AutismKB 2.0

Annotation Detail for ACE


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ACE ( ACE1,CD143,DCP,DCP1,MGC26566,MVCD3 )
Gene Full Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
Band: 17q23.3
Quick LinksEntrez ID:1636; OMIM: 106180; Uniprot ID:ACE_HUMAN; ENSEMBL ID: ENSG00000159640; HGNC ID: 2707
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05142Chagas disease
hsa04614Renin-angiotensin system
No data
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
H00083Allograft rejection
Immune system diseases
Allergies and autoimmune diseases
Desease IDDesease Name
1706Thrombophilia
1709Parkinson disease
1711Familial Mediterranean fever
1716Hypoglycemia
1725Severe acute respiratory syndrome
1740Alzheimer's disease
1749Transient hypertension of pregnancy
1787Heart disease
1800Lupus vulgaris
1804Chronic obstructive airway disease
1818Systemic scleroderma
1822Infectious lung disease
1831Prostate cancer
1834Sarcoidosis
1840Macular degeneration
1845Psoriasis
1848Embryoma
1856Obesity
1864Fibroid tumor
1869Behcet syndrome
1872Chronic simple glaucoma
1901Endometriosis
1907Depression
1909Migraine
1944Breast cancer
1947Subacute sclerosing panencephalitis
1962Respiratory distress syndrome
1974Metabolic syndrome X
1979Testicular dysfunction
1993Esophagus cancer
1841Stomach cancer
2022Liver cancer
2027Connective tissue disease
2031Endometrial cancer
2032Kidney disease
2091Hypertension
2051Leukemia
2053Colon cancer
2054Bronchopulmonary dysplasia
2057Premature birth
2069Schizophrenia
2074Asthma
2083IGA glomerulonephritis
2085Vascular dementia
2039Hyperhomocysteinemia
2094Ulcerative colitis
2107Proteinuria
2111Systemic infection
2146Lupus erythematosus
2174Chronic rejection of renal transplant
2189Ankylosing spondylitis
2197Metabolism disease
2216Chronic fatigue syndrome
2219Mucocutaneous lymph node syndrome
2220Dermatitis
2222Polycythemia
2231Arthritis
2236Cardiovascular disease
2237Neoplasm metastasis
2240Anemia
Desease Name
polycystic kidney disease
insulin sensitivity
Tobacco Use Disorder
diabetic nephropathy
cardiovascular disease
restenosis
Parkinson's disease
Atrial Fibrillation
coronary atherosclerosis
AGING
Atherosclerosis
Thromboembolism
Exercise-induced changes in insulin
NORMALVARIATION
ARDS
atherosclerosis, coronary
blood pressure, arterial
renal disease
cerebral atherosclerosis
Cough
CARDIOVASCULAR
Coronary Artery Disease
myocardial infarct
diabetes, type 1
Gaucher disease
left ventricular hypertrophy
CHEMDEPENDENCY
cardiomyopathy
cognitive impairment
early onset ischemic heart disease.
arterial wall changes
creatinine
diabetic nephropathy and retinopathy.
nephropathy
angiotensin-converting enzyme inhibitors
Systemic Lupus Erythematosus (SLE)
bipolar affective disorder
Alzheimer's disease
polydipsia
affective disorder
carotid wall thickening
Fatigue Syndrome, Chronic
albuminuria hypertension
blood pressure
Angiotensin-converting enzyme activity
PSYCH
stroke, ischemic
anemia C-reactive protein
carotid arterial wall thickness
protein excretion, urinary
progressive renal damage
COPD
serum ACE concentration and CAD
PHARMACOGENOMIC
alcoholism
circulating levels of plasminogen activator inhibitor-1
Kidney Failure, Chronic
kidney transplant
systemic sclerosis
ACEI-related cough
atrial natriuretic peptide activity after exercise
Asthma
nephropathy in other diseases
endurance performance
cardiac death
muscle testing
nephropathy, diabetic
RENAL
coronary artery disease and myocardial infarction
coronary heart disease in non-insulin-dependent diabetic
vascular disease
hypertension
elevated fasting blood glucose levels
early onset of ESRF in PKD1 adult polycystic kidney disease
suicide
myotonic dystrophy
bleeding complications
reflux nephropathy
Essential Hypertension
cardiovascular
IMMUNE
End- Stage Renal Disease (ESRD)
metabolic syndrome
IgA nephropathy
NEUROLOGICAL
sarcoidosis.
nephroangiosclerosis
plasma antigen levels of plasminogen activator inhibitor-1
insulin left ventricular mass
left ventricular mass
malignant vascular injury
pregnancy loss, recurrent
angiotensin-converting enzyme genotype
heart disease
schizophrenia
ACE activity
METABOLIC
PMV after CABG
angiotensin-converting enzyme inhibitor-related cough
Stroke
lipid metabolism
Myocardial Infarction
lupus erythematosus
postprandial hyperglycaemia
VISION
ruptured intracranial aneurysms
increased vascular reactivity
chronic obstructive pulmonary disease/COPD
esophageal varices
posttransplantation erythrocytosis
chronic obstructive pulmonary disease
lipid profiles
congenital anomalies
polymetabolic syndrome
obesity
preeclampsia
obstetric cholestasis
heart rate variability
carotid and femoral artery stiffness
non-ST-elevation acute coronary syndromes
Myocardial Ischemia
renal disease, end stage
antiproteinuric effect of angiotensin I-converting enzyme inhibitors
Lupus
endothelial dysfunction in normal humans.
