AutismKB 2.0

Annotation Detail for DCX


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Basic Information Top
Gene Symbol:DCX ( DBCN,DC,FLJ51296,LISX,SCLH,XLIS )
Gene Full Name: doublecortin
Band: Xq23
Quick LinksEntrez ID:1641; OMIM: 300121; Uniprot ID:DCX_HUMAN; ENSEMBL ID: ENSG00000077279; HGNC ID: 2714
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Axon guidance
Pathway IDPathway Name
200114Lissencephaly gene (LIS1) in neuronal migration and development
No data
Pathway IDPathway Name
500102Neurofascin interactions
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1860Brain tumor
2001Mental retardation
No data
No data
Desease Name
Lissencephaly, X-linked
Subcortical laminal heteropia, X-linked
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DCX mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of DCX mRNAincreases expression 20458559
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene inhibits the reaction [Ethanol results in decreased expression of DCX protein]decreases expression|decreases reaction 17067360
D000431 Ethanol Butylated Hydroxytoluene inhibits the reaction [Ethanol results in decreased expression of DCX protein]decreases expression|decreases reaction 17067360
D000431 Ethanol Ethanol results in decreased expression of DCX proteindecreases expression 17067360
D014212 Tretinoin Tretinoin results in increased expression of DCX mRNAincreases expression 16012519
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 4.4517676605 18926900
MESH:D000138 Acidosis Ammonium Chloride 12.3418287403
MESH:D000138 Acidosis Ethanol 12.3411192467
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3511798837 19825857
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.9315451040 15451039
MESH:D000505 Alopecia Tretinoin 3.9015955085
MESH:D000853 Anophthalmos Ethanol 5.3015513904
MESH:D001008 Anxiety Disorders Ethanol 4.2911141031
MESH:D001169 Arthritis, Experimental Tretinoin 3.2816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3316292516
MESH:D001249 Asthma Tretinoin 2.4316456186
MESH:D001471 Barrett Esophagus Tretinoin 4.8416935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 10.4416206674
MESH:D001778 Blood Coagulation Disorders Tretinoin 10.4416197459 16206674
MESH:D001943 Breast Neoplasms Tretinoin 2.2316166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.1316813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.7311589617
MESH:D002056 Burns Ethanol 5.1416374292
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.7716168501
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.9415553829 16217749 11135700 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Ethanol 4.9418788625 15763234 15289165
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.941917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.4919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.4712490120
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3716096774 16051514
MESH:D006332 Cardiomegaly Ethanol 3.6119332462
MESH:D002386 Cataract Tretinoin 3.2817460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.1316129372
MESH:D002822 Choriocarcinoma Tretinoin 5.7716461808
MESH:D002971 Cleft Lip Ethanol 3.7415513904
MESH:D002972 Cleft Palate Ethanol 6.5715513904
MESH:D002972 Cleft Palate Tretinoin 6.579407595
MESH:D003092 Colitis Tretinoin 4.1917035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.6312609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 4.0710525206
MESH:D019465 Craniofacial Abnormalities Ethanol 4.0719302082 10194807 15451039 15513904 15451040 11873399 11198716
MESH:D019465 Craniofacial Abnormalities Tretinoin 4.0717551590 9142499 10589399 9211117 16925845 9125849 9664655 8800419 14991402 9224671
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.5015213294
MESH:D056486 Drug-Induced Liver Injury Ethanol 2.6811566570
MESH:D004489 Edema, Cardiac Tretinoin 5.0818230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3216569247
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.9512903497
MESH:D004938 Esophageal Neoplasms Ethanol 4.9516704527
MESH:D005124 Eye Abnormalities Tretinoin 3.849664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 9.3415073043
MESH:D005234 Fatty Liver Ethanol 9.3419236843 18620774 16409862
MESH:D005235 Fatty Liver, Alcoholic Ethanol 6.2817920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.8415451040 16946407 15513904 10194807
MESH:D005355 Fibrosis Tretinoin 3.9917994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.7016904648
MESH:D005756 Gastritis Ethanol 5.3015046732
MESH:D005909 Glioblastoma Tretinoin 3.2217312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.7716084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0514991402 9664655
MESH:D006930 Hyperalgesia Ethanol 8.9718783367
MESH:D006930 Hyperalgesia Tretinoin 8.9716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.0516778211
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 4.8517604070
MESH:D007410 Intestinal Diseases Tretinoin 4.2517994277
