AutismKB 2.0

Annotation Detail for PAPD4


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Basic Information Top
Gene Symbol:PAPD4 ( FLJ38499 )
Gene Full Name: PAP associated domain containing 4
Band: 5q14.1
Quick LinksEntrez ID:167153; OMIM: NA; Uniprot ID:GLD2_HUMAN; ENSEMBL ID: ENSG00000164329; HGNC ID: 26776
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PAPD4 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of PAPD4 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of PAPD4 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of PAPD4 mRNAincreases expression 20458559
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PAPD4 mRNAdecreases expression 19150397
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PAPD4 mRNAincreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3111752688 15322242 14514962
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3419825857 11798837
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.923712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.5411289319 1440618
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 10.0716206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.0712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6811589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8816705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.883581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.883084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.8811135700 15073043 15553829 14691202 16217749
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.4019014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.807296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.4212490120
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5216120746 18850075 18670907
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 12.416135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 12.417505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.4120889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.3819486331 9022650
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2115668235 15340226 12621046 8697196 16354765
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3417141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5410525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5410048152 20055451 15322242
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.4418551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4515213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2118759878 12868966 8156756 11906362 2524372 11298694 14531868 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.842952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.5921346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.5918289764 6679447 6482804 7440962 18692083 9328219 11289319 8291058 9653073 1440618 16192314 9022650 18648102
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.5919370779 14725611 16177239 11287661 15619225 12153990 16109766 19416960 16393943 11461765 16227642 18071297 10774834 14986274 12594235 10663392 17562736 12540782 16081117 15968718 12958197 11421492 11529661 17906064 19923254 19739265 19420014 17522070 16485898 12705907 11739529 14550746 12392966 10915739 19085960 11834606 18713872 16781746 19164858 11743745 2444490
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.5920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4218230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3310568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.613581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.6120426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.6112903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver arsenic trioxide 3.6115073043
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.546705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3620067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.6416904648
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.397505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4711294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.896705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3116120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5716354765 15340226 8697196 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3615034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912200463 12878042
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.549022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3612587719 15629191
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.2616705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.266582329
MESH:D007938 Leukemia arsenic trioxide 2.9615070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.1217077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1816467208 20471514 17050201 19850784 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4116966277 17217047 19642359 16331271 19075265 15748426 16891316 16112521 17712046 12679006 15213294 15622746 16823087 17869043 17107899 15336539 12712474 11468182 17649720 12018890 11161223 9834237 19225113 16330433 19035177
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.7316882451
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008107 Liver Diseases Acetaminophen 1.6919014921 11587558 19784758 16611625 12969438 12587719 19460945 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5417185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.987678174
MESH:D008113 Liver Neoplasms arsenic trioxide 7.9814682389
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.9816984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 15.652876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 15.65598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 15.6520377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.6512151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5915213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.3719825857 11798837
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3711884234 19555203
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3219417148 15949261 19549372 11468182 14977855
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3016882451 16105982
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.327678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.3416624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.573581430
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.906679447
MESH:D009436 Neural Tube Defects arsenic trioxide 7.9010525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.9116049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.916482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.543988306
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4816624393 19769630 12452020
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6115580305
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.907296757
MESH:D010235 Paraganglioma arsenic trioxide 4.5119927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.996228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511118676 11896295 11222880 11399792
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2219131511
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.613692021
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.3416646077
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7418551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.971399818 3712494 6587162 7505956 6582329
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.9719014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.4215213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.9116049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.918074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.9112845720 20435036 11780464 12973940
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7810091137
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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