AutismKB 2.0

Annotation Detail for DHFR


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Basic Information Top
Gene Symbol:DHFR ( DHFRP1,DYR )
Gene Full Name: dihydrofolate reductase
Band: 5q14.1
Quick LinksEntrez ID:1719; OMIM: 126060; Uniprot ID:DYR_HUMAN; ENSEMBL ID: ENSG00000228716; HGNC ID: 2861
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00670One carbon pool by folate
hsa01100Metabolic pathways
hsa00790Folate biosynthesis
Pathway IDPathway Name
Cell Cycle, Mitotic
Metabolism of vitamins and cofactors
Pathway IDPathway Name
200027E2F transcription factor network
Pathway IDPathway Name
P02743Formyltetrahydroformate biosynthesis
P02742Tetrahydrofolate biosynthesis
Pathway IDPathway Name
501009Metabolism of folate and pterines
Related Diseases/Disorders Top
No data
No data
Desease Name
Birth Weight
Smith-Lemli-Opitz syndrome
neural tube defects
METABOLIC
folic acid in plasma and red blood cell folate
preterm delivery
DEVELOPMENTAL
REPRODUCTION
No data
Desease Name
Anemia, megaloblastic, due to DHFR deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C090203 1,2-epoxy-3,4-dihydroxy-1,2,3,4-tetrahydrobenzo(c)phenanthrene 1,2-epoxy-3,4-dihydroxy-1,2,3,4-tetrahydrobenzo(c)phenanthrene results in increased mutagenesis of DHFR geneincreases mutagenesis 8417332
2062855
1465420
2371281
C014024 2,4,5,2',4',5'-hexachlorobiphenyl 2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of DHFR mRNAdecreases expression 20005886
C030371 5,6,7,8-tetrahydrofolic acid DHFR protein results in increased chemical synthesis of 5,6,7,8-tetrahydrofolic acidincreases chemical synthesis 17413111
C054852 7-hydroxystaurosporine 7-hydroxystaurosporine results in increased activity of DHFR proteinincreases activity 14653808
C054852 7-hydroxystaurosporine 7-hydroxystaurosporine results in increased expression of DHFR mRNAincreases expression 14653808
D000082 Acetaminophen Acetaminophen affects the expression of DHFR mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DHFR mRNAaffects expression 16483693
C015001 arsenite arsenite results in decreased expression of DHFR mRNAdecreases expression 18929588
C089231 benzo(g)chrysene-11,12-dihydrodiol-13,14-epoxide benzo(g)chrysene-11,12-dihydrodiol-13,14-epoxide results in increased mutagenesis of DHFR exonincreases mutagenesis 7586212
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of DHFR mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DHFR mRNAdecreases expression 20018196
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of DHFR mRNAincreases expression 19150397
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DHFR mRNAaffects cotreatment|decreases expression 20360939
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of DHFR mRNAdecreases expression 17484886
D002699 Chlorambucil DHFR protein polymorphism results in decreased susceptibility to Chlorambucildecreases response to substance 12872145
D003561 Cytarabine Cytarabine results in increased expression of DHFR mRNAincreases expression 19194470
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in decreased expression of DHFR mRNAaffects cotreatment|decreases expression 15784690
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DHFR mRNAaffects cotreatment|decreases expression 20360939
C010920 dihydrofolate DHFR protein results in increased metabolism of dihydrofolateincreases metabolic processing 17413111
D004642 Emodin Emodin results in decreased expression of DHFR mRNAdecreases expression 16045814
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of DHFR mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of DHFR mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DHFR mRNAaffects cotreatment|increases expression 17942748
D005020 Ethyl Methanesulfonate Ethyl Methanesulfonate results in increased mutagenesis of DHFR geneincreases mutagenesis 8417332
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of DHFR geneincreases mutagenesis 8417332
D005472 Fluorouracil Fluorouracil affects the expression of DHFR mRNAaffects expression 16557594
D005472 Fluorouracil Fluorouracil results in increased expression of DHFR mRNAincreases expression 15109396
D005492 Folic Acid Folic Acid affects the expression of DHFR mRNAaffects expression 17311948
D005492 Folic Acid DHFR protein results in increased reduction of Folic Acidincreases reduction 17413111
D005493 Folic Acid Antagonists DHFR protein polymorphism results in decreased susceptibility to Folic Acid Antagonistsdecreases response to substance 12872145
D002955 Leucovorin Leucovorin results in increased expression of DHFR proteinincreases expression 16712799
D007213 Indomethacin Indomethacin results in increased expression of DHFR mRNAincreases expression 18299717
D007213 Indomethacin rebamipide inhibits the reaction [Indomethacin results in increased expression of DHFR mRNA]decreases reaction|increases expression 18299717
D007529 Isoflavones Isoflavones results in decreased expression of DHFR mRNAdecreases expression 17374662
D008727 Methotrexate DHFR protein results in decreased susceptibility to Methotrexatedecreases response to substance 14679136
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of DHFR mRNAincreases expression 20713471
C008493 methylselenic acid methylselenic acid results in decreased expression of DHFR mRNAdecreases expression 12517777
D009588 Nitrogen Mustard Compounds DHFR protein polymorphism results in decreased susceptibility to Nitrogen Mustard Compoundsdecreases response to substance 12872145
C090046 olomoucine olomoucine results in increased activity of DHFR proteinincreases activity 14653808
C085586 pemetrexed pemetrexed results in decreased activity of DHFR proteindecreases activity 17465208
C006253 pirinixic acid pirinixic acid results in increased expression of DHFR mRNAincreases expression 17426115
C025299 polyphenols polyphenols results in decreased expression of DHFR mRNAdecreases expression 16293270
C052785 rebamipide rebamipide inhibits the reaction [Indomethacin results in increased expression of DHFR mRNA]decreases reaction|increases expression 18299717
C104586 roscovitine roscovitine results in increased activity of DHFR proteinincreases activity 14653808
C017947 sodium arsenite sodium arsenite results in increased mutagenesis of DHFR geneincreases mutagenesis 12802802
C017947 sodium arsenite sodium arsenite results in decreased expression of DHFR proteindecreases expression 19072884
D013629 Tamoxifen Tamoxifen results in increased expression of DHFR mRNAincreases expression 15590111
D013629 Tamoxifen Tamoxifen affects the expression of DHFR mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DHFR mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DHFR mRNAincreases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DHFR mRNAincreases expression 16054898
C099150 trabectedin trabectedin results in decreased expression of DHFR mRNAdecreases expression 15961672
D014212 Tretinoin Tretinoin results in decreased expression of DHFR mRNAdecreases expression 18230668
D016597 Trimetrexate DHFR protein polymorphism results in decreased susceptibility to Trimetrexatedecreases response to substance 12872145
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in decreased expression of DHFR mRNAaffects cotreatment|decreases expression 15784690
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.0714745880
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 7.0612039119
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.0615322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.1018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.4717505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.379612607
MESH:D058186 Acute Kidney Injury Folic Acid 3.9216595132 16316344 17003819
MESH:D055371 Acute Lung Injury pirinixic acid 2.6918653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.0320127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.0314692618
MESH:D000230 Adenocarcinoma Fluorouracil 9.0317638652
MESH:D000230 Adenocarcinoma Indomethacin 9.0316537180
MESH:D000236 Adenoma Benzo(a)pyrene 22.616695378
MESH:D000236 Adenoma Diethylnitrosamine 22.6110737359 6695378
MESH:D000236 Adenoma Ethylnitrosourea 22.616695378
MESH:D000236 Adenoma Folic Acid 22.6116963246
MESH:D000236 Adenoma Indomethacin 22.6111497255
MESH:D000236 Adenoma Methylcholanthrene 22.616695378 10545420
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 14.5816434500 18056438 19061943 17162532 19052882 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 14.5816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 14.5816835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.2215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.4316712894 17306315
MESH:D000505 Alopecia Isoflavones 8.3517569567
MESH:D000505 Alopecia Tretinoin 8.3515955085
MESH:D016301 Alveolar Bone Loss Indomethacin 4.9017225004
MESH:D000544 Alzheimer Disease Folic Acid 4.2417116317
MESH:D000544 Alzheimer Disease Indomethacin 4.2415579461 17627676
MESH:D000740 Anemia Fluorouracil 7.3416511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.3411748828
MESH:D000749 Anemia, Megaloblastic marker/mechanism
MESH:D000799 Angioedema Acetaminophen 3.3710982225
MESH:D001014 Aortic Aneurysm Indomethacin 4.4110231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 10.2019183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 10.2010388637
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0111256880
MESH:D018771 Arthralgia Indomethacin 4.692160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.2215885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.2216412693
MESH:D001172 Arthritis, Rheumatoid Indomethacin 6.7711248219
MESH:D001172 Arthritis, Rheumatoid Methotrexate 6.7717286800
MESH:D001172 Arthritis, Rheumatoid Tretinoin 6.7716292516
MESH:D001249 Asthma Tretinoin 2.1916456186
MESH:D050197 Atherosclerosis Methylcholanthrene 3.1711922910
MESH:D001321 Autistic Disorder marker/mechanism 17597297
MESH:D001321 Autistic Disorder Acetaminophen 2.1618445737
MESH:D001321 Autistic Disorder Folic Acid 2.1621388746
MESH:D001471 Barrett Esophagus Tretinoin 3.9616935849
MESH:D001477 Bartter Syndrome Indomethacin 4.5310684365
MESH:D001778 Blood Coagulation Disorders pirinixic acid 12.8619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 12.8612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 12.8616206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4615746008
MESH:D001927 Brain Diseases Ethylnitrosourea 4.4814991843
MESH:D001929 Brain Edema Indomethacin 4.5511481608
MESH:D002545 Brain Ischemia Indomethacin 3.9512524144
MESH:D001932 Brain Neoplasms Ethylnitrosourea 3.8916436596 16357521 18412241 15144691 16651633
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 7.5820146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 7.5817474063
MESH:D001943 Breast Neoplasms Fluorouracil 7.5815136595 16557594 16595493 18357371 19217205 18608205 16110121
MESH:D001943 Breast Neoplasms Folic Acid 7.5816777985
MESH:D001943 Breast Neoplasms Indomethacin 7.5817401462
MESH:D001943 Breast Neoplasms Methotrexate 7.5816978400
MESH:D001943 Breast Neoplasms Methylcholanthrene 7.5817474063
MESH:D001943 Breast Neoplasms pemetrexed 7.5817465208 17575230
MESH:D001943 Breast Neoplasms Tamoxifen 7.5819244106 19155303 16202921 18629630 19059307 20135344 17242785 11161223 19103187 18351453 18984771 19084267 18821012 15668708 16273361 18855134 19142967 19115204 21138602 19011961 20390343 21152245 18425577 20859285 20065188 19189210 16818667 17261762 17049068 20544844 20005174 19200415 18997820 19288272 16873071 19221464 19410462 19189212 17440819 15565566 19066611 17893378 19487384 18815881 19289846
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 7.5820435547
MESH:D001943 Breast Neoplasms Tretinoin 7.5816873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.1216813970
MESH:D002056 Burns Indomethacin 4.2510459503
MESH:D002100 Cachexia Indomethacin 4.5411239499 16537180 15141370 15625704
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.3310355542 3786805 16011737 16227642 18705752 15700767 16124888 15673190 16050911 15721981 16097048 16192424
MESH:D002276 Carcinoid Tumor Fluorouracil 4.1916051944
MESH:D002277 Carcinoma Fluorouracil 11.8517121937
MESH:D002277 Carcinoma Methylcholanthrene 11.8510545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 11.8516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.0519066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.6816168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 15.273084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 15.2718788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 15.2719822196 19519916 19383236 19335982 19107877 17173139 20524982 16807293 18971187 18210153 17162532 19171122 20007298 19052882 20101231 16328049 18056438 3581430 20935162 18785209 16681979 19394651 18691550 17138121 18494052 16288022 20432363 3084413 17428255 18788625 19418558 18506893 16779866 19539802 11831363 17761372 18665156 18393292 21159647 17055752 10737359 19701751 16830150 17978847 16540662 19919837 20214788 10672840 16935385 16878318 16502159 19208518 16698587 20514400 20727157 20084675 18978308 16569478 20512989
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 15.2717088986 17045692 17971768 18930000 16799960 16332177
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 15.2716391822
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 15.2716507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 15.2716924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 15.271917145
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.2611053908
MESH:D018276 Carcinoma, Medullary Indomethacin 4.8814736730 11352223 18791128
MESH:D002289 Carcinoma, Non-Small-Cell Lung pemetrexed 4.4912023789
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 5.9718695887
MESH:D002292 Carcinoma, Renal Cell Indomethacin 5.9717341418
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 12.6520419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 12.6518986760 17066447 16280240 16757204
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 12.6515482327 12636206
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 12.6518572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 12.6516096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.2117572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1018850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases Folic Acid 6.9116755160
MESH:D002318 Cardiovascular Diseases Isoflavones 6.9117689850
MESH:D002386 Cataract Acetaminophen 6.2810977129
MESH:D002386 Cataract Tretinoin 6.2817460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 22.1420889678
MESH:D002471 Cell Transformation, Neoplastic Cytarabine 22.148243401
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 22.1421159647 17174075 2727394 7505956
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 22.1416003739
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 22.1416192471
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 22.1419524636 20056578
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.5117160924
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.1216129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.0219052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.0216835633
MESH:D002764 Cholecystitis Indomethacin 4.6911181007
MESH:D002779 Cholestasis Ethinyl Estradiol 6.5917681005 16919318 16105132 11677210 17110522 17333356 15861022
MESH:D002779 Cholestasis pirinixic acid 6.5919176532
MESH:D002822 Choriocarcinoma Tretinoin 4.6816461808
MESH:D002971 Cleft Lip Folic Acid 3.7221254359
MESH:D002972 Cleft Palate Folic Acid 8.6521254359 8946559
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 8.658697196 15340226 15668235 16354765 12621046
MESH:D002972 Cleft Palate Tretinoin 8.659407595
MESH:D003092 Colitis Tretinoin 3.2517035595
MESH:D003110 Colonic Neoplasms arsenite 7.4715037631
MESH:D003110 Colonic Neoplasms Fluorouracil 7.4717172411 17725105 17169374 16340194 17287894 18772588 17016597 15001691 17018589 16510598
MESH:D003110 Colonic Neoplasms Indomethacin 7.4711260862 15786552 15637740 15936596 15963497 15625704
MESH:D003110 Colonic Neoplasms polyphenols 7.4716293270
MESH:D015179 Colorectal Neoplasms marker/mechanism 15814641
MESH:D015179 Colorectal Neoplasms Fluorouracil 5.9316303861 15289873 15148649 17094418 18288408 17594712 20501625 16391804 16331619 17255274 18383874 14970324 17016601 17695437 18949393 18802399 18509181 18448328 16282729 16524972 17454858 17401013
MESH:D015179 Colorectal Neoplasms Folic Acid 5.9316963246 17087956 16985020 17245555 17116713
MESH:D015179 Colorectal Neoplasms Indomethacin 5.9312606626 17054584 11197048 18059344
MESH:D015179 Colorectal Neoplasms Isoflavones 5.9317116718
MESH:D015179 Colorectal Neoplasms Leucovorin 5.9317454858 17594712 17401013 17255274 16303861 20501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6717141729 14669216
MESH:D018352 Coronavirus Infections Indomethacin 5.2417302372
MESH:D019465 Craniofacial Abnormalities Leucovorin 4.9916925845
MESH:D019465 Craniofacial Abnormalities Methotrexate 4.999562676 12039119
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.9920055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 4.999211117 10589399 9142499 17551590 9125849 14991402 8800419 9664655 16925845 9224671
MESH:D003550 Cystic Fibrosis Methotrexate 3.8419747007
MESH:D007644 Darier Disease Fluorouracil 4.3316733453
MESH:D003711 Demyelinating Diseases Tamoxifen 3.9119031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2018249437
MESH:D003882 Dermatomyositis Methotrexate 4.6820191521
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.3920387270
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 6.3916886840
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.3917107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.0919279558
MESH:D003967 Diarrhea Indomethacin 3.367907874 7237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 10.2919164858 14550746 11529661 18071297 19370779 11287661 17562736 17906064 19420014 10915739 16109766 12540782 18713872 12153990 12392966 16781746 19923254 11421492 2444490 17522070 16485898 14725611 12594235 12958197 11743745 12705907 11739529 15968718 16393943 14986274 10663392 19416960 10774834 11461765 15619225 16227642 16177239 19739265 16081117 11834606 19085960
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 10.297179309 9327722 10092053 16177239 15027814 4309450 11566570 21278145 2869522 17522070 6884620 10915739 19336974 15968718 3786805 19085960 16227642 3732212 15998439 7120509 6623471 7440962
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 10.2919107877
MESH:D056486 Drug-Induced Liver Injury polyphenols 10.2919370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 10.2920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6219426721
MESH:D004362 Drug Toxicity Lamivudine 11.8615040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 11.8611462148
MESH:D004362 Drug Toxicity Zidovudine 11.8615040536
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.6817190690 12774134 16133044 18043480 16326151 18446180
MESH:D004381 Duodenal Ulcer Indomethacin 3.7017351913 11535926 17202747 17045617 11595431 17329845 11991626 11595415 10671773 17151854 16699067
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.5118357618
MESH:D004487 Edema Indomethacin 9.0819703484 10653021 16100529 8985016 7907874 8273558 7990266
MESH:D004487 Edema pirinixic acid 9.0812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.0811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.3618230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 10.3618230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.4812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 7.4819031437
MESH:D016889 Endometrial Neoplasms Folic Acid 10.7517301261
MESH:D016889 Endometrial Neoplasms Tamoxifen 10.7517893378 16202921 20544844 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 10.7516569247
MESH:D004715 Endometriosis Indomethacin 7.7315652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.739294722 10568697
MESH:D019446 Endotoxemia Indomethacin 4.0418509659
MESH:D004751 Enteritis Indomethacin 4.2710567023 17763956 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.5317980183
MESH:D004802 Eosinophilia Indomethacin 3.6111298111
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6416302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.2320426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 9.2316530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 9.2315173087 17638652 16785472 16481741 16337965
MESH:D004938 Esophageal Neoplasms Indomethacin 9.2311005569
MESH:D017889 Exfoliation Syndrome Folic Acid 5.0316504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.6711564622
MESH:D005124 Eye Abnormalities Tretinoin 7.679664655 16938888
MESH:D005234 Fatty Liver arsenite 30.6018296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 30.6017595544 16239168 12631006 16045604 15959796 61145 12795759 19224547
MESH:D005234 Fatty Liver Diethylnitrosamine 30.6021071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 30.6015345470
MESH:D005234 Fatty Liver pirinixic acid 30.6020131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 30.6014986274 19224547
MESH:D005234 Fatty Liver Zidovudine 30.6018299183
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.9416709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0011858732
MESH:D005334 Fever Indomethacin 3.7210431976 17627676 11852909
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.0614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.7219069698
MESH:D005354 Fibrosarcoma Indomethacin 10.5510962813
MESH:D005354 Fibrosarcoma Methylcholanthrene 10.5510962813 14633661
MESH:D005355 Fibrosis arsenite 28.6318296743
MESH:D005355 Fibrosis Carbon Tetrachloride 28.6318705752
MESH:D005355 Fibrosis Emodin 28.6319474275
MESH:D005355 Fibrosis Indomethacin 28.6317994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 28.6320067830
MESH:D005355 Fibrosis Tretinoin 28.6317994277
MESH:D005494 Folic Acid Deficiency marker/mechanism
MESH:D005499 Folliculitis Indomethacin 4.6911298111
MESH:D005756 Gastritis Acetaminophen 16.3616983495
MESH:D005756 Gastritis Folic Acid 16.3617171786
MESH:D005756 Gastritis Indomethacin 16.3615046732
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.2116452187
MESH:D005901 Glaucoma Folic Acid 4.6516504073
MESH:D005909 Glioblastoma Ethylnitrosourea 10.2316436596
MESH:D005909 Glioblastoma Indomethacin 10.2312870263
MESH:D005909 Glioblastoma Tretinoin 10.2317312396
MESH:D005910 Glioma Ethylnitrosourea 8.8816357521 18412241 16651633
MESH:D005910 Glioma Fluorouracil 8.8816145905
MESH:D005910 Glioma Indomethacin 8.8818371953 16487511
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.9111849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1210696789
MESH:D006073 Gout Indomethacin 4.8811248219
MESH:D006086 Graft vs Host Disease Methotrexate 4.6916518429
MESH:D006258 Head and Neck Neoplasms Fluorouracil 11.1515102660 15162350 18337622
MESH:D006258 Head and Neck Neoplasms Indomethacin 11.1515482327
MESH:D006258 Head and Neck Neoplasms Tretinoin 11.1516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.6816084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 13.8720471113
MESH:D006330 Heart Defects, Congenital Folic Acid 13.8716524890 17286298
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 13.8711294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 13.879664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.2420558911
MESH:D006402 Hematologic Diseases Zidovudine 4.2812579204
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9211000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.1515633222
MESH:D006505 Hepatitis Carbon Tetrachloride 3.1619900420 19110552
MESH:D006509 Hepatitis B Lamivudine 4.6817703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 4.6816476009 15631357 15274664 12044531 15309715
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.2415135802
MESH:D006529 Hepatomegaly pirinixic acid 6.7619176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.7615340226 12621046 16120746
MESH:D015658 HIV Infections Lamivudine 6.2020032539 11141242 9296927 17530837
MESH:D015658 HIV Infections Zidovudine 6.2011141242 17358032 20032539 11698656 11363243
MESH:D006679 HIV Seropositivity Folic Acid 5.0317209195
MESH:D006689 Hodgkin Disease Cytarabine 10.4416200630
MESH:D006689 Hodgkin Disease Nitrogen Mustard Compounds 10.4416794504
MESH:D006689 Hodgkin Disease sodium arsenite 10.4412676792
MESH:D019584 Hot Flashes Isoflavones 4.5114716179 17290160
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5715340226 8697196 16354765 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 10.9516870215
MESH:D006930 Hyperalgesia Indomethacin 10.9512727271
MESH:D006930 Hyperalgesia Tretinoin 10.9516870215
MESH:D034321 Hyperamylasemia Indomethacin 5.2417883296
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.0716899240
MESH:D006940 Hyperemia Indomethacin 4.5412524144
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.1116778211
MESH:D006943 Hyperglycemia pirinixic acid 2.7820558911
MESH:D020138 Hyperhomocysteinemia Folic Acid 4.1016865747 16395265 16755160 16397167 16433478
MESH:D006949 Hyperlipidemias Indomethacin 3.7417546600
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.7218850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.6315338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3616945680 16569931
MESH:D007077 Ileal Diseases Indomethacin 4.5518306037 10574470
MESH:D007079 Ileitis Indomethacin 4.8810651667 10647630 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.9016133044
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0312013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.5917937319
MESH:D007248 Infertility, Male sodium arsenite 5.5912646999 15346721
MESH:D007249 Inflammation Diethylnitrosamine 13.1318785209
MESH:D007249 Inflammation Indomethacin 13.133291741 7812673 12568917
MESH:D007249 Inflammation polyphenols 13.1316366677
MESH:D007249 Inflammation Tamoxifen 13.1319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 13.1312200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.3216306350
MESH:D007410 Intestinal Diseases Indomethacin 13.9910210152 17329856 15610444 11713966 18236018 15831440 11855677 17994277 11686837
MESH:D007410 Intestinal Diseases rebamipide 13.9911686837
MESH:D007410 Intestinal Diseases Tretinoin 13.9917994277
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.1810783313
MESH:D019586 Intracranial Hypertension Indomethacin 4.9015241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.5516580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.5517551590 15992940
MESH:D007579 Jejunal Diseases Indomethacin 4.5516133968 10574470 18306037
MESH:D007674 Kidney Diseases Acetaminophen 12.2012587719 15629191
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 12.2015369732
MESH:D007674 Kidney Diseases Indomethacin 12.2017190690
MESH:D007674 Kidney Diseases sodium arsenite 12.2020008137
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 14.7617379185
MESH:D007680 Kidney Neoplasms Fluorouracil 14.7616985049
MESH:D007680 Kidney Neoplasms Tamoxifen 14.7618625569
MESH:D007680 Kidney Neoplasms Zidovudine 14.7612579204
MESH:D007805 Language Development Disorders Methotrexate 4.679562676
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.5311703811 12228301 10320625
MESH:D007938 Leukemia roscovitine 6.1916275999
MESH:D007938 Leukemia Tretinoin 6.1917143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Emodin 8.9117077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 8.9120370541
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.5816572323 15631656 10785260
MESH:D007951 Leukemia, Myeloid Tretinoin 3.2816482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 3.7218360721
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.7216294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 6.8816766008
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 6.8817294898 19029980 16788101 19035177 17506722 17368321 12679006 17339181 16823087 16140955 17712046 15748426 9834237 19642359 16891316 19225113 19075265 16331271 17649720 17301526 17361223 17107899 16935935 16766008 17217047
MESH:D007964 Leukocytosis Indomethacin 4.9016537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.2417980183
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.979224671
MESH:D008064 Lipidoses Tamoxifen 2.8215342952 17567588
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.2411479899
MESH:D008103 Liver Cirrhosis arsenite 13.6018296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 13.6016239168 16943688 17157831 11408273 17334410 16221502 21278145 17174718 11903743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 13.6020032147 19638242 18665156 18407596 18522880
MESH:D008103 Liver Cirrhosis Methotrexate 13.6014986274
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 9.7916011737 15818738 17976157 12741479 16033810 18429990 11481614 18376398 18205269 12586293 13678700 15123356 17766677 17714472 17900296 18251166 16097048 16027843 17721639 17761835 12958196 15996030 10355542 18339082 18156304 15362042 20821823 17922224 15052691 15931870 18279442 17805973 17640975 18472094 12445421 15370692 15959796 17869086 18263696 17557913 14716833 16248980 12632512 12445418 16192424 15925388 17631135 15730626 14724832 12546737 15876570 12389079 18418968 12649538 15893842 18395914 12667390 12632514 17525996 12666154 12609069 16015684 18395095 18705752 18420326 18166357 18187930 15057751 17565644 15338365 15650968 18481824 18412020 14512876 18006644 18472332 16116963 18317297 17481882 16136751 18277467 14748882 17944888 16638106 17698563 12898905 17823541 18210741 15673190 14716496 17708605 14620537 18054572
MESH:D008106 Liver Cirrhosis, Experimental Emodin 9.7915288473
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 9.7918194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 9.7915474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 9.7918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 9.7912878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 9.7918397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 11.0119014921 12587719 19460945 11587558 12969438 16611625 19784758 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 11.0116246199 15720792 17285989 16964402 15830285
MESH:D008107 Liver Diseases Diethylnitrosamine 11.0117034775
MESH:D008107 Liver Diseases Folic Acid 11.0116877991
MESH:D008107 Liver Diseases polyphenols 11.0116698588
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7115123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.0717185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.0716899240 14706259
MESH:D008113 Liver Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 26.2218644402 16835634
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 26.2221137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 26.2219294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 26.2220583210 18754104 19294768 12771043 21167192 20405173 18977376 12112319 19996281 20452335 20434301 19638242 18648771 15175105 19255062 19690152 19850985 19254457 20501860 19812893 21071580 10737359 16942905 21047994 19642983 20101389 2862719 19499222 19256749 20137499 9163691 20492335 19090486 18644402 15885732 19426721 19427195 21278145 19833225 2422723 19073162 19551842 18978307 20118626
MESH:D008113 Liver Neoplasms Fluorouracil 26.2216603448 15113037 17045692 18383874
MESH:D008113 Liver Neoplasms pirinixic acid 26.2220007298 15890375 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 26.2215276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 26.2216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 26.2216984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 11.6712014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 11.6717174075 18079962 19126423 16267830 19519916 17942915 19004024 3124819 18253720 19539802 18164116 19009564 9362446 18775883 2563599 18544905 18093689 18282651 21159647 16842330 17854601 18308698
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 11.671399818 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 11.6712151625
MESH:D008171 Lung Diseases sodium arsenite 2.8619095001
MESH:D017563 Lung Diseases, Interstitial Methotrexate 4.5518516814
MESH:D008175 Lung Neoplasms arsenite 18.8016809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 18.8018816296 18520028 20464547 20135361 20869020 6695378 18569708 17053015 20064080
MESH:D008175 Lung Neoplasms Diethylnitrosamine 18.8020512841 21163286 6695378 20970405
MESH:D008175 Lung Neoplasms Ethylnitrosourea 18.8016019985 17703301 16271038 6695378
MESH:D008175 Lung Neoplasms Fluorouracil 18.8015246190
MESH:D008175 Lung Neoplasms Indomethacin 18.8016537180 11497255 11053908
MESH:D008175 Lung Neoplasms Methylcholanthrene 18.8017909032 16271038 10545420 9230183 11893704 7750092 20970405 15390079 20512841 1399818 6695378 16337739 21163286
MESH:D008175 Lung Neoplasms sodium arsenite 18.8017077188 16712894 19931552 17306315 15276417
MESH:D008175 Lung Neoplasms Tamoxifen 18.8018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 18.8019555203 11884234
MESH:D008175 Lung Neoplasms Zidovudine 18.8018800350
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.3315086387
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.1917718048
MESH:D008223 Lymphoma Chlorambucil 11.0010745627
MESH:D008223 Lymphoma Ethylnitrosourea 11.0015790496
MESH:D008223 Lymphoma Methotrexate 11.0017352296
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 4.5915375218
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.3019428831
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 5.3110838139 10767621 18041768
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.3119196723 14580682 16827153 11731420 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.0719453300
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.2316832597
MESH:D008527 Medulloblastoma Tretinoin 2.5917453147
MESH:D008545 Melanoma sodium arsenite 4.5116487513 19082730
MESH:D008545 Melanoma Tamoxifen 4.5112393984 19393235
MESH:D008545 Melanoma Tretinoin 4.5116752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.7215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1119513568
MESH:D008579 Meningioma Ethylnitrosourea 5.5117943659
MESH:D008591 Meningomyelocele Tretinoin 3.9716940565
MESH:D008661 Metabolism, Inborn Errors marker/mechanism
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.3617358032
MESH:D008881 Migraine Disorders Indomethacin 3.3411903285
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 12.3516381670
MESH:D009062 Mouth Neoplasms Fluorouracil 12.3516757204 18986760
MESH:D009062 Mouth Neoplasms Indomethacin 12.3512636206
MESH:D052016 Mucositis Methotrexate 4.8117488658
MESH:D009135 Muscular Diseases pirinixic acid 3.0516239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.8017596541
MESH:D009203 Myocardial Infarction pirinixic acid 1.9419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6512213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.5916411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.363581430 9029167
MESH:D009362 Neoplasm Metastasis Indomethacin 8.3611053908 11239499 16537180
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.3619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3519410462
MESH:D009369 Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 16.598820588
MESH:D009369 Neoplasms Benzo(a)pyrene 16.5911141357
MESH:D009369 Neoplasms Fluorouracil 16.5918600527 18239605 16928823
MESH:D009369 Neoplasms pirinixic acid 16.5917405874
MESH:D009369 Neoplasms sodium arsenite 16.5911559025
