AutismKB 2.0

Annotation Detail for DHX9


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DHX9 ( DDX9,LKP,NDH2,NDHII,RHA )
Gene Full Name: DEAH (Asp-Glu-Ala-His) box polypeptide 9
Band: 1q25.3
Quick LinksEntrez ID:1660; OMIM: 603115; Uniprot ID:DHX9_HUMAN; ENSEMBL ID: ENSG00000135829; HGNC ID: 2750
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
mRNA Processing
Gene Expression
No data
No data
Pathway IDPathway Name
500866mRNA Splicing - Major Pathway
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2011Leukoencephalopathy
2151Neuroblastoma
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in decreased expression of DHX9 mRNAdecreases expression 16514628
D000082 Acetaminophen Acetaminophen affects the expression of DHX9 mRNAaffects expression 17562736
C103505 AM 251 AM 251 results in decreased expression of DHX9 mRNAdecreases expression 16500647
D001554 Benzene Benzene results in decreased expression of DHX9 mRNAdecreases expression 15120971
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DHX9 mRNAdecreases expression 20018196
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of DHX9 mRNAdecreases expression 15336504
D004958 Estradiol Estradiol results in increased expression of DHX9 mRNAincreases expression 16514628
C070081 fulvestrant fulvestrant results in decreased expression of DHX9 mRNAdecreases expression 16514628
C056507 gemcitabine gemcitabine results in decreased expression of DHX9 mRNAdecreases expression 17039268
D020849 Raloxifene Raloxifene results in decreased expression of DHX9 mRNAdecreases expression 16514628
D043343 Testosterone Propionate Testosterone Propionate results in decreased expression of DHX9 mRNAdecreases expression 15601916
D014810 Vitamin E Vitamin E results in decreased expression of DHX9 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Estradiol 2.1211473722
MESH:D000419 Albuminuria Raloxifene 4.7217451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.5615800139
MESH:D000741 Anemia, Aplastic Benzene 4.4511369114 17661222 14761424
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001284 Atrophy fulvestrant 4.9711514358
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001855 Bone Marrow Diseases Benzene 5.4016183116
MESH:D001930 Brain Injuries Raloxifene 4.6116580743
MESH:D001943 Breast Neoplasms Benzene 2.4217162533 11921183
MESH:D001943 Breast Neoplasms Estradiol 2.4212948864 16675129 17018787 17261762 18497071 14630087 19861407 17289903
MESH:D001943 Breast Neoplasms fulvestrant 2.4218984771
MESH:D001943 Breast Neoplasms gemcitabine 2.4218382427 17039268
MESH:D001943 Breast Neoplasms Raloxifene 2.4217440819 17893378 15572757 15758505 15775269 16912660 17242785 16837676 17049068 17595753 17261762 17952589
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6216111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0716050911
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.863084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 2.8616924424
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.1717572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5215775269
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.8920889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.8918566989
MESH:D003072 Cognition Disorders Raloxifene 4.7615800139
MESH:D019465 Craniofacial Abnormalities Benzene 2.9515643154
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.9519769572
MESH:D003865 Depressive Disorder, Major Raloxifene 4.2617474826
MESH:D003872 Dermatitis Benzene 4.9015902427
MESH:D003928 Diabetic Nephropathies Estradiol 9.3419279558
MESH:D003928 Diabetic Nephropathies Raloxifene 9.3415920148 17451421 17308373
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6111287661 19164858 14986274 19420014 16109766 2444490 16081117 19370779 11461765 12392966 18071297 11739529 16227642 11743745 11834606 14550746 17906064 18713872 19416960 10774834 10915739 19923254 11421492 19085960 17522070 15619225 12958197 16393943 12705907 12594235 12540782 15968718 14725611 17562736 10663392 16177239 12153990 16485898 11529661 19739265 16781746
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:C538011 Eales disease Vitamin E 4.889068938
MESH:D004487 Edema Raloxifene 3.4415860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 4.1215845917
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 8.0219148513
