AutismKB 2.0

Annotation Detail for DECR1


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Basic Information Top
Gene Symbol:DECR1 ( DECR,NADPH,SDR18C1 )
Gene Full Name: 2,4-dienoyl CoA reductase 1, mitochondrial
Band: 8q21.3
Quick LinksEntrez ID:1666; OMIM: 222745; Uniprot ID:DECR_HUMAN; ENSEMBL ID: ENSG00000104325; HGNC ID: 2753
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
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Related Diseases/Disorders Top
No data
Desease IDDesease Name
1959Granulomatous disease
No data
No data
Desease Name
DECR deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of DECR1 mRNAdecreases expression 18281256
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of DECR1 mRNA]decreases expression|increases reaction 18281256
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of DECR1 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of DECR1 mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone affects the expression of DECR1 mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DECR1 mRNAaffects expression 16483693
D001553 Benzbromarone Benzbromarone affects the expression of DECR1 mRNAaffects expression 19483382
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of DECR1 mRNAaffects expression 15963342
D002994 Clofibrate Clofibrate affects the expression of DECR1 mRNAaffects expression 19483382
18246545
D002994 Clofibrate Clofibrate results in increased expression of DECR1 mRNAincreases expression 18246545
D016572 Cyclosporine Cyclosporine results in decreased expression of DECR1 mRNAdecreases expression 20106945
D003907 Dexamethasone Dexamethasone results in increased expression of DECR1 mRNAincreases expression 16962226
D004041 Dietary Fats Dietary Fats results in increased expression of DECR1 mRNAincreases expression 15238619
16357043
18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of DECR1 mRNAaffects expression 17555576
D005001 Ethionine Ethionine affects the expression of DECR1 mRNAaffects expression 19483382
D011345 Fenofibrate Fenofibrate results in increased expression of DECR1 mRNAincreases expression 11798191
D005978 Glutathione Glutathione deficiency results in increased expression of DECR1 mRNAincreases expression 15345336
C008281 limonene limonene results in increased expression of DECR1 mRNAincreases expression 12815608
D008701 Methapyrilene Methapyrilene results in decreased expression of DECR1 mRNAdecreases expression 16393664
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of DECR1 mRNAdecreases expression 17616710
D009853 Omeprazole Omeprazole affects the expression of DECR1 mRNAaffects expression 19483382
C041786 palm oil palm oil results in increased expression of DECR1 mRNAincreases expression 18042831
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of DECR1 mRNAincreases expression 17560707
C023036 perfluorooctanoic acid perfluorooctanoic acid affects the expression of DECR1 mRNAaffects expression 18281256
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of DECR1 mRNAincreases expression 16221955
D010795 Phthalic Acids Phthalic Acids results in decreased expression of DECR1 mRNAdecreases expression 15728792
D010852 Picrotoxin Picrotoxin results in decreased expression of DECR1 mRNAdecreases expression 15170462
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DECR1 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of DECR1 mRNAincreases expression 11798191
17426115
16357043
18301758
C006253 pirinixic acid pirinixic acid affects the expression of DECR1 mRNAaffects expression 19483382
C006253 pirinixic acid pirinixic acid results in increased expression of DECR1 mRNAincreases expression 16940010
D011441 Propylthiouracil Propylthiouracil affects the expression of DECR1 mRNAaffects expression 19483382
D013311 Streptozocin Streptozocin results in increased expression of DECR1 mRNAincreases expression 16684804
D013311 Streptozocin vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of DECR1 mRNA]decreases reaction|increases expression 16684804
D013853 Thioacetamide Thioacetamide affects the expression of DECR1 mRNAaffects expression 19483382
D014303 Trinitrotoluene Trinitrotoluene affects the expression of DECR1 mRNAaffects expression 21346803
C034028 vanadyl sulfate vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of DECR1 mRNA]decreases reaction|increases expression 16684804
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 3.937525203
MESH:D000138 Acidosis Ammonium Chloride 3.3018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6817505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.8818653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.7514692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.603712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.2216434500
MESH:D000799 Angioedema Acetaminophen 3.5810982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.5818218290 18057881 20041841
MESH:D001161 Arteriosclerosis Dietary Fats 9.0515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.0511256880
MESH:D001169 Arthritis, Experimental Dexamethasone 6.8417659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.8415885639
MESH:D001281 Atrial Fibrillation Amiodarone 3.7118651412 19698954
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.1920106747
MESH:D001321 Autistic Disorder Acetaminophen 2.2218445737
MESH:D001321 Autistic Disorder Glutathione 2.2218929414 19056591 19267885 16917939
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.751440618 11289319
MESH:D001778 Blood Coagulation Disorders Amiodarone 46.4819483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 46.4819483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 46.4819483382
MESH:D001778 Blood Coagulation Disorders Ethionine 46.4819483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 46.4819483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 46.4819483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 46.4819483382
MESH:D001778 Blood Coagulation Disorders Thioacetamide 46.4819483382
MESH:D001943 Breast Neoplasms Dietary Fats 2.3420435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.523786805 16011737 16227642 16050911 15673190 16124888 10355542 18705752 15700767 16192424 15721981 16097048
MESH:D002276 Carcinoid Tumor Streptozocin 5.3316051944
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.403581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.403084413
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 8.401701930
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.4018788625
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 8.4017997003
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.557296757
MESH:D002294 Carcinoma, Squamous Cell Glutathione 3.3017015178
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8015710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.8218974383
MESH:D002386 Cataract Acetaminophen 7.0010977129
MESH:D002386 Cataract Trinitrotoluene 7.0014694615 15817613
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 10.217505956
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 10.211399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.2112371664
MESH:D002637 Chest Pain Omeprazole 4.8415447763
MESH:D018281 Cholangiocarcinoma Thioacetamide 4.0718291259
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 17.639022650 19486331
MESH:D002779 Cholestasis Cyclosporine 17.6319486331
MESH:D002779 Cholestasis Ethinyl Estradiol 17.6315861022 17681005 17110522 11677210 17333356 16105132 16919318
MESH:D002779 Cholestasis pirinixic acid 17.6319176532
MESH:D003110 Colonic Neoplasms Dexamethasone 2.4515824018
MESH:D000013 Congenital Abnormalities Trinitrotoluene 4.1815095906
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.2717728286
MESH:D003490 Cyanosis Trinitrotoluene 4.6618551238
MESH:D003550 Cystic Fibrosis Glutathione 4.2619747007
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 6.208970840 11906362 11298694 8156756 2524372 14531868 12868966 18759878
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 6.2012438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3018249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.252952479 3621924
MESH:D003920 Diabetes Mellitus Streptozocin 4.5116285004
MESH:D003921 Diabetes Mellitus, Experimental Streptozocin 8.3516684804 2177838 19298542 15862027 12644472 12446591 19960420 18603373 6379147 19496084 17442507 16286809 11260395 7637645 17874149 15831366 19586609 18715473 1374869 8740154 12083368 11055810 15298345 12093613
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 8.3516684804
MESH:D003922 Diabetes Mellitus, Type 1 Streptozocin 3.5518603373
MESH:D003924 Diabetes Mellitus, Type 2 Streptozocin 3.3019586609 19647726
MESH:D058065 Diabetic Cardiomyopathies Streptozocin 5.4616025228
MESH:D003928 Diabetic Nephropathies Streptozocin 4.4519960420 19682444
MESH:D003930 Diabetic Retinopathy Streptozocin 5.1717662242
MESH:D003967 Diarrhea Dexamethasone 3.457237001
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 14.209653073 18692083 18289764 16192314 7440962 8291058 9022650 6679447 18648102 11289319 6482804 1440618 9328219
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 14.2019370779 19739265 17562736 16781746 16485898 11421492 16177239 17522070 19164858 16227642 16393943 11529661 12594235 14550746 16081117 11834606 19085960 16109766 15968718 18071297 11743745 10663392 19923254 14725611 12392966 17906064 15619225 19416960 10774834 12958197 12153990 10915739 19420014 11461765 18713872 11287661 2444490 14986274 12540782 12705907 11739529
MESH:D056486 Drug-Induced Liver Injury Amiodarone 14.2018218290 15265979
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 14.207120509 10092053 21278145 3786805 7440962 11566570 9327722 15027814 15968718 6623471 19085960 15998439 17522070 19336974 3732212 6884620 16177239 7179309 4309450 2869522 10915739 16227642
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 14.2012963478
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 14.2021346803 18551238
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8319426721
MESH:D004381 Duodenal Ulcer Omeprazole 4.0816613094 15991576 17151854 21218061
MESH:D050171 Dyslipidemias Clofibrate 13.5716707586
MESH:D050171 Dyslipidemias Dietary Fats 13.5718367378
MESH:D050171 Dyslipidemias Fenofibrate 13.5716707586
MESH:D004485 Eczema Dexamethasone 4.2112438553
MESH:D004487 Edema Dexamethasone 10.2519703484
MESH:D004487 Edema perfluorooctanoic acid 10.2517259670 12083418
MESH:D004487 Edema pirinixic acid 10.2512083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9412538720
MESH:D016889 Endometrial Neoplasms Fenofibrate 3.9216569247
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.413581430
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.4115623463 15547733 16510608 15878914 16704527 15150132 15547721 16805852 15264214
MESH:D005218 Fat Necrosis Thioacetamide 5.4516456712
MESH:D005234 Fatty Liver Amiodarone 33.3514986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 33.3516239168 12795759 19224547 15959796 17595544 12631006 61145 16045604
MESH:D005234 Fatty Liver Clofibrate 33.3519224547
MESH:D005234 Fatty Liver Cyclosporine 33.3519224547
MESH:D005234 Fatty Liver Dietary Fats 33.3517967931 19004024 19551842 18296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 33.3515345470
MESH:D005234 Fatty Liver pirinixic acid 33.3520131406 19236843
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.756705139
MESH:D005355 Fibrosis Carbon Tetrachloride 13.2918705752
MESH:D005355 Fibrosis Cyclosporine 13.2912639820 12168785
MESH:D005355 Fibrosis Dietary Fats 13.2918296743
MESH:D005756 Gastritis Acetaminophen 3.4116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.958708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.797505956
MESH:D006331 Heart Diseases Streptozocin 4.1012093613
MESH:D006333 Heart Failure pirinixic acid 2.3820558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1615720958
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.3417276928 18665440 15929193
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 14.276705139
MESH:D006505 Hepatitis Carbon Tetrachloride 14.2719110552 19900420
MESH:D006505 Hepatitis Thioacetamide 14.2716456712
MESH:D006529 Hepatomegaly 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 24.4316109766
MESH:D006529 Hepatomegaly Amiodarone 24.4315265979
MESH:D006529 Hepatomegaly perfluorooctanoic acid 24.433609246
MESH:D006529 Hepatomegaly pirinixic acid 24.4316221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Trinitrotoluene 24.4315817613
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.987520565
MESH:D006930 Hyperalgesia Acetaminophen 7.1816870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 7.1812083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2716899240
MESH:D006937 Hypercholesterolemia Amiodarone 8.389751232 8137927
MESH:D006937 Hypercholesterolemia Dietary Fats 8.3821332399
MESH:D006943 Hyperglycemia pirinixic acid 2.9620558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.3721332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.6815034207
MESH:D006973 Hypertension Cyclosporine 4.9910903974
MESH:D006973 Hypertension Dexamethasone 4.9917042910
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8315338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5516945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 10.7518020914 17991464
MESH:D007037 Hypothyroidism Propylthiouracil 10.758137927 18031379
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.3217937319
MESH:D007248 Infertility, Male Trinitrotoluene 6.3212150543
MESH:D007249 Inflammation Dexamethasone 7.7111099482 8960868
MESH:D007249 Inflammation Dietary Fats 7.7120412841
MESH:D007249 Inflammation perfluorooctanoic acid 7.7112083418
MESH:D007333 Insulin Resistance Dietary Fats 6.6818457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 6.6816306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.758074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1715604871
MESH:D007674 Kidney Diseases Acetaminophen 9.2715629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 9.2718776723 10903974 8314463
MESH:D007674 Kidney Diseases Streptozocin 9.2712093613
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 6.576582329
MESH:D007680 Kidney Neoplasms Cyclosporine 6.5712371664
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.8919248655
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.978812269
MESH:D008064 Lipidoses Amiodarone 3.3215342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.1511408273 17174718 16239168 17334410 16943688 16221502 11903743 21278145 17157831
MESH:D008103 Liver Cirrhosis Dietary Fats 6.1518296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.0315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.4018429990 16248980 16011737 18210741 12586293 18054572 15996030 15370692 16027843 15931870 18156304 14512876 18279442 18395914 17761835 17805973 15876570 18412020 12741479 15338365 18166357 18376398 18420326 17869086 17900296 17698563 10355542 17481882 15123356 18251166 17721639 17922224 12445421 16638106 16097048 12389079 17631135 16136751 18339082 17557913 16192424 18006644 18263696 18472094 18187930 12445418 18205269 12649538 12667390 14620537 12958196 12898905 15362042 12632514 13678700 15925388 12609069 15730626 15052691 12546737 18395095 17714472 15959796 15673190 15818738 20821823 18481824 14748882 12632512 17944888 16033810 16015684 17640975 18472332 17525996 11481614 14716833 18705752 18418968 15057751 17708605 17823541 17766677 17565644 17976157 15650968 18317297 14716496 18277467 15893842 12666154 16116963 14724832
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 6.4016718785
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 6.4015474484
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.4015474484
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 6.4016097051 11481614 15288472 12531686 12085344 15288473 16489207 15334695 12175628 15075984 18606216 11172339 15465738 15316131 17127702 15095483 18263696 18416461 18395095 15474484 17050028 18032466 12891558 16098781 15362042 15716488 17355460 15078482 18615449 18458672 12557150 18380797 16511523 16248980 17292413 17629604 10677585 18295389 14739098 11682029 16343077 18031379 12679928 15158331 16126171
MESH:D008107 Liver Diseases Acetaminophen 8.8819014921 12587719 12969438 11587558 19784758 16611625 19460945 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.8816246199 16964402 15720792 17285989 15830285
MESH:D008107 Liver Diseases limonene 8.881715830
MESH:D008107 Liver Diseases Thioacetamide 8.8818374380 15158337 16337175
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9115123358
MESH:D017114 Liver Failure, Acute Acetaminophen 14.9317185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 14.9316899240 14706259
MESH:D017114 Liver Failure, Acute Thioacetamide 14.9317276928 15313186 12479984 15633222
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 13.2019294768
MESH:D008113 Liver Neoplasms Fenofibrate 13.2018978307
MESH:D008113 Liver Neoplasms Methapyrilene 13.2015890375
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 13.2014757943 18709148
MESH:D008113 Liver Neoplasms pirinixic acid 13.2020007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.053712494 598648 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.0512014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 9.0518775883 18253720
MESH:D008133 Long QT Syndrome Amiodarone 3.3817391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.2012587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.2118516814
MESH:D008175 Lung Neoplasms Dexamethasone 2.2611195469 15824018
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3119513568
MESH:D008661 Metabolism, Inborn Errors marker/mechanism
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5216801185
MESH:D009101 Multiple Myeloma Dexamethasone 3.3215867202 15744524 16118317
MESH:D009135 Muscular Diseases pirinixic acid 3.2516239165
MESH:D009181 Mycoses Amiodarone 4.6312754197 17974566
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.399809623
MESH:D009203 Myocardial Infarction pirinixic acid 2.0319151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7516411023
MESH:D009336 Necrosis Trinitrotoluene 4.5018551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.363581430
MESH:D009369 Neoplasms pirinixic acid 1.8317405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0619348381 18481113
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.756679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6618514411
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 11.209802331
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 11.209802331
MESH:D009765 Obesity Dietary Fats 4.2018457598 21332399 11836018 17217161 20132043 19632207 20518802 18674790 16723640
MESH:D009765 Obesity pirinixic acid 4.2020558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.466482804 4026338
MESH:D009784 Occupational Diseases Trinitrotoluene 8.4614694615 12819281 17852074
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.753988306
MESH:D010146 Pain Acetaminophen 2.1916870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4411578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.237296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.206228378
MESH:D011230 Precancerous Conditions Cyclosporine 3.0012371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.4021297632
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 4.1317132714
MESH:D011537 Pruritus Ethinyl Estradiol 3.0516919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1416882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7511597910 12490602 12832656
MESH:D015427 Reperfusion Injury pirinixic acid 2.2619058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.7711700416 18379247
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.183692021
MESH:D012640 Seizures Picrotoxin 6.158635557 8954991
MESH:D012640 Seizures Trinitrotoluene 6.1518551238
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.8218724381
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6816709447
MESH:D013163 Splenomegaly Trinitrotoluene 4.9415817613
MESH:D013272 Stomach Diseases Dexamethasone 9.5615472012
MESH:D013272 Stomach Diseases Omeprazole 9.5618545984
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.3212958204 17575124
MESH:D013276 Stomach Ulcer Amiodarone 10.8418087811
MESH:D013276 Stomach Ulcer Dexamethasone 10.8415138204
MESH:D013276 Stomach Ulcer Omeprazole 10.8418237397 17977527 11906479 10750652 15991576 16755016
MESH:D013610 Tachycardia Amiodarone 4.0411238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.9419225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9315669648
MESH:D013959 Thyroid Diseases Amiodarone 4.4919731979
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.723712494 6582329 7505956 6587162 1399818
MESH:D013964 Thyroid Neoplasms Propylthiouracil 6.7215710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.6018020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 3.9317467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.188074119
MESH:D014581 Urticaria Acetaminophen 2.7410982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0514692618
MESH:D014605 Uveitis Cyclosporine 10.881336536
MESH:D014605 Uveitis Dexamethasone 10.881336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3015869587 14671159
MESH:D015430 Weight Gain Dietary Fats 3.5216723640
MESH:D014985 Xerophthalmia Cyclosporine 4.1717120751
Pathway ID Pathway Name
REACT:22258 Metabolism of lipids and lipoproteins
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB01907 - Nicotinamide-Adenine-Dinucleotide
DB03461 - 2'-Monophosphoadenosine 5'-Diphosphoribose
DB08604 - TRICLOSAN
DB08605 - 6-METHYL-2(PROPANE-1-SULFONYL)-2H-THIENO[3,2-D][1,2,3]DIAZABORININ-1-OL
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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