MESH:D009369 Neoplasms Tretinoin 16.5916946489 16594593
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 12.7916707424
MESH:D009374 Neoplasms, Experimental Indomethacin 12.7910663608 15625704
MESH:D009374 Neoplasms, Experimental sodium arsenite 12.7920056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.5319196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic arsenite 3.9515738583
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.0514600291
MESH:D009421 Nervous System Malformations Tretinoin 8.059125849
MESH:D009436 Neural Tube Defects Folic Acid 10.4617438019
MESH:D009436 Neural Tube Defects sodium arsenite 10.4612854658
MESH:D009436 Neural Tube Defects Tretinoin 10.469142499
MESH:D009442 Neurilemmoma Ethylnitrosourea 4.9517160924 16651423 16003739
MESH:D019636 Neurodegenerative Diseases Acetaminophen 11.8818514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 11.8820387270
MESH:D019636 Neurodegenerative Diseases Indomethacin 11.8812349958
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6420387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.1216436463
MESH:D009503 Neutropenia Folic Acid 8.8416322990
MESH:D009503 Neutropenia pemetrexed 8.8416322990
MESH:D009765 Obesity pirinixic acid 1.6920558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.696374098
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.5117160924
MESH:D010003 Osteoarthritis Indomethacin 3.387009135
MESH:D010024 Osteoporosis Isoflavones 3.8116562857
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.3317306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 4.3316936753
MESH:D010146 Pain Acetaminophen 9.1016870215
MESH:D010146 Pain Indomethacin 9.1013679232 17440234 17627676 3291741
MESH:D010146 Pain Tretinoin 9.1016870215
MESH:D010149 Pain, Postoperative Indomethacin 4.2112538197 18702446
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 7.5416540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 7.5415113037 19003803 16500647 16929163
MESH:D010190 Pancreatic Neoplasms Tretinoin 7.5415976015
MESH:D010195 Pancreatitis Indomethacin 3.5015028970 17883296
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2611578682
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.2416537180
MESH:D020734 Parkinsonian Disorders Indomethacin 3.7212349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.2411903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7712520081
MESH:D010437 Peptic Ulcer Indomethacin 4.6811148446
MESH:D010518 Periodontitis Indomethacin 4.4417225004
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1218163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.162563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cytarabine 4.1721297632
MESH:D047928 Premature Birth Indomethacin 4.6717000239
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.7311222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0217292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0218626508 19082440
MESH:D011471 Prostatic Neoplasms Isoflavones 2.0216365062 17374662 17219775 17571952
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.0216205645
MESH:D011471 Prostatic Neoplasms roscovitine 2.0216140939
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0216039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0215067354
MESH:D011507 Proteinuria Indomethacin 7.9111849393
MESH:D011507 Proteinuria Tretinoin 7.9116636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.8515861022 16919318
MESH:D011565 Psoriasis Methotrexate 3.2617410198
MESH:D011625 Pterygium Tretinoin 4.3316723453
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6215538739 18286688 18722050 16160472
MESH:D051437 Renal Insufficiency Folic Acid 9.1915728788
MESH:D051437 Renal Insufficiency Methotrexate 9.1917352296
MESH:D015427 Reperfusion Injury Leucovorin 6.2417295595
MESH:D015427 Reperfusion Injury pirinixic acid 6.2419058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3918990726
MESH:D012206 Rhabdomyolysis Lamivudine 5.079296927
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.6716283617 16116481
MESH:D012512 Sarcoma, Ewing's roscovitine 5.3416230394
MESH:D012559 Schizophrenia Folic Acid 2.8316641680
MESH:D012871 Skin Diseases Folic Acid 3.1218709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 11.6010029692 19755658
MESH:D012878 Skin Neoplasms sodium arsenite 11.6018572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 11.6016192470
MESH:D012878 Skin Neoplasms Tretinoin 11.6016467112
MESH:D013088 Spermatocele Ethinyl Estradiol 9.9816709447
MESH:D013088 Spermatocele Tamoxifen 9.9816709447
MESH:D013118 Spinal Cord Diseases Folic Acid 5.0316361298
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.5719457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.4412854658
MESH:D013272 Stomach Diseases Indomethacin 9.1718545984 10215738 16184426 10486359 10192188 15472012 16280098 17160473 18209964 17207306 16113693 15038085 17638125
MESH:D013272 Stomach Diseases rebamipide 9.1716184426
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 13.7720155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 13.7718456281
MESH:D013274 Stomach Neoplasms Fluorouracil 13.7715786421 17172411 17498489 18396642 18567086 19084572 16951190 17522103 19015929 16424979
MESH:D013274 Stomach Neoplasms Folic Acid 13.7717171786
MESH:D013274 Stomach Neoplasms Indomethacin 13.7715609394
MESH:D013274 Stomach Neoplasms pemetrexed 13.7715958060
MESH:D013274 Stomach Neoplasms rebamipide 13.7715993841
MESH:D013274 Stomach Neoplasms Tretinoin 13.7717261132
MESH:D013274 Stomach Neoplasms Zidovudine 13.7717696246
MESH:D013276 Stomach Ulcer Indomethacin 3.1916934674 16150113 17918041 18431645 18193104 17627676 16169175 1323529 16631530 18543354 17977527 15104355 17657623 12077510 17895592 16397915 12498302 10423059 18209962 16755016 11729361 10878458 18299717 18237397 11595415 15138204 18087811 12500499 11595431 11523592 18726076 16252198 17654042 10750652 18181030 11906479 11145282 17135157 12467913 15255614 12787963 14567935
MESH:D020521 Stroke Folic Acid 3.9616517955
MESH:D013576 Syndactyly Methotrexate 4.599562676
MESH:D013705 Temporomandibular Joint Disorders polyphenols 4.7817997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7615669648
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 4.6915790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4312697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 9.997505956
MESH:D013964 Thyroid Neoplasms Indomethacin 9.9914736730 18791128 11352223
MESH:D013964 Thyroid Neoplasms Tretinoin 9.9916026305 17045167
MESH:D014062 Tongue Neoplasms Fluorouracil 8.4916280240
MESH:D014062 Tongue Neoplasms Tretinoin 8.4916051514
MESH:D014376 Tuberculosis Tretinoin 2.9316040207
MESH:D014456 Ulcer Indomethacin 4.4317380554 10574470
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.1317053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 7.1317306315 11723127 16712894 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 7.1316712894 17572228 8653321
MESH:D014581 Urticaria Acetaminophen 2.5510982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 13.5316803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 13.5311813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 13.5316129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.8614692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.1416752155
MESH:D014625 Vaginal Neoplasms Zidovudine 4.3012579204
MESH:D014652 Vascular Diseases sodium arsenite 3.9617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1214671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.6116761959
MESH:D014839 Vomiting Indomethacin 4.2711897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7715886252
MESH:D009396 Wilms Tumor Tretinoin 3.5716287080
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
KEGG:00790 Folate biosynthesis
KEGG:01100 Metabolic pathways
REACT:11193 Metabolism of vitamins and cofactors
KEGG:00670 One carbon pool by folate
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA143
    • Releated gene ID Related gene Name
    PA36679TP53
    Releated disease ID Related disease Name
    PA444101Esophageal Neoplasms
    PA443937Drug Toxicity
    PA445601Osteosarcoma
    PA446166Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
    PA443560Breast Neoplasms
    PA446284Spinal Dysraphism
    PA444750Leukemia
    PA443430Arthritis
    PA445062Neoplasms
    PA443434Arthritis, Rheumatoid
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA445095Neural Tube Defects
    PA446286Spina Bifida Cystica
    PA446108Colorectal Neoplasms
    PA445742Stomach Neoplasms
    PA444367Heart Defects, Congenital
    Releated drug ID Related drug Name
    PA449014cisplatin
    PA449165cyclophosphamide
    PA151917012dactinomycin
    PA449412doxorubicin
    PA451879vincristine
    PA164712913Multivitamins, Plain
    PA449789glycine
    PA451330l-serine
    PA449692folic acid
    PA450428methotrexate
    PA128406956fluorouracil
    PA452622antimetabolites
    PA452621antineoplastic agents
    PA449957ibuprofen
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00157 - NADH Dietary supplement;Micronutrient
    DB00205 inhibitor Sulfaquinoxaline-S Liq Antiprotozoals;Antimalarials;Folic Acid Antagonists;Antiprotozoal Agents
    DB00440 antagonist Trimethoprim Anti-Infectives;Antimalarials;Folic Acid Antagonists;Anti-Infective Agents, Urinary
    DB00563 antagonist Methotrexate Antineoplastic Agents;Antirheumatic Agents;Antimetabolites;Enzyme Inhibitors;Folic Acid Antagonists;Dermatologic Agents;Immunosuppressive Agents;Nucleic Acid Synthesis Inhibitors;Abortifacient Agents, Nonsteroidal;Abortifacient Agents;Antimetabolites, Antineoplastic
    DB00642 antagonist Pemetrexed Antineoplastic Agents;Antimetabolites;Enzyme Inhibitors;Folic Acid Antagonists;Antimetabolites, Antineoplastic
    DB01093 - Synotic Otic Solution Free Radical Scavengers;Analgesics, Non-Narcotic;Solvents;Cryoprotective Agents
    DB01131 antagonist Proguanil Antimetabolites;Antimalarials
    DB01157 antagonist Trimetrexate Antiprotozoals;Folic Acid Antagonists;Antifungal Agents;Antibiotics;Antimetabolites, Antineoplastic
    DB02104 - 2,4-Diamino-5-Methyl-6-[(3,4,5-Trimethoxy-N-Methylanilino)Methyl]Pyrido[2,3-D]Pyrimidine
    DB02427 - 2,4-Diamino-6-[N-(2',5'-Dimethoxybenzyl)-N-Methylamino]Quinazoline
    DB02559 - 6-(Octahydro-1h-Indol-1-Ylmethyl)Decahydroquinazoline-2,4-Diamine
    DB02583 - N6-(2,5-Dimethoxy-Benzyl)-N6-Methyl-Pyrido[2,3-D]Pyrimidine-2,4,6-Triamine
    DB02919 - 2,4-Diamino-6-[N-(3',4',5'-Trimethoxybenzyl)-N-Methylamino]Pyrido[2,3-D]Pyrimidine
    DB03060 - Sri-9662
    DB03125 - 2,4-Diamino-5-(3,4,5-Trimethoxy-Benzyl)-Pyrimidin-1-Ium
    DB03351 - Sri-9439
    DB03461 - 2'-Monophosphoadenosine 5'-Diphosphoribose
    DB03695 - 6-(2,5-Dimethoxy-Benzyl)-5-Methyl-Pyrido[2,3-D]Pyrimidine-2,4-Diamine Antineoplastic Agents;Folic Acid Antagonists
    DB03886 - Biopterin
    DB03987 - 2,4-Diamino-6-[N-(3',5'-Dimethoxybenzyl)-N-Methylamino]Pyrido[2,3-D]Pyrimidine
    DB07140 - 5-[(3R)-3-(5-methoxybiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine
    DB07141 - 5-[(3R)-3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine
    DB07142 - 5-[(3R)-3-(5-methoxy-3',5'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine
    DB07144 - 5-[(3R)-3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine
    DB08234 - 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine
    DB08406 - [N-(2,4-DIAMINOPTERIDIN-6-YL)-METHYL]-DIBENZ[B,F]AZEPINE
    DB08448 - (4aS)-5-[(2,4-diaminopteridin-6-yl)methyl]-4a,5-dihydro-2H-dibenzo[b,f]azepin-8-ol
    DB08642 - (2R,6S)-6-{[methyl(3,4,5-trimethoxyphenyl)amino]methyl}-1,2,5,6,7,8-hexahydroquinazoline-2,4-diamine
    No data
    No data
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    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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