AutismKB 2.0

Annotation Detail for CYB5R3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CYB5R3 ( B5R,DIA1 )
Gene Full Name: cytochrome b5 reductase 3
Band: 22q13.2
Quick LinksEntrez ID:1727; OMIM: 613213; Uniprot ID:NB5R3_HUMAN; ENSEMBL ID: ENSG00000100243; HGNC ID: 2873
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6000gamma-linolenate biosynthesis II (animals)
Pathway IDPathway Name
hsa00520Amino sugar and nucleotide sugar metabolism
Pathway IDPathway Name
Metabolism of vitamins and cofactors
No data
No data
Pathway IDPathway Name
500595Vitamin C (ascorbate) metabolism
Related Diseases/Disorders Top
Desease IDDesease Name
Circulatory system diseases
Hematologic diseases
H00235Methemoglobinemia
No data
No data
No data
Desease Name
Methemoglobinemia, type I
Methemoglobinemia, type II
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CYB5R3 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CYB5R3 mRNAaffects expression 21346803
C019499 2-nitrofluorene 2-nitrofluorene results in decreased expression of CYB5R3 mRNAdecreases expression 14600272
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of CYB5R3 mRNAdecreases expression 14600272
C040534 alpha-hexachlorocyclohexane alpha-hexachlorocyclohexane results in increased expression of CYB5R3 mRNAincreases expression 17785943
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CYB5R3 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of CYB5R3 mRNAincreases expression 15725085
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CYB5R3 mRNAdecreases expression 20018196
D002995 Clofibric Acid Clofibric Acid affects the expression of CYB5R3 mRNAaffects expression 17602206
D009243 NAD CYB5R3 protein binds to NADaffects binding 16469290
D016572 Cyclosporine Cyclosporine results in decreased expression of CYB5R3 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYB5R3 mRNAaffects cotreatment|decreases expression 18544905
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYB5R3 mRNAaffects cotreatment|increases expression 18544905
D004128 Dimethylnitrosamine Dimethylnitrosamine results in decreased expression of CYB5R3 mRNAdecreases expression 14600272
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CYB5R3 mRNAdecreases expression 17108234
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of CYB5R3 mRNAaffects cotreatment|increases expression 17183730
D007213 Indomethacin Indomethacin results in increased expression of CYB5R3 mRNAincreases expression 18299717
C011890 kojic acid [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYB5R3 mRNAaffects cotreatment|decreases expression 18544905
C011890 kojic acid [Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYB5R3 mRNAaffects cotreatment|increases expression 18544905
C004925 methylmercuric chloride methylmercuric chloride results in decreased expression of CYB5R3 mRNAdecreases expression 17961207
C004925 methylmercuric chloride methylmercuric chloride results in decreased expression of CYB5R3 mRNAdecreases expression 19465457
C017947 sodium arsenite sodium arsenite results in increased expression of CYB5R3 mRNAincreases expression 20308225
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CYB5R3 mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CYB5R3 proteinincreases expression 16548065
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of CYB5R3 mRNAaffects cotreatment|increases expression 17183730
C025643 vinclozolin vinclozolin affects the expression of CYB5R3 mRNAaffects expression 19015723
D015032 Zinc Zinc affects the expression of CYB5R3 mRNAaffects expression 16979875
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced methylmercuric chloride 13.496734493
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 13.4911752688 15322242 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 13.498875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.7919490988
MESH:D000138 Acidosis Ammonium Chloride 3.4118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7917505938
MESH:D000169 Acrodermatitis Zinc 5.2517202136 16889938 17190629
MESH:D000230 Adenocarcinoma arsenic trioxide 9.9111798837 19825857
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 9.9116033868
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.9114692618
MESH:D000230 Adenocarcinoma Indomethacin 9.9116537180
MESH:D000236 Adenoma 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 15.3716176798
MESH:D000236 Adenoma Diethylnitrosamine 15.376695378 10737359
MESH:D000236 Adenoma Dimethylnitrosamine 15.3719555203
MESH:D000236 Adenoma Indomethacin 15.3711497255
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.5517620307 16434500 19061943 17162532 19052882 18056438
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.5516835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5515276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.7517306315 16712894
MESH:D016301 Alveolar Bone Loss Indomethacin 5.2217225004
MESH:D000544 Alzheimer Disease Indomethacin 4.4317627676 15579461
MESH:D000544 Alzheimer Disease Zinc 4.4317119284 16410023 16325427 16580781
MESH:D000550 Amblyopia Valproic Acid 5.0817688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8111748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.7516916123
MESH:D001008 Anxiety Disorders Valproic Acid 8.4517497229
MESH:D001008 Anxiety Disorders vinclozolin 8.4519015723
MESH:D001014 Aortic Aneurysm Indomethacin 4.7010231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.7210388637
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3111256880
MESH:D018771 Arthralgia Indomethacin 5.022160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5715885639
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.7911248219
MESH:D001249 Asthma Zinc 2.9117085522
MESH:D001321 Autistic Disorder Valproic Acid 2.0215238991 17157402 20603192 18775368 17507914 19460635 18985861 17688650 18396377 16609825 18940202 19232924 18558336 18177632 18316065
MESH:D001477 Bartter Syndrome Indomethacin 4.8310684365
