESH:D007680 Kidney Neoplasms Zidovudine 15.1712579204
MESH:D007889 Leiomyoma Raloxifene 4.1316973256
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.7819248655
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.0620370541
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.838812269
MESH:D008064 Lipidoses Amiodarone 3.2317567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 9.7316239168 17334410 16221502 21278145 17157831 16943688 17174718 11408273 11903743
MESH:D008103 Liver Cirrhosis Dietary Fats 9.7318296743
MESH:D008103 Liver Cirrhosis Phenobarbital 9.7321047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.959327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.5712445421 18395095 12667390 20821823 18279442 18339082 18418968 11481614 15876570 18317297 16248980 15057751 15673190 13678700 17721639 15362042 18429990 17565644 17525996 12632512 18210741 15959796 16027843 17766677 15338365 18420326 10355542 15996030 15730626 17922224 18156304 16638106 12632514 16097048 17805973 18263696 17640975 18705752 16136751 15123356 17708605 18481824 14716496 12958196 12649538 12586293 17823541 18187930 12666154 17976157 15370692 17944888 14512876 12609069 15818738 15650968 18395914 16011737 17698563 16033810 18277467 14716833 17761835 17631135 12898905 17900296 12389079 15893842 12546737 14724832 18006644 15052691 15925388 16116963 14620537 15931870 17869086 18205269 17557913 18166357 18412020 16192424 18376398 12741479 18472094 18251166 18054572 17481882 14748882 12445418 17714472 18472332 16015684
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 4.5715474484
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.5715474484
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 4.5715078482 17050028 15474484 17127702 11172339 15334695 15095483 15075984 17292413 12175628 11682029 10677585 16343077 12531686 15158331 14739098 15288472 15465738 17355460 18263696 16126171 16097051 15316131 18395095 18032466 12679928 18380797 16489207 18031379 17629604 16511523 15362042 12085344 18295389 18606216 18416461 12891558 11481614 15716488 16098781 18458672 15288473 12557150 16248980 18615449
MESH:D008107 Liver Diseases Acetaminophen 8.4319460945 12587719 19784758 11587558 16611625 16610002 12969438 19014921
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.4316964402 15720792 17285989 16246199 15830285
MESH:D008107 Liver Diseases Phenobarbital 8.4319363144
MESH:D008107 Liver Diseases Thioacetamide 8.4318374380 16337175 15158337
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 14.2816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 14.2814706259 16899240
MESH:D017114 Liver Failure, Acute Thioacetamide 14.2815313186 15633222 17276928 12479984
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 15.8919294768
MESH:D008113 Liver Neoplasms Clofibric Acid 15.8917602206
MESH:D008113 Liver Neoplasms Fenofibrate 15.8918978307
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 15.8914757943 18709148
MESH:D008113 Liver Neoplasms Phenobarbital 15.898742319 19073162 19482888 21047994 19812893 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 15.8920007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 12.126587162 598648 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 12.1215583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 12.1218775883 18253720
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 12.122563599 18308698 6150874 17172636 1399818
MESH:D008133 Long QT Syndrome Amiodarone 3.2815350150 11989578 17391786
MESH:D008171 Lung Diseases Amiodarone 3.1112587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.0818516814
MESH:D008175 Lung Neoplasms bexarotene 2.8617849452
MESH:D008175 Lung Neoplasms Zidovudine 2.8618800350
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.7611161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 3.1619196723 15591091 19196722
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.3916801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.4417358032
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.1515863610
MESH:D009101 Multiple Myeloma Raloxifene 3.1616497877
MESH:D009135 Muscular Diseases Gemfibrozil 9.6216239165
MESH:D009135 Muscular Diseases pirinixic acid 9.6216239165
MESH:D009181 Mycoses Amiodarone 4.5017974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 1.9719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.6516411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.0817484760
MESH:D009232 Myxoma Raloxifene 5.1516343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.3718551238
MESH:D009336 Necrosis Trinitrotoluene 9.3718551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.313581430
MESH:D009369 Neoplasms pirinixic acid 1.7617405874
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.3819196722
MESH:D009395 Nephritis, Interstitial Tetracycline 4.389884423
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.9519348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 3.6016427766 11399458
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.666679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.5518514411
