AutismKB 2.0

Annotation Detail for DMXL1


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Basic Information Top
Gene Symbol:DMXL1 ( DKFZp779O1239,FLJ44772 )
Gene Full Name: Dmx-like 1
Band: 5q23.1
Quick LinksEntrez ID:1657; OMIM: 605671; Uniprot ID:DMXL1_HUMAN; ENSEMBL ID: ENSG00000172869; HGNC ID: 2937
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of DMXL1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of DMXL1 mRNAaffects expression 17562736
C109238 acyline acyline results in increased expression of DMXL1 mRNAincreases expression 17510436
D001104 Arbutin Arbutin results in decreased expression of DMXL1 mRNAdecreases expression 17103032
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of DMXL1 mRNAdecreases expression 20106945
D003010 Clorgyline Clorgyline results in increased expression of DMXL1 mRNAincreases expression 19691856
C011890 kojic acid kojic acid results in decreased expression of DMXL1 mRNAdecreases expression 16595896
C006253 pirinixic acid pirinixic acid results in decreased expression of DMXL1 mRNAdecreases expression 18445702
C025643 vinclozolin vinclozolin affects the expression of DMXL1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001008 Anxiety Disorders vinclozolin 3.8019015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0120146248 17474063
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 2.9016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.903084413
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.906135515
MESH:D002779 Cholestasis pirinixic acid 2.9719176532
MESH:D003456 Cryptorchidism vinclozolin 4.5814966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.2818551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 3.8918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8912153990 14986274 19739265 16109766 14725611 11834606 12540782 11461765 10663392 16227642 16781746 18071297 11529661 19416960 19420014 17906064 16485898 17522070 11739529 11421492 2444490 11287661 19085960 16081117 15619225 12705907 18713872 10915739 16177239 12958197 12594235 19164858 10774834 19370779 16393943 17562736 12392966 15968718 14550746 19923254 11743745
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0516530937
MESH:D005234 Fatty Liver pirinixic acid 2.9720131406 19236843
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2216973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6216417039
MESH:D005910 Glioma marker/mechanism 16865689
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7520471113
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006529 Hepatomegaly pirinixic acid 3.2519176532 16221962 18467677 19772884
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D007248 Infertility, Male vinclozolin 3.1716467254
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3015629191 12587719
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.1516705839
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0216417039
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6719460945 12587719 19014921 11587558 12969438 16611625 19784758 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4317185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.777678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.7721137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 7.7720007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.592876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental kojic acid 6.5918544905
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5618816296 20464547 18569708 17053015 20869020 6695378 18520028 20135361 20064080
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.1518551238 7678174
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1311141357
MESH:D009369 Neoplasms pirinixic acid 5.1317405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.6216049721
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.1818042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.2218220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.5017292933
MESH:D011471 Prostatic Neoplasms Clorgyline 3.5019691856
MESH:D011472 Prostatitis vinclozolin 5.2218629315
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6718551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4510029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2116049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2117053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6010091137
MESH:D014581 Urticaria Acetaminophen 3.2010982225
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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