MESH:D001714 Bipolar Disorder Valproic Acid 3.0017594078 20046352
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.5016206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.5012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.7015746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.708888407
MESH:D001929 Brain Edema Indomethacin 4.8711481608
MESH:D001930 Brain Injuries Zinc 4.5417109824
MESH:D002545 Brain Ischemia Indomethacin 4.2712524144
MESH:D001943 Breast Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 1.9920146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9917474063
MESH:D001943 Breast Neoplasms Indomethacin 1.9917401462
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9920435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1911589617
MESH:D002056 Burns Indomethacin 4.5510459503
MESH:D002100 Cachexia Indomethacin 4.8515141370 16537180 11239499 15625704
MESH:D002277 Carcinoma Dimethylnitrosamine 7.9519555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.9516835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.0716705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.0716705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 11.0714691202 11135700 15553829 15073043 16217749
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 11.0719107877 17761372 3581430 19539802 19335982 19822196 19394651 17978847 19383236 3084413 16698587 11831363 17428255 18506893 16540662 16288022 20007298 18393292 20935162 16779866 16830150 17173139 18785209 20524982 20101231 20214788 20512989 17138121 16807293 20727157 18978308 19208518 17162532 16935385 19519916 21159647 20084675 16569478 18494052 19052882 18788625 16502159 18691550 16328049 20514400 19171122 16878318 17055752 20432363 18210153 10737359 19701751 16681979 18665156 10672840 18971187 18056438 19418558 19919837
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 11.0716391822
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 11.0717306315 16507464 15276417
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.5711053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.2018791128 11352223 14736730
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7219014326
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.3017341418
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9812490120
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 10.5216033868
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 10.5212636206 15482327
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 10.5218572023
MESH:D002294 Carcinoma, Squamous Cell Zinc 10.5216543248
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2818850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Zinc 3.5616936243
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 19.986135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 19.9820889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 19.9812371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 19.982727394 21159647 7505956 17174075
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 19.9819524636 20056578
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6520734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.8919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.8916835633
MESH:D002764 Cholecystitis Indomethacin 5.0211181007
MESH:D002779 Cholestasis Cyclosporine 7.4019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.4016105132 17110522 16919318 15861022 17681005 17333356 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.048697196 12621046 16354765 15668235 15340226
MESH:D003110 Colonic Neoplasms Indomethacin 2.5715637740 15625704 11260862 15963497 15936596 15786552
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6420501625
MESH:D015179 Colorectal Neoplasms Indomethacin 2.6418059344 12606626 17054584 11197048
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9314669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0412609071
MESH:D018352 Coronavirus Infections Indomethacin 5.5717302372
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.2910525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.2910048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 5.2916575769 17688650 8888407
MESH:D019465 Craniofacial Abnormalities Zinc 5.2919302082
MESH:D003456 Cryptorchidism vinclozolin 4.1914966744
MESH:D003490 Cyanosis marker/mechanism 16469290
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.3918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.3918551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9515213294
MESH:D003920 Diabetes Mellitus Zinc 4.0716479319
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.0920387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0917107852
MESH:D003967 Diarrhea Indomethacin 3.657907874 7237001
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 18.0018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 18.0021346803 18551238
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 18.0019107877
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 18.008172417
MESH:D056486 Drug-Induced Liver Injury NAD 18.0011461765
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 18.0020420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 18.001733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6511462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.0018446180 18043480 12774134 17190690 16133044 16326151
MESH:D004381 Duodenal Ulcer Indomethacin 3.9917151854 17202747 10671773 11595431 17045617 11595415 17329845 17351913 11535926 11991626 16699067
MESH:D004421 Dystonia Valproic Acid 3.911851702
MESH:D004487 Edema Indomethacin 6.4610653021 7907874 8985016 16100529 19703484 7990266 8273558
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.4611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7518230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.0412538720
