AutismKB 2.0

Annotation Detail for DFFA


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DFFA ( DFF-45,DFF1,ICAD )
Gene Full Name: DNA fragmentation factor, 45kDa, alpha polypeptide
Band: 1p36.22
Quick LinksEntrez ID:1676; OMIM: 601882; Uniprot ID:DFFA_HUMAN; ENSEMBL ID: ENSG00000160049; HGNC ID: 2772
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04210Apoptosis
Pathway IDPathway Name
Apoptosis
Pathway IDPathway Name
200133HIV-1 Nef: Negative effector of Fas and TNF-alpha
200148Caspase cascade in apoptosis
No data
Pathway IDPathway Name
500275Activation of DNA fragmentation factor
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased cleavage of DFFA protein]decreases reaction|increases cleavage 17196791
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of DFFA mRNAaffects expression 21346803
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of DFFA mRNAdecreases expression 12419474
D000082 Acetaminophen DFFA protein results in increased susceptibility to Acetaminophenincreases response to substance 14725611
D000171 Acrolein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased cleavage of DFFA protein]decreases reaction|increases cleavage 17196791
D000171 Acrolein Acrolein results in increased cleavage of DFFA proteinincreases cleavage 17196791
D000171 Acrolein anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Acrolein results in increased cleavage of DFFA protein]decreases reaction|increases cleavage 17196791
D000171 Acrolein PD 98059 inhibits the reaction [Acrolein results in increased cleavage of DFFA protein]decreases reaction|increases cleavage 17196791
D000171 Acrolein SB 203580 inhibits the reaction [Acrolein results in increased cleavage of DFFA protein]decreases reaction|increases cleavage 17196791
D000171 Acrolein U 0126 inhibits the reaction [Acrolein results in increased cleavage of DFFA protein]decreases reaction|increases cleavage 17196791
D000171 Acrolein wortmannin inhibits the reaction [Acrolein results in increased cleavage of DFFA protein]decreases reaction|increases cleavage 17196791
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DFFA mRNAaffects expression 16483693
C432165 anthra(1,9-cd)pyrazol-6(2H)-one anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Acrolein results in increased cleavage of DFFA protein]decreases reaction|increases cleavage 17196791
D001149 Arsenates [Atrazine co-treated with Arsenates] results in increased expression of DFFA mRNAaffects cotreatment|increases expression 18585445
D001151 Arsenic [Arsenic co-treated with Fluorides] results in decreased expression of DFFA mRNAaffects cotreatment|decreases expression 19962721
C006632 arsenic trioxide arsenic trioxide results in increased expression of DFFA mRNAincreases expression 17530438
C006632 arsenic trioxide arsenic trioxide results in increased expression of DFFA mRNAincreases expression 19730151
D001280 Atrazine [Atrazine co-treated with Arsenates] results in increased expression of DFFA mRNAaffects cotreatment|increases expression 18585445
D001554 Benzene Benzene results in increased expression of DFFA proteinincreases expression 17171516
C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde DFFA protein inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of DFFB protein]decreases reaction|increases ubiquitination 18178165
D002392 Catechin Catechin results in decreased degradation of DFFA proteindecreases degradation 16753784
C060327 dracorhodin dracorhodin analog results in increased cleavage of DFFA proteinincreases cleavage 15684474
16864444
15813022
15215653
D004610 Ellagic Acid Ellagic Acid results in decreased expression of DFFA mRNAdecreases expression 12002526
D005459 Fluorides [Arsenic co-treated with Fluorides] results in decreased expression of DFFA mRNAaffects cotreatment|decreases expression 19962721
D005665 Furosemide Furosemide affects the expression of DFFA mRNAaffects expression 17497460
D007530 Isoflurane Isoflurane results in decreased expression of DFFA mRNAdecreases expression 16978161
D009151 Mustard Gas Mustard Gas results in increased cleavage of DFFA proteinincreases cleavage 12482751
C093973 PD 98059 PD 98059 inhibits the reaction [Acrolein results in increased cleavage of DFFA protein]decreases reaction|increases cleavage 17196791
