AutismKB 2.0

Annotation Detail for PRICKLE2


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Basic Information Top
Gene Symbol:PRICKLE2 ( DKFZp686D143,DKFZp686H1748,DKFZp686M031 )
Gene Full Name: prickle homolog 2 (Drosophila)
Band: 3p14.1
Quick LinksEntrez ID:166336; OMIM: 608501; Uniprot ID:PRIC2_HUMAN; ENSEMBL ID: ENSG00000163637; HGNC ID: 20340
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04310Wnt signaling pathway
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
METABOLIC
folate pathway vitamin levels
Desease Name
Folate pathway vitamin levels
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016572 Cyclosporine Cyclosporine results in decreased expression of PRICKLE2 mRNAdecreases expression 20106945
D002117 Calcitriol Calcitriol results in decreased expression of PRICKLE2 mRNAdecreases expression 16002434
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of PRICKLE2 mRNAdecreases expression 20713471
D010634 Phenobarbital Phenobarbital affects the methylation of PRICKLE2 promoteraffects methylation 19482888
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 4.076195326
MESH:D000236 Adenoma Methylcholanthrene 3.706695378 10545420
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.6017620307
MESH:D050197 Atherosclerosis Methylcholanthrene 3.6611922910
MESH:D001943 Breast Neoplasms Calcitriol 2.5011237771
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.5017474063
MESH:D002277 Carcinoma Methylcholanthrene 4.2910545420
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 1.9520007298 1701930 17173139 20935162 6705139
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.7111237771
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.7312371664
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 7.7316192471
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.814080065
MESH:D002779 Cholestasis Cyclosporine 3.2119486331
MESH:D004421 Dystonia Phenobarbital 4.471851702
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.4415138306
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.673659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.593922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0620417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.916401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.817750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.653659116
MESH:D005234 Fatty Liver Cyclosporine 3.2819224547
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.5714633661 10962813
MESH:D005355 Fibrosis Cyclosporine 3.7012639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.858708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.0515720958
MESH:D006529 Hepatomegaly Phenobarbital 4.0416109766
MESH:D006973 Hypertension Cyclosporine 2.2110903974
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.1615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.5418776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0812371664
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0821047994
MESH:D008107 Liver Diseases Phenobarbital 2.2419363144
MESH:D008113 Liver Neoplasms Phenobarbital 2.4215975961 19812893 8742319 21047994 19482888 19073162
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 6.991399818 598648
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.9918308698 17172636 6150874 1399818 2563599
MESH:D008175 Lung Neoplasms Methylcholanthrene 2.4115390079 16271038 7750092 20512841 16337739 10545420 20970405 11893704 1399818 17909032 9230183 6695378 21163286
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.5116801185
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.1117484760
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.1617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6518481113 19348381
MESH:D010018 Osteomalacia Phenobarbital 5.0017016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.6016965848
MESH:D011230 Precancerous Conditions Cyclosporine 10.2212371664
MESH:D011230 Precancerous Conditions Phenobarbital 10.222563599
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.4115572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.4816644109 16289102 15754350 12479363 18247401
MESH:D019310 Pseudolymphoma Phenobarbital 5.2212752131
MESH:D011565 Psoriasis Cyclosporine 2.3316882103
MESH:D012640 Seizures Phenobarbital 2.953137016 11442880 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.456407741
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.361399818
MESH:D014605 Uveitis Cyclosporine 4.711336536
MESH:D014985 Xerophthalmia Cyclosporine 5.1617120751
Pathway ID Pathway Name
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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