AutismKB 2.0

Annotation Detail for DDT


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Basic Information Top
Gene Symbol:DDT ( DDCT )
Gene Full Name: D-dopachrome tautomerase
Band: 22q11.23
Quick LinksEntrez ID:1652; OMIM: 602750; Uniprot ID:DOPD_HUMAN; ENSEMBL ID: ENSG00000099977; HGNC ID: 2732
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of DDT mRNA]affects expression|affects reaction 19414516
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of DDT mRNA]affects expression|affects reaction 19414516
D000242 Cyclic AMP 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of DDT mRNA]affects expression|affects reaction 19414516
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of DDT proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DDT mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of DDT mRNAdecreases expression 20106945
C032036 bromobenzene bromobenzene metabolite binds to DDT proteinaffects binding 17305373
D003345 Corticosterone Corticosterone results in increased expression of DDT mRNAincreases expression 15755911
D016572 Cyclosporine Cyclosporine results in decreased expression of DDT mRNAdecreases expression 20106945
D005419 Flavonoids Flavonoids results in decreased expression of DDT mRNAdecreases expression 18035473
C056933 fumonisin B1 fumonisin B1 results in decreased expression of DDT mRNAdecreases expression 16221962
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of DDT mRNAaffects cotreatment|increases expression 17183730
C029424 hydrazine hydrazine results in decreased expression of DDT proteindecreases expression 15370871
C006253 pirinixic acid pirinixic acid results in increased expression of DDT mRNAincreases expression 16221962
18301758
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of DDT mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.578875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9819490988
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0020127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.686695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.5616434500
MESH:D000550 Amblyopia Valproic Acid 5.3317688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.6217497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1519183758
MESH:D001321 Autistic Disorder Valproic Acid 2.0017688650 17507914 18177632 18985861 18775368 15238991 17157402 18558336 18396377 20603192 16609825 19232924 18940202 19460635 18316065
MESH:D001714 Bipolar Disorder Valproic Acid 3.1017594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2019483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.438888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0320146248 17474063
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 1.9612907637 21507988 12619106
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0620419170
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.5612371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7220734317
MESH:D002779 Cholestasis Cyclosporine 7.8919486331
MESH:D002779 Cholestasis pirinixic acid 7.8919176532
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.898888407 17688650 16575769
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D056486 Drug-Induced Liver Injury bromobenzene 6.6310092053 12628495
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 6.6316221962
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.6319641884 1733752
MESH:D004421 Dystonia Valproic Acid 4.111851702
MESH:D004487 Edema pirinixic acid 2.5312083418
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.233659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.0116628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9620417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.636254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.377750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.153659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0216530937
MESH:D005234 Fatty Liver Cyclosporine 13.3919224547
MESH:D005234 Fatty Liver pirinixic acid 13.3920131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 13.3919224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 4.9816575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.1918558336 8888407
MESH:D005355 Fibrosis Cyclosporine 3.2112168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6820471113
MESH:D006333 Heart Failure pirinixic acid 2.5720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006529 Hepatomegaly fumonisin B1 9.0116221962
MESH:D006529 Hepatomegaly pirinixic acid 9.0116221962 19176532 19772884 18467677
MESH:D006849 Hydrocephalus Valproic Acid 4.9517688650
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006973 Hypertension Cyclosporine 2.1210903974
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.7016612254
MESH:D007249 Inflammation Flavonoids 2.6717296493
MESH:D007333 Insulin Resistance pirinixic acid 2.6616306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007674 Kidney Diseases Cyclosporine 2.3718776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 2.7812371664
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1616294345 17596541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.5115890375 2125692 18177683 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.5120195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 7.5120007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.778603461
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.3617228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.4314755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4320135361 20064080 18569708 17053015 6695378 18520028 18816296 20869020 20464547
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 3.6612807724
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D008881 Migraine Disorders Valproic Acid 3.2318765137 18803445
MESH:D020326 Migraine without Aura Cyclic AMP 5.2211304026
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2316381670
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.088888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.1817596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9916411023
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9011141357
MESH:D009369 Neoplasms pirinixic acid 4.9017405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3319348381 18481113
MESH:D009436 Neural Tube Defects Valproic Acid 3.1616359493 8888407
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D011230 Precancerous Conditions Cyclosporine 3.2712371664
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 3.9120603192
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9617292933
MESH:D019310 Pseudolymphoma Valproic Acid 4.6412752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2319155313
MESH:D012559 Schizophrenia Valproic Acid 2.0715737665 19110320
MESH:D012640 Seizures Valproic Acid 2.7711738929 11044598 15475178 3137016 17978042 1511512 16876388 14763951
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.3910029692 19755658
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8219490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6412833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D014178 Translocation, Genetic Valproic Acid 5.3317262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.603119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2017053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.718888407
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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