MESH:D016889 Endometrial Neoplasms Estradiol 8.0211473722 19148513 18566989
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1020426865
MESH:D005234 Fatty Liver Raloxifene 3.7317473493
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0416080930
MESH:D006331 Heart Diseases Raloxifene 3.6111110106
MESH:D006402 Hematologic Diseases Benzene 4.7716183116
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 5.2115709030
MESH:D019584 Hot Flashes Estradiol 10.6417088409
MESH:D019584 Hot Flashes Vitamin E 10.6414716179
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006973 Hypertension Benzene 5.7917940673
MESH:D006973 Hypertension Raloxifene 5.7917577099 15787275
MESH:D007248 Infertility, Male fulvestrant 3.8211514358
MESH:D007251 Influenza, Human Vitamin E 4.3916624496
MESH:D007333 Insulin Resistance Estradiol 3.0316627594 16393666
MESH:D007674 Kidney Diseases Acetaminophen 10.3915629191 12587719
MESH:D007674 Kidney Diseases Estradiol 10.3915618244
MESH:D007674 Kidney Diseases Vitamin E 10.3912488133
MESH:D007680 Kidney Neoplasms Estradiol 3.0715610895
MESH:D007889 Leiomyoma Raloxifene 4.6116973256
MESH:D007938 Leukemia Benzene 3.4417119257 18335105 15935818 14694614
MESH:D007951 Leukemia, Myeloid Benzene 4.4317506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.7119478238
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.5316169303
MESH:D008107 Liver Diseases Acetaminophen 1.6512969438 16610002 19784758 16611625 19014921 12587719 19460945 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3417185352 16871587
MESH:D008114 Liver Neoplasms, Experimental Benzene 3.3512562636
MESH:D008171 Lung Diseases Vitamin E 3.2516863852
MESH:D017563 Lung Diseases, Interstitial Benzene 4.9814698565
MESH:D008175 Lung Neoplasms Benzene 2.7712562636
MESH:D008175 Lung Neoplasms Vitamin E 2.7711062179
MESH:D008223 Lymphoma Benzene 3.8117584886 17119257
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.6012562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 6.4511921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.4511807958 17203775 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.6619453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.7315863610
MESH:D009101 Multiple Myeloma Benzene 7.8817119195
MESH:D009101 Multiple Myeloma Raloxifene 7.8816497877
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3616810080
MESH:D009232 Myxoma Raloxifene 5.7316343187
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8917289903
MESH:D009421 Nervous System Malformations Estradiol 3.7811399458 16427766
MESH:D009436 Neural Tube Defects Benzene 3.7415643154
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D009784 Occupational Diseases Benzene 4.2817479406 15612468 17119257 15913788 17178637 15576619 15727169 16737584 15935809
MESH:D010024 Osteoporosis Raloxifene 3.4619059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.3417823083 15758505 15579764 17893378
MESH:D010051 Ovarian Neoplasms Benzene 5.1412562636
MESH:D010051 Ovarian Neoplasms Estradiol 5.1419401270
MESH:D010146 Pain Acetaminophen 7.4016870215
MESH:D010146 Pain AM 251 7.4018987195
MESH:D010190 Pancreatic Neoplasms AM 251 6.2916500647
MESH:D010190 Pancreatic Neoplasms gemcitabine 6.2917440100 11504793 16929163 18992248 18383843
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9920887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.5916740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.5916220300 15731164 16536755
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5915084515
MESH:D011693 Purpura Raloxifene 5.7315770314
MESH:D012871 Skin Diseases Vitamin E 2.4618709164
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.748532709
MESH:D013274 Stomach Neoplasms Benzene 2.4212562636
MESH:D020521 Stroke Raloxifene 9.0116837676
MESH:D020521 Stroke Vitamin E 9.0116517955
MESH:D013953 Thymus Neoplasms Benzene 5.1110850423
MESH:D013978 Tibial Fractures Estradiol 14.3019048282
MESH:D013978 Tibial Fractures Raloxifene 14.3019048282
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 2.8517572228
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014594 Uterine Neoplasms Benzene 4.4612562636
MESH:D054556 Venous Thromboembolism Raloxifene 5.3816837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.7316343187
Pathway ID Pathway Name
REACT:71 Gene Expression
REACT:1675 mRNA Processing
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved