Annotation Detail for MMAA
Basic Information
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| Gene Symbol: | MMAA ( MGC120010,MGC120011,MGC120012,MGC120013,cblA ) |
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| Gene Full Name: | methylmalonic aciduria (cobalamin deficiency) cblA type |
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| Band: | 4q31.21 |
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| Quick Links | Entrez ID:166785; OMIM: 607481; Uniprot ID:MMAA_HUMAN; ENSEMBL ID: ENSG00000151611; HGNC ID: 18871 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Desease ID | Desease Name |
|---|
| H00174 | Methylmalonic aciduria |
| Inherited disorders of amino acid metabolism |
| Genetic disorders |
| Desease Name |
|---|
| Methylmalonic aciduria, vitamin B12-responsive |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| C023514 |
2,6-dinitrotoluene |
2,6-dinitrotoluene affects the expression of MMAA mRNA | affects expression | 21346803
|
| D000082 |
Acetaminophen |
Acetaminophen affects the expression of MMAA mRNA | affects expression | 17562736
|
| D014303 |
Trinitrotoluene |
Trinitrotoluene affects the expression of MMAA mRNA | affects expression | 21346803
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000014 |
Abnormalities, Drug-Induced |
|
Trinitrotoluene |
4.93 | 7525203 |
| MESH:D000799 |
Angioedema |
|
Acetaminophen |
4.71 | 10982225 |
| MESH:D001321 |
Autistic Disorder |
|
Acetaminophen |
1.39 | 18445737 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,6-dinitrotoluene |
2.97 | 16705839 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
Acetaminophen |
2.97 | 3084413 |
| MESH:D002386 |
Cataract |
|
Acetaminophen |
8.28 | 10977129 |
| MESH:D002386 |
Cataract |
|
Trinitrotoluene |
8.28 | 15817613 14694615 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
2,6-dinitrotoluene |
3.06 | 6135515 |
| MESH:D000013 |
Congenital Abnormalities |
|
Trinitrotoluene |
4.82 | 15095906 |
| MESH:D003490 |
Cyanosis |
|
2,6-dinitrotoluene |
13.50 | 18551238 |
| MESH:D003490 |
Cyanosis |
|
Trinitrotoluene |
13.50 | 18551238 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
2,6-dinitrotoluene |
6.90 | 21346803 18551238 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Acetaminophen |
6.90 | 11529661 16109766 18071297 10915739 11461765 11287661 12540782 19420014 19923254 16081117 12153990 11834606 11739529 14725611 18713872 15968718 14550746 19085960 11743745 16177239 16485898 11421492 19370779 12705907 19416960 14986274 17562736 16227642 16393943 17906064 19164858 19739265 10774834 15619225 10663392 16781746 12594235 17522070 2444490 12958197 12392966 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Trinitrotoluene |
6.90 | 18551238 21346803 |
| MESH:D056487 |
Drug-Induced Liver Injury, Chronic |
|
Acetaminophen |
4.96 | 19426721 |
| MESH:D005756 |
Gastritis |
|
Acetaminophen |
4.54 | 16983495 |
| MESH:D006529 |
Hepatomegaly |
|
Trinitrotoluene |
4.88 | 15817613 |
| MESH:D006930 |
Hyperalgesia |
|
Acetaminophen |
3.06 | 16870215 |
| MESH:D007248 |
Infertility, Male |
|
Trinitrotoluene |
3.95 | 12150543 |
| MESH:D007674 |
Kidney Diseases |
|
Acetaminophen |
2.42 | 15629191 12587719 |
| MESH:D007680 |
Kidney Neoplasms |
|
2,6-dinitrotoluene |
3.36 | 16705839 |
| MESH:D008107 |
Liver Diseases |
|
Acetaminophen |
1.71 | 19460945 12587719 12969438 16611625 19784758 11587558 19014921 16610002 |
| MESH:D017114 |
Liver Failure, Acute |
|
Acetaminophen |
3.68 | 17185352 16871587 |
| MESH:D008113 |
Liver Neoplasms |
|
2,6-dinitrotoluene |
2.28 | 7678174 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
2,6-dinitrotoluene |
2.79 | 6135515 2876786 2876784 |
| MESH:D008546 |
Melanoma, Experimental |
|
Acetaminophen |
4.22 | 19513568 |
| OMIM:251100 |
METHYLMALONIC ACIDURIA, cblA TYPE |
marker/mechanism |
|
| |
| MESH:D009336 |
Necrosis |
|
2,6-dinitrotoluene |
13.29 | 18551238 7678174 |
| MESH:D009336 |
Necrosis |
|
Trinitrotoluene |
13.29 | 18551238 |
| MESH:D019636 |
Neurodegenerative Diseases |
|
Acetaminophen |
3.26 | 18514411 |
| MESH:D009784 |
Occupational Diseases |
|
2,6-dinitrotoluene |
10.74 | 16049721 |
| MESH:D009784 |
Occupational Diseases |
|
Trinitrotoluene |
10.74 | 17852074 14694615 12819281 |
| MESH:D010146 |
Pain |
|
Acetaminophen |
2.77 | 16870215 |
| MESH:D012640 |
Seizures |
|
2,6-dinitrotoluene |
7.18 | 18551238 |
| MESH:D012640 |
Seizures |
|
Trinitrotoluene |
7.18 | 18551238 |
| MESH:D013163 |
Splenomegaly |
|
Trinitrotoluene |
5.85 | 15817613 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,6-dinitrotoluene |
2.42 | 16049721 |
| MESH:D014571 |
Urologic Neoplasms |
|
2,6-dinitrotoluene |
5.06 | 10091137 |
| MESH:D014581 |
Urticaria |
|
Acetaminophen |
3.50 | 10982225 |
| Drugbank ID |
Action |
Drug Name |
Description |
|---|
| DB00115 |
- |
Liver-Stomach Concentrate with Intrinsic Factor |
Antianemic Agents;Essential Vitamin;Vitamins (Vitamin B Complex) |
| DB00200 |
other/unknown |
Vege 1 Daily Caplet |
Nutritional Supplement;Anti-anemic Agents;Vitamin B Complex;Hematinics |
Related Pathway Information