AutismKB 2.0

Annotation Detail for COL22A1


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Basic Information Top
Gene Symbol:COL22A1 ( - )
Gene Full Name: collagen, type XXII, alpha 1
Band: 8q24.23-q24.3
Quick LinksEntrez ID:169044; OMIM: 610026; Uniprot ID:COMA1_HUMAN; ENSEMBL ID: ENSG00000169436; HGNC ID: 22989
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
HEMATOLOGICAL
serum creatinine
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of COL22A1 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of COL22A1 mRNAdecreases expression 20064835
C014347 decitabine decitabine inhibits the reaction [tobacco tar results in decreased expression of COL22A1 mRNA]decreases expression|decreases reaction 19559774
D004041 Dietary Fats Dietary Fats results in increased expression of COL22A1 mRNAincreases expression 18042831
D002117 Calcitriol Calcitriol results in increased expression of COL22A1 mRNAincreases expression 16002434
C041786 palm oil palm oil results in increased expression of COL22A1 mRNAincreases expression 18042831
C024746 tobacco tar decitabine inhibits the reaction [tobacco tar results in decreased expression of COL22A1 mRNA]decreases expression|decreases reaction 19559774
C024746 tobacco tar tobacco tar results in decreased expression of COL22A1 mRNAdecreases expression 19559774
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001161 Arteriosclerosis Dietary Fats 4.2515238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0217474063 20146248
MESH:D001943 Breast Neoplasms Calcitriol 2.0211237771
MESH:D001943 Breast Neoplasms decitabine 2.0219208741 18320071
MESH:D001943 Breast Neoplasms Dietary Fats 2.0220435547
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.403084413
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.9820419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 7.9811237771
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.9819215824
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 4.1319559774
MESH:D003110 Colonic Neoplasms decitabine 2.3717616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6516227642 14725611 19085960 16781746 16081117 12958197 14986274 12705907 19370779 15968718 16485898 17522070 10774834 11461765 17562736 18071297 16393943 19416960 12392966 11421492 11834606 17906064 16109766 11739529 16177239 15619225 18713872 12594235 11287661 19739265 11529661 2444490 12540782 10915739 19420014 19164858 14550746 10663392 11743745 19923254 12153990
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6518367378
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.2615138306
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.5619294695
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005234 Fatty Liver Dietary Fats 3.5218296743 17967931 19004024 19551842
MESH:D005355 Fibrosis Dietary Fats 3.8818296743
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006258 Head and Neck Neoplasms decitabine 3.6619215824
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7820471113
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8721332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.9221332399
MESH:D007248 Infertility, Male decitabine 3.3817581917
MESH:D007249 Inflammation Dietary Fats 2.5520412841
MESH:D007333 Insulin Resistance Dietary Fats 3.2711836018 18457598
MESH:D007674 Kidney Diseases Acetaminophen 2.3412587719 15629191
MESH:D007938 Leukemia decitabine 3.1919235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.2819117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4118460780 17679729 19010910 18704418 18206229 19387464
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.9118055864
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0118296743
MESH:D008107 Liver Diseases Acetaminophen 1.6812969438 16611625 19460945 16610002 19784758 12587719 19014921 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1220195826 21137059
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5720464547 18569708 6695378 18816296 20869020 17053015 18520028 20135361 20064080
MESH:D008223 Lymphoma decitabine 3.6119470736
MESH:D008545 Melanoma decitabine 2.2717785578 16505122
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D009101 Multiple Myeloma decitabine 3.5418172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.5219010910 16882708 19157545 18608210
MESH:D009369 Neoplasms Benzo(a)pyrene 5.5111141357
MESH:D009369 Neoplasms decitabine 5.5117925555 19116145 19470736
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009765 Obesity Dietary Fats 2.3420132043 17217161 19632207 20518802 18457598 21332399 16723640 18674790 11836018
MESH:D010051 Ovarian Neoplasms decitabine 2.7219259094 19331143
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010190 Pancreatic Neoplasms decitabine 2.8419294695
MESH:D055728 Primary Myelofibrosis decitabine 5.0917616702
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.1815572423
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2217292933
MESH:D011471 Prostatic Neoplasms Calcitriol 3.2216289102 15754350 16644109 18247401 12479363
MESH:D012208 Rhabdomyosarcoma decitabine 4.7119155313
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4819755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.5120155912 2093021
MESH:D013274 Stomach Neoplasms decitabine 2.5119037991
MESH:D013964 Thyroid Neoplasms decitabine 3.5417967635
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.4417053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.4417616700 19087683
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D014604 Uveal Neoplasms decitabine 5.3617785578
MESH:D015430 Weight Gain Dietary Fats 3.9916723640
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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