MESH:D004715 Endometriosis Indomethacin 8.6215652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.6210568697 9294722
MESH:D019446 Endotoxemia Indomethacin 4.3518509659
MESH:D004751 Enteritis Indomethacin 4.5910567023 17763956 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.8317980183
MESH:D004802 Eosinophilia Indomethacin 3.9011298111
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.003659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.7716628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.8618234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.467562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.157750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.913659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9716302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 13.4420426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 13.4412903497
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 13.4417016578
MESH:D004938 Esophageal Neoplasms Indomethacin 13.4411005569
MESH:D004938 Esophageal Neoplasms Zinc 13.4416543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005234 Fatty Liver arsenic trioxide 23.1715073043
MESH:D005234 Fatty Liver Cyclosporine 23.1719224547
MESH:D005234 Fatty Liver Diethylnitrosamine 23.1720387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 23.1715345470
MESH:D005234 Fatty Liver Valproic Acid 23.1714986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D005315 Fetal Diseases Valproic Acid 4.7416575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.9818558336 8888407
MESH:D005334 Fever Indomethacin 3.9810431976 11852909 17627676
MESH:D005354 Fibrosarcoma Indomethacin 4.7410962813
MESH:D005355 Fibrosis Cyclosporine 13.9212639820 12168785
MESH:D005355 Fibrosis Indomethacin 13.9217994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.9220067830
MESH:D005499 Folliculitis Indomethacin 5.0211298111
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1116904648
MESH:D005756 Gastritis Indomethacin 11.0615046732
MESH:D005756 Gastritis Zinc 11.0617241300
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.7816973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.1516417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5316452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.078708960
MESH:D005909 Glioblastoma Indomethacin 3.4712870263
MESH:D005910 Glioma Indomethacin 3.1716487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.1611849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006073 Gout Indomethacin 5.2011248219
MESH:D006130 Growth Disorders Zinc 3.8717217573
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.6415482327
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2510048152 11294989
MESH:D006333 Heart Failure Zinc 3.5217162251
MESH:D006335 Heart Injuries Zinc 5.6217074742
MESH:D016481 Helicobacter Infections Zinc 4.3917241300
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.4315633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.5315135802
MESH:D006527 Hepatolenticular Degeneration Zinc 4.5417276780
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7415340226 16120746 12621046
MESH:D006689 Hodgkin Disease sodium arsenite 3.0312676792
MESH:D006849 Hydrocephalus Valproic Acid 4.7117688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.898697196 16959395 15340226 16354765 18606429
MESH:D006930 Hyperalgesia Indomethacin 3.6512727271
MESH:D034321 Hyperamylasemia Indomethacin 5.5717883296
MESH:D006940 Hyperemia Indomethacin 4.8512524144
MESH:D006949 Hyperlipidemias Indomethacin 4.0217546600
MESH:D006973 Hypertension Cyclosporine 4.7510903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7518670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.4716612254
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6616945680 16569931
MESH:D007077 Ileal Diseases Indomethacin 4.8718306037 10574470
MESH:D007079 Ileitis Indomethacin 5.2010651667 16133968 10647630
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.2216133044
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.6217937319
MESH:D007248 Infertility, Male sodium arsenite 10.6212646999 15346721
MESH:D007248 Infertility, Male vinclozolin 10.6216467254
MESH:D007249 Inflammation Diethylnitrosamine 7.9018785209
MESH:D007249 Inflammation Indomethacin 7.907812673 12568917 3291741
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.9012878042 12200463
MESH:D007410 Intestinal Diseases Indomethacin 4.1711855677 17329856 15610444 17994277 11686837 11713966 10210152 15831440 18236018
MESH:D019586 Intracranial Hypertension Indomethacin 5.2215241188
MESH:D007511 Ischemia Zinc 4.4816584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2016580747
MESH:D007579 Jejunal Diseases Indomethacin 4.8710574470 16133968 18306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2915604871
MESH:D007674 Kidney Diseases Cyclosporine 13.798314463 18776723 10903974
MESH:D007674 Kidney Diseases Indomethacin 13.7917190690
MESH:D007674 Kidney Diseases sodium arsenite 13.7920008137
MESH:D007674 Kidney Diseases Zinc 13.7916960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.2816518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.6416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.6416705839
MESH:D007680 Kidney Neoplasms Cyclosporine 11.6412371664
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.7812228301 10320625 11703811
MESH:D007938 Leukemia arsenic trioxide 2.7615070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6612560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1516972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 8.1814633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 8.1810785260 15631656 16572323
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.6219077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 6.0316467208 16968895 17050201 20471514 19850784
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 6.0318360721
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 6.0316294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.1219642359 9834237 12018890 16823087 16112521 17107899 17217047 17649720 11161223 12712474 11468182 17712046 12679006 19075265 16331271 17869043 15748426 15622746 16330433 16891316 19225113 15213294 19035177 15336539 16966277
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.2016882451
MESH:D007964 Leukocytosis Indomethacin 5.2216537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.5717980183
MESH:D007984 Leydig Cell Tumor vinclozolin 4.5816417039
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.5711479899
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.7419638242 18522880 18407596 18665156 20032147
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 3.5215138612 18629640 17348192 15504291 15864749 15723089 15086199 15744066 17432682 15793283 16042886 15571005 15798949 16570917 18637143 17724770 15479170 16009107 18210741 17534399 12925901 14568256 15067225 15577212 14659978 17198567 18237412 17203207 15339415 18239293 18567088 14643895 17465448 15591649 16544323 16603200 15842777 16169303 12918455 17666798 17881167 17201889 17640959 17719030 15298665 17036385 15366600 15383259 15942678 15099470 18371158 14726149 15763062 18095165 18672772 18364076 16270385 15369754 14709902 16627068 15733078 15081153 17196135 15492853 15161499
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 3.5218194892
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5212878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.0617034775
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 4.2717457977
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 29.087678174
MESH:D008113 Liver Neoplasms 2-nitrofluorene 29.0815890375
MESH:D008113 Liver Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 29.0815890375
MESH:D008113 Liver Neoplasms arsenic trioxide 29.0814682389
MESH:D008113 Liver Neoplasms Clofibric Acid 29.0817602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 29.0819638242 15885732 18644402 19256749 12112319 9163691 19499222 19833225 21278145 16942905 20137499 21167192 19294768 19996281 12771043 19850985 20452335 19255062 19426721 21047994 15175105 20434301 19073162 20405173 18754104 20492335 18977376 10737359 20101389 19427195 18648771 20583210 19812893 21071580 19254457 2862719 19690152 2422723 20118626 19090486 19551842 18978307 20501860 19642983
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 29.083113478 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 29.0816712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 29.0816984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 22.166135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 22.1620377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 22.1619126423 2563599 18544905 9362446 18079962 17174075 18775883 16267830 17942915 19539802 21159647 19004024 18093689 19009564 18308698 19519916 18164116 17854601 3124819 18253720 16842330 18282651
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 22.166150874 15603536 1848544
MESH:D008114 Liver Neoplasms, Experimental kojic acid 22.1618544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 22.1612151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2315213294
MESH:D008171 Lung Diseases sodium arsenite 3.0719095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.1117228818
MESH:D008175 Lung Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 10.4214755239 19931552 18508827 16061637 15172992 18813816 16401635 9255578 17139156 15893417 12438228
MESH:D008175 Lung Neoplasms arsenic trioxide 10.4219825857 11798837
MESH:D008175 Lung Neoplasms Diethylnitrosamine 10.4220970405 20512841 21163286 6695378
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 10.4216061637 19555203 11884234
MESH:D008175 Lung Neoplasms Indomethacin 10.4216537180 11497255 11053908
MESH:D008175 Lung Neoplasms sodium arsenite 10.4219931552 17306315 15276417 17077188 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.4219555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Zinc 3.2012773700
MESH:D008545 Melanoma sodium arsenite 2.0116487513 19082730
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6416801185
MESH:D008708 Methemoglobinemia marker/mechanism 16469290
OMIM:250800 METHEMOGLOBINEMIA DUE TO DEFICIENCY OF METHEMOGLOBIN REDUCTASE marker/mechanism
MESH:D008881 Migraine Disorders Indomethacin 7.3611903285
MESH:D008881 Migraine Disorders Valproic Acid 7.3618803445 18765137
MESH:D009062 Mouth Neoplasms Indomethacin 3.8712636206
MESH:D009101 Multiple Myeloma arsenic trioxide 3.0019417148 14977855 15949261 19549372 11468182
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.898888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.1316105982 16882451
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.1317596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9012213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.8418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.847678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.8116624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.763581430 9029167
MESH:D009362 Neoplasm Metastasis Indomethacin 5.7611239499 16537180 11053908
MESH:D009369 Neoplasms sodium arsenite 2.4311559025
MESH:D009374 Neoplasms, Experimental Indomethacin 8.7815625704 10663608
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.7820056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1519348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0714600291
MESH:D009436 Neural Tube Defects arsenic trioxide 11.6010525206
MESH:D009436 Neural Tube Defects sodium arsenite 11.6012854658
MESH:D009436 Neural Tube Defects Valproic Acid 11.6016359493 8888407
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.1620387270
MESH:D019636 Neurodegenerative Diseases Indomethacin 8.1612349958
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9720387270
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.026374098