MESH:D007569 Jaw Abnormalities Ethanol 11.6015513904
MESH:D007569 Jaw Abnormalities Tretinoin 11.6017551590 15992940
MESH:D007859 Learning Disorders Ethanol 4.6915451040
MESH:D007938 Leukemia arsenic trioxide 6.8515070760
MESH:D007938 Leukemia Tretinoin 6.8517143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.1712560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.8516972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 10.7419077051
MESH:D007951 Leukemia, Myeloid Tretinoin 10.7416482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0517050201 16968895 19850784 20471514 16467208
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.0516294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 8.3611468182 12679006 17217047 17649720 15336539 16823087 16112521 15213294 17107899 16891316 12018890 19035177 16966277 19075265 15622746 17712046 19225113 12712474 17869043 19642359 15748426 9834237 16331271 11161223 16330433
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 8.3617339181 17506722 17649720 12679006 19225113 16140955 19075265 17217047 19035177 17368321 17361223 17712046 16891316 16331271 17301526 15748426 17294898 9834237 16935935 16766008 16788101 19029980 16823087 19642359 17107899
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.7916882451
MESH:D017880 Limb Deformities, Congenital Ethanol 9.1517676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 9.159224671
OMIM:300067 LISSENCEPHALY, X-LINKED, 1 marker/mechanism
MESH:D008103 Liver Cirrhosis Ethanol 3.5415289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.6418295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 2.7818166357
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.7818397230 16248980
MESH:D008108 Liver Diseases, Alcoholic Ethanol 5.1417347304 17207112
MESH:D008113 Liver Neoplasms arsenic trioxide 5.4114682389
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 5.4118177683
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.9320377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.6215213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.9711798837 19825857
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 2.9716337739 19925653 15390079 11246140 11696405 18597497 19359593
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 3.961500032
MESH:D008527 Medulloblastoma Tretinoin 2.9017453147
MESH:D008545 Melanoma Tretinoin 1.9816752155
MESH:D008569 Memory Disorders Ethanol 4.6315451040 18411066
MESH:D008591 Meningomyelocele Tretinoin 4.9116940565
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3515949261 11468182 19417148 19549372 14977855
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.2818349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.9916882451 16105982
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.9917596541
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.4016624393
MESH:D009369 Neoplasms Tretinoin 2.5516946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 4.229125849
MESH:D009436 Neural Tube Defects arsenic trioxide 8.0310525206
MESH:D009436 Neural Tube Defects Tretinoin 8.039142499
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.1716624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Tretinoin 5.1716936753
MESH:D010146 Pain Tretinoin 3.2016870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 9.3015580305
MESH:D010190 Pancreatic Neoplasms Ethanol 9.3012384795
MESH:D010190 Pancreatic Neoplasms Tretinoin 9.3015976015
MESH:D010235 Paraganglioma arsenic trioxide 4.5719927285
MESH:D011014 Pneumonia Butylated Hydroxytoluene 5.7011893704
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2219131511
MESH:D011507 Proteinuria Tretinoin 4.0116636307
MESH:D011625 Pterygium Tretinoin 5.3316723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.5016116481 16283617
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.4016646077
MESH:D012640 Seizures Ethanol 3.409754883
MESH:D012878 Skin Neoplasms Tretinoin 2.7516467112
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.5817007042
MESH:D013274 Stomach Neoplasms Ethanol 3.5818456281
MESH:D013274 Stomach Neoplasms Tretinoin 3.5817261132
MESH:D013276 Stomach Ulcer Ethanol 3.9016755016 17189318 17918041 9562338 11906479 9211565
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.609754883
MESH:D013964 Thyroid Neoplasms arsenic trioxide 8.1319014326
MESH:D013964 Thyroid Neoplasms Tretinoin 8.1317045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.1416051514
MESH:D016171 Torsades de Pointes arsenic trioxide 4.5015213294
MESH:D014376 Tuberculosis Tretinoin 3.4316040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5912973940 11780464 12845720 20435036
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.0216129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.2216752155
MESH:D014820 Vitiligo Tretinoin 4.5016761959
MESH:D009396 Wilms Tumor Tretinoin 4.2916287080
Pathway ID Pathway Name
REACT:18266 Axon guidance
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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