AutismKB 2.0

Annotation Detail for AP1G1


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Basic Information Top
Gene Symbol:AP1G1 ( ADTG,CLAPG1,MGC18255 )
Gene Full Name: adaptor-related protein complex 1, gamma 1 subunit
Band: 16q22.2
Quick LinksEntrez ID:164; OMIM: 603533; Uniprot ID:AP1G1_HUMAN; ENSEMBL ID: ENSG00000166747; HGNC ID: 555
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04142Lysosome
Pathway IDPathway Name
Membrane Trafficking
HIV Infection
No data
No data
Pathway IDPathway Name
500013Clathrin derived vesicle budding
500014Golgi Associated Vesicle Biogenesis
500015Lysosome Vesicle Biogenesis
500758Nef mediated downregulation of MHC class I complex cell surface expression
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of AP1G1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of AP1G1 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of AP1G1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of AP1G1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of AP1G1 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of AP1G1 mRNAdecreases expression 19150397
D004390 Chlorpyrifos Chlorpyrifos results in decreased expression of AP1G1 mRNAdecreases expression 17452286
D003976 Diazinon Diazinon results in decreased expression of AP1G1 mRNAdecreases expression 17452286
D002117 Calcitriol Calcitriol results in increased expression of AP1G1 mRNAincreases expression 14996990
D011397 Promegestone [Promegestone co-treated with methoxyacetic acid] results in increased expression of AP1G1 mRNAaffects cotreatment|increases expression 15103026
D004958 Estradiol Estradiol affects the expression of AP1G1 mRNAaffects expression 14699072
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of AP1G1 mRNAincreases expression 17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AP1G1 mRNAaffects cotreatment|increases expression 17942748
C013598 methoxyacetic acid [Promegestone co-treated with methoxyacetic acid] results in increased expression of AP1G1 mRNAaffects cotreatment|increases expression 15103026
D020849 Raloxifene Raloxifene affects the expression of AP1G1 mRNAaffects expression 14699072
D013629 Tamoxifen Tamoxifen affects the expression of AP1G1 mRNAaffects expression 14699072
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AP1G1 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5814745880
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 14.587525203
MESH:D000014 Abnormalities, Drug-Induced methoxyacetic acid 14.583652986 12805644 1761407 1761404 15959878
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 14.5815322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D000230 Adenocarcinoma Estradiol 4.2211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2214692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4016835633
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 9.2416611668 17119214 11874814
MESH:D000382 Agricultural Workers' Diseases Diazinon 9.2416487989
MESH:D000419 Albuminuria Raloxifene 4.6017308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5415800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9511748828
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6615885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7615746008
MESH:D001930 Brain Injuries Raloxifene 4.4916580743
MESH:D001943 Breast Neoplasms Calcitriol 2.3411237771
MESH:D001943 Breast Neoplasms Estradiol 2.3419861407 16675129 17261762 12948864 18497071 17289903 14630087 17018787
MESH:D001943 Breast Neoplasms Raloxifene 2.3415572757 17440819 17893378 15758505 17261762 15775269 16837676 17049068 17242785 17952589 16912660 17595753
MESH:D001943 Breast Neoplasms Tamoxifen 2.3417440819 18821012 20544844 18351453 15565566 19189210 19221464 16202921 20859285 19066611 15668708 17242785 19200415 16818667 16873071 19084267 19115204 20065188 18815881 19155303 19011961 16273361 17893378 20135344 19289846 18997820 21152245 19189212 19487384 19244106 19410462 19059307 19103187 19142967 17049068 11161223 20005174 18855134 18984771 18629630 20390343 18425577 19288272 17261762 21138602
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3420435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4816111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5219066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.8716705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.8716705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.873084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.8716924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.8716924424
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6211237771
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.5117572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.5117572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3718670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Raloxifene 3.4515775269
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.4314694615
MESH:D002386 Cataract Acetaminophen 7.4310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.186135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.1820889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.1818566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8817110522 15861022 11677210 16919318 17333356 17681005 16105132
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1012621046 16354765 15668235 15340226 8697196
MESH:D003072 Cognition Disorders Raloxifene 4.6315800139
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.2015095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.2017141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2515322242 20055451 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.9418551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3819031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1617474826
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D003928 Diabetic Nephropathies Estradiol 15.0419279558
MESH:D003928 Diabetic Nephropathies Raloxifene 15.0415920148 17308373 17451421
MESH:D003928 Diabetic Nephropathies Tamoxifen 15.0419279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.0318551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.0321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 12.0321346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.0319923254 11461765 16081117 12153990 19164858 19416960 12594235 12705907 19420014 17906064 17522070 16781746 11421492 14725611 16109766 18071297 19739265 18713872 2444490 17562736 16177239 19370779 16227642 16485898 19085960 11529661 15968718 12392966 11834606 16393943 12958197 12540782 15619225 11739529 10915739 14550746 14986274 10663392 11287661 11743745 10774834
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.0320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7611462148
MESH:D004417 Dyspnea Diazinon 4.8316487989
MESH:D004487 Edema Raloxifene 6.8715860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9316714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 22.0415138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 22.0412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 22.0415845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 22.0419031437