D010424 Pentobarbital Pentobarbital results in decreased expression of DFFA mRNAdecreases expression 16978161
D010936 Plant Extracts Plant Extracts results in increased cleavage of DFFA proteinincreases cleavage 17619071
C025299 polyphenols polyphenols results in decreased expression of DFFA mRNAdecreases expression 16293270
C059514 resveratrol resveratrol results in decreased expression of DFFA mRNAdecreases expression 12002526
C059514 resveratrol resveratrol results in increased expression of DFFA mRNAincreases expression 12569576
C093642 SB 203580 SB 203580 inhibits the reaction [Acrolein results in increased cleavage of DFFA protein]decreases reaction|increases cleavage 17196791
C040115 shogaol shogaol results in increased degradation of DFFA proteinincreases degradation 18384088
C017947 sodium arsenite sodium arsenite results in decreased expression of DFFA mRNAdecreases expression 12760830
C113580 U 0126 U 0126 inhibits the reaction [Acrolein results in increased cleavage of DFFA protein]decreases reaction|increases cleavage 17196791
C009687 wortmannin wortmannin inhibits the reaction [Acrolein results in increased cleavage of DFFA protein]decreases reaction|increases cleavage 17196791
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.2818287403
MESH:D000168 Acrocephalosyndactylia U 0126 5.2017694057
MESH:D058186 Acute Kidney Injury resveratrol 3.6016538975
MESH:D055371 Acute Lung Injury Acrolein 4.4521297076 20525806
MESH:D000230 Adenocarcinoma arsenic trioxide 4.9411798837 19825857
MESH:D000230 Adenocarcinoma dracorhodin 4.9415215653
MESH:D000236 Adenoma resveratrol 3.1615688382
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4215276417
MESH:D018246 Adrenocortical Adenoma Arsenic 12.8517306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 12.8517306315 16712894
MESH:D000382 Agricultural Workers' Diseases Atrazine 3.9511874814
MESH:D000544 Alzheimer Disease Acrolein 6.4917570602 15207723 14715435
MESH:D000544 Alzheimer Disease Plant Extracts 6.4916962711
MESH:D000544 Alzheimer Disease resveratrol 6.4916183991 16162502
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.9310965797
MESH:D000741 Anemia, Aplastic Benzene 4.1611369114 14761424 17661222
MESH:D000799 Angioedema Acetaminophen 3.5610982225
MESH:D001008 Anxiety Disorders Pentobarbital 4.5118313124 11141031
MESH:D020261 Arsenic Poisoning Arsenic 2.7912569548 18414634 16251483 16835338
MESH:D001161 Arteriosclerosis Acrolein 4.7315014928
MESH:D001169 Arthritis, Experimental Plant Extracts 7.2614686799
MESH:D001169 Arthritis, Experimental resveratrol 7.2617115116
MESH:D001249 Asthma Mustard Gas 2.6310378619
MESH:D050197 Atherosclerosis Acrolein 10.2316037261 16126721 17363696
MESH:D050197 Atherosclerosis Arsenic 10.2312928151 19371607
MESH:D050197 Atherosclerosis resveratrol 10.2317967414 16873680
MESH:D001321 Autistic Disorder Acetaminophen 1.4518445737
MESH:D001768 Blister Mustard Gas 4.8819167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.4216206674
MESH:D001855 Bone Marrow Diseases Benzene 4.9516183116
MESH:D002545 Brain Ischemia Plant Extracts 9.5416041641
MESH:D002545 Brain Ischemia resveratrol 9.5417600658
MESH:D001943 Breast Neoplasms Benzene 2.6317162533 11921183
MESH:D001943 Breast Neoplasms resveratrol 2.6317651959 17534123 16393696
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.8815286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.6917687719 10378619
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0711589617
MESH:D002057 Burns, Chemical Plant Extracts 5.059625245
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.4415504454 17687452
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 16.0716705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.073084413
MESH:D006528 Carcinoma, Hepatocellular anthra(1,9-cd)pyrazol-6(2H)-one 16.0719418558
MESH:D006528 Carcinoma, Hepatocellular Arsenic 16.0716507464 17306315
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 16.0714691202 15553829 16217749 15073043 11135700
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 16.0718834353
MESH:D006528 Carcinoma, Hepatocellular resveratrol 16.0716227395 19321006
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 16.0716507464 17306315 15276417
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.3116675471
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.5919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8812490120
