Annotation Detail for DENND1B
Basic Information
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| Gene Symbol: | DENND1B ( C1ORF18,C1orf218,DKFZp547O0715,FAM31B,FLJ20054,FLJ21179,FLJ33888,MGC103810,MGC27044 ) |
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| Gene Full Name: | DENN/MADD domain containing 1B |
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| Band: | 1q31.3 |
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| Quick Links | Entrez ID:163486; OMIM: 613292; Uniprot ID:DEN1B_HUMAN; ENSEMBL ID: ENSG00000213047; HGNC ID: 28404 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D016604 |
Aflatoxin B1 |
Aflatoxin B1 affects the expression of DENND1B protein | affects expression | 20106945
|
| D001564 |
Benzo(a)pyrene |
Benzo(a)pyrene results in decreased expression of DENND1B mRNA | decreases expression | 20106945
|
| D015123 |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DENND1B mRNA | decreases expression | 20018196
|
| D002117 |
Calcitriol |
Calcitriol results in increased expression of DENND1B mRNA | increases expression | 16002434
|
| C025643 |
vinclozolin |
vinclozolin affects the expression of DENND1B mRNA | affects expression | 19015723
|
| D014810 |
Vitamin E |
Vitamin E results in decreased expression of DENND1B mRNA | decreases expression | 19244175
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000230 |
Adenocarcinoma |
|
Benzo(a)pyrene |
2.04 | 20127859 20464547 |
| MESH:D000236 |
Adenoma |
|
Benzo(a)pyrene |
2.82 | 6695378 |
| MESH:D001008 |
Anxiety Disorders |
|
vinclozolin |
3.89 | 19015723 |
| MESH:D017544 |
Aortic Aneurysm, Abdominal |
|
Benzo(a)pyrene |
4.49 | 19183758 |
| MESH:D001943 |
Breast Neoplasms |
|
Benzo(a)pyrene |
2.20 | 20146248 17474063 |
| MESH:D001943 |
Breast Neoplasms |
|
Calcitriol |
2.20 | 11237771 |
| MESH:D002252 |
Carbon Tetrachloride Poisoning |
|
Vitamin E |
4.35 | 16050911 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
Aflatoxin B1 |
1.98 | 12907637 21507988 12619106 |
| MESH:D002294 |
Carcinoma, Squamous Cell |
|
Benzo(a)pyrene |
4.94 | 20419170 |
| MESH:D002294 |
Carcinoma, Squamous Cell |
|
Calcitriol |
4.94 | 11237771 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
2.93 | 20889678 |
| MESH:D019465 |
Craniofacial Abnormalities |
|
Vitamin E |
1.92 | 19769572 |
| MESH:D003424 |
Crohn Disease |
marker/mechanism |
|
| 21102463 |
| MESH:D003456 |
Cryptorchidism |
|
vinclozolin |
4.72 | 14966744 |
| MESH:C538011 |
Eales disease |
|
Vitamin E |
5.22 | 9068938 |
| MESH:D004681 |
Encephalomyelitis, Autoimmune, Experimental |
|
Calcitriol |
4.31 | 15138306 |
| MESH:D004938 |
Esophageal Neoplasms |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
4.57 | 20426865 |
| MESH:D004938 |
Esophageal Neoplasms |
|
Benzo(a)pyrene |
4.57 | 16530937 |
| MESH:D030342 |
Genetic Diseases, Inborn |
|
vinclozolin |
5.40 | 16973722 |
| MESH:D005832 |
Genital Diseases, Male |
|
vinclozolin |
5.82 | 16417039 |
| MESH:D006330 |
Heart Defects, Congenital |
|
Benzo(a)pyrene |
7.18 | 20471113 |
| MESH:D006330 |
Heart Defects, Congenital |
|
Vitamin E |
7.18 | 16080930 |
| MESH:D006548 |
Hernia, Diaphragmatic |
|
Vitamin E |
2.79 | 16863852 16490937 |
| MESH:D019584 |
Hot Flashes |
|
Vitamin E |
4.49 | 14716179 |
| MESH:D007248 |
Infertility, Male |
|
vinclozolin |
3.24 | 16467254 |
| MESH:D007251 |
Influenza, Human |
|
Vitamin E |
4.73 | 16624496 |
| MESH:D007674 |
Kidney Diseases |
|
Vitamin E |
2.96 | 12488133 |
| MESH:D007984 |
Leydig Cell Tumor |
|
vinclozolin |
5.19 | 16417039 |
| MESH:D008105 |
Liver Cirrhosis, Biliary |
marker/mechanism |
|
| 21399635 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Vitamin E |
1.90 | 16169303 |
| MESH:D008113 |
Liver Neoplasms |
|
Aflatoxin B1 |
4.89 | 9163691 18177683 2125692 15890375 |
| MESH:D008113 |
Liver Neoplasms |
|
Benzo(a)pyrene |
4.89 | 20195826 21137059 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
Aflatoxin B1 |
2.92 | 8603461 |
| MESH:D008171 |
Lung Diseases |
|
Vitamin E |
3.37 | 16863852 |
| MESH:D008175 |
Lung Neoplasms |
|
Aflatoxin B1 |
3.60 | 14755239 |
| MESH:D008175 |
Lung Neoplasms |
|
Benzo(a)pyrene |
3.60 | 18569708 17053015 20464547 6695378 20869020 18520028 18816296 20135361 20064080 |
| MESH:D008175 |
Lung Neoplasms |
|
Vitamin E |
3.60 | 11062179 |
| MESH:D009062 |
Mouth Neoplasms |
|
Benzo(a)pyrene |
3.43 | 16381670 |
| MESH:D009369 |
Neoplasms |
|
Benzo(a)pyrene |
2.30 | 11141357 |
| MESH:D011297 |
Prenatal Exposure Delayed Effects |
|
vinclozolin |
4.36 | 18220299 19015723 18042343 |
| MESH:D011469 |
Prostatic Diseases |
|
vinclozolin |
5.40 | 18220299 |
| MESH:D011470 |
Prostatic Hyperplasia |
|
Calcitriol |
5.24 | 15572423 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Benzo(a)pyrene |
2.53 | 17292933 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Calcitriol |
2.53 | 16289102 12479363 16644109 15754350 18247401 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Vitamin E |
2.53 | 15084515 |
| MESH:D011472 |
Prostatitis |
|
vinclozolin |
5.40 | 18629315 |
| MESH:D012871 |
Skin Diseases |
|
Vitamin E |
2.50 | 18709164 |
| MESH:D012878 |
Skin Neoplasms |
|
Benzo(a)pyrene |
2.49 | 19755658 10029692 |
| MESH:D013274 |
Stomach Neoplasms |
|
Benzo(a)pyrene |
1.56 | 20155912 2093021 |
| MESH:D020521 |
Stroke |
|
Vitamin E |
3.77 | 16517955 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
Benzo(a)pyrene |
2.28 | 17053015 |
Related Pathway Information