MESH:D016889 Endometrial Neoplasms Estradiol 7.4019148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.4016202921 20544844 17893378 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.029294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0720426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0111564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.1915345470
MESH:D005234 Fatty Liver Raloxifene 13.1917473493
MESH:D005234 Fatty Liver Tamoxifen 13.1919224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2416709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5514745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.2019069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.9620067830
MESH:D005532 Foot Deformities, Congenital methoxyacetic acid 5.733652986
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3310048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.5411110106
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006505 Hepatitis Diazinon 4.5816487989
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9116120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.0615709030
MESH:D019584 Hot Flashes Estradiol 3.7817088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0815340226 18606429 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7016870215
MESH:D006973 Hypertension Raloxifene 5.2315787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2318670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male Diazinon 6.9512948887 16466525
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.9517937319
MESH:D007249 Inflammation Tamoxifen 4.8919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.8912200463 12878042
MESH:D007333 Insulin Resistance Estradiol 2.9716393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3416580747
MESH:D007674 Kidney Diseases Acetaminophen 5.8915629191 12587719
MESH:D007674 Kidney Diseases Estradiol 5.8915618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 17.7816705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 17.7816705839
MESH:D007680 Kidney Neoplasms Estradiol 17.7815610895
MESH:D007680 Kidney Neoplasms Tamoxifen 17.7818625569
MESH:D007889 Leiomyoma Raloxifene 4.5016973256
MESH:D017880 Limb Deformities, Congenital methoxyacetic acid 4.7415959878 12805644
MESH:D008064 Lipidoses Tamoxifen 3.1615342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.4314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.4318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4312878042
MESH:D008107 Liver Diseases Acetaminophen 4.2619784758 16611625 12587719 12969438 16610002 11587558 19014921 19460945
MESH:D008107 Liver Diseases Chlorpyrifos 4.2615991261
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2416871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.387678174
MESH:D008113 Liver Neoplasms Tamoxifen 7.3816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.3816984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.742876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.7412151625
MESH:D008175 Lung Neoplasms Tamoxifen 2.2518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2511884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7819428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.9717203775 16891317 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.9711731420 14580682 19196723 19196722 16827153
MESH:D020149 Manganese Poisoning Estradiol 12.7519453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.7519453300
MESH:D008545 Melanoma Tamoxifen 1.8819393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.2015990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.5815863610
MESH:D009101 Multiple Myeloma Raloxifene 3.4416497877
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.2816810080
MESH:D009232 Myxoma Raloxifene 5.5816343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.4118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.4118551238 7678174
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5219410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0319200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7517289903
MESH:D009421 Nervous System Malformations Estradiol 9.5016427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.5014600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8718514411
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.1715081274
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 15.1816049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.1816049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 15.1814694615
MESH:D010024 Osteoporosis Raloxifene 3.3917882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.2315758505 17823083 17893378 15579764
MESH:D010051 Ovarian Neoplasms Estradiol 2.2219401270
MESH:D010146 Pain Acetaminophen 2.3916870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D011041 Poisoning Diazinon 4.3617603234
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2111896295 11399792 11118676 11222880
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.8015572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8920887781
MESH:D011471 Prostatic Neoplasms Calcitriol 2.0916289102 18247401 15754350 16644109 12479363
MESH:D011471 Prostatic Neoplasms Estradiol 2.0916740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.0916220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0915067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.3316919318 15861022
MESH:D011693 Purpura Raloxifene 5.5815770314
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.6517119214 16611668 11874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.9216611668 17119214
MESH:D012640 Seizures 2,4-dinitrotoluene 5.8718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.8718551238
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.126418539
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.6616709447
MESH:D013088 Spermatocele Tamoxifen 11.6616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0619457130
MESH:D020521 Stroke Raloxifene 3.8216837676
MESH:D013576 Syndactyly methoxyacetic acid 5.641761404 1761407
MESH:D013733 Testicular Diseases methoxyacetic acid 5.356499806 18486176
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D013978 Tibial Fractures Estradiol 13.8219048282
MESH:D013978 Tibial Fractures Raloxifene 13.8219048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.9516049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.9516049721
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 11.9517572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.958653321 17572228 16712894
MESH:D014570 Urologic Diseases Diazinon 5.3116487989
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.0610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.0610091137
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3114692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.2416837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5414671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.5816343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
Pathway ID Pathway Name
REACT:6185 HIV Infection
KEGG:04142 Lysosome
REACT:11123 Membrane Trafficking
Pharmacogenomics Knowledge Base Top
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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