AutismKB 2.0

Annotation Detail for DLG1


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Basic Information Top
Gene Symbol:DLG1 ( DKFZp761P0818,DKFZp781B0426,DLGH1,SAP-97,SAP97,dJ1061C18.1.1,hdlg )
Gene Full Name: discs, large homolog 1 (Drosophila)
Band: 3q29
Quick LinksEntrez ID:1739; OMIM: 601014; Uniprot ID:DLG1_HUMAN; ENSEMBL ID: ENSG00000075711; HGNC ID: 2900
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04660T cell receptor signaling pathway
Pathway IDPathway Name
Synaptic Transmission
Axon guidance
Pathway IDPathway Name
200105E-cadherin signaling in the nascent adherens junction
200057CDC42 signaling events
No data
Pathway IDPathway Name
500171Trafficking of AMPA receptors
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of DLG1 mRNAdecreases expression 20406850
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of DLG1 mRNAincreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DLG1 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of DLG1 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DLG1 mRNAdecreases expression 19150397
D016291 Dizocilpine Maleate Dizocilpine Maleate results in increased expression of DLG1 mRNAincreases expression 11169168
D005472 Fluorouracil DLG1 protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]affects cotreatment|affects response to substance 18927307
C051890 irinotecan DLG1 protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]affects cotreatment|affects response to substance 18927307
C051890 irinotecan irinotecan analog results in decreased expression of DLG1 mRNAdecreases expression 18927307
D009151 Mustard Gas Mustard Gas affects the expression of DLG1 mRNAaffects expression 15651846
D012643 Selenium Selenium results in decreased expression of DLG1 mRNAdecreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DLG1 mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0415322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5120464547 20127859
MESH:D000230 Adenocarcinoma Fluorouracil 4.5117638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.853712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.856695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000740 Anemia Fluorouracil 9.1215504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.1211748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001249 Asthma Mustard Gas 2.7510378619
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.2411289319 1440618
MESH:D001768 Blister Mustard Gas 5.3519167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8320146248 17474063
MESH:D001943 Breast Neoplasms Fluorouracil 1.8315136595 16110121 16557594 18357371 16595493 18608205 19217205
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8320435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.3515286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1917687719 10378619
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8916051944
MESH:D002277 Carcinoma Fluorouracil 8.5617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.5616835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7116705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.713581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.7117088986 17045692 17971768 16332177 18930000 16799960
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.697296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.6918695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7620419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.7618986760 16280240 17066447 16757204
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418850075 16120746 18670907
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.726135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.727505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.7220889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.259022650 19486331
MESH:D002972 Cleft Palate marker/mechanism 11238884
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1515340226 8697196 15668235 16354765 12621046
MESH:D003092 Colitis Selenium 3.9517936198
MESH:D003110 Colonic Neoplasms Fluorouracil 4.0417018589 17725105 17172411 18772588 17169374 16510598 17016597 15001691 16340194 17287894
MESH:D003110 Colonic Neoplasms irinotecan 4.0417725105 17287894
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.7614970324 17695437 17255274 18448328 16391804 15148649 15289873 16524972 18383874 16331619 18509181 20501625 17016601 17401013 17454858 16282729 18949393 18802399 18288408 17094418 17594712 16303861
MESH:D015179 Colorectal Neoplasms irinotecan 2.7616391804 18259882 17159606 18509181 16303861 17454858 15273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1918551238
MESH:D007644 Darier Disease Fluorouracil 4.9916733453
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.972524372 11906362 8970840 8156756 14531868 12868966 11298694 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.643621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.2821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.286679447 16192314 18692083 7440962 18289764 9022650 9653073 11289319 18648102 8291058 6482804 9328219 1440618
MESH:D056486 Drug-Induced Liver Injury Selenium 9.2815131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.2820420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema Mustard Gas 7.3111402378 9260866 11428631 11428647
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.3112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1215322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D004890 Erythema Mustard Gas 5.359357497
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 10.663581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.6620426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 10.6616530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 10.6615173087 16481741 16337965 17638652 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.246705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1220067830
MESH:D005910 Glioma Fluorouracil 2.9216145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.197505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4815102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6711294989 10048152
MESH:D006333 Heart Failure Selenium 3.1517162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.676705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0715340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2616959395 15340226 8697196 18606429 16354765
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1115034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518850075 18670907
MESH:D007249 Inflammation Mustard Gas 5.279357497 9260866 16001271 17524151 11428631 11428620 11428647 8975870 11402378
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2712200463 12878042
MESH:D007251 Influenza, Human Selenium 4.4116624496
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.249022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007676 Kidney Failure, Chronic Selenium 4.0216518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.1416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.146582329
MESH:D007680 Kidney Neoplasms Fluorouracil 13.1416985049
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.289327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.097678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.0921137059 20195826
MESH:D008113 Liver Neoplasms Fluorouracil 11.0915113037 17045692 16603448 18383874
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.0916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.262876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.266587162 1399818 598648 3712494
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.2612151625
MESH:D008171 Lung Diseases Mustard Gas 3.5418702808 18161513
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9718520028 20464547 20135361 18816296 6695378 18569708 20064080 20869020 17053015
MESH:D008175 Lung Neoplasms Fluorouracil 4.9715246190
MESH:D008175 Lung Neoplasms Mustard Gas 4.973148597 8781369
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9719555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9915086387
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8515318939
MESH:D008654 Mesothelioma Selenium 2.8415107826
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.8916381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.8916757204 18986760
MESH:D052016 Mucositis irinotecan 5.2017159606
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.057678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.093581430
MESH:D009362 Neoplasm Metastasis irinotecan 6.0918259882
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2811141357
MESH:D009369 Neoplasms Fluorouracil 5.2818600527 16928823 18239605
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.006679447
MESH:D009447 Neuroblastoma irinotecan 3.548761367
MESH:D017599 Neuroectodermal Tumors irinotecan 4.928761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5316436463
MESH:D009503 Neutropenia Mustard Gas 4.127688884 16761898
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.3316049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.336482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.243988306
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7119003803 16929163 15113037 16500647
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.667296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.696228378
MESH:D010954 Plasmacytoma Selenium 5.1115087411
MESH:D011041 Poisoning Mustard Gas 3.9415727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811118676 11399792 11896295 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1917292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.1919082440 18626508
MESH:D011537 Pruritus Mustard Gas 4.2918058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9717720292 17266442 17620002 17894541 10334151
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1416160472 15538739 18722050 18286688
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.483692021
MESH:D012559 Schizophrenia marker/mechanism 18665322 20691406 12421351
MESH:D012640 Seizures 2,6-dinitrotoluene 6.8918551238
MESH:D012640 Seizures Dizocilpine Maleate 6.8911218047 17157343 12660363
MESH:D012871 Skin Diseases Mustard Gas 2.7416961503 12880345 15451306
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.6710029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6716192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.5020155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 3.5018567086 19084572 19015929 17498489 16424979 17172411 18396642 17522103 16951190 15786421
MESH:D013274 Stomach Neoplasms irinotecan 3.5015723263
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.993712494 6587162 1399818 6582329 7505956
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1216280240
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.5516049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.558074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.5517053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5110091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0116803524
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
Pathway ID Pathway Name
REACT:18266 Axon guidance
REACT:13685 Synaptic Transmission
KEGG:04660 T cell receptor signaling pathway
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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