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.4412819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.4416049721
MESH:D010003 Osteoarthritis Indomethacin 3.587009135
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.7516624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.7517306315 15276417
MESH:D010146 Pain Indomethacin 3.3417627676 13679232 3291741 17440234
MESH:D010149 Pain, Postoperative Indomethacin 4.5312538197 18702446
MESH:D010190 Pancreatic Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 8.4312384795
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.4315580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.4316540662
MESH:D010195 Pancreatitis Indomethacin 3.7815028970 17883296
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5411578682
MESH:D010235 Paraganglioma arsenic trioxide 4.0219927285
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.5716537180
MESH:D020734 Parkinsonian Disorders Indomethacin 3.9812349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.5711903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D010437 Peptic Ulcer Indomethacin 5.0011148446
MESH:D010518 Periodontitis Indomethacin 4.7617225004
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.5112371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.512563599
MESH:D011225 Pre-Eclampsia Zinc 4.0617114810
MESH:D047928 Premature Birth Indomethacin 4.9817000239
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.3611896295 11118676 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 15.3620603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 15.3618220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.7818220299
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.7119131511
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.7116039940
MESH:D011471 Prostatic Neoplasms Zinc 2.7116700911 16517595 12429649 16606632
MESH:D011472 Prostatitis vinclozolin 4.7818629315
MESH:D011507 Proteinuria Indomethacin 4.0211849393
MESH:D011537 Pruritus Ethinyl Estradiol 3.1616919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.3911422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012162 Retinal Degeneration Zinc 4.0116584753
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.0319155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.8116646077
MESH:D012559 Schizophrenia Valproic Acid 2.0519110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 9.2218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 9.2218551238
MESH:D012640 Seizures Valproic Acid 9.223137016 16876388 1511512 15475178 11044598 17978042 14763951 11738929
MESH:D012878 Skin Neoplasms sodium arsenite 5.3619524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.3616192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7916709447
MESH:D016135 Spinal Dysraphism sodium arsenite 9.1612854658
MESH:D016135 Spinal Dysraphism Valproic Acid 9.1619490988
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.1212587719
MESH:D013226 Status Epilepticus Valproic Acid 4.3912833885
MESH:D013272 Stomach Diseases Indomethacin 4.2710192188 15038085 17207306 10215738 18545984 10486359 16113693 15472012 16280098 18209964 17638125 17160473 16184426
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.6517007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.6518456281
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 4.6516033868
MESH:D013274 Stomach Neoplasms Indomethacin 4.6515609394
MESH:D013276 Stomach Ulcer Indomethacin 3.4510878458 16252198 18209962 12500499 1323529 12787963 10423059 11145282 18181030 16934674 17895592 18726076 17135157 18087811 10750652 17654042 11595415 17657623 18543354 11595431 14567935 18237397 16397915 11523592 15138204 15255614 17918041 18193104 17627676 16169175 18431645 11906479 18299717 16755016 15104355 17977527 16150113 16631530 12498302 12077510 12467913 11729361
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7512697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 11.3819014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.387505956
MESH:D013964 Thyroid Neoplasms Indomethacin 11.3814736730 11352223 18791128
MESH:D014062 Tongue Neoplasms Zinc 4.2616543248
MESH:D016171 Torsades de Pointes arsenic trioxide 3.8115213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.0817262798
MESH:D014456 Ulcer Indomethacin 4.7417380554 10574470
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.373119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.4416049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.4416049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 11.4412845720 12973940 11780464 20435036
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 11.4417306315 16452187 16712894 11723127
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.498888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.4810091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.4810091137
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.6311813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1514692618
MESH:D014605 Uveitis Cyclosporine 3.831336536
MESH:D014652 Vascular Diseases sodium arsenite 4.2717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4015869587 14671159
MESH:D014839 Vomiting Indomethacin 4.5911897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
MESH:D014985 Xerophthalmia Cyclosporine 4.2917120751
Pathway ID Pathway Name
KEGG:00520 Amino sugar and nucleotide sugar metabolism
REACT:11193 Metabolism of vitamins and cofactors
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27331
    • No data
    Releated disease ID Related disease Name
    PA443936Drug Hypersensitivity
    Releated drug ID Related drug Name
    PA449780glutathione
    PA451898vitamin c
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00157 - NADH Dietary supplement;Micronutrient
    DB01907 - Nicotinamide-Adenine-Dinucleotide
    DB03147 - Flavin-Adenine Dinucleotide
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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