AutismKB 2.0

Annotation Detail for DDX3X


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Basic Information Top
Gene Symbol:DDX3X ( DBX,DDX14,DDX3,HLP2 )
Gene Full Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked
Band: Xp11.4
Quick LinksEntrez ID:1654; OMIM: 300160; Uniprot ID:DDX3X_HUMAN; ENSEMBL ID: ENSG00000215301; HGNC ID: 2745
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04622RIG-I-like receptor signaling pathway
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of DDX3X mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of DDX3X mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of DDX3X mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DDX3X mRNAdecreases expression 19150397
D004958 Estradiol Estradiol affects the expression of DDX3X mRNAaffects expression 15598610
D019800 Phenol Phenol results in decreased expression of DDX3X mRNAdecreases expression 17547211
D018038 Sodium Selenite Sodium Selenite results in increased expression of DDX3X mRNAincreases expression 18175754
C025643 vinclozolin vinclozolin affects the expression of DDX3X mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4520464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 4.4511473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.786695378
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001008 Anxiety Disorders vinclozolin 3.8319015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001859 Bone Neoplasms Phenol 5.4710556009
MESH:D001913 Bowen's Disease Phenol 6.1319293009
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0320146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 2.0317289903 19861407 12948864 17261762 18497071 16675129 14630087 17018787
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8016111702
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.693084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.6916924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 12.116135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.1120889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 12.1118566989
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0615894690
MESH:D003456 Cryptorchidism vinclozolin 4.6214966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3218551238
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9916285004
MESH:D003928 Diabetic Nephropathies Estradiol 3.6319279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.5721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5718713872 11287661 10663392 12958197 12153990 16081117 17906064 12392966 19164858 16485898 19923254 16781746 10774834 19739265 15619225 10915739 14550746 15968718 2444490 19416960 11739529 17562736 11743745 16393943 19420014 12705907 11529661 11461765 12540782 14725611 12594235 19370779 18071297 11834606 16227642 16109766 16177239 14986274 11421492 17522070 19085960
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.5715131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D016889 Endometrial Neoplasms Estradiol 3.1318566989 11473722 19148513
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5216530937
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6816417039
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7720471113
MESH:D006558 Herpes Genitalis Estradiol 5.4115709030
MESH:D019584 Hot Flashes Estradiol 4.1317088409
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D007248 Infertility, Male vinclozolin 3.1916467254
MESH:D007333 Insulin Resistance Estradiol 7.9316393666 16627594
MESH:D007333 Insulin Resistance Sodium Selenite 7.9314714311
MESH:D055623 Keratosis, Actinic Phenol 6.8219293009
MESH:D007674 Kidney Diseases Acetaminophen 6.3112587719 15629191
MESH:D007674 Kidney Diseases Estradiol 6.3115618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.0416705839
MESH:D007680 Kidney Neoplasms Estradiol 8.0415610895
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0716417039
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814659978 14716833
MESH:D008107 Liver Diseases Acetaminophen 1.6719014921 11587558 12969438 16611625 19460945 12587719 16610002 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.757678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.7521137059 20195826
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.682876784 2876786 6135515
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.566695378 17053015 20135361 18520028 20869020 18569708 20064080 18816296 20464547
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.3214737004
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7016891317 11807958 17203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.8619453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4616810080
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.207678174 18551238
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2711141357
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0717289903
MESH:D009421 Nervous System Malformations Estradiol 3.9316427766 11399458
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.6616049721
MESH:D010051 Ovarian Neoplasms Estradiol 2.2819401270
MESH:D010146 Pain Acetaminophen 7.7416870215
MESH:D010146 Pain Phenol 7.7417610455
MESH:D010392 Pemphigus Phenol 6.8217163923 16522979
MESH:D010864 Pilonidal Sinus Phenol 6.8215622588 19655223
MESH:D011041 Poisoning Phenol 4.978825745
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.2318220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.2718220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1320887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.4917292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.4916740699
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.4918760546
MESH:D011472 Prostatitis vinclozolin 5.2718629315
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6918551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4619755658 10029692
MESH:D013088 Spermatocele Phenol 6.0218646496
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013978 Tibial Fractures Estradiol 5.0619048282
MESH:D014277 Trigeminal Neuralgia Phenol 6.8216527771 10223447
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2416049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2417053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6610091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014860 Warts Phenol 6.4719122958
Pathway ID Pathway Name
KEGG:04622 RIG-I-like receptor signaling pathway
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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