AutismKB 2.0

Annotation Detail for DHCR7


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DHCR7 ( SLOS )
Gene Full Name: 7-dehydrocholesterol reductase
Band: 11q13.4
Quick LinksEntrez ID:1717; OMIM: 602858; Uniprot ID:DHCR7_HUMAN; ENSEMBL ID: ENSG00000172893; HGNC ID: 2860
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY66-341cholesterol biosynthesis I
PWY66-4cholesterol biosynthesis III (via desmosterol)
PWY66-3cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
Pathway IDPathway Name
hsa01100Metabolic pathways
hsa00100Steroid biosynthesis
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
No data
Pathway IDPathway Name
500825Cholesterol biosynthesis
Related Diseases/Disorders Top
Desease IDDesease Name
H00161Smith-Lemli-Opitz syndrome
Inherited disorders of lipid/glycolipid metabolism
Genetic disorders
No data
No data
Desease Name
Vitamin D insufficiency
Desease Name
Smith-Lemli-Opitz syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C049325 1,2-dithiol-3-thione 1,2-dithiol-3-thione results in decreased expression of DHCR7 mRNAdecreases expression 15302862
C003585 22-hydroxycholesterol 22-hydroxycholesterol results in decreased expression of DHCR7 mRNAdecreases expression 19426978
C021296 2-ethoxyethanol 2-ethoxyethanol results in increased expression of DHCR7 mRNAincreases expression 19643169
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of DHCR7 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of DHCR7 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of DHCR7 proteinaffects expression 20106945
C430898 AGN 194204 AGN 194204 results in increased expression of DHCR7 mRNAincreases expression 15302862
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DHCR7 mRNAaffects expression 16483693
D016718 Arachidonic Acid Arachidonic Acid results in decreased expression of DHCR7 mRNAdecreases expression 16704987
D001554 Benzene Benzene affects the expression of DHCR7 mRNAaffects expression 15878777
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of DHCR7 mRNAdecreases expression 20106945
C095105 bexarotene bexarotene results in increased expression of DHCR7 mRNAincreases expression 16648578
C006780 bisphenol A bisphenol A results in decreased expression of DHCR7 mRNAdecreases expression 15901920
D003024 Clozapine Clozapine results in increased expression of DHCR7 mRNAincreases expression 17052361
D016572 Cyclosporine Cyclosporine results in decreased expression of DHCR7 mRNAdecreases expression 20106945
D004128 Dimethylnitrosamine Dimethylnitrosamine results in decreased expression of DHCR7 mRNAdecreases expression 17547211
D000431 Ethanol [Fish Oils co-treated with Ethanol] results in increased expression of DHCR7 mRNAaffects cotreatment|increases expression 17347304
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of DHCR7 mRNAincreases expression 16872691
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of DHCR7 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DHCR7 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of DHCR7 mRNAdecreases expression 15901920
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of DHCR7 mRNAincreases expression 16174780
D005395 Fish Oils [Fish Oils co-treated with Ethanol] results in increased expression of DHCR7 mRNAaffects cotreatment|increases expression 17347304
D006861 Hydrogen Peroxide [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of DHCR7 mRNAaffects cotreatment|increases expression 18032389
C016527 isoquercitrin [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of DHCR7 mRNAaffects cotreatment|increases expression 18032389
C005219 methyl cellosolve methyl cellosolve results in increased expression of DHCR7 mRNAincreases expression 19643169
C016599 mono-(2-ethylhexyl)phthalate mono-(2-ethylhexyl)phthalate affects the expression of DHCR7 mRNAaffects expression 16809437
C016599 mono-(2-ethylhexyl)phthalate mono-(2-ethylhexyl)phthalate results in decreased expression of DHCR7 mRNAdecreases expression 16809437
D005996 Nitroglycerin Nitroglycerin results in decreased expression of DHCR7 mRNAdecreases expression 12102619
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of DHCR7 mRNAdecreases expression 17616710
D010126 Ozone Ozone results in decreased expression of DHCR7 mRNAdecreases expression 16716893
D010269 Paraquat Paraquat results in decreased expression of DHCR7 mRNAdecreases expression 16328009
D010656 Phenylephrine Phenylephrine results in increased expression of DHCR7 mRNAincreases expression 18158353
D010795 Phthalic Acids Phthalic Acids results in decreased expression of DHCR7 mRNAdecreases expression 15728792
D010852 Picrotoxin Picrotoxin results in decreased expression of DHCR7 mRNAdecreases expression 15170462
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DHCR7 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of DHCR7 mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased expression of DHCR7 mRNAincreases expression 11798191
17426115
D011374 Progesterone Progesterone results in increased expression of DHCR7 mRNAincreases expression 18070364
C045950 propiconazole propiconazole results in increased expression of DHCR7 mRNAincreases expression 17178688
D012643 Selenium Selenium results in increased expression of DHCR7 mRNAincreases expression 19244175
D012967 Sodium Dodecyl Sulfate Sodium Dodecyl Sulfate results in decreased expression of DHCR7 mRNAdecreases expression 12815608
C025462 sulindac sulfide sulindac sulfide results in decreased expression of DHCR7 mRNAdecreases expression 16184548
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DHCR7 mRNAaffects cotreatment|increases expression 17942748
C066340 tolcapone tolcapone binds to DHCR7 proteinaffects binding 19783845
D001371 trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride results in decreased activity of DHCR7 proteindecreases activity 16814115
C034613 triacsin C triacsin C results in decreased expression of DHCR7 mRNAdecreases expression 16704987
C032910 triadimefon triadimefon results in increased expression of DHCR7 mRNAincreases expression 17178688
D014810 Vitamin E Vitamin E affects the expression of DHCR7 mRNAaffects expression 15370891
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 2-ethoxyethanol 22.027151721 6499812 6499820 6499823 6499796
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 22.027525203
MESH:D000014 Abnormalities, Drug-Induced Ethanol 22.0217676605 18926900
MESH:D000014 Abnormalities, Drug-Induced methyl cellosolve 22.026474471 6499812 3652986
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 22.0215322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 9.0018287403
MESH:D000138 Acidosis Ethanol 9.0011192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.4917505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.7118653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.3420127859 20464547
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 6.3416033868
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.3414692618
MESH:D000236 Adenoma Benzo(a)pyrene 6.006695378
MESH:D000236 Adenoma Dimethylnitrosamine 6.0019555203
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.4316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.4316835633
MESH:D000380 Agranulocytosis Clozapine 4.6214617031 16160616 12649775
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.3311874814
MESH:D017109 Akathisia, Drug-Induced tolcapone 5.8411080934
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.8715451040 15451039
MESH:D000544 Alzheimer Disease Ozone 6.1815513908
MESH:D000544 Alzheimer Disease sulindac sulfide 6.1818759972
MESH:D000544 Alzheimer Disease tolcapone 6.1820150427
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.5711748828
MESH:D000741 Anemia, Aplastic Benzene 4.0317661222 14761424 11369114
MESH:D000748 Anemia, Macrocytic methyl cellosolve 5.903699323
MESH:D000799 Angioedema Acetaminophen 3.3910982225
MESH:D000853 Anophthalmos Ethanol 4.3915513904
MESH:D001008 Anxiety Disorders Ethanol 3.6611141031
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.6419183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.7317460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0311256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.3915885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.4515570426
MESH:D053627 Asthenozoospermia 2-ethoxyethanol 11.136499807 10689203 6499823
MESH:D053627 Asthenozoospermia methyl cellosolve 11.133987992
MESH:D001249 Asthma Ozone 2.4916373670 17854713
MESH:D001259 Ataxia 2-ethoxyethanol 5.057151721
MESH:D001284 Atrophy 2-ethoxyethanol 10.016499799 15850284
MESH:D001284 Atrophy methyl cellosolve 10.012626667 3699323 6705890
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.0620106747
MESH:D001321 Autistic Disorder marker/mechanism 14659996
MESH:D001321 Autistic Disorder Acetaminophen 2.2318445737
MESH:D001321 Autistic Disorder Arachidonic Acid 2.2318582451
MESH:D053713 Azoospermia 2-ethoxyethanol 5.146492198 6499807
MESH:D001724 Birth Weight 2-ethoxyethanol 6.062884743 6499823
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.4619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.4612125929
MESH:D001836 Body Weight Changes 2-ethoxyethanol 10.527151721 6499796
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 10.5215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4715746008
MESH:D001855 Bone Marrow Diseases Benzene 4.7816183116
MESH:D001862 Bone Resorption bisphenol A 3.4711985600
MESH:D001919 Bradycardia Phenylephrine 4.1015306635
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.8917868700
MESH:D001930 Brain Injuries Progesterone 3.8315665606 15845082 15380490
MESH:D001943 Breast Neoplasms Benzene 2.7111921183 17162533
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.7117474063 20146248
MESH:D001943 Breast Neoplasms bexarotene 2.7116344269 16818667
MESH:D001943 Breast Neoplasms bisphenol A 2.7117123778
MESH:D001943 Breast Neoplasms Progesterone 2.7115562024 17614352 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.7120435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.3315516495 17626835 18417511 14754758 18315731 16777450 19059883
MESH:D002056 Burns Ethanol 4.2216374292
MESH:D002100 Cachexia Ozone 4.3016183385
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.5016050911
MESH:D002277 Carcinoma Dimethylnitrosamine 7.1919555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.1916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.143084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.1421507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Ethanol 4.1418788625 15289165 15763234
MESH:D002278 Carcinoma in Situ bisphenol A 4.5417123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 5.4516247446
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 5.4512391285
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.3220419170
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 4.3216033868
MESH:D006332 Cardiomegaly Ethanol 10.0019332462
MESH:D006332 Cardiomegaly Phenylephrine 10.0016170337 11179087 17124262 11754973 17287366 15728586
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 10.0018670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.2116936243
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 6.5314694615
MESH:D002386 Cataract Acetaminophen 6.5310977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.2312371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.7916835633
MESH:D002764 Cholecystitis 2-ethoxyethanol 12.156499794
MESH:D002764 Cholecystitis methyl cellosolve 12.156499794
MESH:D002779 Cholestasis Cyclosporine 11.4319486331
MESH:D002779 Cholestasis Ethinyl Estradiol 11.4317681005 11677210 16105132 17110522 16919318 15861022 17333356
MESH:D002779 Cholestasis pirinixic acid 11.4319176532
MESH:D002971 Cleft Lip Ethanol 3.3415513904
MESH:D002972 Cleft Palate Ethanol 8.8215513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 8.8215668235 16354765 12621046 8697196 15340226
MESH:D002972 Cleft Palate triadimefon 8.8216781842
MESH:D003072 Cognition Disorders Clozapine 4.5317123785
MESH:D003092 Colitis Selenium 3.3517936198
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 13.5115095906
MESH:D000013 Congenital Abnormalities methyl cellosolve 13.516499821 12530607
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 13.5114669216 17141729
MESH:D019465 Craniofacial Abnormalities Benzene 6.7115643154
MESH:D019465 Craniofacial Abnormalities Ethanol 6.7115451039 15513904 19302082 10194807 11198716 15451040 11873399
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.7115322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities triadimefon 6.7116875885 15834900
MESH:D019465 Craniofacial Abnormalities Vitamin E 6.7119769572
MESH:D003643 Death 2-ethoxyethanol 5.516499796
MESH:D003866 Depressive Disorder tolcapone 3.997768276 11224284
MESH:D003865 Depressive Disorder, Major tolcapone 4.5310440460
MESH:D003872 Dermatitis Benzene 4.3315902427
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2118249437
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.0916402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0917107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.0617187935
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.1015331141
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 16.3521346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 16.3510774834 17906064 17562736 11421492 19420014 18071297 16393943 12958197 11834606 16177239 19164858 17522070 14986274 11287661 15619225 19085960 11529661 15968718 19923254 10915739 12153990 16081117 12392966 16109766 12594235 12705907 18713872 19416960 16227642 11461765 12540782 16781746 2444490 14725611 11743745 19739265 19370779 10663392 14550746 11739529 16485898
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 16.358172417
MESH:D056486 Drug-Induced Liver Injury Ethanol 16.3511566570
MESH:D056486 Drug-Induced Liver Injury Selenium 16.3515131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 16.3520420201
MESH:D056486 Drug-Induced Liver Injury tolcapone 16.3516604736 19783845
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6519426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4311462148
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 4.9511455177
MESH:D050171 Dyslipidemias Clozapine 3.8616402076
MESH:C538011 Eales disease Vitamin E 4.259068938
MESH:D004487 Edema Arachidonic Acid 9.2611698051 9831321 16716910 7990266 15177302 9599246
MESH:D004487 Edema pirinixic acid 9.2612083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.2611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.4518230668 15322242 16714409
MESH:D020964 Embryo Loss 2-ethoxyethanol 6.066499796
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.6412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 7.6417692515
MESH:D004715 Endometriosis Progesterone 7.6616134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.6610568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 9.3616530937
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 9.3617016578
MESH:D004938 Esophageal Neoplasms Ethanol 9.3616704527
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 9.3616805852 16510608 15623463 15264214 15150132 15547733 15547721 15878914 16704527
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 5.4919578428
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6811564622
MESH:D005234 Fatty Liver Cyclosporine 20.4819224547
MESH:D005234 Fatty Liver Ethanol 20.4819236843 18620774 16409862
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.4815345470
MESH:D005234 Fatty Liver Fish Oils 20.4818620774
MESH:D005234 Fatty Liver pirinixic acid 20.4819236843 20131406
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.2117920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.8616946407 10194807 15513904 15451040
MESH:D005313 Fetal Death 2-ethoxyethanol 9.406499823 7151721 6499820 7198755 2884743
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 9.4011858732
MESH:D005317 Fetal Growth Retardation 2-ethoxyethanol 4.996499796
MESH:D005327 Fetal Resorption 2-ethoxyethanol 11.176499812 6499820
MESH:D005327 Fetal Resorption methyl cellosolve 11.176474471 3987992 6499821 6499812
MESH:D020567 Fetal Weight 2-ethoxyethanol 12.157151721 6499820 2884743
MESH:D020567 Fetal Weight methyl cellosolve 12.156474471 6499812 6499821
MESH:D005334 Fever Arachidonic Acid 4.2811852909
MESH:D005355 Fibrosis Cyclosporine 7.0512639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.0520067830
MESH:D005532 Foot Deformities, Congenital methyl cellosolve 5.063652986
MESH:D005756 Gastritis Acetaminophen 9.6316983495
MESH:D005756 Gastritis Ethanol 9.6315046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.788708960
MESH:D005911 Gliosis Paraquat 4.7111124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1410696789
MESH:D006261 Headache Nitroglycerin 4.7411284996 11554966
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.6820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.6811294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 9.6816080930
MESH:D006333 Heart Failure pirinixic acid 6.0220558911
MESH:D006333 Heart Failure Selenium 6.0217162251
MESH:D006345 Heart Septal Defects, Ventricular methyl cellosolve 5.346499821
MESH:D006402 Hematologic Diseases 2-ethoxyethanol 9.9710514026 20172899
MESH:D006402 Hematologic Diseases Benzene 9.9716183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.9815720958
MESH:D006461 Hemolysis 2-ethoxyethanol 10.8419051582 17874071
MESH:D006461 Hemolysis methyl cellosolve 10.8417874071
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9411000095
MESH:D006529 Hepatomegaly pirinixic acid 17.2316221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly propiconazole 17.2317178689 17178688
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 17.2315340226 12621046 16120746
MESH:D006529 Hepatomegaly triadimefon 17.2317178688 17178689
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.5416490937 16863852
MESH:D019584 Hot Flashes Vitamin E 3.5214716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5916959395 8697196 18606429 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 6.6516870215
MESH:D006930 Hyperalgesia Ethanol 6.6518783367
MESH:D006943 Hyperglycemia pirinixic acid 2.8020558911
MESH:D006948 Hyperkinesis Clozapine 4.4716046005
MESH:D006949 Hyperlipidemias Fish Oils 4.3515752949
MESH:D006968 Hypersensitivity, Delayed Fish Oils 5.0511484837
MESH:D006973 Hypertension Benzene 10.8717940673
MESH:D006973 Hypertension Cyclosporine 10.8710903974
MESH:D006973 Hypertension Phenylephrine 10.8712717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 10.8718670907 18850075
MESH:D006984 Hypertrophy Phenylephrine 4.1612791704 18502941
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3816569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.9715869954
MESH:D007247 Infertility, Female 2-ethoxyethanol 9.046499823
MESH:D007247 Infertility, Female Ethinyl Estradiol 9.0412013081
MESH:D007248 Infertility, Male 2-ethoxyethanol 13.706499823
MESH:D007248 Infertility, Male Ethinyl Estradiol 13.7017937319
MESH:D007248 Infertility, Male methyl cellosolve 13.703987992
MESH:D007248 Infertility, Male Paraquat 13.704850670
MESH:D007249 Inflammation Arachidonic Acid 7.059831321 15177302 17371808
MESH:D007249 Inflammation Progesterone 7.0515869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.0512878042 12200463
MESH:D007251 Influenza, Human Selenium 9.4616624496
MESH:D007251 Influenza, Human Vitamin E 9.4616624496
MESH:D007333 Insulin Resistance bisphenol A 6.3316393666
MESH:D007333 Insulin Resistance pirinixic acid 6.3316306350
MESH:D007569 Jaw Abnormalities Ethanol 15.0315513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 15.0316580747
MESH:D007569 Jaw Abnormalities triadimefon 15.0315992940 15834900
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.9915604871
MESH:D007674 Kidney Diseases Acetaminophen 8.4715629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 8.4718776723 8314463 10903974
MESH:D007674 Kidney Diseases Vitamin E 8.4712488133
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 8.7116518626
MESH:D007676 Kidney Failure, Chronic Selenium 8.7116518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.3812371664
MESH:D007859 Learning Disorders Ethanol 3.7815451040
MESH:D007938 Leukemia Benzene 3.1617119257 18335105 14694614 15935818
MESH:D007951 Leukemia, Myeloid Benzene 3.9317506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.6219478238
MESH:D017880 Limb Deformities, Congenital Ethanol 7.6917676605
MESH:D017880 Limb Deformities, Congenital methyl cellosolve 7.696499821
MESH:D008064 Lipidoses Clozapine 7.8117567588
MESH:D008064 Lipidoses trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride 7.8115342952
MESH:D008103 Liver Cirrhosis Ethanol 3.1215289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.6518295389
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 6.0316009107 15366600 17198567 15298665 16570917 15086199 14568256 17881167 17534399 15733078 15504291 18637143 18629640 16042886 15798949 12918455 15744066 16270385 15723089 15339415 15793283 14659978 15161499 15842777 16169303 15864749 15571005 15067225 14643895 17640959 15591649 18567088 16603200 17432682 15577212 15081153 18239293 16544323 17203207 18672772 17724770 15942678 17719030 17348192 18095165 18237412 15099470 18210741 16627068 17196135 17666798 12925901 15492853 15138612 17201889 17465448 14726149 15479170 15383259 18364076 17036385 14709902 15763062 18371158 15369754
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 6.0318166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.0315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.0312878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.0316169303
MESH:D008107 Liver Diseases Acetaminophen 6.0019784758 16611625 11587558 12969438 12587719 16610002 19014921 19460945
MESH:D008107 Liver Diseases propiconazole 6.0019363144
MESH:D008107 Liver Diseases triadimefon 6.0019363144
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.2217207112 17347304
MESH:D017114 Liver Failure, Acute Acetaminophen 8.4016871587 17185352
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 8.4017457977
MESH:D008113 Liver Neoplasms Aflatoxin B1 19.052125692 18177683 9163691 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 19.0521137059 20195826
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 19.053113478 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 19.0516377806 20007298 15890375
MESH:D008113 Liver Neoplasms propiconazole 19.0519028983
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 19.0516984957
MESH:D008113 Liver Neoplasms triadimefon 19.0519028983
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 19.708603461
MESH:D008114 Liver Neoplasms, Experimental Benzene 19.7012562636
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 19.706150874 15603536 1848544
MESH:D008114 Liver Neoplasms, Experimental propiconazole 19.7017178689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 19.7012151625
MESH:D008114 Liver Neoplasms, Experimental triadimefon 19.7017178689
MESH:D008171 Lung Diseases Ozone 6.5119066396 8266340
MESH:D008171 Lung Diseases Vitamin E 6.5116863852
MESH:D017563 Lung Diseases, Interstitial Benzene 4.3614698565
MESH:D055370 Lung Injury Ozone 3.4220417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 11.7914755239
MESH:D008175 Lung Neoplasms Benzene 11.7912562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 11.7920064080 20464547 17053015 18569708 6695378 18816296 18520028 20135361 20869020
MESH:D008175 Lung Neoplasms bexarotene 11.7917849452
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 11.7919555203 16061637 11884234
MESH:D008175 Lung Neoplasms Ozone 11.797614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 11.7911884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 11.7911062179
MESH:D008223 Lymphoma Benzene 3.4217119257 17584886
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.7111161223
MESH:D008231 Lymphopenia methyl cellosolve 5.343699323
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.0012562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 11.9511921183
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 11.9519196722 19196723 15591091
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 11.9511408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Selenium 11.9515318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1419513568
MESH:D008569 Memory Disorders Ethanol 3.7715451040 18411066
MESH:D001523 Mental Disorders Clozapine 3.5216856516
MESH:D008654 Mesothelioma Selenium 2.6015107826
MESH:D024821 Metabolic Syndrome X Clozapine 4.0519142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.3416801185
MESH:D008679 Metaplasia Ozone 4.6510496685
MESH:D008708 Methemoglobinemia Nitroglycerin 4.333537620
MESH:D020326 Migraine without Aura Nitroglycerin 4.7014659530
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.8516381670
MESH:D009101 Multiple Myeloma Benzene 3.3517119195
MESH:D009135 Muscular Diseases pirinixic acid 3.0816239165
MESH:D009203 Myocardial Infarction Nitroglycerin 5.3514729435
MESH:D009203 Myocardial Infarction pirinixic acid 5.3519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6712213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.6116411023
MESH:D009336 Necrosis 2-ethoxyethanol 4.9020172899
MESH:D009369 Neoplasms Benzo(a)pyrene 4.0611141357
MESH:D009369 Neoplasms pirinixic acid 4.0617405874
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.3319196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.9917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.9119348381 18481113
MESH:D009410 Nerve Degeneration Paraquat 3.3816893418
MESH:D009421 Nervous System Malformations bisphenol A 8.1911399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.1914600291
MESH:D009436 Neural Tube Defects Benzene 3.3815643154
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.5118514411
MESH:D009765 Obesity Clozapine 4.2819142110 18515891
MESH:D009765 Obesity pirinixic acid 4.2820558911
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 8.1314694615
MESH:D009784 Occupational Diseases Benzene 8.1317178637 15913788 17119257 15935809 17479406 16737584 15576619 15612468 15727169
MESH:D009845 Oligospermia 2-ethoxyethanol 9.9120172899
MESH:D009845 Oligospermia methyl cellosolve 9.913987992
MESH:D010049 Ovarian Diseases bisphenol A 4.5411985600
MESH:D010051 Ovarian Neoplasms Benzene 4.6312562636
MESH:D010051 Ovarian Neoplasms Progesterone 4.6316525653 17393432
MESH:D010146 Pain Acetaminophen 2.0516870215
MESH:D010190 Pancreatic Neoplasms Ethanol 2.8012384795
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2811578682
MESH:D010212 Papilloma Hydrogen Peroxide 3.6612065085
MESH:D010300 Parkinson Disease Paraquat 5.2015824117 12911755 16140633 15451049 16510128 11445065 11181820 11124998
MESH:D010300 Parkinson Disease tolcapone 5.209708959 17089403 16758261 11793426 8635184 7566641 1977408 10651109 20216409 8739811 9305320 9333106 9591521 11586115 11746615 20334432 19578428 18328768 11432539 19783845 9754991
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.0016190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8012520081
MESH:D010538 Peritonitis Ozone 3.7016369182
MESH:D010954 Plasmacytoma Selenium 4.4415087411
MESH:D011014 Pneumonia Ozone 9.5918929643 18007984 18381685
MESH:D011014 Pneumonia Paraquat 9.5912504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1418163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.8512371664
MESH:D011297 Prenatal Exposure Delayed Effects 2-ethoxyethanol 19.727198755 2884743 6499817
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 19.7210548101
MESH:D011297 Prenatal Exposure Delayed Effects methyl cellosolve 19.726499817 12530607 7974496
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 19.7211896295 11222880 11399792 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 3.8120887781
MESH:D011471 Prostatic Neoplasms AGN 194204 2.2316000583
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.2317292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.2316740699
MESH:D011471 Prostatic Neoplasms Vitamin E 2.2315084515
MESH:D011537 Pruritus Ethinyl Estradiol 2.8716919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.0616882103
MESH:D011618 Psychotic Disorders Clozapine 3.8615331141
MESH:D011629 Puberty, Precocious bisphenol A 4.3410548101
MESH:D011658 Pulmonary Fibrosis Paraquat 2.7316324872 17997886
MESH:D015427 Reperfusion Injury pirinixic acid 2.1619058328
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.5011700416
MESH:D012135 Respiratory Sounds Paraquat 3.6311874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4218990726
MESH:D012162 Retinal Degeneration Paraquat 3.5416458197
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6918045962
MESH:D012559 Schizophrenia Clozapine 2.6719369910 18855531 16141801 20452607 18806925 20521326 17123785 11763009 11151749 20107430 20521320 17726453 20580759 17667964 20168265
MESH:D012640 Seizures Ethanol 5.639754883
MESH:D012640 Seizures Picrotoxin 5.638635557 8954991
MESH:D012852 Sinusitis Phenylephrine 4.267327846
MESH:D012871 Skin Diseases Vitamin E 2.3218709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.1510029692 19755658
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 8.1512065085
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.1516192470
MESH:D019082 Smith-Lemli-Opitz Syndrome marker/mechanism 12818773 16814115 11254748 12906934 14659996
MESH:D013088 Spermatocele Ethinyl Estradiol 3.4916709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.8415862959 16503802
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.8212587719
MESH:D013274 Stomach Neoplasms Benzene 5.8312562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 5.8320155912 2093021
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 5.8316033868
MESH:D013274 Stomach Neoplasms Ethanol 5.8318456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 5.8317575124 12958204
MESH:D013276 Stomach Ulcer 2-ethoxyethanol 6.596499799
MESH:D013276 Stomach Ulcer Ethanol 6.5911906479 17189318 17918041 9562338 16755016 9211565
MESH:D020521 Stroke Vitamin E 3.1716517955
MESH:D019966 Substance-Related Disorders bisphenol A 3.5416684133 16045194
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.879754883
MESH:D013733 Testicular Diseases 2-ethoxyethanol 9.5910514026 10048760 6499806
MESH:D013733 Testicular Diseases methyl cellosolve 9.596499806
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7815669648
MESH:D013953 Thymus Neoplasms Benzene 4.5110850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4512697716
MESH:D013964 Thyroid Neoplasms triadimefon 3.7517178689
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 5.4919578428
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.0017053015
MESH:D014581 Urticaria Acetaminophen 2.5710982225
MESH:D014591 Uterine Diseases bisphenol A 4.5614652134
MESH:D014594 Uterine Neoplasms Benzene 13.7512562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 13.7514692618
MESH:D014594 Uterine Neoplasms sulindac sulfide 13.7518645019
MESH:D014605 Uveitis Cyclosporine 3.531336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1414671159 15869587
MESH:D014820 Vitiligo tolcapone 4.7710573327
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8015886252
MESH:D015430 Weight Gain Clozapine 4.1020107430 17502770 16141801 16402076 20564506 20521320
MESH:D015431 Weight Loss Clozapine 4.6317933447
MESH:D014985 Xerophthalmia Cyclosporine 3.9917120751
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:00100 Steroid biosynthesis
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00157 - NADH Dietary supplement;Micronutrient
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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