AutismKB 2.0

Annotation Detail for SPATA5


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Basic Information Top
Gene Symbol:SPATA5 ( AFG2,SPAF )
Gene Full Name: spermatogenesis associated 5
Band: 4q28.1
Quick LinksEntrez ID:166378; OMIM: NA; Uniprot ID:SPAT5_HUMAN; ENSEMBL ID: ENSG00000145375; HGNC ID: 18119
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SPATA5 mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SPATA5 mRNAdecreases expression 20018196
20382639
D004041 Dietary Fats Dietary Fats results in increased expression of SPATA5 mRNAincreases expression 18503570
D014212 Tretinoin Tretinoin results in decreased expression of SPATA5 mRNAdecreases expression 16604517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0620127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.866695378
MESH:D000505 Alopecia Tretinoin 3.9415955085
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.6419183758
MESH:D001161 Arteriosclerosis Dietary Fats 4.4515238619
MESH:D001169 Arthritis, Experimental Tretinoin 3.3016412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3316292516
MESH:D001249 Asthma Tretinoin 2.4316456186
MESH:D001471 Barrett Esophagus Tretinoin 4.9116935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 4.0316197459 16206674
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8817474063 20146248
MESH:D001943 Breast Neoplasms Dietary Fats 1.8820435547
MESH:D001943 Breast Neoplasms Tretinoin 1.8816166294 16873071 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.2216813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.8816168501
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 1.921917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8720419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.8716096774 16051514
MESH:D002386 Cataract Tretinoin 3.3017460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9820889678
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.2216129372
MESH:D002822 Choriocarcinoma Tretinoin 5.8816461808
MESH:D002972 Cleft Palate Tretinoin 2.809407595
MESH:D003092 Colitis Tretinoin 4.2617035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8310589399 9125849 17551590 9224671 8800419 9664655 16925845 9211117 9142499 14991402
MESH:D050171 Dyslipidemias Dietary Fats 3.7318367378
MESH:D004489 Edema, Cardiac Tretinoin 5.1918230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3516569247
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.6220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.6216530937
MESH:D005124 Eye Abnormalities Tretinoin 3.8716938888 9664655
MESH:D005234 Fatty Liver Dietary Fats 3.6619551842 17967931 19004024 18296743
MESH:D005355 Fibrosis Dietary Fats 10.7618296743
MESH:D005355 Fibrosis Tretinoin 10.7617994277
MESH:D005909 Glioblastoma Tretinoin 3.2417312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.8816084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 7.2620471113
MESH:D006330 Heart Defects, Congenital Tretinoin 7.269664655 14991402
MESH:D006930 Hyperalgesia Tretinoin 3.5316870215
MESH:D006937 Hypercholesterolemia Dietary Fats 4.0221332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.1316778211
MESH:D006949 Hyperlipidemias Dietary Fats 4.0821332399
MESH:D007249 Inflammation Dietary Fats 2.6020412841
MESH:D007333 Insulin Resistance Dietary Fats 3.3418457598 11836018
MESH:D007410 Intestinal Diseases Tretinoin 4.3317994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.3317551590 15992940
MESH:D007938 Leukemia Tretinoin 2.9317143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.1216932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1219850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3917368321 17301526 16823087 17649720 17712046 16891316 9834237 16788101 16331271 19075265 17294898 12679006 17339181 17506722 19642359 19225113 17361223 16935935 19035177 16140955 15748426 19029980 16766008 17217047 17107899
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.589224671
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0718296743
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8118397230 16248980
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1521137059 20195826
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5718569708 17053015 18816296 6695378 18520028 20135361 20464547 20064080 20869020
MESH:D008527 Medulloblastoma Tretinoin 2.9117453147
MESH:D008545 Melanoma Tretinoin 1.9816752155
MESH:D008591 Meningomyelocele Tretinoin 4.9916940565
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5016381670
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2817596541
MESH:D009369 Neoplasms Benzo(a)pyrene 5.5611141357
MESH:D009369 Neoplasms Tretinoin 5.5616946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 4.289125849
MESH:D009436 Neural Tube Defects Tretinoin 3.299142499
MESH:D009765 Obesity Dietary Fats 2.3619632207 20518802 18457598 20132043 18674790 17217161 16723640 21332399 11836018
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4416936753
MESH:D010146 Pain Tretinoin 3.2416870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5715976015
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9117292933
MESH:D011507 Proteinuria Tretinoin 4.0716636307
MESH:D011625 Pterygium Tretinoin 5.4216723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.5616283617 16116481
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.2110029692 19755658
MESH:D012878 Skin Neoplasms Tretinoin 6.2116467112
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4220155912 2093021
MESH:D013274 Stomach Neoplasms Tretinoin 2.4217261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.3316026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.1816051514
MESH:D014376 Tuberculosis Tretinoin 3.4516040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.3017053015
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.0716129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.3316752155
MESH:D014820 Vitiligo Tretinoin 4.5616761959
MESH:D015430 Weight Gain Dietary Fats 4.1116723640
MESH:D009396 Wilms Tumor Tretinoin 4.3416287080
Pathway ID Pathway Name
KEGG:03008 Ribosome biogenesis in eukaryotes
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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