MESH:D002294 Carcinoma, Squamous Cell Arsenic 7.1518922899 17687452 15504454
MESH:D002294 Carcinoma, Squamous Cell resveratrol 7.1516227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.1518572023
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.8418640142
MESH:D006332 Cardiomegaly Plant Extracts 3.6517645561
MESH:D002318 Cardiovascular Diseases Arsenic 6.9317938729 15738583 19152805
MESH:D002318 Cardiovascular Diseases resveratrol 6.9315458977
MESH:D002340 Carotid Artery Diseases Arsenic 4.0816973168 18022660
MESH:D002386 Cataract Acetaminophen 2.4210977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.116135515
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.1119524636 20056578
MESH:D003092 Colitis resveratrol 3.8616474422
MESH:D003110 Colonic Neoplasms polyphenols 3.8916293270
MESH:D003110 Colonic Neoplasms resveratrol 3.8916338953
MESH:D015179 Colorectal Neoplasms Acrolein 3.4617597105
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.4620501625
MESH:D015179 Colorectal Neoplasms resveratrol 3.4616550006
MESH:D003327 Coronary Disease resveratrol 3.5716507316
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.8210525206
MESH:D019465 Craniofacial Abnormalities Benzene 2.8215643154
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.7418551238
MESH:D003556 Cystitis Acrolein 5.1112161096
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.8415213294
MESH:D003872 Dermatitis Benzene 4.4915902427
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.5516873680
MESH:D003928 Diabetic Nephropathies Plant Extracts 8.6119706694
MESH:D003928 Diabetic Nephropathies resveratrol 8.6116286809
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 5.7718551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.7714986274 10915739 16177239 19739265 16081117 11287661 16227642 10663392 16109766 12153990 16485898 19923254 14725611 11743745 12705907 2444490 17906064 18713872 16781746 11529661 11421492 19420014 10774834 12540782 17522070 19164858 12958197 12594235 15968718 19370779 11834606 14550746 19416960 15619225 18071297 11739529 19085960 17562736 11461765 12392966 16393943
MESH:D056486 Drug-Induced Liver Injury polyphenols 5.7719370779
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8119426721
MESH:D004417 Dyspnea Furosemide 4.6616935035
MESH:D004487 Edema Furosemide 14.5511834646
MESH:D004487 Edema Mustard Gas 14.559260866 11402378 11428631 11428647
MESH:D004487 Edema Plant Extracts 14.5512787963
MESH:D004487 Edema resveratrol 14.558985016
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 3.7617872969
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 5.4015268973
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.5717923197
MESH:D004827 Epilepsy Plant Extracts 3.5919439326 19700373
MESH:D004890 Erythema Mustard Gas 4.889357497
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.2412903497
MESH:D005234 Fatty Liver arsenic trioxide 7.3915073043
MESH:D005234 Fatty Liver Plant Extracts 7.3915975614
MESH:D005534 Foot Diseases Arsenic 5.276392382
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0016904648
MESH:D005756 Gastritis Acetaminophen 3.3916983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4016452187
MESH:D034381 Hearing Loss Furosemide 4.5917868369
MESH:D006333 Heart Failure Furosemide 7.2316845234 16011733 12660669
MESH:D006333 Heart Failure Plant Extracts 7.2318097624
MESH:D006402 Hematologic Diseases Benzene 4.4016183116
MESH:D006561 Herpes Simplex Plant Extracts 9.1910715843
MESH:D006561 Herpes Simplex resveratrol 9.1916876885
MESH:D015658 HIV Infections Plant Extracts 3.5412878215
MESH:D006689 Hodgkin Disease sodium arsenite 2.9312676792
MESH:D019584 Hot Flashes Plant Extracts 4.4714716179 17454163 16566672
MESH:D006930 Hyperalgesia Acetaminophen 2.4816870215
MESH:D006934 Hypercalcemia Furosemide 4.8217652376
MESH:D053565 Hypercalciuria Furosemide 5.3717652376
MESH:D006937 Hypercholesterolemia resveratrol 3.7617188708
MESH:D020138 Hyperhomocysteinemia Catechin 9.1517292331
MESH:D020138 Hyperhomocysteinemia Plant Extracts 9.1516484555
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.2117050553
MESH:D006949 Hyperlipidemias Plant Extracts 8.7515268973 15975614
MESH:D006949 Hyperlipidemias resveratrol 8.7516873680
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 5.5915086907
MESH:D006973 Hypertension Arsenic 5.3016076760 11953799 9931084
MESH:D006973 Hypertension Benzene 5.3017940673
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 5.0116612254
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.0617488730
MESH:D006987 Hypesthesia Arsenic 5.2716093927
MESH:C537153 Hypomagnesemia primary Furosemide 5.3711041285
MESH:D007019 Hypoproteinemia Furosemide 5.5916096441
MESH:D007022 Hypotension Furosemide 9.0111041285
MESH:D007022 Hypotension Isoflurane 9.0112967683
MESH:D007024 Hypotension, Orthostatic Furosemide 5.1315811171
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.3717600658
MESH:D007248 Infertility, Male Atrazine 6.4812948887
MESH:D007248 Infertility, Male sodium arsenite 6.4812646999 15346721
MESH:D007249 Inflammation Mustard Gas 10.8811428620 16001271 8975870 11428631 17524151 9357497 9260866 11428647 11402378
MESH:D007249 Inflammation Plant Extracts 10.8812787963 16366677 15997105 19332304
MESH:D007249 Inflammation polyphenols 10.8816366677
MESH:D007249 Inflammation resveratrol 10.8816366677
MESH:D007251 Influenza, Human resveratrol 4.2616624496
MESH:D007414 Intestinal Neoplasms Plant Extracts 4.3812584176 12628509 12351151
MESH:D007642 Keratosis Arsenic 4.7116930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 13.2215629191 12587719
MESH:D007674 Kidney Diseases Acrolein 13.2212488133
MESH:D007674 Kidney Diseases Furosemide 13.2211041285
MESH:D007674 Kidney Diseases sodium arsenite 13.2220008137
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 2.7616705839
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 9.8712970779
MESH:D007938 Leukemia arsenic trioxide 9.8715070760
MESH:D007938 Leukemia Benzene 9.8718335105 17119257 14694614 15935818
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.5517077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute anthra(1,9-cd)pyrazol-6(2H)-one 25.7716972261
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 25.7716972261
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 25.7716972261
MESH:D007948 Leukemia, Monocytic, Acute U 0126 25.7716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2214633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.8719077051
MESH:D007951 Leukemia, Myeloid Benzene 8.8717506065
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.9316467208 16968895 17050201 20471514 19850784
MESH:D015470 Leukemia, Myeloid, Acute Benzene 3.9319478238
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 16.8117339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 16.8119035177 16966277 15748426 17217047 17712046 15336539 16331271 16330433 12712474 12679006 19642359 17869043 16112521 11161223 16823087 19225113 9834237 12018890 17107899 16891316 19075265 17649720 11468182 15622746 15213294
MESH:D015473 Leukemia, Promyelocytic, Acute dracorhodin 16.8116864444
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 16.8116087638
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.0916882451
MESH:D008103 Liver Cirrhosis Plant Extracts 3.5817157831
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 2.6615479170
MESH:D008107 Liver Diseases Acetaminophen 8.8312969438 16610002 19460945 16611625 19014921 12587719 19784758 11587558
MESH:D008107 Liver Diseases Arsenic 8.8311134558
MESH:D008107 Liver Diseases Plant Extracts 8.8317034775
MESH:D008107 Liver Diseases polyphenols 8.8316698588
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9917185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 16.587678174
MESH:D008113 Liver Neoplasms Arsenic 16.5816368122
MESH:D008113 Liver Neoplasms arsenic trioxide 16.5814682389
MESH:D008113 Liver Neoplasms Plant Extracts 16.5819168119
MESH:D008113 Liver Neoplasms resveratrol 16.5820405173 19073162 19321006 19812893
MESH:D008113 Liver Neoplasms sodium arsenite 16.5815276417 16712894
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 8.952876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 8.9520377131
MESH:D008114 Liver Neoplasms, Experimental Benzene 8.9512562636
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1415213294
MESH:D008171 Lung Diseases Acrolein 11.4411504702
MESH:D008171 Lung Diseases Mustard Gas 11.4418702808 18161513
MESH:D008171 Lung Diseases sodium arsenite 11.4419095001
