AutismKB 2.0

Annotation Detail for AFP


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:AFP ( FETA,HPAFP )
Gene Full Name: alpha-fetoprotein
Band: 4q13.3
Quick LinksEntrez ID:174; OMIM: 104150; Uniprot ID:FETA_HUMAN; ENSEMBL ID: ENSG00000081051; HGNC ID: 317
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
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Pathway IDPathway Name
200073FOXA2 and FOXA3 transcription factor networks
200077Glucocorticoid receptor regulatory network
200101Direct p53 effectors
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
2052Infection
Desease Name
CANCER
alpha-fetoprotein
No data
Desease Name
AFP deficiency, congenital
Hereditary persistence of alpha-fetoprotein
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of AFP mRNAincreases expression 19933214
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of AFP mRNAincreases expression 20713471
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of AFP mRNAaffects expression 21346803
C016617 2-nitropropane 2-nitropropane results in increased expression of AFP proteinincreases expression 15804453
C016617 2-nitropropane diphenyldiselenide inhibits the reaction [2-nitropropane results in increased expression of AFP protein]decreases reaction|increases expression 15804453
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of AFP mRNAaffects expression 9327722
D000082 Acetaminophen Acetaminophen affects the expression of AFP mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of AFP proteinincreases expression 70250
D012436 S-Adenosylmethionine S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of AFP mRNA]decreases reaction|increases expression 18098314
D012436 S-Adenosylmethionine S-Adenosylmethionine results in decreased expression of AFP mRNAdecreases expression 18098314
D016604 Aflatoxin B1 Aflatoxin B1 results in increased expression of AFP mRNAincreases expression 11133813
D016604 Aflatoxin B1 ebselen inhibits the reaction [Aflatoxin B1 results in increased expression of AFP mRNA]decreases reaction|increases expression 11133813
C006463 allyl alcohol allyl alcohol results in increased expression of AFP proteinincreases expression 70250
C006463 allyl alcohol allyl alcohol results in increased expression of AFP proteinincreases expression 61145
C034499 allyl formate allyl formate results in increased expression of AFP proteinincreases expression 61145
D000607 Aminoacetonitrile Aminoacetonitrile inhibits the reaction [Carbon Tetrachloride results in increased expression of AFP protein]decreases reaction|increases expression 61145
D000643 Ammonium Chloride Ammonium Chloride affects the expression of AFP mRNAaffects expression 16483693
D001149 Arsenates Arsenates results in increased expression of AFP mRNAincreases expression 15345372
C015001 arsenite arsenite results in increased expression of AFP mRNAincreases expression 15345372
18991936
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of AFP mRNAincreases expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of AFP mRNAincreases expression 20713471
C006780 bisphenol A bisphenol A results in increased expression of AFP mRNAincreases expression 17785945
C006780 bisphenol A bisphenol A affects the expression of AFP mRNAaffects expression 14967926
D002101 Cacodylic Acid Cacodylic Acid results in increased expression of AFP mRNAincreases expression 15345372
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of AFP mRNAincreases expression 17668883
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of AFP proteinincreases expression 70250
16965562
D002251 Carbon Tetrachloride [2-Acetylaminofluorene co-treated with Carbon Tetrachloride] affects the expression of AFP proteinaffects cotreatment|affects expression 11813887
D002251 Carbon Tetrachloride Aminoacetonitrile inhibits the reaction [Carbon Tetrachloride results in increased expression of AFP protein]decreases reaction|increases expression 61145
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of AFP proteinincreases expression 61145
16965562
D002251 Carbon Tetrachloride N,N'-diphenyl-4-phenylenediamine inhibits the reaction [Carbon Tetrachloride results in increased expression of AFP protein]decreases reaction|increases expression 61145
D002794 Choline [2-Acetylaminofluorene co-treated with Choline deficiency] results in increased expression of AFP proteinaffects cotreatment|increases expression 6187438
D016572 Cyclosporine Cyclosporine results in increased expression of AFP mRNAincreases expression 20106945
D003997 Dicarbethoxydihydrocollidine Dicarbethoxydihydrocollidine results in increased expression of AFP mRNAincreases expression 18098314
D003997 Dicarbethoxydihydrocollidine S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of AFP mRNA]decreases reaction|increases expression 18098314
D004052 Diethylnitrosamine Diethylnitrosamine affects the expression of AFP mRNAaffects expression 19822196
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of AFP proteinincreases expression 19394651
D004052 Diethylnitrosamine FR 118487 inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]decreases reaction|increases expression 19394651
D004054 Diethylstilbestrol [Diethylstilbestrol co-treated with sodium arsenite] results in increased expression of AFP mRNAaffects cotreatment|increases expression 19665456
D004054 Diethylstilbestrol Diethylstilbestrol binds to AFP proteinaffects binding 9748407
D004054 Diethylstilbestrol Diethylstilbestrol inhibits the reaction [Estradiol binds to AFP protein]affects binding|decreases reaction 9748407
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of AFP mRNAincreases expression 17072980
C061132 diphenyldiselenide diphenyldiselenide inhibits the reaction [2-nitropropane results in increased expression of AFP protein]decreases reaction|increases expression 15804453
D004365 Drugs, Chinese Herbal Drugs, Chinese Herbal affects the expression of AFP proteinaffects expression 19850985
C042986 ebselen ebselen inhibits the reaction [Aflatoxin B1 results in increased expression of AFP mRNA]decreases reaction|increases expression 11133813
D004958 Estradiol [Estradiol co-treated with Progesterone] results in increased expression of AFP proteinaffects cotreatment|increases expression 18497072
D004958 Estradiol Diethylstilbestrol inhibits the reaction [Estradiol binds to AFP protein]affects binding|decreases reaction 9748407
D004958 Estradiol Estradiol binds to AFP proteinaffects binding 9748407
