AutismKB 2.0

Annotation Detail for AKR1C2


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Basic Information Top
Gene Symbol:AKR1C2 ( AKR1C-pseudo,BABP,DD,DD2,DDH2,FLJ53800,HAKRD,HBAB,MCDR2 )
Gene Full Name: aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
Band: 10p15.1
Quick LinksEntrez ID:1646; OMIM: 600450; Uniprot ID:AK1C2_HUMAN; ENSEMBL ID: ENSG00000151632; HGNC ID: 385
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00140Steroid hormone biosynthesis
hsa00980Metabolism of xenobiotics by cytochrome P450
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1944Breast cancer
2060Glaucoma
2098Esophageal disease
2125Bladder cancer
2164Barrett's esophagus
No data
No data
Desease Name
Obesity, hyperphagia, and developmental delay
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone AKR1C2 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneincreases metabolic processing 11306090
C005399 9,10-phenanthrenequinone AKR1C2 protein results in increased metabolism of 9,10-phenanthrenequinoneincreases metabolic processing 17950253
D004092 20-alpha-Dihydroprogesterone AKR1C2 protein results in increased chemical synthesis of 20-alpha-Dihydroprogesteroneincreases chemical synthesis 11158055
D013196 Dihydrotestosterone AKR1C2 protein results in increased metabolism of and results in decreased activity of Dihydrotestosteronedecreases activity|increases metabolic processing 17170221
D013196 Dihydrotestosterone AKR1C2 protein results in increased reduction of Dihydrotestosteroneincreases reduction 11158055
D015113 Androstane-3,17-diol AKR1C2 protein results in increased chemical synthesis of Androstane-3,17-diolincreases chemical synthesis 11158055
17170221
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in decreased expression of AKR1C2 mRNAdecreases expression 18687144
D001564 Benzo(a)pyrene AKR1C2 protein affects the susceptibility to Benzo(a)pyreneaffects response to substance 19800895
D001564 Benzo(a)pyrene AKR1C2 protein affects the susceptibility to [Benzo(a)pyrene co-treated with methylparaoxon]affects cotreatment|affects response to substance 19800895
D001564 Benzo(a)pyrene AKR1C2 protein affects the susceptibility to [Benzo(a)pyrene co-treated with Methyl Parathion]affects cotreatment|affects response to substance 19800895
D001564 Benzo(a)pyrene Benzo(a)pyrene promotes the reaction [Methyl Parathion results in increased activity of AKR1C2 protein]increases activity|increases reaction 19800895
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of AKR1C2 mRNAincreases expression 19800895
15735009
20106945
D001564 Benzo(a)pyrene Methyl Parathion promotes the reaction [Benzo(a)pyrene results in increased expression of AKR1C2 mRNA]increases expression|increases reaction 19800895
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of AKR1C2 mRNAincreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of AKR1C2 mRNAincreases expression 12414654
15336504
D002104 Cadmium Cadmium results in increased expression of AKR1C2 mRNAincreases expression 21172416
D002635 Chenodeoxycholic Acid Chenodeoxycholic Acid binds to AKR1C2 proteinaffects binding 8486699
D003630 Daunorubicin Daunorubicin results in increased activity of AKR1C2 proteinincreases activity 15588138
D004178 Diquat Diquat results in increased expression of AKR1C2 mRNAincreases expression 21172416
C108373 dutasteride dutasteride results in increased expression of AKR1C2 mRNAincreases expression 16806904
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of AKR1C2 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of AKR1C2 mRNAincreases expression 19619570
D005472 Fluorouracil AKR1C2 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
C106014 gedunin gedunin results in increased expression of AKR1C2 mRNAincreases expression 17010675
C071834 glycidamide glycidamide results in increased expression of AKR1C2 mRNAincreases expression 17822822
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of AKR1C2 mRNAaffects cotreatment|increases expression 17183730
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of AKR1C2 mRNAincreases expression 12414654
D008095 Lithocholic Acid Lithocholic Acid binds to AKR1C2 proteinaffects binding 8486699
D008294 Malathion Malathion results in increased expression of AKR1C2 mRNAincreases expression 16079077
C008480 methylparaoxon AKR1C2 protein affects the susceptibility to [Benzo(a)pyrene co-treated with methylparaoxon]affects cotreatment|affects response to substance 19800895
C008480 methylparaoxon methylparaoxon results in increased expression of AKR1C2 mRNAincreases expression 19800895
D008743 Methyl Parathion AKR1C2 protein affects the susceptibility to [Benzo(a)pyrene co-treated with Methyl Parathion]affects cotreatment|affects response to substance 19800895
D008743 Methyl Parathion Benzo(a)pyrene promotes the reaction [Methyl Parathion results in increased activity of AKR1C2 protein]increases activity|increases reaction 19800895
D008743 Methyl Parathion Methyl Parathion promotes the reaction [Benzo(a)pyrene results in increased expression of AKR1C2 mRNA]increases expression|increases reaction 19800895
D008743 Methyl Parathion Methyl Parathion results in increased activity of AKR1C2 proteinincreases activity 19800895
D008743 Methyl Parathion Methyl Parathion results in increased expression of AKR1C2 mRNAincreases expression 19800895
D017239 Paclitaxel AKR1C2 mRNA results in increased susceptibility to Paclitaxelincreases response to substance 16322897
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of AKR1C2 mRNAdecreases expression 17681415
C006253 pirinixic acid pirinixic acid results in decreased expression of AKR1C2 mRNAdecreases expression 18467677
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of AKR1C2 mRNA]decreases expression|increases reaction 18467677
D011374 Progesterone AKR1C2 protein results in increased reduction of Progesteroneincreases reduction 11158055
C017947 sodium arsenite sodium arsenite results in increased expression of AKR1C2 mRNAincreases expression 19696165
C017947 sodium arsenite sodium arsenite results in increased expression of AKR1C2 proteinincreases expression 19696165
D014284 Triiodothyronine Triiodothyronine results in increased expression of AKR1C2 mRNAincreases expression 15507505
C004648 testosterone enanthate testosterone enanthate affects the expression of AKR1C2 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of AKR1C2 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of AKR1C2 mRNAdecreases expression 19619570
C050414 tripterine tripterine results in increased expression of AKR1C2 mRNAincreases expression 17010675
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of AKR1C2 mRNAaffects cotreatment|increases expression 17183730
D014810 Vitamin E Vitamin E results in increased expression of AKR1C2 mRNAincreases expression 19244175
D024483 Vitamin K 3 Vitamin K 3 results in increased expression of AKR1C2 mRNAincreases expression 12414654
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of AKR1C2 mRNAincreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.0515322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.058875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.5919490988
MESH:D000138 Acidosis Zinc Sulfate 4.537265320
MESH:D055371 Acute Lung Injury pirinixic acid 2.7718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.4520464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 6.4511473722
MESH:D000230 Adenocarcinoma Fluorouracil 6.4517638652
MESH:D000236 Adenoma 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 6.2616176798
MESH:D000236 Adenoma Benzo(a)pyrene 6.266695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.6316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.6316835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3115276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5116712894 17306315
MESH:D000382 Agricultural Workers' Diseases Malathion 4.6017119214 11874814
MESH:D000550 Amblyopia Valproic Acid 4.8417688650
MESH:D000740 Anemia Fluorouracil 7.5917963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.5911748828
MESH:D000860 Anoxia Zinc Sulfate 4.647265320
MESH:D001008 Anxiety Disorders Valproic Acid 3.2717497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7019183758
MESH:D050197 Atherosclerosis Cadmium 3.4215687053
MESH:D001321 Autistic Disorder Valproic Acid 2.0517157402 18316065 16609825 17507914 18775368 18940202 17688650 20603192 19232924 18558336 18177632 18985861 19460635 15238991 18396377
MESH:D001714 Bipolar Disorder Valproic Acid 2.8817594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.6419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.6412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.2015746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.208888407
MESH:D001859 Bone Neoplasms Paclitaxel 4.2215867366
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9517868700
MESH:D001930 Brain Injuries Progesterone 3.8915665606 15845082 15380490
MESH:D001943 Breast Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 5.4020146248
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 5.4017474063 20146248
MESH:D001943 Breast Neoplasms dutasteride 5.4016806904
MESH:D001943 Breast Neoplasms Estradiol 5.4016675129 17018787 12948864 17261762 17289903 14630087 18497071 19861407
MESH:D001943 Breast Neoplasms Fluorouracil 5.4019217205 18357371 16595493 16110121 16557594 18608205 15136595
MESH:D001943 Breast Neoplasms Malathion 5.4012762645
MESH:D001943 Breast Neoplasms Paclitaxel 5.4018323546 18234424 16273361 18223236 16244791 11325840 15136595 16115903
MESH:D001943 Breast Neoplasms Progesterone 5.4015562024 17614352 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.4020435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0816111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.5616050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.2816051944
MESH:D002277 Carcinoma Fluorouracil 7.1917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.1916835633
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.0416924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.0417971768 16332177 16799960 18930000 17088986 17045692
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 6.0416313753
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.0416507464 15276417 17306315
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.8318695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 6.8220419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 6.8216757204 16280240 17066447 18986760
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 6.8218572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1518670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.2516936243
MESH:D002471 Cell Transformation, Neoplastic marker/mechanism 19696165
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 13.9020889678
MESH:D002471 Cell Transformation, Neoplastic Cadmium 13.9017332340
MESH:D002471 Cell Transformation, Neoplastic Estradiol 13.9018566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 13.9019524636 20056578
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5620734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D002779 Cholestasis Lithocholic Acid 7.6719965603
MESH:D002779 Cholestasis pirinixic acid 7.6719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9412621046 8697196 16354765 15340226 15668235
MESH:D003110 Colonic Neoplasms Fluorouracil 2.1717169374 16510598 17287894 17725105 17016597 15001691 18772588 16340194 17018589 17172411
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.6618288408 17454858 17255274 18509181 17594712 16303861 15148649 20501625 14970324 18802399 17401013 18383874 16331619 16282729 16391804 17695437 18448328 16524972 18949393 17016601 17094418 15289873
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.6618802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.5020055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.5017688650 16575769 8888407
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.5019769572
MESH:D007644 Darier Disease Fluorouracil 4.4116733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2418249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5717107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.0919279558
MESH:D003929 Diabetic Neuropathies 20-alpha-Dihydroprogesterone 11.3617187935
MESH:D003929 Diabetic Neuropathies Progesterone 11.3617187935
MESH:D056486 Drug-Induced Liver Injury Diquat 5.6818164269 18445702
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.6820420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 5.681733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4811462148
MESH:D004421 Dystonia Valproic Acid 3.701851702
MESH:C538011 Eales disease Vitamin E 4.329068938
MESH:D004487 Edema perfluorooctanoic acid 9.5217259670 12083418
MESH:D004487 Edema pirinixic acid 9.5212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.5211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5118230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.4217692515
MESH:D016889 Endometrial Neoplasms Estradiol 2.7319148513 18566989 11473722
MESH:D004715 Endometriosis Progesterone 7.8416134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.8410568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.783659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.5316628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.7418234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.277562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.927750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.683659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.5020426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 9.5016530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 9.5015173087 16481741 17638652 16785472 16337965
MESH:D004938 Esophageal Neoplasms Paclitaxel 9.5016481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7311564622
MESH:D005234 Fatty Liver pirinixic acid 6.6020131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 6.6019224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0811858732
MESH:D005315 Fetal Diseases Valproic Acid 4.5016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.778888407 18558336
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.5820067830
MESH:D005756 Gastritis Diquat 5.1915046732
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3016452187
MESH:D005910 Glioma Fluorouracil 2.7116145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2110696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.1315102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.9020471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.9010048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 9.9016080930
MESH:D006333 Heart Failure pirinixic acid 2.3020558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0011000095
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 4.6217063115
MESH:D006529 Hepatomegaly perfluorooctanoic acid 12.313609246
MESH:D006529 Hepatomegaly pirinixic acid 12.3119772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.3115340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.5616490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.6415709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.3617440010
MESH:D006689 Hodgkin Disease sodium arsenite 2.8412676792
MESH:D019584 Hot Flashes Estradiol 8.7617088409
MESH:D019584 Hot Flashes Vitamin E 8.7614716179
MESH:D006849 Hydrocephalus Valproic Acid 4.4817688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6615340226 16959395 16354765 18606429 8697196
MESH:D006930 Hyperalgesia perfluorooctanoic acid 3.5612083418
MESH:D006943 Hyperglycemia pirinixic acid 2.8520558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.7618850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.2516612254
MESH:D007022 Hypotension Zinc Sulfate 4.127265320
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.0315869954
MESH:D007248 Infertility, Male Diquat 6.464850670
MESH:D007248 Infertility, Male sodium arsenite 6.4612646999 15346721
MESH:D007249 Inflammation perfluorooctanoic acid 7.2012083418
MESH:D007249 Inflammation Progesterone 7.2015869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.2012878042 12200463
MESH:D007251 Influenza, Human Vitamin E 3.8316624496
MESH:D007333 Insulin Resistance Estradiol 6.3616393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 6.3616306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0016580747
MESH:D007674 Kidney Diseases Cadmium 12.6516226777 16962696 16322080
MESH:D007674 Kidney Diseases Estradiol 12.6515618244
MESH:D007674 Kidney Diseases sodium arsenite 12.6520008137
MESH:D007674 Kidney Diseases Vitamin E 12.6512488133
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 3.9316518626
MESH:D007680 Kidney Neoplasms Estradiol 6.4715610895
MESH:D007680 Kidney Neoplasms Fluorouracil 6.4716985049
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 3.9615237267
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.0816294345 17596541
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.858812269
MESH:D008080 Liposarcoma Paclitaxel 4.4717353645
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.4814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.4815474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.4812878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 4.4816169303
MESH:D008113 Liver Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 19.5115890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 19.5121137059 20195826
MESH:D008113 Liver Neoplasms Fluorouracil 19.5115113037 16603448 17045692 18383874
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 19.5118709148 14757943
MESH:D008113 Liver Neoplasms pirinixic acid 19.5115890375 20007298 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 19.5116712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 19.5116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 1.8812151625
MESH:D008171 Lung Diseases sodium arsenite 6.5919095001
MESH:D008171 Lung Diseases Vitamin E 6.5916863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.8717228818
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.6517365036
MESH:D008175 Lung Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 7.8418508827 18813816 17139156 9255578 16401635 15172992 14755239 12438228 15893417 16061637 19931552
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 7.8418569708 18520028 18816296 17053015 6695378 20464547 20869020 20064080 20135361
MESH:D008175 Lung Neoplasms Fluorouracil 7.8415246190
MESH:D008175 Lung Neoplasms sodium arsenite 7.8417306315 15276417 16712894 17077188 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 7.8411884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 7.8411062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.4115086387
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 3.7814749477
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.2417203775 11408345 16891317 11807958
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 5.2411408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.0919453300
MESH:D008545 Melanoma Paclitaxel 4.9112025231 12040289 16342250
MESH:D008545 Melanoma sodium arsenite 4.9119082730 16487513
MESH:D008545 Melanoma Vitamin K 3 4.9119082730
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.0318303189 16966607 16166281
MESH:D008881 Migraine Disorders Valproic Acid 2.9218765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.5616381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.5616757204 18986760
MESH:D009101 Multiple Myeloma Paclitaxel 3.4214749477
MESH:D009135 Muscular Diseases pirinixic acid 3.1416239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.698888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 2.9317596541
MESH:D009203 Myocardial Infarction pirinixic acid 1.9819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.2816810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.2816411023
MESH:D009362 Neoplasm Metastasis Paclitaxel 3.1015867366
MESH:D009369 Neoplasms Benzo(a)pyrene 10.2311141357
MESH:D009369 Neoplasms Fluorouracil 10.2318600527 16928823 18239605
MESH:D009369 Neoplasms pirinixic acid 10.2317405874
MESH:D009369 Neoplasms sodium arsenite 10.2311559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3020056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3517289903
MESH:D009421 Nervous System Malformations Estradiol 8.2616427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.2614600291
MESH:D009436 Neural Tube Defects sodium arsenite 6.5012854658
MESH:D009436 Neural Tube Defects Valproic Acid 6.5016359493 8888407
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 12.1716436463
MESH:D020258 Neurotoxicity Syndromes Malathion 12.1715081274
MESH:D020258 Neurotoxicity Syndromes Methyl Parathion 12.1719784758
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.589802331
MESH:D009765 Obesity pirinixic acid 1.7220558911
MESH:D010014 Osteolysis Paclitaxel 4.6015867366
MESH:D010051 Ovarian Neoplasms Estradiol 10.2419401270
MESH:D010051 Ovarian Neoplasms Paclitaxel 10.2411161223
MESH:D010051 Ovarian Neoplasms Progesterone 10.2416525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 10.2417306315 15276417
MESH:D010190 Pancreatic Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 5.2112384795
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.2116929163 16500647 19003803 15113037
MESH:D010212 Papilloma Hydrogen Peroxide 3.7212065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8612520081
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.0015687053
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.5210923243
MESH:D011041 Poisoning Methyl Parathion 4.6917603234
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2018163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Daunorubicin 4.5621297632
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 14.1017132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.1011222880 11896295 11399792 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 14.1020603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5420887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0417292933
MESH:D011471 Prostatic Neoplasms Cadmium 2.0417075824
MESH:D011471 Prostatic Neoplasms Estradiol 2.0416740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0418626508 19082440
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.0417136230 17172428 16729912 16356831
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0416039940
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0415084515
MESH:D019310 Pseudolymphoma Valproic Acid 4.1511422049 12752131
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.8817365031 17322281 17975199 15814490
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6916160472 18286688 15538739 18722050
MESH:D015427 Reperfusion Injury pirinixic acid 2.2019058328
MESH:D012135 Respiratory Sounds Malathion 4.9011874814 17119214
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4718990726
MESH:D012140 Respiratory Tract Diseases Malathion 5.1417119214
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.8219155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7218045962
MESH:D012559 Schizophrenia Valproic Acid 2.0215737665 19110320
MESH:D012640 Seizures Valproic Acid 2.4911738929 1511512 16876388 15475178 14763951 17978042 3137016 11044598
MESH:D012871 Skin Diseases Vitamin E 2.3418709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 15.9319755658 10029692
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 15.9312065085
MESH:D012878 Skin Neoplasms sodium arsenite 15.9319524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 15.938532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 15.9316192470
MESH:D013119 Spinal Cord Injuries Progesterone 3.9015862959 16503802
MESH:D016135 Spinal Dysraphism sodium arsenite 8.5712854658
MESH:D016135 Spinal Dysraphism Valproic Acid 8.5719490988
MESH:D013226 Status Epilepticus Valproic Acid 4.1512833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.212093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 3.2117522103 17498489 18567086 15786421 18396642 17172411 16951190 19015929 19084572 16424979
MESH:D013274 Stomach Neoplasms Paclitaxel 3.2118506536 18396642
MESH:D020521 Stroke Vitamin E 3.2216517955
MESH:D024801 Tauopathies Daunorubicin 10.6516930453
MESH:D024801 Tauopathies Paclitaxel 10.6516930453
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5112697716
MESH:D013978 Tibial Fractures Estradiol 4.3019048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.6616280240
MESH:D014178 Translocation, Genetic Valproic Acid 4.8417262798
MESH:D014376 Tuberculosis Chenodeoxycholic Acid 4.8016040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.143119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.5317053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 4.5317306315 16452187 16712894 11723127
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.278888407
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.3916803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.3911813266
MESH:D014652 Vascular Diseases sodium arsenite 4.0417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8615886252
Pathway ID Pathway Name
KEGG:00980 Metabolism of xenobiotics by cytochrome P450
KEGG:00140 Steroid hormone biosynthesis
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00157 - NADH Dietary supplement;Micronutrient
DB01586 agonist Ursodeoxycholic acid Cholagogues and Choleretics
DB03461 - 2'-Monophosphoadenosine 5'-Diphosphoribose
DB04184 - Acetate Ion Indicators and Reagents
DB07768 - (10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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