MESH:D017563 Lung Diseases, Interstitial Benzene 4.5214698565
MESH:D008175 Lung Neoplasms Arsenic 8.0817306315 17976673 19168569
MESH:D008175 Lung Neoplasms arsenic trioxide 8.0819825857 11798837
MESH:D008175 Lung Neoplasms Benzene 8.0812562636
MESH:D008175 Lung Neoplasms Mustard Gas 8.083148597 8781369
MESH:D008175 Lung Neoplasms Plant Extracts 8.0820869020
MESH:D008175 Lung Neoplasms sodium arsenite 8.0815276417 16712894 17077188 17306315 19931552
MESH:D008223 Lymphoma Benzene 3.5417584886 17119257
MESH:D016393 Lymphoma, B-Cell resveratrol 4.0417088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.6514749477
MESH:D015674 Mammary Neoplasms, Animal Benzene 9.3212562636
MESH:D015674 Mammary Neoplasms, Animal resveratrol 9.3215688416
MESH:D008325 Mammary Neoplasms, Experimental Benzene 5.8411921183
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 5.848985016 11606380
MESH:D008545 Melanoma dracorhodin 5.1215684474
MESH:D008545 Melanoma resveratrol 5.1217992120
MESH:D008545 Melanoma sodium arsenite 5.1219082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 10.0719513568
MESH:D008546 Melanoma, Experimental Acrolein 10.0710803710
MESH:D008654 Mesothelioma Atrazine 3.421916698
MESH:D008659 Metabolic Diseases resveratrol 4.1317112576
MESH:D009101 Multiple Myeloma arsenic trioxide 11.0811468182 19417148 19549372 14977855 15949261
MESH:D009101 Multiple Myeloma Benzene 11.0817119195
MESH:D009101 Multiple Myeloma resveratrol 11.0817164350 17049120 17935668 16490592 14749477 16267019
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.5917962980
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.3918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 2.9816882451 16105982
MESH:D009203 Myocardial Infarction resveratrol 2.9116525036 17188708 16317513 17015251 16456233 17125593
MESH:D017202 Myocardial Ischemia Arsenic 8.6415371236
MESH:D017202 Myocardial Ischemia resveratrol 8.6417015251 17125593
MESH:D009205 Myocarditis resveratrol 4.4817322642
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.587678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.6916624393
MESH:D009369 Neoplasms Acrolein 5.0717329238
MESH:D009369 Neoplasms sodium arsenite 5.0711559025
MESH:D009374 Neoplasms, Experimental resveratrol 8.328985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.3220056578
MESH:D009393 Nephritis Acrolein 6.0012653641
MESH:D009397 Nephrocalcinosis Furosemide 5.5915086907
MESH:D009436 Neural Tube Defects Arsenic 15.9016620997
MESH:D009436 Neural Tube Defects arsenic trioxide 15.9010525206
MESH:D009436 Neural Tube Defects Benzene 15.9015643154
MESH:D009436 Neural Tube Defects sodium arsenite 15.9012854658
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.9117168769
MESH:D019636 Neurodegenerative Diseases Acetaminophen 12.9118514411
MESH:D019636 Neurodegenerative Diseases Acrolein 12.9111342003
MESH:D019636 Neurodegenerative Diseases resveratrol 12.9117652729
MESH:D020078 Neurogenic Inflammation Arsenic 9.8417056641
MESH:D020078 Neurogenic Inflammation resveratrol 9.8417929310
MESH:D009503 Neutropenia Mustard Gas 3.7116761898 7688884
MESH:D053206 Nocturnal Enuresis Furosemide 5.5917945291
MESH:D009765 Obesity Plant Extracts 3.0819056576 20132043
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.3616049721
MESH:D009784 Occupational Diseases Benzene 8.3615935809 15612468 17479406 16737584 15576619 15913788 17178637 17119257 15727169
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.0017513867
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 17.6916211241
MESH:D010051 Ovarian Neoplasms Arsenic 17.6917306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 17.6916624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Benzene 17.6912562636
MESH:D010051 Ovarian Neoplasms sodium arsenite 17.6917306315 15276417
MESH:D010051 Ovarian Neoplasms U 0126 17.6916211241
MESH:D010146 Pain Acetaminophen 2.1716870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.4315580305
MESH:D010212 Papilloma Plant Extracts 4.2216517061 15173996
MESH:D010235 Paraganglioma arsenic trioxide 3.9019927285
MESH:D010300 Parkinson Disease Acrolein 5.6217690948
MESH:D010300 Parkinson Disease Atrazine 5.6217218051
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.9116093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.7116905509 6392382 15371236
MESH:D010538 Peritonitis Isoflurane 4.9517414419
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 12.5111550810
MESH:D010787 Photosensitivity Disorders Acrolein 12.5111550810
MESH:D011041 Poisoning Mustard Gas 3.5415727166
MESH:D011141 Polyuria Furosemide 5.3717945291
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 3.9016679765
MESH:D011471 Prostatic Neoplasms Arsenic 1.9116140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.9119131511
MESH:D011471 Prostatic Neoplasms Plant Extracts 1.9117804756 14666653
MESH:D011471 Prostatic Neoplasms resveratrol 1.9117718901 17675339 16731767 17804756 15767336 17636462
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.9116039940
MESH:D011507 Proteinuria Arsenic 3.7521343184
MESH:D011537 Pruritus Mustard Gas 3.8118058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8217720292 17894541 17620002 17266442 10334151
MESH:D012021 Reflex, Abnormal Pentobarbital 5.7410930210
MESH:D051437 Renal Insufficiency Acrolein 4.7312732208
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.3016325855
MESH:D015427 Reperfusion Injury Furosemide 6.6716526316
MESH:D015427 Reperfusion Injury resveratrol 6.6716314181 17520802 17058453 15827377 16317513
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 4.3612394941 15912074 16096441
MESH:D012135 Respiratory Sounds Atrazine 4.2411874814
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.6916646077
MESH:D012640 Seizures 2,6-dinitrotoluene 5.7518551238
MESH:D012640 Seizures Pentobarbital 5.7510087439 9754883
MESH:D018805 Sepsis Isoflurane 4.7617414419
MESH:D012871 Skin Diseases Arsenic 4.8817453740 19834688 17548696 16353154 6392382 16759981 16702368 18709164 15952646 17938729 17050553
MESH:D012871 Skin Diseases Mustard Gas 4.8816961503 15451306 12880345
MESH:D012878 Skin Neoplasms Arsenic 12.5717976673 17029826 15504454 16251483 19538983 17050553
MESH:D012878 Skin Neoplasms Plant Extracts 12.5716517061 15173996
MESH:D012878 Skin Neoplasms resveratrol 12.5715837718 8985016
MESH:D012878 Skin Neoplasms sodium arsenite 12.5719524636 18572023
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5812854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.4417007042
MESH:D013274 Stomach Neoplasms Benzene 3.4412562636
MESH:D013274 Stomach Neoplasms Furosemide 3.4417052386
MESH:D013276 Stomach Ulcer Plant Extracts 3.6518193104 17135157 18237397 15255614 12787963
MESH:D020521 Stroke Acrolein 4.3416269634
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.2416321402
MESH:D013375 Substance Withdrawal Syndrome Pentobarbital 4.7411529278 9754883
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 12.3317997062
MESH:D013705 Temporomandibular Joint Disorders polyphenols 12.3317997062
MESH:D013953 Thymus Neoplasms Benzene 4.6810850423
MESH:D013964 Thyroid Neoplasms arsenic trioxide 2.8819014326
MESH:D014062 Tongue Neoplasms resveratrol 3.9716227395
MESH:D016171 Torsades de Pointes arsenic trioxide 3.6815213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.0316049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 11.0311144890 18640142 19322015 15987713 17976673 17306315 19429237
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 11.0311780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 11.0316452187 11723127 17306315 16712894
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.0410091137
MESH:D014581 Urticaria Acetaminophen 2.7210982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 8.7617473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.7611813266
MESH:D014594 Uterine Neoplasms Benzene 8.9912562636
MESH:D014594 Uterine Neoplasms resveratrol 8.9917044934
MESH:D014652 Vascular Diseases Arsenic 10.9117056641
MESH:D014652 Vascular Diseases sodium arsenite 10.9117056641
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 9.6218097624
MESH:D018487 Ventricular Dysfunction, Left resveratrol 9.6217488730
MESH:D020257 Ventricular Remodeling Plant Extracts 5.0418097624
MESH:D014947 Wounds and Injuries Plant Extracts 4.0320213670 19894650
Pathway ID Pathway Name
REACT:578 Apoptosis
KEGG:04210 Apoptosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27254
    • No data
    Releated disease ID Related disease Name
    PA445742Stomach Neoplasms
    Releated drug ID Related drug Name
    PA449957ibuprofen
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved