AutismKB 2.0

Annotation Detail for GLIS3


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Basic Information Top
Gene Symbol:GLIS3 ( FLJ38999,FLJ90578,MGC33662,ZNF515 )
Gene Full Name: GLIS family zinc finger 3
Band: 9p24.2
Quick LinksEntrez ID:169792; OMIM: 610192; Uniprot ID:GLIS3_HUMAN; ENSEMBL ID: ENSG00000107249; HGNC ID: 28510
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
CHEMDEPENDENCY
type 1 diabetes
IMMUNE
fasting glucose-related traits
smoking cessation
METABOLIC
Desease Name
Type 1 diabetes
Fasting glucose-related traits
Desease Name
Diabetes mellitus, neonatal, with congenital hypothyroidism
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of GLIS3 mRNAaffects expression 17331233
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of GLIS3 mRNAdecreases expression 20064835
20106945
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of GLIS3 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of GLIS3 mRNAincreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of GLIS3 mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5220127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.5211473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.846695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.5619183758
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0220146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 2.0219861407 18497071 17289903 17261762 12948864 14630087 16675129 17018787
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.0016111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.263786805 16227642 18705752 15700767 16192424 15721981 16011737 15673190 16124888 10355542 16050911 16097048
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1218788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.1216924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.3612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.3618566989
MESH:D002779 Cholestasis Cyclosporine 3.1719486331
OMIM:610199 DIABETES MELLITUS, NEONATAL, WITH CONGENITAL HYPOTHYROIDISM marker/mechanism
MESH:D003922 Diabetes Mellitus, Type 1 marker/mechanism 19430480
MESH:D003928 Diabetic Nephropathies Estradiol 3.7419279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.1115998439 9327722 7120509 2869522 3732212 16227642 11566570 7440962 15968718 17522070 19085960 10915739 6884620 4309450 16177239 7179309 6623471 21278145 19336974 15027814 10092053 3786805
MESH:D016889 Endometrial Neoplasms Estradiol 3.2011473722 18566989 19148513
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.9712795759 17595544 12631006 16045604 19224547 61145 16239168 15959796
MESH:D005234 Fatty Liver Cyclosporine 8.9719224547
MESH:D005355 Fibrosis Carbon Tetrachloride 10.3318705752
MESH:D005355 Fibrosis Cyclosporine 10.3312639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8220471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006505 Hepatitis Carbon Tetrachloride 4.0319110552 19900420
MESH:D006558 Herpes Genitalis Estradiol 5.6415709030
MESH:D019584 Hot Flashes Estradiol 4.3617088409
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.0716899240
MESH:D006973 Hypertension Cyclosporine 2.2010903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5715338365
MESH:D007333 Insulin Resistance Estradiol 3.1816393666 16627594
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007674 Kidney Diseases Cyclosporine 6.5518776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 6.5515618244
MESH:D007680 Kidney Neoplasms Cyclosporine 8.3012371664
MESH:D007680 Kidney Neoplasms Estradiol 8.3015610895
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9816943688 17157831 11408273 11903743 17174718 16221502 17334410 16239168 21278145
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.5312586293 15673190 18481824 18205269 12667390 12546737 16033810 15730626 15362042 12389079 18187930 12898905 18166357 17698563 18339082 17869086 15123356 18395914 16097048 14716496 17766677 15925388 17900296 17714472 17640975 18376398 12445421 16248980 14724832 18251166 18395095 14748882 17631135 12445418 16192424 17708605 12632512 18412020 17525996 18054572 15876570 16015684 18317297 13678700 17944888 12632514 12609069 17805973 17721639 15931870 17565644 18006644 18705752 17481882 15057751 18472332 16116963 17922224 18420326 17823541 18156304 15338365 16027843 17557913 11481614 16638106 18279442 15818738 15996030 17761835 14716833 18210741 20821823 14512876 12958196 16136751 10355542 15370692 12741479 14620537 18418968 12666154 18429990 15893842 18472094 16011737 15959796 12649538 18263696 18277467 15052691 15650968 17976157
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5314716833 14659978
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1516246199 15720792 15830285 17285989 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.6515123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.0416899240 14706259
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.8820195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.8819294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.8112014681 15583823
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.5017365036
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5718816296 6695378 18569708 20064080 20464547 17053015 18520028 20135361 20869020
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7711408345 11807958 17203775 16891317
MESH:D020149 Manganese Poisoning Estradiol 5.0919453300
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.3018303189 16166281 16966607
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4616381670
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5516810080
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3111141357
MESH:D009389 Neovascularization, Pathologic Estradiol 4.2717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6118481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 4.0911399458 16427766
MESH:D010051 Ovarian Neoplasms Estradiol 2.3019401270
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.3810923243
MESH:D011230 Precancerous Conditions Cyclosporine 3.5512371664
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.2620887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0317292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.0316740699
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.1417365031 17975199 15814490 17322281
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5119755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013978 Tibial Fractures Estradiol 5.3019048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2917053015
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134878768
    • No data
    Releated disease ID Related disease Name
    PA443890Diabetes Mellitus, Type 2
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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