Leukoaraiosis
DEVELOPMENTAL
failure of renoprotective therapy
hypertension, pregnancy induced
coronary heart disease
REPRODUCTION
diabetes, type 2
longevity
coronary artery plaque calcification
elevated ACE
Age-associated memory impairment
Type 2 Diabetes Mellitus
carotid atherosclerosis
Heart Failure
sarcoidosis
athletic performance
proliferative diabetic retinopathy
higher blood pressure after hospitalization in normotensi
Aortic atherosclerosis in diabetes mellitus
sleep apnea
cardiovascular risk factors
the extent of exercise-induced left ventricular growth in endurance athletes
Ischemia
Insulin Resistance
Desease Name
Angiotensin-converting enzyme activity
Desease Name
Microvascular complications of diabetes 3
SARS, progression of
Angiotensin I-converting enzyme, benign serum increase
Alzheimer disease, susceptibility to
Myocardial infarction, susceptibility to
Renal tubular dysgenesis
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C412373 AG 1879 AG 1879 inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]decreases reaction|increases expression 15932931
D000450 Aldosterone AG 1879 inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]decreases reaction|increases expression 15932931
D000450 Aldosterone Aldosterone results in increased activity of ACE proteinincreases activity 15932931
D000450 Aldosterone Aldosterone results in increased expression of ACE mRNAincreases expression 15932931
D000450 Aldosterone alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]decreases reaction|increases expression 15932931
D000450 Aldosterone Dactinomycin inhibits the reaction [Aldosterone results in increased activity of ACE protein]decreases reaction|increases activity 15932931
D000450 Aldosterone Dactinomycin inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]decreases reaction|increases expression 15932931
D000450 Aldosterone Genistein inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]decreases reaction|increases expression 15932931
D000450 Aldosterone Spironolactone inhibits the reaction [Aldosterone results in increased activity of ACE protein]decreases reaction|increases activity 15932931
D000450 Aldosterone Spironolactone inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]decreases reaction|increases expression 15932931
D000450 Aldosterone tyrphostin AG 1478 inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]decreases reaction|increases expression 15932931
C095512 alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]decreases reaction|increases expression 15932931
D000535 Aluminum Aluminum results in decreased activity of ACE proteindecreases activity 12008977
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ACE mRNAaffects expression 16483693
D000806 Angiotensin-Converting Enzyme Inhibitors Angiotensin-Converting Enzyme Inhibitors results in decreased activity of ACE proteindecreases activity 15667801
D001149 Arsenates [Atrazine co-treated with Arsenates] results in increased expression of ACE mRNAaffects cotreatment|increases expression 18585445
D001280 Atrazine [Atrazine co-treated with Arsenates] results in increased expression of ACE mRNAaffects cotreatment|increases expression 18585445
C044946 benazepril benazepril results in decreased activity of ACE proteindecreases activity 16364833
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ACE mRNAaffects cotreatment|decreases expression 18164116
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ACE proteinincreases expression 12629582
C511403 CGS 35601 CGS 35601 results in decreased activity of ACE proteindecreases activity 16364833
D003345 Corticosterone Corticosterone results in increased expression of ACE mRNAincreases expression 15755911
D003474 Curcumin Curcumin inhibits the reaction [Paraquat affects the expression of ACE protein]affects expression|decreases reaction 10666014
D003609 Dactinomycin Dactinomycin inhibits the reaction [Aldosterone results in increased activity of ACE protein]decreases reaction|increases activity 15932931
D003609 Dactinomycin Dactinomycin inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]decreases reaction|increases expression 15932931
D003907 Dexamethasone Dexamethasone results in increased expression of ACE mRNAincreases expression 15932931
D003907 Dexamethasone Mifepristone inhibits the reaction [Dexamethasone results in increased expression of ACE mRNA]decreases reaction|increases expression 15932931
D004041 Dietary Fats Dietary Fats results in increased expression of ACE mRNAincreases expression 18503570
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ACE mRNAaffects cotreatment|decreases expression 18164116
D004656 Enalapril Enalapril promotes the reaction [Folic Acid results in increased expression of ACE mRNA]increases expression|increases reaction 15728788
D004656 Enalapril Enalapril results in decreased activity of ACE proteindecreases activity 15816410
15728788
D004656 Enalapril Enalapril results in increased expression of ACE mRNAincreases expression 15728788
D004656 Enalapril Enalapril results in decreased activity of ACE proteindecreases activity 16327016
D004966 Estrogens, Conjugated (USP) Estrogens, Conjugated (USP) results in decreased activity of ACE proteindecreases activity 11345361
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ACE mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACE mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in decreased expression of ACE mRNAdecreases expression 18035473
D005492 Folic Acid Enalapril promotes the reaction [Folic Acid results in increased expression of ACE mRNA]increases expression|increases reaction 15728788
D005492 Folic Acid Folic Acid results in increased expression of ACE mRNAincreases expression 15728788
D005632 Fructose Fructose results in increased expression of ACE mRNAincreases expression 17587757
C057580 gallocatechol gallocatechol results in decreased activity of ACE proteindecreases activity 16390204
D019833 Genistein Genistein inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]decreases reaction|increases expression 15932931
C010980 hippuryl-histidyl-leucine ACE protein affects the metabolism of hippuryl-histidyl-leucineaffects metabolic processing 15932931
C078006 imidaprilat imidaprilat results in decreased activity of ACE proteindecreases activity 16406270
D015735 Mifepristone Mifepristone inhibits the reaction [Dexamethasone results in increased expression of ACE mRNA]decreases reaction|increases expression 15932931
D009151 Mustard Gas ACE gene affects the susceptibility to Mustard Gasaffects response to substance 18702808
D009151 Mustard Gas Mustard Gas affects the expression of ACE mRNAaffects expression 15651846
D009569 Nitric Oxide ACE protein inhibits the reaction [KNG1 protein results in increased abundance of Nitric Oxide]decreases reaction|increases abundance 12672649
C106266 omapatrilat omapatrilat results in decreased activity of ACE proteindecreases activity 11762555
D010269 Paraquat Paraquat results in decreased activity of ACE proteindecreases activity 15297733
D010269 Paraquat Paraquat results in decreased activity of ACE proteindecreases activity 12161173
D010269 Paraquat pimagedine inhibits the reaction [Paraquat results in decreased activity of ACE protein]decreases activity|decreases reaction 12161173
D010269 Paraquat Curcumin inhibits the reaction [Paraquat affects the expression of ACE protein]affects expression|decreases reaction 10666014
D010269 Paraquat Paraquat affects the expression of ACE proteinaffects expression 10666014
D010269 Paraquat Paraquat results in decreased activity of ACE proteindecreases activity 16182431
D052638 Particulate Matter Particulate Matter results in decreased activity of ACE proteindecreases activity 12396869
D052638 Particulate Matter Particulate Matter results in decreased expression of ACE mRNAdecreases expression 12396869
D010656 Phenylephrine ACE protein affects the susceptibility to Phenylephrineaffects response to substance 18431347
C004479 pimagedine pimagedine inhibits the reaction [Paraquat results in decreased activity of ACE protein]decreases activity|decreases reaction 12161173
C006253 pirinixic acid pirinixic acid results in decreased expression of ACE mRNAdecreases expression 17426115
D044945 Proanthocyanidins Proanthocyanidins results in decreased activity of ACE proteindecreases activity 16390204
D044945 Proanthocyanidins Proanthocyanidins results in decreased activity of ACE proteindecreases activity 16390204
D011794 Quercetin Quercetin results in increased expression of ACE mRNAincreases expression 18095365
C041125 quinapril quinapril results in decreased activity of ACE proteindecreases activity 15728788
D020849 Raloxifene Raloxifene results in decreased expression of ACE mRNAdecreases expression 15849065
D013148 Spironolactone Spironolactone inhibits the reaction [Aldosterone results in increased activity of ACE protein]decreases reaction|increases activity 15932931
D013148 Spironolactone Spironolactone inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]decreases reaction|increases expression 15932931
D013974 Thyroxine Thyroxine results in increased expression of ACE mRNAincreases expression 18093424
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACE mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ACE mRNAincreases expression 19490992
C101044 tyrphostin AG 1478 tyrphostin AG 1478 inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]decreases reaction|increases expression 15932931
C025643 vinclozolin vinclozolin affects the expression of ACE mRNAaffects expression 19015723
D015032 Zinc Zinc results in decreased activity of ACE proteindecreases activity 17114810
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.3614514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.0618287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.4317505938
MESH:D000169 Acrodermatitis Zinc 4.9016889938 17202136 17190629
MESH:D058186 Acute Kidney Injury Folic Acid 3.8917003819 16316344 16595132
MESH:D055371 Acute Lung Injury Particulate Matter 7.9512396868
MESH:D055371 Acute Lung Injury pirinixic acid 7.9518653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.8614692618
MESH:D000230 Adenocarcinoma Genistein 3.8611473722
MESH:D000236 Adenoma beta-Naphthoflavone 9.5919389873
MESH:D000236 Adenoma Diethylnitrosamine 9.5910737359 6695378
MESH:D000236 Adenoma Folic Acid 9.5916963246
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 14.4018056438 19052882 17162532 19061943 17620307 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 14.4016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 14.4016835633
MESH:D000382 Agricultural Workers' Diseases Atrazine 7.2811874814
MESH:D000382 Agricultural Workers' Diseases Paraquat 7.2811874814
MESH:D000419 Albuminuria Raloxifene 4.1217308373 17451421
MESH:D019973 Alcohol-Related Disorders Curcumin 4.5717887948
MESH:D000544 Alzheimer Disease marker/mechanism 17192785
MESH:D000544 Alzheimer Disease Aluminum 17.2617662457 10721010
MESH:D000544 Alzheimer Disease Curcumin 17.2615590663
MESH:D000544 Alzheimer Disease Folic Acid 17.2617116317
MESH:D000544 Alzheimer Disease Nitric Oxide 17.2617556102
MESH:D000544 Alzheimer Disease Particulate Matter 17.2615513908
MESH:D000544 Alzheimer Disease Raloxifene 17.2615800139
MESH:D000544 Alzheimer Disease Zinc 17.2617119284 16325427 16580781 16410023
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.5211748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.7917084956
MESH:D000755 Anemia, Sickle Cell Zinc 4.4316916123
MESH:D001002 Anuria marker/mechanism
MESH:D001008 Anxiety Disorders vinclozolin 3.2419015723
MESH:D001145 Arrhythmias, Cardiac marker/mechanism 15331425
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.6817460149
MESH:D001161 Arteriosclerosis Dietary Fats 8.3015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.3011256880
MESH:D001169 Arthritis, Experimental Dexamethasone 6.3117659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.3115885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.6116807698
MESH:D001249 Asthma Mustard Gas 4.6110378619
MESH:D001249 Asthma Zinc 4.6117085522
MESH:D001260 Ataxia Telangiectasia Quercetin 4.4815336622
MESH:D050197 Atherosclerosis Curcumin 3.0218704882
MESH:D001281 Atrial Fibrillation marker/mechanism 15331425
MESH:D001321 Autistic Disorder Folic Acid 2.8921388746
MESH:D001327 Autoimmune Diseases Curcumin 9.2519761891
MESH:D001327 Autoimmune Diseases Quercetin 9.2519761891
MESH:D001607 Berylliosis marker/mechanism 10194187
MESH:D001768 Blister Mustard Gas 4.6619167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.2919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4315746008
MESH:D019046 Bone Marrow Neoplasms Dactinomycin 5.0314601052
MESH:D001919 Bradycardia Phenylephrine 4.0515306635
MESH:D001930 Brain Injuries Raloxifene 9.5116580743
MESH:D001930 Brain Injuries Zinc 9.5117109824
MESH:D002545 Brain Ischemia Curcumin 3.8416770732
MESH:D001932 Brain Neoplasms Curcumin 3.5117596214
MESH:D001943 Breast Neoplasms Curcumin 5.2016243823 19250217 18462866 18593918
MESH:D001943 Breast Neoplasms Dietary Fats 5.2020435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 5.2017474063
MESH:D001943 Breast Neoplasms Folic Acid 5.2016777985
MESH:D001943 Breast Neoplasms Genistein 5.2016873071 16541309 17200150
MESH:D001943 Breast Neoplasms Nitric Oxide 5.2015631943
MESH:D001943 Breast Neoplasms Quercetin 5.2018628248
MESH:D001943 Breast Neoplasms Raloxifene 5.2016837676 17952589 16912660 17049068 17595753 17893378 15775269 15572757 17440819 17261762 17242785 15758505
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.2020435547
MESH:D016535 Bronchial Hyperreactivity tyrphostin AG 1478 4.4912794006
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.6615286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.4717687719 10378619
MESH:D002105 Cadmium Poisoning Quercetin 5.0416962696
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.3016050911 10355542 18705752 3786805 16124888 15673190 16192424 15700767 16097048 15721981 16011737 16227642
MESH:D002277 Carcinoma Curcumin 6.9718593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.9716835633
MESH:D006528 Carcinoma, Hepatocellular therapeutic 16328049
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 5.7918788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 5.7920101231 17761372 20524982 19052882 20007298 16807293 17162532 20084675 18691550 3084413 16681979 17428255 18056438 18785209 20935162 19394651 20432363 3581430 18971187 18393292 18494052 17138121 16779866 19701751 11831363 17173139 19418558 19539802 21159647 17978847 10737359 19335982 18665156 16288022 19107877 18506893 19383236 19171122 19822196 16878318 20727157 19519916 20214788 18210153 18978308 16540662 20512989 16569478 16935385 18788625 16328049 16830150 17055752 16502159 16698587 19919837 10672840 20514400 19208518
MESH:D006528 Carcinoma, Hepatocellular Genistein 5.7916924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 5.7919519916 12508355
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.7918414057
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.4717234771
MESH:D002294 Carcinoma, Squamous Cell Curcumin 4.4918462866
MESH:D002294 Carcinoma, Squamous Cell Zinc 4.4916543248
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.6417572228
MESH:D006332 Cardiomegaly Phenylephrine 13.9817124262 17287366 15728586 11179087 11754973 16170337
MESH:D006332 Cardiomegaly Quercetin 13.9819794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 13.9816120746 18850075 18670907
MESH:D006332 Cardiomegaly Thyroxine 13.9818093424
MESH:D009202 Cardiomyopathies pimagedine 4.5316612575
MESH:D002318 Cardiovascular Diseases marker/mechanism 11498459
MESH:D002318 Cardiovascular Diseases Aldosterone 28.7511230374
MESH:D002318 Cardiovascular Diseases Folic Acid 28.7516755160
MESH:D002318 Cardiovascular Diseases Genistein 28.7516332659
MESH:D002318 Cardiovascular Diseases Particulate Matter 28.7512396868
MESH:D002318 Cardiovascular Diseases Raloxifene 28.7515775269
MESH:D002318 Cardiovascular Diseases Spironolactone 28.7511230374
MESH:D002318 Cardiovascular Diseases Zinc 28.7516936243
MESH:D002386 Cataract pimagedine 4.4715003327 17936468
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.527505956 21159647 17174075 2727394
MESH:D002493 Central Nervous System Diseases marker/mechanism
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.9319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.9316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 11.3916105132 17333356 17681005 17110522 11677210 15861022 16919318
MESH:D002779 Cholestasis Nitric Oxide 11.3916919318
MESH:D002779 Cholestasis pirinixic acid 11.3919176532
MESH:D002971 Cleft Lip Folic Acid 3.7021254359
MESH:D002972 Cleft Palate Folic Acid 5.338946559 21254359
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.3316354765 8697196 15668235 12621046 15340226
MESH:D003072 Cognition Disorders Raloxifene 4.1315800139
MESH:D003092 Colitis Curcumin 3.6918200517 16782535 16804969
MESH:D003103 Coloboma Curcumin 4.1018809619
MESH:D003110 Colonic Neoplasms Curcumin 7.3719359593 16340194
MESH:D003110 Colonic Neoplasms Dexamethasone 7.3715824018
MESH:D003110 Colonic Neoplasms Genistein 7.3717182828
MESH:D003110 Colonic Neoplasms Quercetin 7.3711134977 19056647 15741050 17191121 17148506 16640504 19440933
MESH:D015179 Colorectal Neoplasms Folic Acid 2.7817245555 17087956 17116713 16963246 16985020
MESH:D015179 Colorectal Neoplasms Quercetin 2.7818095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6414669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.4118497527
MESH:D003324 Coronary Artery Disease marker/mechanism 14989558
MESH:D003327 Coronary Disease Fructose 4.1418504504
MESH:D003371 Cough Enalapril 5.7211725383
MESH:D019465 Craniofacial Abnormalities Dexamethasone 3.5117728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.5110048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Zinc 3.5119302082
MESH:D003456 Cryptorchidism vinclozolin 3.8714966744
MESH:D003645 Death, Sudden marker/mechanism 15331425
MESH:D015140 Dementia, Vascular Nitric Oxide 5.4617556102
MESH:D003865 Depressive Disorder, Major Raloxifene 3.7417474826
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 2.9512438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1818249437
MESH:D003920 Diabetes Mellitus Zinc 3.7916479319
MESH:D003921 Diabetes Mellitus, Experimental Fructose 7.4718603373
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 7.4719496084
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 15.2818403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 15.2820387270
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 15.2816886840
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 15.2818603373
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 15.2816647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 15.2817107852
MESH:D003928 Diabetic Nephropathies marker/mechanism
MESH:D003928 Diabetic Nephropathies Curcumin 7.8418204486
MESH:D003928 Diabetic Nephropathies Raloxifene 7.8417451421 17308373 15920148
MESH:D003967 Diarrhea Dexamethasone 3.247237001
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 5.193786805 15027814 7440962 2869522 7120509 10092053 6623471 7179309 3732212 6884620 16227642 16177239 11566570 17522070 19336974 4309450 15998439 21278145 10915739 19085960 15968718 9327722
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 5.1919107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.1920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.3911462148
MESH:D004381 Duodenal Ulcer Curcumin 3.5817351913
MESH:D050171 Dyslipidemias Dietary Fats 3.0918367378
MESH:D004485 Eczema Dexamethasone 3.9912438553
MESH:D004487 Edema Dexamethasone 16.9819703484
MESH:D004487 Edema Mustard Gas 16.9811428631 9260866 11428647 11402378
MESH:D004487 Edema pirinixic acid 16.9812083418
MESH:D004487 Edema Raloxifene 16.9815860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 16.9812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.3918230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.5512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 7.5515845917
MESH:D004714 Endometrial Hyperplasia Genistein 4.0916402032
MESH:D016889 Endometrial Neoplasms Folic Acid 6.7717301261
MESH:D016889 Endometrial Neoplasms Genistein 6.7711473722
MESH:D004715 Endometriosis Mifepristone 7.7216134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.729294722 10568697
MESH:D004890 Erythema Mustard Gas 4.669357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6116302075
MESH:D004938 Esophageal Neoplasms Zinc 2.7216543248
MESH:D017889 Exfoliation Syndrome Folic Acid 4.9916504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6411564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 35.5415959796 12631006 12795759 16045604 16239168 61145 17595544 19224547
MESH:D005234 Fatty Liver Curcumin 35.5419297423
MESH:D005234 Fatty Liver Dietary Fats 35.5417967931 19551842 19004024 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 35.5421071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 35.5415345470
MESH:D005234 Fatty Liver Fructose 35.5418395287 18641190 19196556
MESH:D005234 Fatty Liver pirinixic acid 35.5420131406 19236843
MESH:D005234 Fatty Liver Raloxifene 35.5417473493
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9711858732
MESH:D005355 Fibrosis Carbon Tetrachloride 28.2318705752
MESH:D005355 Fibrosis Curcumin 28.2318705752
MESH:D005355 Fibrosis Dietary Fats 28.2318296743
MESH:D005355 Fibrosis Fructose 28.2318504504
MESH:D005355 Fibrosis Quercetin 28.2319474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 28.2320067830
MESH:D005756 Gastritis Folic Acid 10.0017171786
MESH:D005756 Gastritis Zinc 10.0017241300
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.2118462866
MESH:D005776 Gaucher Disease marker/mechanism 12359135
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.4416973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.7916417039
MESH:D005901 Glaucoma Folic Acid 4.6216504073
MESH:D005909 Glioblastoma Curcumin 10.0617596214
MESH:D005909 Glioblastoma Genistein 10.0616598420
MESH:D005909 Glioblastoma Quercetin 10.0619804834
MESH:D005910 Glioma Quercetin 2.8417643826
MESH:D005911 Gliosis Paraquat 4.6611124998
MESH:D005922 Glomerulonephritis, IGA marker/mechanism
MESH:D015432 Glomerulonephritis, Membranoproliferative Spironolactone 5.5316928621
MESH:D018149 Glucose Intolerance Fructose 4.8619165636
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0910696789
MESH:D006130 Growth Disorders Zinc 3.6317217573
MESH:D006261 Headache Nitric Oxide 4.6711554966 11284996
MESH:D006258 Head and Neck Neoplasms Curcumin 3.3118462866 18829502
MESH:D006330 Heart Defects, Congenital Folic Acid 5.9316524890 17286298
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.9311294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.1911110106
MESH:D006333 Heart Failure Enalapril 10.2712514674 10979640
MESH:D006333 Heart Failure pirinixic acid 10.2720558911
MESH:D006333 Heart Failure Zinc 10.2717162251
MESH:D006335 Heart Injuries Zinc 5.2617074742
MESH:D016481 Helicobacter Infections Zinc 4.0717241300
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8911000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.1319900420 19110552
MESH:D006527 Hepatolenticular Degeneration Zinc 4.2017276780
MESH:D006529 Hepatomegaly pirinixic acid 6.6618467677 19176532 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.6615340226 12621046 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.5517701891
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.887520565
MESH:D006679 HIV Seropositivity Folic Acid 4.9917209195
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.548697196 18606429 16959395 15340226 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.0316899240
MESH:D006937 Hypercholesterolemia Curcumin 7.7618704882
MESH:D006937 Hypercholesterolemia Dietary Fats 7.7621332399
MESH:D006940 Hyperemia Nitric Oxide 5.1111156591
MESH:D006943 Hyperglycemia pirinixic acid 7.8120558911
MESH:D006943 Hyperglycemia Quercetin 7.8118262572 11834736
MESH:D020138 Hyperhomocysteinemia Folic Acid 4.0816865747 16433478 16755160 16397167 16395265
MESH:D006946 Hyperinsulinism Fructose 4.4815752949 18563319 18360027 19008412 14757778
MESH:D006949 Hyperlipidemias Dietary Fats 8.0421332399
MESH:D006949 Hyperlipidemias Fructose 8.0415752949
MESH:D006973 Hypertension benazepril 29.9418390891 12692753
MESH:D006973 Hypertension CGS 35601 29.9416364833
MESH:D006973 Hypertension Dexamethasone 29.9417042910
MESH:D006973 Hypertension Enalapril 29.9412717102 10903974
MESH:D006973 Hypertension Fructose 29.9414568997 16843071 19008412 14633139 14573337
MESH:D006973 Hypertension Phenylephrine 29.948949925 12717712
MESH:D006973 Hypertension Quercetin 29.9418356687
MESH:D006973 Hypertension Raloxifene 29.9415787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 29.9418850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.6015338365
MESH:D006976 Hypertension, Pulmonary marker/mechanism 12359135
MESH:D006976 Hypertension, Pulmonary Nitric Oxide 4.0615838368
MESH:D015228 Hypertriglyceridemia Fructose 4.6419342510 19799862
MESH:D006984 Hypertrophy Phenylephrine 4.1118502941 12791704
MESH:D020514 Hypokalemic Periodic Paralysis Spironolactone 5.6719822448
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0012013081
MESH:D007248 Infertility, Male marker/mechanism 8642790
MESH:D007248 Infertility, Male Atrazine 13.2812948887
MESH:D007248 Infertility, Male Ethinyl Estradiol 13.2817937319
MESH:D007248 Infertility, Male Paraquat 13.284850670
MESH:D007248 Infertility, Male vinclozolin 13.2816467254
MESH:D007249 Inflammation Aluminum 23.7516052892
MESH:D007249 Inflammation Curcumin 23.7516956363 18403477 17151092
MESH:D007249 Inflammation Dexamethasone 23.758960868 11099482
MESH:D007249 Inflammation Dietary Fats 23.7520412841
MESH:D007249 Inflammation Diethylnitrosamine 23.7518785209
MESH:D007249 Inflammation Flavonoids 23.7517296493
MESH:D007249 Inflammation Mustard Gas 23.7511428631 9260866 11402378 11428620 16001271 8975870 9357497 17524151 11428647
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 23.7512200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 2.9918596194 18200517
MESH:D007251 Influenza, Human Quercetin 4.0016624496
MESH:D007333 Insulin Resistance Dietary Fats 10.5111836018 18457598
MESH:D007333 Insulin Resistance Fructose 10.5118981581 19008412 19799862 14573337 17133782 19342510 18057795 14757778 19586609 18563319 14633139
MESH:D007333 Insulin Resistance pirinixic acid 10.5116306350
MESH:D007410 Intestinal Diseases Nitric Oxide 9.1211574821 11713966 10210152
MESH:D007410 Intestinal Diseases pimagedine 9.1211713966
MESH:D007414 Intestinal Neoplasms Curcumin 3.7910783313
MESH:D007511 Ischemia Zinc 4.1516584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.8916580747
MESH:D007627 Keloid Quercetin 4.4717086741
MESH:D007674 Kidney Diseases marker/mechanism 8642790
MESH:D007674 Kidney Diseases Enalapril 8.7910903974
MESH:D007674 Kidney Diseases Quercetin 8.7916962696
MESH:D007674 Kidney Diseases Zinc 8.7916960431
MESH:D007676 Kidney Failure, Chronic Zinc 3.9816518626
MESH:D007889 Leiomyoma Curcumin 9.6318555241
MESH:D007889 Leiomyoma Raloxifene 9.6316973256
MESH:D007896 Leishmaniasis Nitric Oxide 4.2417218153
MESH:D007938 Leukemia Curcumin 9.0518462866
MESH:D007938 Leukemia Genistein 9.0518980019 17468513
MESH:D007938 Leukemia Quercetin 9.0517468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.7616106398
MESH:D015458 Leukemia, T-Cell Curcumin 4.2916106398
MESH:D007984 Leydig Cell Tumor vinclozolin 4.2316417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 9.3216943688 17334410 17157831 17174718 11903743 11408273 21278145 16221502 16239168
MESH:D008103 Liver Cirrhosis Dietary Fats 9.3218296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 9.3219638242 20032147 18407596 18665156 18522880
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 11.8217976157 12389079 18187930 16015684 16011737 16136751 16033810 15057751 12958196 18705752 16097048 18412020 17766677 12649538 13678700 17481882 18205269 17922224 17900296 17698563 18279442 18472094 15052691 14724832 17721639 15338365 18156304 18472332 10355542 14620537 11481614 20821823 14716833 15925388 18263696 18317297 15876570 18166357 15959796 17944888 12445421 15893842 17640975 18481824 12667390 14748882 17525996 12666154 17631135 14512876 16192424 18277467 12632512 15650968 18420326 18054572 18418968 16116963 18395095 17869086 12609069 18395914 18429990 15370692 12586293 17565644 15996030 14716496 18376398 16638106 18251166 17823541 12546737 18006644 17761835 15931870 18339082 17805973 15673190 18210741 17557913 12445418 12741479 12898905 17714472 15730626 16027843 17708605 15362042 15123356 16248980 12632514 15818738
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 11.8218006644 17355460 18705752
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 11.8216718785
MESH:D008106 Liver Cirrhosis, Experimental Enalapril 11.8217347453
MESH:D008106 Liver Cirrhosis, Experimental Genistein 11.8217823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 11.8215474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 11.8212741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 11.8212878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.1616246199 17285989 15720792 15830285 16964402
MESH:D008107 Liver Diseases Curcumin 8.1616956363
MESH:D008107 Liver Diseases Diethylnitrosamine 8.1617034775
MESH:D008107 Liver Diseases Folic Acid 8.1616877991
MESH:D017093 Liver Failure Carbon Tetrachloride 3.6815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.2616899240 14706259
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 15.1919389873 21295105
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 15.1919294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 15.1918978307 19255062 20118626 19996281 19642983 19294768 16942905 19254457 20501860 19850985 21071580 18648771 19427195 20583210 15885732 15175105 19090486 20434301 2422723 20101389 2862719 18977376 19073162 21167192 19551842 20137499 20492335 19833225 19256749 19638242 10737359 18754104 12771043 12112319 21047994 20452335 9163691 19426721 21278145 19499222 19690152 20405173 18644402 19812893
MESH:D008113 Liver Neoplasms pirinixic acid 15.1915890375 20007298 16377806
MESH:D008113 Liver Neoplasms Quercetin 15.1918980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 15.1916984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 15.2318164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 15.2315583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 15.2321159647 17942915 18282651 18544905 17854601 19009564 16267830 18079962 18308698 18093689 16842330 3124819 19126423 18775883 19004024 19539802 18253720 18164116 9362446 2563599 19519916 17174075
MESH:D008114 Liver Neoplasms, Experimental Quercetin 15.2319519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.2312151625
MESH:D008171 Lung Diseases marker/mechanism 18702808
MESH:D008171 Lung Diseases Aluminum 6.9416052892
MESH:D008171 Lung Diseases Mustard Gas 6.9418161513 18702808
MESH:D055370 Lung Injury Nitric Oxide 4.2411395602
MESH:D008175 Lung Neoplasms Curcumin 7.5416243823 19359593 18462866
MESH:D008175 Lung Neoplasms Dexamethasone 7.5411195469 15824018
MESH:D008175 Lung Neoplasms Diethylnitrosamine 7.5421163286 20970405 6695378 20512841
MESH:D008175 Lung Neoplasms Mustard Gas 7.543148597 8781369
MESH:D008175 Lung Neoplasms Quercetin 7.5416280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 7.5419555203 11884234
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.1817718048
MESH:D008223 Lymphoma Curcumin 6.8918462866
MESH:D008223 Lymphoma Nitric Oxide 6.8916166326
MESH:D016399 Lymphoma, T-Cell Curcumin 4.2116173963
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 8.3012807724
MESH:D008325 Mammary Neoplasms, Experimental Genistein 8.3012929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Zinc 8.3012773700
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.2016832597
MESH:D008545 Melanoma Curcumin 2.3417885582 18462866
MESH:D008569 Memory Disorders Curcumin 3.6817263510
MESH:D008654 Mesothelioma Atrazine 3.311916698
MESH:D024821 Metabolic Syndrome X Fructose 4.4119165636 17098227 17261469 18497449 16815490
OMIM:603933 MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 1 marker/mechanism
OMIM:612624 MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 3 marker/mechanism
MESH:D008881 Migraine Disorders Nitric Oxide 3.9211701602
MESH:D020326 Migraine without Aura Nitric Oxide 4.6411304026 14659530
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.0515863610
MESH:D009101 Multiple Myeloma Curcumin 10.1619372569
MESH:D009101 Multiple Myeloma Dexamethasone 10.1616118317 15867202 15744524
MESH:D009101 Multiple Myeloma Raloxifene 10.1616497877
MESH:D020528 Multiple Sclerosis, Chronic Progressive Aluminum 5.8717086897
MESH:D020529 Multiple Sclerosis, Relapsing-Remitting Aluminum 5.8717086897
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.4217962980
MESH:D009135 Muscular Diseases pirinixic acid 3.0216239165
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.249809623
MESH:D009203 Myocardial Infarction marker/mechanism
MESH:D009203 Myocardial Infarction Genistein 8.1517141266
MESH:D009203 Myocardial Infarction pirinixic acid 8.1519151258
MESH:D009203 Myocardial Infarction Quercetin 8.1519595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6212213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 12.0117141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.0116411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 12.0119207477
MESH:D009205 Myocarditis Particulate Matter 5.4612563109
MESH:D009232 Myxoma Raloxifene 5.0516343187
MESH:D009361 Neoplasm Invasiveness Curcumin 3.9018495463
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.359029167 3581430
MESH:D009369 Neoplasms pirinixic acid 4.1817405874
MESH:D009369 Neoplasms Quercetin 4.1815185748
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.0312497104
MESH:D009410 Nerve Degeneration Paraquat 3.3316893418
MESH:D009421 Nervous System Malformations Genistein 8.0416427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.0414600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.1218462866
MESH:D009436 Neural Tube Defects Folic Acid 3.6217438019
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 2.9420387270
MESH:D020078 Neurogenic Inflammation Quercetin 3.9017929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6120387270
MESH:D009503 Neutropenia Folic Acid 8.0816322990
MESH:D009503 Neutropenia Mustard Gas 8.087688884 16761898
MESH:D009765 Obesity Curcumin 9.4519297423
MESH:D009765 Obesity Dietary Fats 9.4520132043 11836018 18457598 20518802 16723640 17217161 19632207 21332399 18674790
MESH:D009765 Obesity Fructose 9.4517707055 18585860
MESH:D009765 Obesity pirinixic acid 9.4520558911
MESH:D010024 Osteoporosis Curcumin 10.1118719352
MESH:D010024 Osteoporosis Genistein 10.1119401787
MESH:D010024 Osteoporosis Raloxifene 10.1117882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Genistein 14.2416169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 14.2419495926
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 14.2415579764 17823083 15758505 17893378
MESH:D010051 Ovarian Neoplasms Curcumin 9.8718462866 19020741
MESH:D010051 Ovarian Neoplasms Genistein 9.8719005980
MESH:D010051 Ovarian Neoplasms Mifepristone 9.8716525653
MESH:D010051 Ovarian Neoplasms Quercetin 9.8719005980
MESH:D010190 Pancreatic Neoplasms Curcumin 7.5317440100 19196508 19401701
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 7.5316540662
MESH:D010190 Pancreatic Neoplasms Quercetin 7.5316965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2311578682
MESH:D010300 Parkinson Disease Atrazine 4.9917218051
MESH:D010300 Parkinson Disease Paraquat 4.9915451049 11181820 11445065 15824117 12911755 16140633 11124998 16510128
MESH:D010302 Parkinson Disease, Secondary Paraquat 3.9516190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7412520081
MESH:D011014 Pneumonia Paraquat 3.9612504350
MESH:D011015 Pneumonia, Aspiration Nitric Oxide 4.8418573544
MESH:D011041 Poisoning Mustard Gas 3.3515727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0918163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.832563599
MESH:D011230 Precancerous Conditions Quercetin 7.8319056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.2521297632
MESH:D011225 Pre-Eclampsia marker/mechanism 17114810
MESH:D011225 Pre-Eclampsia Zinc 3.7917114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 7.8411896295 11118676 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 7.8418220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.4418220299
MESH:D011471 Prostatic Neoplasms marker/mechanism 17465223
MESH:D011471 Prostatic Neoplasms Curcumin 1.9511398177 18769126 15129424 18156803 10851300 12497104 18226269
MESH:D011471 Prostatic Neoplasms Genistein 1.9516925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms Quercetin 1.9514715546 17292933
MESH:D011471 Prostatic Neoplasms Raloxifene 1.9516536755 16220300 15731164
MESH:D011471 Prostatic Neoplasms Zinc 1.9516700911 16606632 16517595 12429649
MESH:D011472 Prostatitis vinclozolin 4.4418629315
MESH:D011537 Pruritus Ethinyl Estradiol 7.8816919318 15861022
MESH:D011537 Pruritus Mustard Gas 7.8818058305
MESH:D011656 Pulmonary Emphysema Curcumin 4.0919168576
MESH:D011658 Pulmonary Fibrosis Enalapril 11.6117265423
MESH:D011658 Pulmonary Fibrosis Mustard Gas 11.6117620002 10334151 17720292 17266442 17894541
MESH:D011658 Pulmonary Fibrosis Paraquat 11.6117997886 16324872
MESH:D011658 Pulmonary Fibrosis Particulate Matter 11.6112475806
MESH:D011693 Purpura Raloxifene 5.0515770314
MESH:D051437 Renal Insufficiency Enalapril 14.9815728788
MESH:D051437 Renal Insufficiency Folic Acid 14.9815728788
MESH:D051437 Renal Insufficiency quinapril 14.9815728788
OMIM:267430 RENAL TUBULAR DYSGENESIS marker/mechanism
MESH:D015427 Reperfusion Injury pirinixic acid 2.1319058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 12.6118379247 10666014
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 12.6111700416 18379247
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 12.6111700416
MESH:D012135 Respiratory Sounds Atrazine 8.2911874814
MESH:D012135 Respiratory Sounds Paraquat 8.2911874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3618990726
MESH:D012162 Retinal Degeneration Paraquat 7.9416458197
MESH:D012162 Retinal Degeneration Zinc 7.9416584753
MESH:D012509 Sarcoma Curcumin 3.6918462866
MESH:D012512 Sarcoma, Ewing's Dactinomycin 4.6114601052
MESH:D012554 Schistosomiasis japonica Quercetin 5.0416862918
MESH:D012555 Schistosomiasis mansoni Nitric Oxide 4.979673227
MESH:D012559 Schizophrenia Folic Acid 2.8216641680
MESH:D018805 Sepsis Curcumin 3.6718389075
MESH:D012852 Sinusitis Phenylephrine 4.217327846
MESH:D012871 Skin Diseases Folic Acid 4.8118709164
MESH:D012871 Skin Diseases Mustard Gas 4.8115451306 12880345 16961503
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.8016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.4316709447
MESH:D013118 Spinal Cord Diseases Folic Acid 4.9916361298
MESH:D013272 Stomach Diseases Dexamethasone 3.8315472012
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.6018456281
MESH:D013274 Stomach Neoplasms Folic Acid 2.6017171786
MESH:D013276 Stomach Ulcer Curcumin 13.7019188055 16631530
MESH:D013276 Stomach Ulcer Dexamethasone 13.7015138204
MESH:D013276 Stomach Ulcer Nitric Oxide 13.7015138204
MESH:D013276 Stomach Ulcer pimagedine 13.7018209962
MESH:D020521 Stroke marker/mechanism
MESH:D020521 Stroke Folic Acid 7.6916517955
MESH:D020521 Stroke Raloxifene 7.6916837676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.6912697716
MESH:D013959 Thyroid Diseases Thyroxine 10.6919910387
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.617505956
MESH:D013978 Tibial Fractures Raloxifene 4.7019048282
MESH:D014062 Tongue Neoplasms Zinc 3.9716543248
MESH:D001749 Urinary Bladder Neoplasms Curcumin 7.2218593936
MESH:D001749 Urinary Bladder Neoplasms Quercetin 7.2216720314
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 7.2217572228
MESH:D014565 Urogenital Neoplasms Curcumin 4.7718462866
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.8314692618
MESH:D014605 Uveitis Dexamethasone 4.311336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0912125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.7016837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0915869587 14671159
MESH:D014846 Vulvar Neoplasms Raloxifene 5.0516343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7415886252
MESH:D015430 Weight Gain Dietary Fats 3.3216723640
Pathway ID Pathway Name
KEGG:05142 Chagas disease (American trypanosomiasis)
KEGG:00564 Glycerophospholipid metabolism
KEGG:05410 Hypertrophic cardiomyopathy (HCM)
KEGG:04614 Renin-angiotensin system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA139
    • Releated gene ID Related gene Name
    PA24910APP
    PA139ACE
    Releated disease ID Related disease Name
    PA444570Hypoglycemia
    PA443421Arrhythmias, Cardiac
    PA159018367Brugada syndrome
    PA443633Cardiomyopathy, Hypertrophic
    PA446379Death, Sudden, Cardiac
    PA444368Heart Diseases
    PA444807Long QT Syndrome
    PA445769Sudden Infant Death
    PA445848Thromboembolism
    PA446294Torsades de Pointes
    PA446028Ventricular Fibrillation
    PA446438Kidney Failure
    PA444682Kidney Diseases
    PA445018Cardiomyopathies
    PA443890Diabetes Mellitus, Type 2
    PA445431Proteinuria
    PA444602Immune System Diseases
    PA444938Metabolic Diseases
    PA445062Neoplasms
    PA446858Neurodegenerative Diseases
    PA447054Stroke
    PA443853Dementia
    PA444910Memory Disorders
    PA446479Hypertrophy, Left Ventricular
    PA443223Congenital Abnormalities
    PA446717Cardiovascular Abnormalities
    PA444169Fetal Death
    PA443803Cough
    PA444606Erectile Dysfunction
    PA447216Schizophrenia
    PA443888Diabetes Mellitus, Type 1
    PA447296nondiabetic proteinuric nephropathy
    PA447325Coronary Restenosis
    PA445019Myocardial Infarction
    PA447298venous thromboembolism
    PA446969Venous Thrombosis
    PA443797Coronary Disease
    PA443459Atrial Fibrillation
    PA444370Heart Failure
    PA443796Coronary Artery Disease
    PA443319Alzheimer Disease
    PA443309Alcoholism
    PA444552Hypertension
    PA444287Glomerulonephritis
    PA447258Glomerulosclerosis
    PA443425Arteriosclerosis
    PA443371Angioedema
    PA447283glomerular disease
    PA447286visceral obesity
    PA443635Cardiovascular Diseases
    PA444584Hypotension
    PA443886Diabetes Mellitus
    PA447199Bipolar Disorder
    PA443959Dyskinesia, Drug-Induced
    PA443970Dystonia
    PA446736Hypokinesia
    PA444993Muscle Rigidity
    PA445917Tremor
    Releated drug ID Related drug Name
    PA10432thiazide derivatives
    PA151249535diuretics
    PA164712445Antihypertensives
    PA164712372Angiotensin II Antagonists
    PA164712547Beta blocking agents, selective
    PA451906warfarin
    PA164712535Beta Blocking Agents
    PA10072epoetin alfa
    PA145007158torcetrapib
    PA448388amlodipine
    PA450268losartan
    PA448561benazepril
    PA450877perindopril
    PA164712368Angiotensin II antagonists and calcium channel blockers
    PA450084irbesartan
    PA451089pravastatin
    PA164748302cilazapril
    PA451346sildenafil
    PA452233antipsychotics
    PA133950441hmg coa reductase inhibitors
    PA452640imidapril
    PA164712308Ace Inhibitors, Plain
    PA449899hydrochlorothiazide
    PA450631nifedipine
    PA448073ethanol
    PA450242lisinopril
    PA448780captopril
    PA449456enalapril
    PA448499atenolol
    PA449710fosinopril
    PA449688fluvastatin
    PA449750gemfibrozil
    PA450935phenylephrine
    PA164712462Antiinflammatory agents, non-steroids
    PA448970chlorthalidone
    PA449407doxazosin
    PA143487910aliskiren
    PA451483spironolactone
    PA451257risperidone
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00178 antagonist Altace HCT Antihypertensive Agents;Angiotensin-converting Enzyme Inhibitors
    DB00492 antagonist Monopril-HCT Antihypertensive Agents;Angiotensin-converting Enzyme Inhibitors
    DB00519 antagonist Tarka Antihypertensive Agents;Angiotensin-converting Enzyme Inhibitors
    DB00542 antagonist Lotrel Antihypertensive Agents;Angiotensin-converting Enzyme Inhibitors
    DB00584 antagonist Vaseretic Antihypertensive Agents;Angiotensin-converting Enzyme Inhibitors
    DB00616 antagonist Candoxatril Antihypertensive Agents;Protease Inhibitors;Prodrugs
    DB00691 antagonist Uniretic Antihypertensive Agents;Angiotensin-converting Enzyme Inhibitors
    DB00722 antagonist Zestoretic Tab 20/25mg Antihypertensive Agents;Angiotensin-converting Enzyme Inhibitors
    DB00790 antagonist Preterax Antihypertensive Agents;Angiotensin-converting Enzyme Inhibitors
    DB00881 antagonist Stadapress Antihypertensive Agents;Angiotensin-converting Enzyme Inhibitors
    DB01180 inhibitor Rescinnamine Antihypertensive Agents
    DB01197 antagonist Capozide Antihypertensive Agents;Angiotensin-converting Enzyme Inhibitors
    DB01340 antagonist Cilazapril Antihypertensive Agents;Angiotensin-converting Enzyme Inhibitors
    DB01348 antagonist Spirapril Antihypertensive Agents;Angiotensin-converting Enzyme Inhibitors
    DB02032 - 1-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic Acid
    DB03740 - 2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose
    DB04184 - Acetate Ion Indicators and Reagents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved