AutismKB 2.0

Annotation Detail for CLYBL


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Basic Information Top
Gene Symbol:CLYBL ( CLB,bA134O15.1 )
Gene Full Name: citrate lyase beta like
Band: 13q32.3
Quick LinksEntrez ID:171425; OMIM: 609686; Uniprot ID:CLYBL_HUMAN; ENSEMBL ID: ENSG00000125246; HGNC ID: 18355
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P02772Pyruvate metabolism
No data
Related Diseases/Disorders Top
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Desease Name
ADHD
PSYCH
attention-deficit hyperactivity disorder
Desease Name
Attention deficit hyperactivity disorder
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CLYBL mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CLYBL mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of CLYBL mRNAdecreases expression 16788091
D000082 Acetaminophen Acetaminophen affects the expression of CLYBL mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of CLYBL proteinaffects expression 20106945
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CLYBL mRNAaffects cotreatment|decreases expression 18164116
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CLYBL mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in decreased expression of CLYBL mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CLYBL mRNAaffects cotreatment|decreases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CLYBL mRNAaffects cotreatment|affects expression 17602206
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of CLYBL mRNAaffects cotreatment|increases expression 17183730
C006253 pirinixic acid pirinixic acid results in increased expression of CLYBL mRNAincreases expression 17426115
18301758
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of CLYBL mRNAaffects cotreatment|increases expression 17183730
D014635 Valproic Acid Valproic Acid results in increased expression of CLYBL mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.648875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0419490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000236 Adenoma beta-Naphthoflavone 7.0819389873
MESH:D000236 Adenoma Diethylnitrosamine 7.086695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.6116434500 19052882 19061943 17620307 17162532 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.6116434500
MESH:D000550 Amblyopia Valproic Acid 5.4117688650
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.6617497229
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8518316065 16609825 18558336 20603192 17688650 18177632 17157402 15238991 17507914 18775368 18985861 18940202 19460635 19232924 18396377
MESH:D001714 Bipolar Disorder Valproic Acid 3.1320046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2619483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.478888407
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2217474063
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.0416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.0416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.043084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 9.0421507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 9.0418665156 18788625 11831363 20727157 16681979 19701751 18971187 16878318 20524982 3084413 16779866 18506893 19519916 17138121 3581430 19171122 17428255 17978847 20432363 16502159 18691550 19539802 10737359 20514400 18056438 16328049 19418558 17173139 20512989 16288022 17761372 19919837 19822196 10672840 21159647 17055752 16807293 16540662 20101231 20214788 18210153 16830150 19383236 16698587 19335982 16935385 20007298 18978308 19107877 19208518 19394651 16569478 18494052 18785209 18393292 20935162 19052882 20084675 17162532
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.596135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.5912371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.5917174075 2727394 7505956 21159647
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7420734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7819052882
MESH:D002779 Cholestasis Cyclosporine 8.0319486331
MESH:D002779 Cholestasis pirinixic acid 8.0319176532
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 8888407 16575769
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.3618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.3618551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2120387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.3421346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.3421346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.3410915739 16109766 12153990 11834606 11287661 17522070 17906064 19370779 18713872 16227642 19739265 14986274 10663392 12705907 2444490 16393943 19923254 19416960 11529661 17562736 15619225 18071297 12594235 11421492 19164858 16485898 12540782 16081117 11743745 11461765 11739529 19085960 19420014 15968718 14550746 12958197 14725611 16781746 12392966 16177239 10774834
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.3419107877
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 12.341733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004421 Dystonia Valproic Acid 4.171851702
MESH:D004487 Edema pirinixic acid 2.5912083418
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.293659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.0916628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9918234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.686254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.447750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.223659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2916302075
MESH:D005234 Fatty Liver Cyclosporine 19.7019224547
MESH:D005234 Fatty Liver Diethylnitrosamine 19.7020387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 19.7020131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 19.7014986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.0616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.2618558336 8888407
MESH:D005355 Fibrosis Cyclosporine 3.2812639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006529 Hepatomegaly pirinixic acid 3.1318467677 16221962 19772884 19176532
MESH:D006849 Hydrocephalus Valproic Acid 5.0217688650
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006973 Hypertension Cyclosporine 2.1310903974
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.7616612254
MESH:D007249 Inflammation Diethylnitrosamine 2.4318785209
MESH:D007333 Insulin Resistance pirinixic acid 2.7016306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Acetaminophen 5.9915629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 5.9918776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.9116705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.9116705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.9112371664
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1716294345 17596541
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8818407596 18665156 20032147 18522880 19638242
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Acetaminophen 3.9916610002 12969438 19784758 19460945 12587719 19014921 16611625 11587558
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9917034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3417185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 18.517678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 18.519163691 2125692 15890375 18177683
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 18.5121295105 19389873
MESH:D008113 Liver Neoplasms Clofibric Acid 18.5117602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 18.5119255062 10737359 15175105 19090486 20101389 19850985 20583210 20434301 18977376 19073162 19254457 19551842 21071580 20492335 2862719 19427195 21167192 15885732 19996281 19642983 18648771 19812893 19499222 18978307 19638242 21047994 19294768 9163691 19426721 19256749 21278145 20501860 18644402 19833225 19690152 20452335 12112319 18754104 12771043 20405173 20137499 2422723 20118626 16942905
MESH:D008113 Liver Neoplasms pirinixic acid 18.5115890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.726135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 14.728603461
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 14.7218164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.7217174075 16267830 21159647 19539802 19126423 18775883 18093689 19009564 17854601 18282651 17942915 16842330 2563599 9362446 18164116 18308698 18253720 19519916 3124819 18544905 18079962 19004024
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4417228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.5214755239
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.5220970405 6695378 21163286 20512841
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D008881 Migraine Disorders Valproic Acid 3.2718803445 18765137
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.148888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2117596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.8718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.8718551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.609029167 3581430
MESH:D009369 Neoplasms pirinixic acid 1.9917405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3818481113 19348381
MESH:D009436 Neural Tube Defects Valproic Acid 3.2016359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.4918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.4920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2920387270
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.2316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.2316049721
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4516540662
MESH:D011230 Precancerous Conditions Cyclosporine 9.2712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.272563599
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 3.9820603192
MESH:D019310 Pseudolymphoma Valproic Acid 4.7112752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2919155313
MESH:D012559 Schizophrenia Valproic Acid 2.0815737665 19110320
MESH:D012640 Seizures 2,4-dinitrotoluene 10.2518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.2518551238
MESH:D012640 Seizures Valproic Acid 10.253137016 17978042 11738929 15475178 11044598 16876388 1511512 14763951
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.7112833885
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.077505956
MESH:D014178 Translocation, Genetic Valproic Acid 5.4117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.673119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.1416049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1416049721
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.788888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.5110091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.5110091137
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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