AutismKB 2.0

Annotation Detail for DDX5


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Basic Information Top
Gene Symbol:DDX5 ( DKFZp434E109,DKFZp686J01190,G17P1,HLR1,HUMP68,p68 )
Gene Full Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
Band: 17q23.3
Quick LinksEntrez ID:1655; OMIM: 180630; Uniprot ID:DDX5_HUMAN; ENSEMBL ID: ENSG00000108654; HGNC ID: 2746
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03040Spliceosome
No data
Pathway IDPathway Name
200101Direct p53 effectors
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
2053Colon cancer
Desease Name
Hepatitis C, Chronic
INFECTION
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of DDX5 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of DDX5 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of DDX5 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DDX5 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of DDX5 mRNAincreases expression 20127859
D004040 Dietary Carbohydrates Dietary Carbohydrates results in increased expression of DDX5 mRNAincreases expression 17490981
D007657 Ketone Bodies Ketone Bodies results in increased expression of DDX5 mRNAincreases expression 16807920
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to DDX5 protein]affects binding|increases reaction 17220478
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of DDX5 mRNAincreases expression 17616710
C017947 sodium arsenite sodium arsenite results in decreased expression of DDX5 mRNAdecreases expression 19072884
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220127859 20464547
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.913712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.916695378
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9615276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1717306315 16712894
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.2811289319 1440618
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0120146248 17474063
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7516705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.757296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.753084413
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.7516507464 17306315 15276417
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.757296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7420419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.7418572023
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.127505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.1219524636 20056578
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.279022650 19486331
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2318551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0111298694 12868966 8970840 8156756 2524372 18759878 14531868 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.673621924 2952479
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.4321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.439328219 8291058 6679447 9022650 18692083 18648102 1440618 6482804 16192314 7440962 9653073 18289764 11289319
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4310663392 11461765 12392966 14725611 12153990 17906064 19420014 11421492 11739529 12958197 11743745 16227642 17562736 19416960 12594235 16781746 19164858 16177239 16485898 11834606 15619225 16081117 18713872 19085960 2444490 16109766 19923254 15968718 16393943 12705907 12540782 18071297 10915739 10774834 19739265 14986274 11287661 19370779 14550746 17522070 11529661
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.513581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.5116530937
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 7.5115547721 15264214 16805852 15547733 15150132 15878914 16704527 15623463 16510608
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.9216452187
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7420471113
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.716705139
MESH:D006689 Hodgkin Disease sodium arsenite 3.3012676792
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D007248 Infertility, Male sodium arsenite 3.1012646999 15346721
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.288074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 6.2715629191 12587719
MESH:D007674 Kidney Diseases sodium arsenite 6.2720008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.8416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.846582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3015034207 9327722
MESH:D008107 Liver Diseases Acetaminophen 1.6619014921 11587558 19460945 16611625 12969438 12587719 19784758 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4017185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.7621137059 20195826
MESH:D008113 Liver Neoplasms sodium arsenite 4.7616712894 15276417
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.633712494 598648 6587162 1399818
MESH:D008171 Lung Diseases sodium arsenite 3.2819095001
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4720869020 18569708 18520028 18816296 6695378 20464547 20135361 20064080 17053015
MESH:D008175 Lung Neoplasms sodium arsenite 2.4716712894 17077188 17306315 15276417 19931552
MESH:D008545 Melanoma sodium arsenite 2.0519082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0918551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.533581430
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2811141357
MESH:D009369 Neoplasms sodium arsenite 5.2811559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8820056578
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.626679447
MESH:D009436 Neural Tube Defects sodium arsenite 7.6212854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.4316049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.436482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4817306315 15276417
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1517292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.1516039940
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.503692021
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6418551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.9619755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 5.9618572023 19524636
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9312854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.582093021 20155912
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.5812958204 17575124
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.016582329 7505956 1399818 3712494 6587162
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.4216049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 12.428074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.4217053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 12.4216712894 16452187 17306315 11723127
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5510091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9311813266
MESH:D014652 Vascular Diseases sodium arsenite 4.6617056641
Pathway ID Pathway Name
KEGG:03040 Spliceosome
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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