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 10.789802331
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 10.789802331
MESH:D009765 Obesity Dietary Fats 4.0611836018 21332399 17217161 18674790 18457598 20518802 16723640 20132043 19632207
MESH:D009765 Obesity pirinixic acid 4.0620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 13.2212819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 13.224026338 6482804
MESH:D009784 Occupational Diseases Trinitrotoluene 13.2212819281 14694615 17852074
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.623988306
MESH:D010018 Osteomalacia Phenobarbital 3.9717016548
MESH:D010024 Osteoporosis Raloxifene 3.1519059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.8717823083 15758505 15579764 17893378
MESH:D010049 Ovarian Diseases bisphenol A 4.5911985600
MESH:D010146 Pain Acetaminophen 2.0916870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.3516965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3211578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.107296757
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.0311026799
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.076228378
MESH:D011230 Precancerous Conditions Cyclosporine 7.8712371664
MESH:D011230 Precancerous Conditions Phenobarbital 7.872563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.6410548101
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 8.6417132714
MESH:D017096 Prion Diseases Tetracycline 5.0210903871
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 3.8520887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.8716740699
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.8716205645
MESH:D011471 Prostatic Neoplasms Raloxifene 2.8715731164 16220300 16536755
MESH:D011537 Pruritus Ethinyl Estradiol 2.9216919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.0912752131
MESH:D011565 Psoriasis Cyclosporine 2.0816882103
MESH:D011629 Puberty, Precocious bisphenol A 4.3910548101
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7012490602 12832656 11597910
MESH:D011693 Purpura Raloxifene 5.1515770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.1919058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.083692021
MESH:D012206 Rhabdomyolysis Lamivudine 5.149296927
MESH:D012640 Seizures 2,4-dinitrotoluene 8.3718551238
MESH:D012640 Seizures Phenobarbital 8.373137016 11442880 16876388 4039156
MESH:D012640 Seizures Trinitrotoluene 8.3718551238
MESH:D003294 Seizures, Febrile Phenobarbital 4.436407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.6918724381
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.508532709
MESH:D013088 Spermatocele Ethinyl Estradiol 3.5416709447
MESH:D013163 Splenomegaly Trinitrotoluene 4.8215817613
MESH:D013272 Stomach Diseases Omeprazole 4.2218545984
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.7717575124 12958204
MESH:D013274 Stomach Neoplasms Zidovudine 2.7717696246
MESH:D013276 Stomach Ulcer Amiodarone 6.4318087811
MESH:D013276 Stomach Ulcer Omeprazole 6.4318237397 11906479 16755016 17977527 10750652 15991576
MESH:D020521 Stroke Raloxifene 3.5116837676
MESH:D019966 Substance-Related Disorders bisphenol A 3.5916045194 16684133
MESH:D013610 Tachycardia Amiodarone 3.9211238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.8219225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8215669648
MESH:D013959 Thyroid Diseases Amiodarone 4.3619731979
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 10.323712494 6582329 6587162 1399818 7505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 10.321399818
MESH:D013964 Thyroid Neoplasms Propylthiouracil 10.3215710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.4719584973 18020914
MESH:D013978 Tibial Fractures Raloxifene 4.8119048282
MESH:D016171 Torsades de Pointes Amiodarone 3.8017467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 7.3816049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 7.388074119
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 7.3817572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.9210091137
MESH:D014581 Urticaria Acetaminophen 2.6210982225
MESH:D014591 Uterine Diseases bisphenol A 4.6114652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9314692618
MESH:D014605 Uveitis Cyclosporine 3.581336536
MESH:D014625 Vaginal Neoplasms Zidovudine 4.3712579204
MESH:D014689 Venous Insufficiency coumarin 5.3712708602
MESH:D054556 Venous Thromboembolism Raloxifene 4.8116837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1914671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.1516343187
MESH:D015430 Weight Gain Dietary Fats 3.4116723640
MESH:D014985 Xerophthalmia Cyclosporine 4.0417120751
Pathway ID Pathway Name
KEGG:00071 Fatty acid metabolism
REACT:22258 Metabolism of lipids and lipoproteins
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB02910 - Octanoyl-Coenzyme A
DB03127 - Benzamidine Serine Proteinase Inhibitors
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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