AutismKB 2.0

Annotation Detail for ASXL1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ASXL1 ( KIAA0978,MGC117280,MGC71111 )
Gene Full Name: additional sex combs like 1 (Drosophila)
Band: 20q11.21
Quick LinksEntrez ID:171023; OMIM: 612990; Uniprot ID:ASXL1_HUMAN; ENSEMBL ID: ENSG00000171456; HGNC ID: 18318
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ASXL1 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ASXL1 mRNAdecreases expression 19150397
20018196
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ASXL1 mRNAincreases expression 20382639
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of ASXL1 mRNAdecreases expression 15336504
D012643 Selenium Selenium results in decreased expression of ASXL1 mRNAdecreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of ASXL1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.4116050911
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.403084413
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9620889678
MESH:D003092 Colitis Selenium 4.2617936198
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0711461765 18713872 14550746 2444490 17906064 19923254 10663392 16393943 11529661 15619225 12705907 19164858 11421492 19370779 12958197 12594235 12540782 17562736 16227642 16485898 14725611 11743745 16781746 11739529 19739265 19420014 18071297 10774834 19416960 12392966 12153990 16081117 17522070 16109766 10915739 19085960 11287661 16177239 11834606 14986274 15968718
MESH:D056486 Drug-Induced Liver Injury Selenium 4.0715131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:C538011 Eales disease Vitamin E 5.329068938
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1420426865
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1516080930
MESH:D006333 Heart Failure Selenium 3.2717162251
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.8016863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.5814716179
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D007251 Influenza, Human Selenium 13.0916624496
MESH:D007251 Influenza, Human Vitamin E 13.0916624496
MESH:D007674 Kidney Diseases Acetaminophen 6.5815629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 6.5812488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.2616518626
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008107 Liver Diseases Acetaminophen 1.6919784758 16610002 19014921 12587719 19460945 11587558 12969438 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5817185352 16871587
MESH:D008171 Lung Diseases Vitamin E 3.4016863852
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9715318939
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D008654 Mesothelioma Selenium 2.9015107826
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010954 Plasmacytoma Selenium 5.5015087411
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2515084515
MESH:D012871 Skin Diseases Vitamin E 2.5118709164
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.838532709
MESH:D020521 Stroke Vitamin E 3.8116517955
MESH:D014581 Urticaria Acetaminophen 3.3810982225
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved