AutismKB 2.0

Annotation Detail for ADAMTS18


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ADAMTS18 ( ADAMTS21 )
Gene Full Name: ADAM metallopeptidase with thrombospondin type 1 motif, 18
Band: 16q23.1
Quick LinksEntrez ID:170692; OMIM: 607512; Uniprot ID:ATS18_HUMAN; ENSEMBL ID: ENSG00000140873; HGNC ID: 17110
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
Bone Mineral Density
METABOLIC
Desease Name
Bone mineral density
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C017947 sodium arsenite sodium arsenite results in increased expression of ADAMTS18 mRNAincreases expression 16014739
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ADAMTS18 mRNAincreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.7314514962 15322242 11752688
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.2616835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.7715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.9717306315 16712894
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.4511748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.5912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.8615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0515746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6620435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 2.0116507464 17306315 15276417
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4818572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.6018850075 16120746 18670907
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.3119524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.6316835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2616354765 15340226 15668235 8697196 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.5314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 20055451 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7517107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.1211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.9212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.9716714409 18230668 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.539294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3811564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.2211858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.7120067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.5716452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.6610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5510048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.8911000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.6512621046 15340226 16120746
MESH:D006689 Hodgkin Disease sodium arsenite 3.6212676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 5.1215340226 8697196 16354765 18606429 16959395
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0418850075 18670907
MESH:D007248 Infertility, Male sodium arsenite 3.2915346721 12646999
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0612200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.8916580747
MESH:D007674 Kidney Diseases sodium arsenite 3.0420008137
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008113 Liver Neoplasms sodium arsenite 4.9316712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.9316984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3812151625
MESH:D008171 Lung Diseases sodium arsenite 3.4819095001
MESH:D008175 Lung Neoplasms sodium arsenite 2.4117077188 19931552 17306315 15276417 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4119555203 11884234
MESH:D008545 Melanoma sodium arsenite 2.0816487513 19082730
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.4312213967
MESH:D009369 Neoplasms sodium arsenite 2.6911559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.4320056578
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.8914600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.4412854658
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5415276417 17306315
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 5.3212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.2318163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 4.0811896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2316039940
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.5118990726
MESH:D012878 Skin Neoplasms sodium arsenite 6.2319524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.2316192470
MESH:D016135 Spinal Dysraphism sodium arsenite 4.1812854658
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.9712697716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.6516712894 16452187 11723127 17306315
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.2711813266
MESH:D014652 Vascular Diseases sodium arsenite 5.3117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.6612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 5.3215886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24544
    • Releated gene ID Related gene Name
    PA24544ADAMTS18
    Releated disease ID Related disease Name
    PA445190Osteoporosis
    PA443532Bone Diseases
    PA443536Bone Diseases, Metabolic
    PA444222Fractures, Bone
    PA443756Colonic Neoplasms
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved