AutismKB 2.0

Annotation Detail for GBP6


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Basic Information Top
Gene Symbol:GBP6 ( DKFZp686G0786,FLJ39135 )
Gene Full Name: guanylate binding protein family, member 6
Band: 1p22.2
Quick LinksEntrez ID:163351; OMIM: 612467; Uniprot ID:GBP6_HUMAN; ENSEMBL ID: ENSG00000183347; HGNC ID: 25395
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of GBP6 mRNAincreases expression 19933214
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of GBP6 mRNAincreases expression 14729362
15003993
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of GBP6 mRNAaffects expression 17484886
C006253 pirinixic acid pirinixic acid results in decreased expression of GBP6 mRNAdecreases expression 18445702
17426115
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GBP6 mRNAincreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3811752688 15322242 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.7716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.7716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2911748828
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9715746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2618705752 15700767 16097048 15721981 16192424 15673190 16050911 16227642 16124888 3786805 16011737 10355542
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0916835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8618788625
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5418850075 16120746 18670907
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4916835633
MESH:D002779 Cholestasis pirinixic acid 3.0819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2215340226 8697196 15668235 16354765 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 15322242 20055451
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7317107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.0016177239 19336974 7120509 11566570 16227642 10092053 10915739 15998439 2869522 3732212 19085960 7179309 6623471 15027814 4309450 3786805 17522070 6884620 7440962 15968718 21278145 9327722
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.0020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D004487 Edema pirinixic acid 7.7912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.7911000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.5118230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.379294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2711564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.9412795759 61145 15959796 19224547 12631006 16239168 17595544 16045604
MESH:D005234 Fatty Liver pirinixic acid 8.9420131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D005355 Fibrosis Carbon Tetrachloride 10.2618705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.2620067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4910048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 4.0319900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 9.9218467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.9212621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.6615340226 18606429 8697196 16354765 16959395
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.0716899240
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0118850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5715338365
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0112200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7116580747
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9811408273 21278145 16943688 17157831 16221502 16239168 17174718 17334410 11903743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5615876570 18006644 15959796 14748882 14724832 17805973 15996030 18054572 15052691 12632514 12586293 12898905 12741479 17481882 12632512 17557913 15650968 17698563 17640975 17761835 20821823 18472332 16027843 17869086 18263696 15818738 18205269 17714472 18279442 17708605 18166357 15931870 18339082 15673190 17900296 12546737 18376398 15925388 16097048 12649538 12445421 15730626 18395095 18472094 16011737 18277467 10355542 18395914 17766677 16638106 17631135 14620537 15123356 18210741 18187930 17922224 12958196 12389079 18251166 12445418 14716833 16248980 16033810 16136751 11481614 15370692 18481824 14512876 17721639 18412020 16192424 15338365 18418968 14716496 12609069 12666154 18429990 17823541 17976157 15057751 18420326 17565644 15362042 16015684 12667390 18317297 13678700 18705752 18156304 16116963 15893842 17944888 17525996
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5612878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1515830285 16964402 15720792 16246199 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.6515123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.0416899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.9919294768
MESH:D008113 Liver Neoplasms pirinixic acid 7.9915890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.9916984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.4512014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.4512151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009369 Neoplasms pirinixic acid 2.0917405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.6514600291
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.7311896295 11222880 11399792 11118676
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 6.078532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0716192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.5112697716
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
Pathway ID Pathway Name
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134964409
    • No data
    Releated disease ID Related disease Name
    PA153906318Autism Spectrum Disorder
    PA443434Arthritis, Rheumatoid
    Releated drug ID Related drug Name
    PA451257risperidone
    PA10004adalimumab
    PA449515etanercept
    PA452639infliximab
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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