D004964 Estriol Estriol results in increased expression of AFP proteinincreases expression 18497072
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of AFP mRNAdecreases expression 17108234
D005001 Ethionine Ethionine results in increased expression of AFP proteinincreases expression 61145
D005419 Flavonoids Flavonoids results in increased expression of AFP mRNAincreases expression 18035473
D015073 2-Acetylaminofluorene [2-Acetylaminofluorene co-treated with Carbon Tetrachloride] affects the expression of AFP proteinaffects cotreatment|affects expression 11813887
D015073 2-Acetylaminofluorene [2-Acetylaminofluorene co-treated with Choline deficiency] results in increased expression of AFP proteinaffects cotreatment|increases expression 6187438
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of AFP mRNAincreases expression 17538966
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of AFP proteinincreases expression 17538966
11350689
15133858
C096036 FR 118487 FR 118487 inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]decreases reaction|increases expression 19394651
D005688 Galactosamine Galactosamine results in increased expression of AFP proteinincreases expression 16965562
61145
D006063 Chorionic Gonadotropin Chorionic Gonadotropin results in increased expression of AFP proteinincreases expression 18497072
D008770 Methylnitrosourea AFP protein modified form results in decreased susceptibility to Methylnitrosoureadecreases response to substance 16322315
C091888 monoisoamyl-2,3-dimercaptosuccinate monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased expression of AFP mRNA]decreases expression|decreases reaction 19615344
C091888 monoisoamyl-2,3-dimercaptosuccinate monoisoamyl-2,3-dimercaptosuccinate results in decreased expression of AFP mRNAdecreases expression 19615344
C020300 monomethylarsonic acid monomethylarsonic acid results in increased expression of AFP mRNAincreases expression 15345372
C004845 N,N'-diphenyl-4-phenylenediamine N,N'-diphenyl-4-phenylenediamine inhibits the reaction [Carbon Tetrachloride results in increased expression of AFP protein]decreases reaction|increases expression 61145
C002741 N-nitrosomorpholine N-nitrosomorpholine results in increased expression of AFP proteinincreases expression 16965562
D009705 Nucleosides Nucleosides results in increased expression of AFP mRNAincreases expression 15173389
D010126 Ozone TTPA protein affects the reaction [Ozone results in increased expression of AFP mRNA]affects reaction|increases expression 19555225
C055778 panaxydol panaxydol results in decreased secretion of AFP proteindecreases secretion 19450571
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of AFP mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of AFP mRNAincreases expression 19482888
D010672 Phenytoin Phenytoin results in decreased expression of AFP mRNAdecreases expression 14741686
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of AFP mRNAaffects binding|decreases expression|increases activity 19710929
D011374 Progesterone [Estradiol co-treated with Progesterone] results in increased expression of AFP proteinaffects cotreatment|increases expression 18497072
C017947 sodium arsenite monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased expression of AFP mRNA]decreases expression|decreases reaction 19615344
C017947 sodium arsenite sodium arsenite results in decreased expression of AFP mRNAdecreases expression 19615344
C017947 sodium arsenite [Diethylstilbestrol co-treated with sodium arsenite] results in increased expression of AFP mRNAaffects cotreatment|increases expression 19665456
C017947 sodium arsenite sodium arsenite affects the expression of AFP mRNAaffects expression 16507464
C017947 sodium arsenite [sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of AFP mRNAaffects cotreatment|increases expression 16368122
C017947 sodium arsenite [sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of AFP proteinaffects cotreatment|increases expression 16368122
C017947 sodium arsenite sodium arsenite results in increased expression of AFP mRNAincreases expression 17077188
15276417
16322246
14691202
C017947 sodium arsenite sodium arsenite results in increased expression of AFP proteinincreases expression 17077188
16507464
C017947 sodium arsenite sodium arsenite results in increased expression of AFP mRNAincreases expression 16876216
C017947 sodium arsenite sodium arsenite results in increased expression of AFP proteinincreases expression 16876216
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of AFP mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of AFP mRNAincreases expression 16083274
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of AFP proteinincreases expression 16083274
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of AFP mRNAincreases expression 19933214
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of AFP mRNAincreases expression 15644576
D013755 Tetradecanoylphorbol Acetate [sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of AFP mRNAaffects cotreatment|increases expression 16368122
D013755 Tetradecanoylphorbol Acetate [sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of AFP proteinaffects cotreatment|increases expression 16368122
D013853 Thioacetamide Thioacetamide results in increased expression of AFP proteinincreases expression 61145
D014212 Tretinoin Tretinoin results in increased expression of AFP mRNAincreases expression 16619266
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 11.136195326
MESH:D000014 Abnormalities, Drug-Induced Phenytoin 11.138986270 10563481 9677735 9118846 6195326 3425630
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.1314514962 15322242 11752688
MESH:D000038 Abscess Drugs, Chinese Herbal 5.7415043669
MESH:D000138 Acidosis Ammonium Chloride 3.0118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.3817505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.6118653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 11.6620127859 20464547
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 11.6616033868
MESH:D000230 Adenocarcinoma Estradiol 11.6611473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 11.6614692618
MESH:D000230 Adenocarcinoma Methylnitrosourea 11.6615688392 15113128
MESH:D000236 Adenoma 2-Acetylaminofluorene 17.3710737359
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 17.373712494
MESH:D000236 Adenoma Benzo(a)pyrene 17.376695378
MESH:D000236 Adenoma Diethylnitrosamine 17.376695378 10737359
MESH:D000236 Adenoma Dimethylnitrosamine 17.3719555203
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.446705139
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 20.3019061943 18056438 19052882 17162532 16434500 17620307
MESH:D018248 Adenoma, Liver Cell Phenobarbital 20.3017620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 20.3016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 20.3016835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.1315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.3316712894 17306315
MESH:D000505 Alopecia Tretinoin 3.1715955085
MESH:D000544 Alzheimer Disease Ozone 2.3015513908
MESH:D000686 Amyloidosis Diethylstilbestrol 3.9515469931
MESH:D000740 Anemia Drugs, Chinese Herbal 7.4215504547 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.4211748828
MESH:D000787 Angina Pectoris Drugs, Chinese Herbal 4.8511477813
MESH:D000799 Angioedema Acetaminophen 3.2810982225
MESH:D001004 Anus Diseases Drugs, Chinese Herbal 5.4015043669
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.5319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.9211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.0015885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.0016412693
MESH:D015210 Arthritis, Gouty Drugs, Chinese Herbal 5.2019655406
MESH:D001172 Arthritis, Rheumatoid Ozone 4.1215570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.1216292516
MESH:D001249 Asthma Ozone 4.2716373670 17854713
MESH:D001249 Asthma Tretinoin 4.2716456186
MESH:D050197 Atherosclerosis Phenytoin 3.5815136057
MESH:D001321 Autistic Disorder Acetaminophen 2.3818445737
MESH:D001321 Autistic Disorder Choline 2.3816818868
MESH:D001321 Autistic Disorder S-Adenosylmethionine 2.3819056591 16917939
MESH:D001471 Barrett Esophagus Tretinoin 3.8716935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.4511289319 1440618
MESH:D001778 Blood Coagulation Disorders Ethionine 23.5519483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 23.5519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 23.5512125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 23.5519483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 23.5516206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.3915746008
MESH:D001862 Bone Resorption bisphenol A 8.1811985600
MESH:D001862 Bone Resorption Drugs, Chinese Herbal 8.189881647
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.7717868700
MESH:D001930 Brain Injuries Progesterone 3.7215845082 15665606 15380490
MESH:D001943 Breast Neoplasms therapeutic 18497072
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 7.3511921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 7.3517474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 7.3517123778
MESH:D001943 Breast Neoplasms Cacodylic Acid 7.3517474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 7.3517474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 7.3517129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 7.3517289903 12948864 14630087 17261762 19861407 18497071 17018787 16675129
MESH:D001943 Breast Neoplasms Methylnitrosourea 7.3516253758 11306469 14633655
MESH:D001943 Breast Neoplasms Progesterone 7.3516175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 7.3520435547
MESH:D001943 Breast Neoplasms Tretinoin 7.3516443354 16166294 16873071
MESH:D016535 Bronchial Hyperreactivity Ozone 3.2317626835 15516495 19059883 18315731 18417511 16777450 14754758
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.0316813970
MESH:D002100 Cachexia Ozone 4.1816183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9116111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.243786805 16124888 10355542 16011737 15673190 16097048 15721981 18705752 15700767 16050911 16227642 16192424
MESH:D002277 Carcinoma Dimethylnitrosamine 6.8819555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.8816835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.5916168501
MESH:D006528 Carcinoma, Hepatocellular marker/mechanism 9029167 15276417
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 39.2216705839
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 39.223581430 3084413 6705139 17761372 10737359
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 39.223581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 39.223084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 39.2212619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 39.2218788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 39.2217055752 17173139 16569478 18506893 16540662 17138121 20214788 17428255 16935385 20935162 16698587 19519916 20727157 18788625 16328049 3581430 20512989 18785209 16502159 18393292 10672840 20084675 19208518 19171122 18978308 16878318 16830150 19052882 20514400 19919837 16779866 19394651 11831363 16288022 18056438 17978847 18691550 17761372 16681979 18210153 20007298 19539802 17162532 19335982 20524982 19701751 20101231 16807293 18665156 3084413 10737359 19418558 19383236 19107877 19822196 18971187 21159647 20432363 18494052
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 39.2215948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 39.2216924424
MESH:D006528 Carcinoma, Hepatocellular FR 118487 39.2219394651
MESH:D006528 Carcinoma, Hepatocellular N-nitrosomorpholine 39.2215543204 9466558 16935385 8364915 15010824 1701930 11509945 19383236 1967229 2885971 10629087 9311599 19335982 9029167 1917145
MESH:D006528 Carcinoma, Hepatocellular panaxydol 39.2219450571
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 39.2217173139 20007298 20935162 1701930 6705139
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 39.2217306315 15276417 16507464
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 39.2217997003
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 39.221917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.4317123778
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.157296757
MESH:D002292 Carcinoma, Renal Cell N-nitrosomorpholine 6.157921415 1429202
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 12.2220419170
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 12.2216033868
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 12.2218572023
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 12.2218922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 12.2216051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.0418850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 10.4010977129
MESH:D002386 Cataract Methylnitrosourea 10.4012484553
MESH:D002386 Cataract Tretinoin 10.4017460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 25.737505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 25.7312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 25.7317174075 21159647 7505956 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 25.7318566989
MESH:D002471 Cell Transformation, Neoplastic Galactosamine 25.737505956
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 25.732727394 7505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 25.7320056578 19524636
MESH:D002493 Central Nervous System Diseases Phenobarbital 9.864080065
MESH:D002493 Central Nervous System Diseases Phenytoin 9.864080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.0316129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 13.3919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 13.3916835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 13.3918291259
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 15.7619486331 9022650
MESH:D002779 Cholestasis Cyclosporine 15.7619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 15.7616105132 11677210 17681005 16919318 15861022 17333356 17110522
MESH:D002779 Cholestasis pirinixic acid 15.7619176532
OMIM:601042 CHOREOATHETOSIS/SPASTICITY, EPISODIC Phenytoin 5.3111748493
MESH:D002822 Choriocarcinoma Tretinoin 4.5916461808
MESH:D002971 Cleft Lip Phenytoin 3.842227380
MESH:D002972 Cleft Palate Phenytoin 8.3810789828 6856622 1687470 6862529 3877104 2227380
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 8.3812621046 8697196 15340226 16354765 15668235
MESH:D002972 Cleft Palate Tretinoin 8.389407595
MESH:D003092 Colitis Tretinoin 3.1717035595
MESH:D003103 Coloboma Phenytoin 4.659212184
MESH:D003110 Colonic Neoplasms arsenite 2.4815037631
MESH:D000013 Congenital Abnormalities Phenytoin 7.8210627286
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 7.8214669216 17141729
MESH:D019465 Craniofacial Abnormalities Phenytoin 3.458986270 9212184 19952982
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.4520055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.4510589399 8800419 9664655 9125849 14991402 9224671 17551590 9142499 16925845 9211117
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.0316002989 12952375
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.4718551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.308156756 18759878 2524372 11298694 12868966 14531868 11906362 8970840
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1418249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 2.983621924 2952479
MESH:D002658 Developmental Disabilities Choline 4.2816818868
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 3.6520387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.6517107852
MESH:D003928 Diabetic Nephropathies Estradiol 2.9419279558
MESH:D003929 Diabetic Neuropathies Progesterone 3.9517187935
OMIM:607208 DRAVET SYNDROME Phenytoin 4.8411748493
MESH:D003875 Drug Eruptions Phenytoin 4.9615024534
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 35.9318551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2-nitropropane 35.9316445897 20517888 15804453
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 35.931440618 11289319 16192314 9653073 7440962 18692083 9022650 18648102 6679447 18289764 8291058 6482804 9328219
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 35.9316109766 11743745 16485898 14550746 10774834 17906064 19420014 11529661 15619225 10663392 16177239 12153990 19370779 18071297 17562736 12540782 12594235 18713872 2444490 11287661 19164858 10915739 15968718 11739529 16081117 14986274 16393943 19739265 19085960 12958197 19923254 16781746 12392966 14725611 11421492 17522070 19416960 11461765 16227642 11834606 12705907
MESH:D056486 Drug-Induced Liver Injury allyl alcohol 35.937440962
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 35.937179309 17522070 6884620 16177239 2869522 19085960 15027814 15968718 10092053 4309450 6623471 10915739 16227642 21278145 3786805 9327722 15998439 7440962 19336974 3732212 7120509 11566570
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 35.9319107877
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 35.938172417
MESH:D056486 Drug-Induced Liver Injury diphenyldiselenide 35.9315804453 16445897
MESH:D056486 Drug-Induced Liver Injury Drugs, Chinese Herbal 35.9315027814
MESH:D056486 Drug-Induced Liver Injury Galactosamine 35.9315968718
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 35.9320420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 35.9312963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.3411462148
MESH:D004421 Dystonia Phenobarbital 3.491851702
MESH:D004487 Edema pirinixic acid 8.6212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 8.6211000095 12711302
MESH:D004487 Edema Tetradecanoylphorbol Acetate 8.629599246 11698051 8273558 15177302 8113982 7812673 16716910
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.0615322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.0618230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 12.4312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Phenytoin 12.4317654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 12.4317692515
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 10.5916402032
MESH:D004714 Endometrial Hyperplasia Estriol 10.5916402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 10.2715700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 10.2719148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Tretinoin 10.2716569247
MESH:D004715 Endometriosis Progesterone 7.3216134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.329294722 10568697
MESH:D004816 Epidermal Necrolysis, Toxic Phenytoin 4.6720235791
MESH:D004820 Epidermolysis Bullosa Phenytoin 5.671399206 6251365
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.573659116
MESH:D004828 Epilepsies, Partial Phenobarbital 8.463922381 11558140
MESH:D004828 Epilepsies, Partial Phenytoin 8.4611558140 17116037
MESH:D004827 Epilepsy Phenobarbital 5.9920417680
MESH:D004827 Epilepsy Phenytoin 5.9911434505 821787 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.076401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 9.867750514
MESH:D017029 Epilepsy, Complex Partial Phenytoin 9.867750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 9.003659116
MESH:D004830 Epilepsy, Tonic-Clonic Phenytoin 9.003659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.5516302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.253581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.2516530937
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 6.2517016578
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.4311564622
MESH:D005124 Eye Abnormalities Tretinoin 7.4316938888 9664655
MESH:D005218 Fat Necrosis Thioacetamide 5.1516456712
MESH:D005234 Fatty Liver arsenite 24.2818296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 24.2817595544 19224547 15959796 61145 12795759 12631006 16045604 16239168
MESH:D005234 Fatty Liver Cyclosporine 24.2819224547
MESH:D005234 Fatty Liver Diethylnitrosamine 24.2820387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 24.2815345470
MESH:D005234 Fatty Liver pirinixic acid 24.2819236843 20131406
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.3016513791 16611131 16002989 16534752 15751030
MESH:D005313 Fetal Death Phenytoin 8.9310627286
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 8.9311858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.456705139
MESH:D005354 Fibrosarcoma Methylnitrosourea 4.6711555667
MESH:D005355 Fibrosis arsenite 22.0118296743
MESH:D005355 Fibrosis Carbon Tetrachloride 22.0118705752
MESH:D005355 Fibrosis Cyclosporine 22.0112639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 22.0120067830
MESH:D005355 Fibrosis Tretinoin 22.0117994277
MESH:D005756 Gastritis Acetaminophen 3.1116983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 10.9616452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 10.9616452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 11.068708960
MESH:D005885 Gingival Hyperplasia Phenytoin 11.069029455
MESH:D019214 Gingival Overgrowth Phenytoin 5.6714659971 16390469
MESH:D005909 Glioblastoma Tretinoin 2.6317312396
MESH:D005910 Glioma Methylnitrosourea 3.329825942
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.527505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0310696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.8016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.5916084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.2320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.2310048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 9.2314991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.1820558911
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 4.756705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 3.916705139
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.8615720958
MESH:D006461 Hemolysis allyl alcohol 5.682222504
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8411000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.0717276928 18665440 15929193
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 23.796705139
MESH:D006505 Hepatitis allyl alcohol 23.7911394713
MESH:D006505 Hepatitis Carbon Tetrachloride 23.7919900420 19110552
MESH:D006505 Hepatitis Drugs, Chinese Herbal 23.7918339527
MESH:D006505 Hepatitis Thioacetamide 23.7916456712
MESH:D006529 Hepatomegaly Phenobarbital 11.2616109766
MESH:D006529 Hepatomegaly pirinixic acid 11.2618467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 11.2615340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.4615709030
MESH:D006689 Hodgkin Disease sodium arsenite 2.7012676792
MESH:D019584 Hot Flashes Estradiol 3.1917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.488697196 18606429 16354765 15340226 16959395
MESH:D006930 Hyperalgesia Acetaminophen 6.1516870215
MESH:D006930 Hyperalgesia Tretinoin 6.1516870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.9716899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.0216778211
MESH:D006943 Hyperglycemia pirinixic acid 2.7020558911
MESH:D020138 Hyperhomocysteinemia Phenytoin 4.2010459572
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 9.0315034207
MESH:D006965 Hyperplasia Diethylstilbestrol 9.0314722030 12960047
MESH:D006973 Hypertension Cyclosporine 4.1410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.1418670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.5415338365
MESH:D007021 Hypospadias Diethylstilbestrol 9.4416002989
MESH:D007021 Hypospadias Ethinyl Estradiol 9.4416569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.8615869954
MESH:D007246 Infertility Diethylstilbestrol 3.8315036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.9512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.0717937319
MESH:D007248 Infertility, Male Methylnitrosourea 9.077193160
MESH:D007248 Infertility, Male sodium arsenite 9.0715346721 12646999
MESH:D007249 Inflammation Diethylnitrosamine 12.5118785209
MESH:D007249 Inflammation Flavonoids 12.5117296493
MESH:D007249 Inflammation Progesterone 12.5115869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 12.5112878042 12200463
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 12.517812673 15177302 8273558 11698051 7562506
MESH:D007333 Insulin Resistance bisphenol A 10.1116393666
MESH:D007333 Insulin Resistance Estradiol 10.1116627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 10.1116306350
MESH:D007410 Intestinal Diseases Tretinoin 3.2317994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.459022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.2716580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.2717551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.8715604871
MESH:D007674 Kidney Diseases Acetaminophen 11.5915629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 11.5918776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 11.5915618244
MESH:D007674 Kidney Diseases sodium arsenite 11.5920008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 18.5216705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 18.526582329
MESH:D007680 Kidney Neoplasms Cyclosporine 18.5212371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 18.5216762066 15003126 14681315
MESH:D007680 Kidney Neoplasms Estradiol 18.5215610895
MESH:D007859 Learning Disorders Diethylstilbestrol 3.5217184923
MESH:D007938 Leukemia Tretinoin 2.4717143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Drugs, Chinese Herbal 3.6715802533
MESH:D007951 Leukemia, Myeloid Tretinoin 3.2019285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 1.9716294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.7717649720 16935935 19075265 19225113 9834237 12679006 16891316 16788101 17712046 19029980 17361223 17506722 19642359 17301526 16331271 17294898 16140955 16823087 17368321 17107899 17217047 19035177 17339181 15748426 16766008
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 7.0915526292
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.099224671
MESH:D008103 Liver Cirrhosis arsenite 17.2418296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 17.2417334410 16943688 17174718 16221502 11903743 16239168 17157831 11408273 21278145
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 17.2419638242 20032147 18522880 18665156 18407596
MESH:D008103 Liver Cirrhosis Drugs, Chinese Herbal 17.2417163593
MESH:D008103 Liver Cirrhosis Phenobarbital 17.2421047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.839327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental marker/mechanism 17072980
MESH:D008106 Liver Cirrhosis, Experimental allyl alcohol 18.6018564211 11063159
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 18.6014512876 12546737 20821823 18429990 14716496 17714472 15925388 15673190 18006644 15818738 12666154 12898905 18210741 17761835 18412020 15730626 14748882 18339082 12649538 18376398 17565644 15123356 17698563 18251166 16248980 12741479 18166357 17557913 17922224 12632514 17944888 17708605 15057751 15362042 15931870 12586293 14724832 15996030 18054572 16027843 16136751 15959796 18705752 14716833 18472332 18263696 16015684 17721639 18317297 15052691 17869086 10355542 18395914 18279442 18472094 17900296 12445418 16097048 15650968 13678700 12389079 18205269 14620537 18418968 17805973 16033810 11481614 17766677 15370692 12667390 18481824 15893842 16638106 17525996 17481882 12445421 18277467 17640975 17823541 12958196 15338365 15876570 16116963 16011737 18187930 17976157 18395095 12609069 18156304 18420326 17631135 16192424 12632512
MESH:D008106 Liver Cirrhosis, Experimental Dicarbethoxydihydrocollidine 18.6016015684
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 18.6018567088 15763062 16627068 17198567 14568256 15571005 17534399 17432682 15369754 15479170 15798949 14643895 15161499 15067225 15577212 16042886 14726149 16009107 18637143 17465448 15383259 17724770 17201889 15081153 15504291 18672772 12918455 15942678 15298665 16169303 15339415 18239293 15744066 18364076 18629640 15864749 17640959 14709902 18095165 17348192 14659978 15591649 18237412 16570917 15842777 17203207 15099470 15723089 12925901 18371158 15733078 15138612 17036385 17196135 15366600 17719030 16270385 18210741 17666798 17881167 16603200 16544323 15793283 15492853 15086199
MESH:D008106 Liver Cirrhosis, Experimental Drugs, Chinese Herbal 18.6015744066 17348192 16610055 15383259 18606216 15754396 17881167 17629604 18237412 18567088 15818738 15864749 15849816 12632512 15763062 18371158 17036385 17666798 15339415 15641146
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 18.6014659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 18.6015474484
MESH:D008106 Liver Cirrhosis, Experimental S-Adenosylmethionine 18.6015983038
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 18.6012878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 18.6017127702 15334695 17050028 11682029 16097051 12531686 16489207 11172339 12891558 15474484 18395095 15075984 12085344 16098781 18606216 12679928 18263696 15095483 10677585 14739098 12557150 11481614 16343077 15078482 17292413 17629604 18380797 18416461 16511523 15288473 12175628 18032466 15716488 16126171 18031379 15316131 17355460 16248980 15288472 18458672 18615449 18295389 15158331 15362042 15465738
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 18.6018397230 16248980
MESH:D008107 Liver Diseases marker/mechanism 16965562
MESH:D008107 Liver Diseases Acetaminophen 16.6011587558 19460945 12587719 19014921 16611625 12969438 19784758 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 16.6015830285 16246199 17285989 15720792 16964402
MESH:D008107 Liver Diseases Diethylnitrosamine 16.6017034775
MESH:D008107 Liver Diseases Drugs, Chinese Herbal 16.6017207593
MESH:D008107 Liver Diseases Phenobarbital 16.6019363144
MESH:D008107 Liver Diseases Phenytoin 16.6014986274
MESH:D008107 Liver Diseases Thioacetamide 16.6018374380 15158337 16337175
MESH:D017093 Liver Failure Carbon Tetrachloride 10.1615123358
MESH:D017093 Liver Failure Galactosamine 10.1611023982
MESH:D017114 Liver Failure, Acute Acetaminophen 19.2817185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 19.2816899240 14706259
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 19.2817457977
MESH:D017114 Liver Failure, Acute Thioacetamide 19.2815313186 12479984 15633222 17276928
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 36.8616273603 14678523 10672840 18001218 10737359 11376686
MESH:D008113 Liver Neoplasms Aflatoxin B1 36.8618177683 15890375 2125692 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 36.8620195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 36.8619294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 36.8619073162 19996281 19427195 20583210 15885732 20101389 2862719 18648771 16942905 18977376 20501860 19254457 18978307 21167192 20118626 19255062 21071580 20434301 19551842 15175105 19642983 19294768 2422723 19850985 19090486 10737359 19833225 20452335 19690152 20492335 19638242 21278145 19256749 9163691 19812893 21047994 12112319 18644402 19499222 20137499 18754104 12771043 19426721 20405173
MESH:D008113 Liver Neoplasms Diethylstilbestrol 36.8615890375 16712894
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 36.8615890375 3113478
MESH:D008113 Liver Neoplasms Drugs, Chinese Herbal 36.8618339527
MESH:D008113 Liver Neoplasms Phenobarbital 36.8615975961 19482888 19073162 21047994 19812893 8742319
MESH:D008113 Liver Neoplasms pirinixic acid 36.8616377806 15890375 20007298
MESH:D008113 Liver Neoplasms sodium arsenite 36.8615276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 36.8616984957
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 26.856150874 1399818 534488
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 26.85598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 26.858603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 26.8512014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 26.8518253720 3124819 18164116 18093689 9362446 16267830 19004024 17942915 19126423 18775883 21159647 18544905 17174075 19539802 2563599 19009564 19519916 18079962 16842330 18308698 17854601 18282651
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 26.8515603536 6150874 1848544
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 26.852563599 1399818 18308698 17172636 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 26.8512151625
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 4.9216080182
MESH:D008171 Lung Diseases Ozone 6.228266340 19066396
MESH:D008171 Lung Diseases sodium arsenite 6.2219095001
MESH:D055370 Lung Injury Ozone 3.3120417186
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 20.7711376686
MESH:D008175 Lung Neoplasms Aflatoxin B1 20.7714755239
MESH:D008175 Lung Neoplasms arsenite 20.7716809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 20.7720869020 20464547 6695378 18520028 18569708 17053015 20135361 18816296 20064080
MESH:D008175 Lung Neoplasms Diethylnitrosamine 20.7720970405 6695378 20512841 21163286
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 20.7719555203 11884234 16061637
MESH:D008175 Lung Neoplasms Drugs, Chinese Herbal 20.7718339527
MESH:D008175 Lung Neoplasms Methylnitrosourea 20.7718062963
MESH:D008175 Lung Neoplasms Ozone 20.778597069 7614698
MESH:D008175 Lung Neoplasms sodium arsenite 20.7717306315 19931552 16712894 15276417 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 20.7719555203 11884234
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 20.7711807781
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.5915166399
MESH:D008223 Lymphoma Diethylstilbestrol 6.5915700306
MESH:D008223 Lymphoma Methylnitrosourea 6.5911418001 16257854
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 4.2614633661
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 4.9516002989
MESH:D008325 Mammary Neoplasms, Experimental therapeutic 16322315
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 18.7411921183
MESH:D008325 Mammary Neoplasms, Experimental Drugs, Chinese Herbal 18.7414758024
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 18.7416891317 11807958 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 18.7417131329 15688392 17020996 10838139 10767621 16944150 15313902 12931682 14633655 14999141 11807958 16619500 11751437 16827153 16051031 19196723 15113128
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 18.7411408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 18.748985016
MESH:D020149 Manganese Poisoning Estradiol 3.9219453300
MESH:D008527 Medulloblastoma Tretinoin 2.5417453147
MESH:D008545 Melanoma sodium arsenite 2.9516487513 19082730
MESH:D008545 Melanoma Tretinoin 2.9516752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0219513568
MESH:D008591 Meningomyelocele Tretinoin 3.8816940565
MESH:D008607 Mental Retardation Phenytoin 3.469212184
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.2216801185
MESH:D008679 Metaplasia Ozone 4.5410496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.7616381670
MESH:D009135 Muscular Diseases pirinixic acid 2.9716239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.7417596541
MESH:D009203 Myocardial Infarction pirinixic acid 1.8919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.5712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 6.8116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 6.8116411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 10.6417484760
MESH:D020191 Myoclonic Epilepsies, Progressive Phenytoin 10.6417484760
MESH:D009224 Myotonia Congenita Phenytoin 4.851896199
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.1318551238
MESH:D009336 Necrosis 2-nitropropane 9.1312195237
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 4.853581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 4.853581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 15.8411141357
MESH:D009369 Neoplasms Diethylstilbestrol 15.8415313581
MESH:D009369 Neoplasms Methylnitrosourea 15.8415533788
MESH:D009369 Neoplasms pirinixic acid 15.8417405874
MESH:D009369 Neoplasms sodium arsenite 15.8411559025
MESH:D009369 Neoplasms Tretinoin 15.8416946489 16594593
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 7.6112696579
MESH:D009374 Neoplasms, Experimental sodium arsenite 7.6120056578
MESH:D009389 Neovascularization, Pathologic arsenite 8.3115738583
MESH:D009389 Neovascularization, Pathologic Estradiol 8.3117289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.8717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.8118481113 19348381
MESH:D009421 Nervous System Malformations bisphenol A 25.1516427766 11399458
MESH:D009421 Nervous System Malformations Diethylstilbestrol 25.1511399458
MESH:D009421 Nervous System Malformations Estradiol 25.1516427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 25.1514600291
MESH:D009421 Nervous System Malformations Tretinoin 25.159125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 14.256679447
MESH:D009436 Neural Tube Defects Phenytoin 14.259118846
MESH:D009436 Neural Tube Defects sodium arsenite 14.2512854658
MESH:D009436 Neural Tube Defects Tretinoin 14.259142499
MESH:D009442 Neurilemmoma Methylnitrosourea 4.9311555667
MESH:D019636 Neurodegenerative Diseases Acetaminophen 6.6618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 6.6620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.5520387270
MESH:D009765 Obesity pirinixic acid 1.6620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.2712819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 7.274026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.453988306
MESH:D010018 Osteomalacia Phenobarbital 10.2217016548
MESH:D010018 Osteomalacia Phenytoin 10.2217016548
MESH:D015663 Osteoporosis, Postmenopausal Drugs, Chinese Herbal 4.4716548355
MESH:D010049 Ovarian Diseases bisphenol A 4.4311985600
MESH:D010051 Ovarian Neoplasms Estradiol 9.5519401270
MESH:D010051 Ovarian Neoplasms Progesterone 9.5517393432 16525653
MESH:D010051 Ovarian Neoplasms sodium arsenite 9.5517306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 9.5516936753
MESH:D010146 Pain Acetaminophen 8.7316870215
MESH:D010146 Pain Phenytoin 8.7315215642
MESH:D010146 Pain Tretinoin 8.7316870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 13.8316540662
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 13.8316965848
MESH:D010190 Pancreatic Neoplasms Phenobarbital 13.8316965848
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 13.8315976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 13.8315976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.1711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 7.607296757
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 7.6012065085 18922899 18404319 8330346
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.6812520081
MESH:D010538 Peritonitis Ozone 3.5916369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 3.906228378
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.6014722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.1315687265 16977796
MESH:D011014 Pneumonia Ozone 3.8418381685 18929643 18007984
MESH:D017689 Polydactyly Phenytoin 4.579212184
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0318163543
MESH:D011230 Precancerous Conditions Cyclosporine 12.5512371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 12.552563599
MESH:D011230 Precancerous Conditions Phenobarbital 12.552563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 13.0710548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 13.0717184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 13.0711399792 11896295 11222880 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 8.8920887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 8.8920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8717292933
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8716740699
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.8717136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 1.8716740699
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 1.8715682402 12376480
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8716039940
MESH:D011507 Proteinuria Tretinoin 3.0916636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.7615861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 10.6712752131
MESH:D019310 Pseudolymphoma Phenytoin 10.6712752131 1419762 8603615
MESH:D011565 Psoriasis Cyclosporine 2.0116882103
MESH:D011625 Pterygium Tretinoin 4.2416723453
MESH:D011629 Puberty, Precocious bisphenol A 4.2310548101
MESH:D011658 Pulmonary Fibrosis Drugs, Chinese Herbal 3.4816987627
MESH:D012003 Rectal Fistula Drugs, Chinese Herbal 5.4015043669
MESH:D015427 Reperfusion Injury pirinixic acid 2.0919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3118990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 7.703692021
MESH:D012162 Retinal Degeneration Methylnitrosourea 7.7018155124 18172121
MESH:D012175 Retinoblastoma Methylnitrosourea 4.9311555667
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.5916116481 16283617
MESH:D012221 Rhinitis, Allergic, Perennial Drugs, Chinese Herbal 4.7115015336
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6318045962
MESH:D012640 Seizures 2,4-dinitrotoluene 7.7118551238
MESH:D012640 Seizures Phenobarbital 7.713137016 11442880 16876388 4039156
MESH:D012640 Seizures Phenytoin 7.7110029267 3691417 3137016 16876388 11044598 15946322 19919933 9844417
MESH:D003294 Seizures, Febrile Phenobarbital 4.266407741
MESH:D012871 Skin Diseases monomethylarsonic acid 3.8521378128
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 14.8219755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 14.8218572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 14.8216192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 14.8218404319 12065085 8330346 11807781 8985016
MESH:D012878 Skin Neoplasms Tretinoin 14.8216467112
MESH:D013088 Spermatocele Diethylstilbestrol 9.8316709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 9.8316709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.7216503802 15862959
MESH:D016135 Spinal Dysraphism sodium arsenite 3.3612854658
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.7012587719
MESH:D013262 Stevens-Johnson Syndrome Phenytoin 4.6120235791
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 7.292093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 7.2918456281
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 7.2916033868
MESH:D013274 Stomach Neoplasms Drugs, Chinese Herbal 7.2918339527
MESH:D013274 Stomach Neoplasms Methylnitrosourea 7.2915930296 16257854 18593901
MESH:D013274 Stomach Neoplasms Tretinoin 7.2917261132
MESH:D013345 Subarachnoid Hemorrhage Drugs, Chinese Herbal 5.2017634840
MESH:D019966 Substance-Related Disorders bisphenol A 3.4316684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.6815669648
MESH:D013953 Thymus Neoplasms Methylnitrosourea 4.6711418001
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3312697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 17.936587162 3712494 7505956 6582329 1399818
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 17.937505956
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 17.933078959 7505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 17.931399818
MESH:D013964 Thyroid Neoplasms Tretinoin 17.9317045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.1219048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.3016051514
MESH:D014376 Tuberculosis Tretinoin 2.8616040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 20.2716049721
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 20.271399818 15867355 15289314
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 20.278074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 20.2717053015
MESH:D001749 Urinary Bladder Neoplasms Cacodylic Acid 20.2715537745
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 20.2717306315 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 20.2716712894 16452187 11723127 17306315
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.7610091137
MESH:D014581 Urticaria Acetaminophen 2.4710982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 13.0816175088
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 13.0811813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 13.0816129372
MESH:D014591 Uterine Diseases bisphenol A 11.9314652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 11.9314652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 7.7215809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 7.7214692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.0416752155
MESH:D014605 Uveitis Cyclosporine 3.421336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 3.8916002989 16513791
MESH:D014652 Vascular Diseases sodium arsenite 3.8717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0415869587 14671159
MESH:D014820 Vitiligo Tretinoin 3.5316761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.6815886252
MESH:D009396 Wilms Tumor Tretinoin 3.4916287080
MESH:D014947 Wounds and Injuries Drugs, Chinese Herbal 4.0816313111
MESH:D014985 Xerophthalmia Cyclosporine 3.8717120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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