AutismKB 2.0

Annotation Detail for DHX15


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Basic Information Top
Gene Symbol:DHX15 ( DBP1,DDX15,HRH2,PRP43,PRPF43,PrPp43p )
Gene Full Name: DEAH (Asp-Glu-Ala-His) box polypeptide 15
Band: 4p15.2
Quick LinksEntrez ID:1665; OMIM: 603403; Uniprot ID:DHX15_HUMAN; ENSEMBL ID: ENSG00000109606; HGNC ID: 2738
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DHX15 mRNAdecreases expression 19150397
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of DHX15 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of DHX15 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of DHX15 mRNAdecreases expression 17108234
D005472 Fluorouracil Fluorouracil results in increased expression of DHX15 mRNAincreases expression 16584549
D007657 Ketone Bodies Ketone Bodies results in increased expression of DHX15 mRNAincreases expression 16807920
D008727 Methotrexate DHX15 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D011374 Progesterone Progesterone results in decreased expression of DHX15 mRNAdecreases expression 18037150
D013629 Tamoxifen Tamoxifen affects the expression of DHX15 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DHX15 mRNAincreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9214745880
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 9.7412039119
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.7415322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.5114692618
MESH:D000230 Adenocarcinoma Fluorouracil 4.5117638652
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000740 Anemia Fluorouracil 9.4516511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.4511748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.1417286800
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.7117868700
MESH:D001930 Brain Injuries Progesterone 4.5615665606 15845082 15380490
MESH:D001943 Breast Neoplasms Fluorouracil 2.4115136595 18357371 18608205 19217205 16557594 16595493 16110121
MESH:D001943 Breast Neoplasms Methotrexate 2.4116978400
MESH:D001943 Breast Neoplasms Progesterone 2.4117614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tamoxifen 2.4118815881 20065188 17049068 19289846 19189210 19410462 20390343 21152245 19487384 16273361 17893378 20859285 19288272 21138602 19221464 19200415 19189212 19059307 19011961 17242785 17261762 16873071 16202921 17440819 15668708 19066611 18855134 16818667 18425577 19244106 19115204 18997820 18351453 18821012 19103187 18984771 19084267 18629630 19142967 15565566 20005174 20544844 20135344 19155303 11161223
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.4120435547
MESH:D002276 Carcinoid Tumor Fluorouracil 5.0416051944
MESH:D002277 Carcinoma Fluorouracil 8.8317121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.8316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8119066611
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.2017045692 17971768 16332177 18930000 17088986 16799960
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.2016924424
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1118695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5517066447 16280240 18986760 16757204
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8820889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0515861022 17333356 17110522 17681005 11677210 16919318 16105132
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1915340226 12621046 8697196 16354765 15668235
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2615001691 16340194 18772588 17169374 17725105 17018589 16510598 17016597 17172411 17287894
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0016331619 18802399 15148649 20501625 16524972 17594712 18383874 18288408 17695437 15289873 16282729 14970324 17401013 18509181 18448328 17016601 16391804 17094418 17454858 16303861 18949393 17255274
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D019465 Craniofacial Abnormalities Methotrexate 2.819562676 12039119
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.8115322242 10048152 20055451
MESH:D003550 Cystic Fibrosis Methotrexate 4.4719747007
MESH:D007644 Darier Disease Fluorouracil 5.1316733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6719031437
MESH:D003882 Dermatomyositis Methotrexate 5.4120191521
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6919279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.8017187935
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 17.0312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 17.0317692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 17.0319031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1920544844 17893378 19155303 16202921
MESH:D004715 Endometriosis Progesterone 9.7016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.7010568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.6820426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.6816481741 15173087 16785472 16337965 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.5115345470
MESH:D005234 Fatty Liver Tamoxifen 8.5119224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5219069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2520067830
MESH:D005910 Glioma Fluorouracil 2.9516145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006086 Graft vs Host Disease Methotrexate 5.4516518429
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5415162350 15102660 18337622
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4410048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2015340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4216959395 15340226 16354765 18606429 8697196
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.7115869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007249 Inflammation Progesterone 8.9715869954
MESH:D007249 Inflammation Tamoxifen 8.9719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.9712878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007680 Kidney Neoplasms Fluorouracil 8.1916985049
MESH:D007680 Kidney Neoplasms Tamoxifen 8.1918625569
MESH:D007805 Language Development Disorders Methotrexate 5.369562676
MESH:D008064 Lipidoses Tamoxifen 3.3217567588 15342952
MESH:D008103 Liver Cirrhosis Methotrexate 3.8214986274
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3412878042
MESH:D008113 Liver Neoplasms Fluorouracil 7.8816603448 17045692 15113037 18383874
MESH:D008113 Liver Neoplasms Tamoxifen 7.8816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.8816984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2412151625
MESH:D017563 Lung Diseases, Interstitial Methotrexate 5.4018516814
MESH:D008175 Lung Neoplasms Fluorouracil 3.5215246190
MESH:D008175 Lung Neoplasms Tamoxifen 3.5218625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5219555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.1315086387
MESH:D008223 Lymphoma Methotrexate 4.1217352296
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1019428831
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.5711408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.5719196723 19196722 14580682 16827153 11731420
MESH:D020149 Manganese Poisoning Tamoxifen 4.9219453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5215990972
MESH:D009062 Mouth Neoplasms Fluorouracil 3.8116757204 18986760
MESH:D052016 Mucositis Methotrexate 5.6217488658
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5819410462
MESH:D009369 Neoplasms Fluorouracil 2.7116928823 18600527 18239605
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3819196722 19189210 19200415
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5916436463
MESH:D010051 Ovarian Neoplasms Progesterone 2.5816525653 17393432
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7316500647 16929163 15113037 19003803
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311118676 11222880 11896295 11399792
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.2418626508 19082440
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2415067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.6515861022 16919318
MESH:D011565 Psoriasis Methotrexate 3.5017410198
MESH:D012004 Rectal Neoplasms Fluorouracil 4.2316160472 15538739 18722050 18286688
MESH:D051437 Renal Insufficiency Methotrexate 5.0217352296
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9218045962
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.8516709447
MESH:D013088 Spermatocele Tamoxifen 12.8516709447
MESH:D013119 Spinal Cord Injuries Progesterone 12.0216503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 12.0219457130
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0018567086 16424979 19015929 18396642 17522103 16951190 17498489 19084572 15786421 17172411
MESH:D013576 Syndactyly Methotrexate 5.329562676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D014062 Tongue Neoplasms Fluorouracil 4.2216280240
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.438653321 16712894 17572228
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.1116803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
Pathway ID Pathway Name
KEGG:03040 Spliceosome
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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