AutismKB 2.0

Annotation Detail for DCTD


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Basic Information Top
Gene Symbol:DCTD ( MGC111062 )
Gene Full Name: dCMP deaminase
Band: 4q35.1
Quick LinksEntrez ID:1635; OMIM: 607638; Uniprot ID:DCTD_HUMAN; ENSEMBL ID: ENSG00000129187; HGNC ID: 2710
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00240Pyrimidine metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of nucleotides
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of DCTD mRNAdecreases expression 20406850
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of DCTD mRNAincreases expression 18648102
D016572 Cyclosporine Cyclosporine results in increased expression of DCTD mRNAincreases expression 20106945
D017239 Paclitaxel DCTD protein affects the susceptibility to Paclitaxelaffects response to substance 16217747
C066340 tolcapone tolcapone binds to DCTD proteinaffects binding 19783845
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.933712494
MESH:D017109 Akathisia, Drug-Induced tolcapone 6.9111080934
MESH:D000544 Alzheimer Disease tolcapone 3.3420150427
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.631440618 11289319
MESH:D001859 Bone Neoplasms Paclitaxel 4.9715867366
MESH:D001943 Breast Neoplasms Paclitaxel 2.8815136595 18234424 16273361 18223236 16244791 18323546 16115903 11325840
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.9116705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.917296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 4.9116313753
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.817296757
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 12.546135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 12.547505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.5412371664
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.7519486331 9022650
MESH:D002779 Cholestasis Cyclosporine 8.7519486331
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.4518802399
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.5018551238
MESH:D003866 Depressive Disorder tolcapone 4.557768276 11224284
MESH:D003865 Depressive Disorder, Major tolcapone 5.2310440460
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.288156756 12868966 11298694 18759878 11906362 2524372 8970840 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.893621924 2952479
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.9021346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.909328219 7440962 6679447 6482804 18692083 16192314 8291058 1440618 18289764 9022650 18648102 11289319 9653073
MESH:D056486 Drug-Induced Liver Injury tolcapone 6.9016604736 19783845
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 6.0111455177
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.933581430
MESH:D004938 Esophageal Neoplasms Paclitaxel 4.9316481741
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 6.5619578428
MESH:D005234 Fatty Liver Cyclosporine 3.2319224547
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.636705139
MESH:D005355 Fibrosis Cyclosporine 3.6212639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.447505956
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.956705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.4215034207
MESH:D006973 Hypertension Cyclosporine 2.2010903974
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.638074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007674 Kidney Diseases Cyclosporine 2.5218776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 14.1916705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 14.196582329
MESH:D007680 Kidney Neoplasms Cyclosporine 14.1912371664
MESH:D008080 Liposarcoma Paclitaxel 5.2317353645
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4015034207 9327722
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.257678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.582876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.58598648 3712494 6587162 1399818
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 4.4014749477
MESH:D008545 Melanoma Paclitaxel 2.6212025231 16342250 12040289
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D009101 Multiple Myeloma Paclitaxel 3.9314749477
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.407678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.343581430
MESH:D009362 Neoplasm Metastasis Paclitaxel 6.3415867366
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6118481113 19348381
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.136679447
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 10.0616049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 10.066482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.633988306
MESH:D010014 Osteolysis Paclitaxel 5.5215867366
MESH:D010051 Ovarian Neoplasms Paclitaxel 3.0711161223
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.977296757
MESH:D010300 Parkinson Disease tolcapone 3.709591521 10651109 9305320 11793426 8635184 17089403 16758261 7566641 20216409 9708959 1977408 9333106 11746615 9754991 11586115 20334432 11432539 19578428 8739811 18328768 19783845
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.086228378
MESH:D011230 Precancerous Conditions Cyclosporine 3.5512371664
MESH:D011471 Prostatic Neoplasms Paclitaxel 3.8017172428 16729912 16356831 17136230
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.643692021
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7618551238
MESH:D013274 Stomach Neoplasms Paclitaxel 2.4518506536 18396642
MESH:D024801 Tauopathies Paclitaxel 5.3516930453
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.157505956 6582329 6587162 1399818 3712494
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 6.5619578428
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.3916049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.398074119
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.8610091137
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D014820 Vitiligo tolcapone 5.6310573327
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
REACT:1698 Metabolism of nucleotides
KEGG:00240 Pyrimidine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA138
    • No data
    Releated disease ID Related disease Name
    PA444760Leukemia, Myeloid, Acute
    PA444818Lung Neoplasms
    PA445062Neoplasms
    PA445218Pancreatic Neoplasms
    PA444283Glioblastoma
    Releated drug ID Related drug Name
    PA449177cytarabine
    PA10090l-glutamine
    PA449748gemcitabine
    PA452621antineoplastic agents
    PA448771capecitabine
    Drug Bank Top

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    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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