AutismKB 2.0

Annotation Detail for DDC


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DDC ( AADC )
Gene Full Name: dopa decarboxylase (aromatic L-amino acid decarboxylase)
Band: 7p12.2-p12.1
Quick LinksEntrez ID:1644; OMIM: 107930; Uniprot ID:DDC_HUMAN; ENSEMBL ID: ENSG00000132437; HGNC ID: 2719
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY66-301catecholamine biosynthesis
PWY-6307tryptophan degradation X (mammalian, via tryptamine)
PWY-6030serotonin and melatonin biosynthesis
Pathway IDPathway Name
hsa00360Phenylalanine metabolism
hsa00380Tryptophan metabolism
hsa00350Tyrosine metabolism
hsa01100Metabolic pathways
hsa00340Histidine metabolism
Pathway IDPathway Name
Synaptic Transmission
Hormone biosynthesis
Metabolism of amino acids and derivatives
No data
Pathway IDPathway Name
P00001Adrenaline and noradrenaline biosynthesis
P043715-Hydroxytryptamine biosynthesis
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1727Pancreas disease
2045Bipolar disorder
2069Schizophrenia
2124Autistic disorder
2151Neuroblastoma
Desease Name
CHEMDEPENDENCY
CANCER
nicotine dependence smoking behavior
malaria
INFECTION
Acute lymphoblastic leukemia (childhood)
Desease Name
Malaria
Desease Name
Aromatic L-amino acid decarboxylase deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of DDC mRNAdecreases expression 19933214
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of DDC mRNAaffects expression 21346803
C099630 3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine [3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine binds to and results in decreased activity of DRD4 protein] which results in increased activity of DDC proteinaffects binding|decreases activity|increases activity 16415089
C004297 3-hydroxybenzylhydrazine 3-hydroxybenzylhydrazine results in decreased activity of DDC proteindecreases activity 16415089
D000082 Acetaminophen Acetaminophen affects the expression of DDC mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of DDC proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DDC mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in decreased expression of DDC proteindecreases expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of DDC mRNAdecreases expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of DDC mRNAincreases expression 17879257
D002713 Chlorine Chlorine results in decreased expression of DDC mRNAdecreases expression 18636392
D002713 Chlorine [Ozone co-treated with Chlorine] affects the expression of DDC mRNAaffects cotreatment|affects expression 18636392
D003024 Clozapine Clozapine results in increased expression of and results in increased activity of DDC proteinincreases activity|increases expression 16415089
D003024 Clozapine Clozapine results in increased expression of DDC mRNAincreases expression 16415089
D016572 Cyclosporine Cyclosporine results in decreased expression of DDC mRNAdecreases expression 20106945
C017180 decamethrin decamethrin results in decreased expression of DDC mRNAdecreases expression 19017407
D003993 Dibutyl Phthalate Dibutyl Phthalate results in decreased expression of DDC proteindecreases expression 15728792
D004958 Estradiol Estradiol results in increased expression of DDC mRNAincreases expression 20068009
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of DDC mRNAdecreases expression 15901920
15834898
D019833 Genistein Genistein results in increased expression of DDC mRNAincreases expression 15378649
D007650 Ketanserin Ketanserin results in increased activity of DDC proteinincreases activity 16415089
D007657 Ketone Bodies Ketone Bodies results in decreased expression of DDC mRNAdecreases expression 16807920
D008711 Metergoline Metergoline results in increased activity of DDC proteinincreases activity 16415089
D010126 Ozone [Ozone co-treated with Chlorine] affects the expression of DDC mRNAaffects cotreatment|affects expression 18636392
D026023 Permethrin Permethrin results in decreased expression of DDC mRNAdecreases expression 19017407
D010634 Phenobarbital Phenobarbital results in decreased expression of DDC mRNAdecreases expression 19270015
D010634 Phenobarbital Phenobarbital results in increased expression of DDC mRNAincreases expression 12807726
D010795 Phthalic Acids Phthalic Acids results in decreased expression of DDC mRNAdecreases expression 15728792
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of DDC mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of DDC mRNAdecreases expression 19933214
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of DDC mRNAdecreases expression 19490992
D014212 Tretinoin Tretinoin results in increased expression of DDC mRNAincreases expression 16604517
C090413 WAY 100635 [WAY 100635 binds to and results in decreased activity of HTR1A protein] which results in increased activity of DDC proteinaffects binding|decreases activity|increases activity 16415089
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.596195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.5915322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.3518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7317505938
MESH:D055371 Acute Lung Injury Chlorine 4.1320601635
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.7120464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 9.7111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.7114692618
MESH:D000230 Adenocarcinoma Genistein 9.7111473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.536695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 9.3817620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.3816835633
MESH:D000380 Agranulocytosis Clozapine 4.8512649775 14617031 16160616
MESH:D000505 Alopecia Tretinoin 3.4515955085
MESH:D000544 Alzheimer Disease Ozone 2.3915513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7611748828
MESH:D000799 Angioedema Acetaminophen 3.6310982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8719183758
MESH:C537437 Aromatic amino acid decarboxylase deficiency marker/mechanism
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7815885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.7816412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.5015570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.5016292516
MESH:D001249 Asthma Ozone 4.7316373670 17854713
MESH:D001249 Asthma Tretinoin 4.7316456186
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.2220106747
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001471 Barrett Esophagus Tretinoin 4.2016935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.3116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6315746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.2620146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 2.2612948864 17261762 19861407 18497071 16675129 17289903 14630087 17018787
MESH:D001943 Breast Neoplasms Genistein 2.2616873071 16541309 17200150
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2620435547
MESH:D001943 Breast Neoplasms Tretinoin 2.2616873071 16443354 16166294
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5119059883 15516495 14754758 18315731 18417511 17626835 16777450
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3816813970
MESH:D002100 Cachexia Ozone 4.5316183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6316835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9516168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.5516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.553084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.5521507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.5516924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 13.5516924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 13.5517173139 1701930 6705139 20935162 20007298
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.551917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.3620419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.3616096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2518850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Genistein 3.1616332659
MESH:D002386 Cataract Acetaminophen 6.8210977129
MESH:D002386 Cataract Tretinoin 6.8217460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.1012371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.1018566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.044080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3816129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D002779 Cholestasis Cyclosporine 7.2719486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.2715861022 11677210 17110522 17333356 17681005 16105132 16919318
MESH:D002822 Choriocarcinoma Tretinoin 4.9516461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4715668235 8697196 16354765 12621046 15340226
MESH:D002972 Cleft Palate Tretinoin 5.479407595
MESH:D003072 Cognition Disorders Clozapine 4.7617123785
MESH:D003092 Colitis Tretinoin 3.5017035595
MESH:D003110 Colonic Neoplasms Genistein 2.2517182828
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8814669216 17141729
MESH:D019465 Craniofacial Abnormalities decamethrin 5.3319861644
MESH:D019465 Craniofacial Abnormalities Permethrin 5.3319861644
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.3320055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.3316925845 9664655 17551590 8800419 10589399 9224671 9211117 9125849 9142499 14991402
MESH:D003456 Cryptorchidism Dibutyl Phthalate 5.2516037377
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.8118551238
MESH:D003877 Dermatitis, Contact Permethrin 4.8014617103
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 6.9016402076
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.9016647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.9017107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2419279558
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.3415331141
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 5.7421346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.7410774834 19739265 16109766 10915739 12392966 16781746 16081117 19416960 15619225 17522070 19164858 17906064 19370779 16177239 17562736 19085960 11529661 11421492 12594235 11287661 16393943 14986274 11739529 12540782 11743745 14550746 18713872 12958197 10663392 12153990 2444490 12705907 19420014 15968718 19923254 11461765 16485898 18071297 14725611 11834606 16227642
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.7420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6111462148
MESH:D050171 Dyslipidemias Clozapine 4.0316402076
MESH:D004417 Dyspnea Chlorine 4.4120016425
MESH:D004421 Dystonia Phenobarbital 3.811851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.2011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.2316714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.2318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9912538720
MESH:D004714 Endometrial Hyperplasia Genistein 4.3816402032
MESH:D016889 Endometrial Neoplasms Estradiol 11.6811473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 11.6811473722
MESH:D016889 Endometrial Neoplasms Tretinoin 11.6816569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8410568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.903659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.6611558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.7820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.376401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.047750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.813659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.3211564622
MESH:D005124 Eye Abnormalities Tretinoin 8.3216938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 6.9519224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 6.9515345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2511858732
MESH:D005355 Fibrosis Cyclosporine 13.5212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.5220067830
MESH:D005355 Fibrosis Tretinoin 13.5217994277
MESH:D005739 Gas Poisoning Chlorine 4.8020016425
MESH:D005756 Gastritis Acetaminophen 3.4616983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.018708960
MESH:D005909 Glioblastoma Genistein 6.7616598420
MESH:D005909 Glioblastoma Tretinoin 6.7617312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3810696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9516084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.4620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.4611294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.4614991402 9664655
MESH:D018883 Heat Stroke Ketanserin 6.9616205318
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1511000095
MESH:D006529 Hepatomegaly Phenobarbital 7.7516109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.7515340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.8215709030
MESH:D019584 Hot Flashes Estradiol 3.5417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8315340226 16959395 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 7.0816870215
MESH:D006930 Hyperalgesia Tretinoin 7.0816870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3616778211
MESH:D006948 Hyperkinesis Clozapine 4.7016046005
MESH:D006973 Hypertension Cyclosporine 4.6810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6818670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6016945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3517937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.7512878042 12200463
MESH:D007299 Insect Bites and Stings decamethrin 12.4315189238
MESH:D007299 Insect Bites and Stings Permethrin 12.4312749493 12971516 15189238
MESH:D007333 Insulin Resistance Estradiol 2.8316627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 3.5617994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.3016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.3017551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2315604871
MESH:D007674 Kidney Diseases Acetaminophen 9.2812587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.2810903974 18776723 8314463
MESH:D007674 Kidney Diseases Estradiol 9.2815618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.3816705839
MESH:D007680 Kidney Neoplasms Cyclosporine 11.3812371664
MESH:D007680 Kidney Neoplasms Estradiol 11.3815610895
MESH:D007938 Leukemia Genistein 10.0717468513 18980019
MESH:D007938 Leukemia Permethrin 10.0712937054
MESH:D007938 Leukemia Tretinoin 10.0717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.5116482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0416294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0219225113 19035177 19029980 16823087 17301526 17506722 16766008 17294898 16935935 12679006 15748426 19075265 16331271 17712046 17368321 16891316 17217047 17649720 17339181 16788101 16140955 9834237 17107899 17361223 19642359
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.169224671
MESH:D008064 Lipidoses Clozapine 3.8117567588
MESH:D008103 Liver Cirrhosis Phenobarbital 2.7821047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.7414659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 4.7417823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.7412878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.7418397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 3.7512969438 11587558 19014921 16610002 19784758 12587719 19460945 16611625
MESH:D008107 Liver Diseases Phenobarbital 3.7519363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0516871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 10.0318177683 15890375 9163691 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.0320195826 21137059
MESH:D008113 Liver Neoplasms Phenobarbital 10.0319812893 8742319 19073162 19482888 15975961 21047994
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.0316984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 9.078603461
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 9.0718308698 17172636 2563599 1399818 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.0712151625
MESH:D008171 Lung Diseases Ozone 3.2419066396 8266340
MESH:D055370 Lung Injury Ozone 3.6420417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.6314755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.6318569708 20135361 20064080 18520028 20869020 6695378 18816296 17053015 20464547
MESH:D008175 Lung Neoplasms Ozone 4.638597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.6311884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.6411807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 5.6412929590 14578162
MESH:D020149 Manganese Poisoning Estradiol 4.2719453300
MESH:D008527 Medulloblastoma Tretinoin 2.7017453147
MESH:D008545 Melanoma Tretinoin 1.9216752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3619513568
MESH:D008591 Meningomyelocele Tretinoin 4.2216940565
MESH:D001523 Mental Disorders Clozapine 3.7416856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.2419142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5816801185
MESH:D008679 Metaplasia Ozone 4.8910496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0316381670
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9617596541
MESH:D009203 Myocardial Infarction Genistein 2.7717141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.9816810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 7.9817141266
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2617484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.6518551238
MESH:D009369 Neoplasms Benzo(a)pyrene 4.6511141357
MESH:D009369 Neoplasms Tretinoin 4.6516594593 16946489
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1118481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 21.7716427766 11399458
MESH:D009421 Nervous System Malformations Genistein 21.7716427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 21.7714600291
MESH:D009421 Nervous System Malformations Tretinoin 21.779125849
MESH:D009436 Neural Tube Defects Tretinoin 2.929142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7018514411
MESH:D009765 Obesity Clozapine 2.9719142110 18515891
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.2512819281 16049721
MESH:D010018 Osteomalacia Phenobarbital 4.1517016548
MESH:D010024 Osteoporosis Genistein 3.1319401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.8916169203
MESH:D010051 Ovarian Neoplasms Estradiol 7.5019401270
MESH:D010051 Ovarian Neoplasms Genistein 7.5019005980
MESH:D010051 Ovarian Neoplasms Tretinoin 7.5016936753
MESH:D010146 Pain Acetaminophen 6.0316870215
MESH:D010146 Pain Tretinoin 6.0316870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.0216965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.0215976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0412520081
MESH:D010538 Peritonitis Ozone 3.9216369182
MESH:D011014 Pneumonia Ozone 4.1818007984 18929643 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3618163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.3812371664
MESH:D011230 Precancerous Conditions Phenobarbital 8.382563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9811896295 11399792 11118676 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6117292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.6116740699
MESH:D011471 Prostatic Neoplasms Genistein 2.6115256057 15378649 16925846
MESH:D011507 Proteinuria Tretinoin 3.4116636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.1016919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.2812752131
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011618 Psychotic Disorders Clozapine 4.0315331141
MESH:D011625 Pterygium Tretinoin 4.5816723453
MESH:D012120 Respiration Disorders Chlorine 5.0018579056
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6418990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9016283617 16116481
MESH:D012559 Schizophrenia Clozapine 2.7118806925 17726453 20168265 20452607 20521320 16141801 11151749 20107430 17123785 20580759 17667964 18855531 19369910 11763009 20521326
MESH:D012640 Seizures 2,4-dinitrotoluene 5.4618551238
MESH:D012640 Seizures Phenobarbital 5.463137016 11442880 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.616407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.8110029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.8116192470
MESH:D012878 Skin Neoplasms Tretinoin 8.8116467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7316709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.2920155912 2093021
MESH:D013274 Stomach Neoplasms Tretinoin 2.2917261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6912697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.671399818
MESH:D013964 Thyroid Neoplasms Tretinoin 6.6716026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.4719048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.6016051514
MESH:D014376 Tuberculosis Tretinoin 3.1016040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 4.7016049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.7017053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.1010091137
MESH:D014581 Urticaria Acetaminophen 2.7810982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4916129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1014692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.4016752155
MESH:D014605 Uveitis Cyclosporine 3.771336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3514671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.8516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0415886252
MESH:D015430 Weight Gain Clozapine 4.2920521320 20107430 16141801 17502770 16402076 20564506
MESH:D015431 Weight Loss Clozapine 4.8717933447
MESH:D009396 Wilms Tumor Tretinoin 3.7916287080
MESH:D014985 Xerophthalmia Cyclosporine 4.2317120751
Pathway ID Pathway Name
KEGG:00340 Histidine metabolism
REACT:15314 Hormone biosynthesis
KEGG:01100 Metabolic pathways
REACT:13 Metabolism of amino acids and derivatives
KEGG:00360 Phenylalanine metabolism
REACT:13685 Synaptic Transmission
KEGG:00380 Tryptophan metabolism
KEGG:00350 Tyrosine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA140
    • No data
    Releated disease ID Related disease Name
    PA445876Tobacco Use Disorder
    PA447062Parkinsonian Disorders
    PA443450Asthma
    Releated drug ID Related drug Name
    PA451898vitamin c
    PA450626nicotine
    PA133822447catecholamines
    PA450213levodopa
    PA449396dopamine
    PA451822l-tyrosine
    PA161990676tetrahydrobiopterin
    PA10323l-tryptophan
    PA448068salbutamol
    PA134687887selective beta-2-adrenoreceptor agonists
    PA164713253Selective beta-2-adrenoreceptor agonists
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00114 - Pyridoxal Phosphate Dietary supplement;Micronutrient;Vitamin B Complex
    DB00150 - L-Tryptophan Dietary supplement;Micronutrient;Essential Amino Acids;Antidepressive Agents, Second-Generation
    DB00190 antagonist Sinemet CR Dopamine Agents;Antiparkinson Agents;Antidyskinetics;Enzyme Inhibitors
    Drugbank ID Action Drug Name Description
    DB00114 - Pyridoxal Phosphate Dietary supplement;Micronutrient;Vitamin B Complex
    DB00150 - L-Tryptophan Dietary supplement;Micronutrient;Essential Amino Acids;Antidepressive Agents, Second-Generation
    DB00409 - Remoxipride Antipsychotics;Dopamine Antagonists;Antipsychotic Agents
    DB00875 - Flupenthixol Antipsychotics;Dopamine Antagonists;Antipsychotic Agents;Thioxanthenes
    DB00915 - Amantadine Antiviral Agents;Dopamine Agents;Antiparkinson Agents;Analgesics, Non-Narcotic
    DB01100 - Pimozide Dopamine Antagonists;Antipsychotic Agents;Anti-Dyskinesia Agents
    DB01235 - Sinemet CR Dopamine Agents;Antiparkinson Agents;Antidyskinetics
    DB06262 substrate Droxidopa Vasoconstrictor Agents;Sympathomimetics;Adrenergic alpha-Agonists
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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